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Items: 24


Breaking the Glass Ceiling in Simulation and Modeling: Women in Pharmaceutical Discovery.

Damm-Ganamet KL, DesJarlais RL, Marrone T, Shih AY, Schiffer JM, Perez-Benito L, Mirzadegan T.

J Med Chem. 2020 Mar 12;63(5):1929-1936. doi: 10.1021/acs.jmedchem.9b01512. Epub 2020 Jan 22.


Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity.

Chambers JM, Miller W, Quichocho G, Upadhye V, Matteo DA, Bobkov AA, Sohl CD, Schiffer JM.

Biochemistry. 2020 Feb 4;59(4):479-490. doi: 10.1021/acs.biochem.9b01023. Epub 2020 Jan 13.


Improving the Efficiency of Ligand-Binding Protein Design with Molecular Dynamics Simulations.

Barros EP, Schiffer JM, Vorobieva A, Dou J, Baker D, Amaro RE.

J Chem Theory Comput. 2019 Oct 8;15(10):5703-5715. doi: 10.1021/acs.jctc.9b00483. Epub 2019 Sep 10.


Surfactant Charge Modulates Structure and Stability of Lipase-Embedded Monolayers at Marine-Relevant Aerosol Surfaces.

Luo M, Dommer AC, Schiffer JM, Rez DJ, Mitchell AR, Amaro RE, Grassian VH.

Langmuir. 2019 Jul 9;35(27):9050-9060. doi: 10.1021/acs.langmuir.9b00689. Epub 2019 Jun 25.


Conformational communication mediates the reset step in t6A biosynthesis.

Luthra A, Paranagama N, Swinehart W, Bayooz S, Phan P, Quach V, Schiffer JM, Stec B, Iwata-Reuyl D, Swairjo MA.

Nucleic Acids Res. 2019 Jul 9;47(12):6551-6567. doi: 10.1093/nar/gkz439.


Sea Spray Aerosol: Where Marine Biology Meets Atmospheric Chemistry.

Schiffer JM, Mael LE, Prather KA, Amaro RE, Grassian VH.

ACS Cent Sci. 2018 Dec 26;4(12):1617-1623. doi: 10.1021/acscentsci.8b00674. Epub 2018 Dec 14. Review.


Mechanisms for Benzene Dissociation through the Excited State of T4 Lysozyme L99A Mutant.

Feher VA, Schiffer JM, Mermelstein DJ, Mih N, Pierce LCT, McCammon JA, Amaro RE.

Biophys J. 2019 Jan 22;116(2):205-214. doi: 10.1016/j.bpj.2018.09.035. Epub 2018 Dec 8.


Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants.

Avellaneda Matteo D, Wells GA, Luna LA, Grunseth AJ, Zagnitko O, Scott DA, Hoang A, Luthra A, Swairjo MA, Schiffer JM, Sohl CD.

Biochem J. 2018 Oct 22;475(20):3221-3238. doi: 10.1042/BCJ20180424.


Impacts of Lipase Enzyme on the Surface Properties of Marine Aerosols.

Schiffer JM, Luo M, Dommer AC, Thoron G, Pendergraft M, Santander MV, Lucero D, Pecora de Barros E, Prather KA, Grassian VH, Amaro RE.

J Phys Chem Lett. 2018 Jul 19;9(14):3839-3849. doi: 10.1021/acs.jpclett.8b01363. Epub 2018 Jun 29.


Protein Cofactors Are Essential for High-Affinity DNA Binding by the Nuclear Factor κB RelA Subunit.

Mulero MC, Shahabi S, Ko MS, Schiffer JM, Huang DB, Wang VY, Amaro RE, Huxford T, Ghosh G.

Biochemistry. 2018 May 22;57(20):2943-2957. doi: 10.1021/acs.biochem.8b00158. Epub 2018 May 10.


Capturing Invisible Motions in the Transition from Ground to Rare Excited States of T4 Lysozyme L99A.

Schiffer JM, Feher VA, Malmstrom RD, Sida R, Amaro RE.

Biophys J. 2016 Oct 18;111(8):1631-1640. doi: 10.1016/j.bpj.2016.08.041.


Model of the Ankyrin and SOCS Box Protein, ASB9, E3 Ligase Reveals a Mechanism for Dynamic Ubiquitin Transfer.

Schiffer JM, Malmstrom RD, Parnell J, Ramirez-Sarmiento C, Reyes J, Amaro RE, Komives EA.

Structure. 2016 Aug 2;24(8):1248-1256. doi: 10.1016/j.str.2016.05.016. Epub 2016 Jul 7.


Evaluation of early immune response-survival relationship in cynomolgus macaques after Anthrax Vaccine Adsorbed vaccination and Bacillus anthracis spore challenge.

Sivko GS, Stark GV, Tordoff KP, Taylor KL, Glaze E, VanRaden M, Schiffer JM, Hewitt JA, Quinn CP, Nuzum EO.

Vaccine. 2016 Dec 12;34(51):6518-6528. doi: 10.1016/j.vaccine.2016.04.048. Epub 2016 May 4.


Recent developments in the understanding and use of anthrax vaccine adsorbed: achieving more with less.

Schiffer JM, McNeil MM, Quinn CP.

Expert Rev Vaccines. 2016 Sep;15(9):1151-62. doi: 10.1586/14760584.2016.1162104. Epub 2016 Mar 25. Review.


Humoral and Cell-Mediated Immune Responses to Alternate Booster Schedules of Anthrax Vaccine Adsorbed in Humans.

Quinn CP, Sabourin CL, Schiffer JM, Niemuth NA, Semenova VA, Li H, Rudge TL, Brys AM, Mittler RS, Ibegbu CC, Wrammert J, Ahmed R, Parker SD, Babcock J, Keitel W, Poland GA, Keyserling HL, El Sahly H, Jacobson RM, Marano N, Plikaytis BD, Wright JG.

Clin Vaccine Immunol. 2016 Apr 4;23(4):326-38. doi: 10.1128/CVI.00696-15. Print 2016 Apr.


Bridging non-human primate correlates of protection to reassess the Anthrax Vaccine Adsorbed booster schedule in humans.

Schiffer JM, Chen L, Dalton S, Niemuth NA, Sabourin CL, Quinn CP.

Vaccine. 2015 Jul 17;33(31):3709-16. doi: 10.1016/j.vaccine.2015.05.091. Epub 2015 Jun 10.


Comprehensive analysis and selection of anthrax vaccine adsorbed immune correlates of protection in rhesus macaques.

Chen L, Schiffer JM, Dalton S, Sabourin CL, Niemuth NA, Plikaytis BD, Quinn CP.

Clin Vaccine Immunol. 2014 Nov;21(11):1512-20. doi: 10.1128/CVI.00469-14. Epub 2014 Sep 3.


Detection of anthrax protective antigen (PA) using europium labeled anti-PA monoclonal antibody and time-resolved fluorescence.

Stoddard RA, Quinn CP, Schiffer JM, Boyer AE, Goldstein J, Bagarozzi DA, Soroka SD, Dauphin LA, Hoffmaster AR.

J Immunol Methods. 2014 Jun;408:78-88. doi: 10.1016/j.jim.2014.05.008. Epub 2014 May 22.


Quantitative assessment of anthrax vaccine immunogenicity using the dried blood spot matrix.

Schiffer JM, Maniatis P, Garza I, Steward-Clark E, Korman LT, Pittman PR, Mei JV, Quinn CP.

Biologicals. 2013 Mar;41(2):98-103. doi: 10.1016/j.biologicals.2012.11.003. Epub 2012 Dec 21.


Anthrax vaccine-induced antibodies provide cross-species prediction of survival to aerosol challenge.

Fay MP, Follmann DA, Lynn F, Schiffer JM, Stark GV, Kohberger R, Quinn CP, Nuzum EO.

Sci Transl Med. 2012 Sep 12;4(151):151ra126. doi: 10.1126/scitranslmed.3004073.


A two-stage, multilevel quality control system for serological assays in anthrax vaccine clinical trials.

Soroka SD, Schiffer JM, Semenova VA, Li H, Foster L, Quinn CP.

Biologicals. 2010 Nov;38(6):675-83. doi: 10.1016/j.biologicals.2010.09.001. Epub 2010 Sep 28.


Protein design by binary patterning of polar and nonpolar amino acids.

Kamtekar S, Schiffer JM, Xiong H, Babik JM, Hecht MH.

Science. 1993 Dec 10;262(5140):1680-5.


Excision of arteriovenous malformation of the vein of galen complicated by congestive heart failure.

Bartal AD, Schiffer JM, Goodwin DR.

Neurochirurgia (Stuttg). 1974 Jan;17(1):16-23. No abstract available.


Microneurosurgical excision of an intra- and extramedullary cervical angioma.

Bartal AD, Heilbronn YD, Schiffer JM.

Isr J Med Sci. 1973 Jan;9(1):92-7. No abstract available.


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