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Items: 27

1.

MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer.

de Leeuw R, McNair C, Schiewer MJ, Neupane NP, Brand LJ, Augello MA, Li Z, Cheng LC, Yoshida A, Courtney SM, Hazard ES, Hardiman G, Hussain MH, Diehl JA, Drake JM, Kelly WK, Knudsen KE.

Clin Cancer Res. 2018 May 8. doi: 10.1158/1078-0432.CCR-18-0410. [Epub ahead of print]

PMID:
29739788
2.

DNA Damage Response in Prostate Cancer.

Schiewer MJ, Knudsen KE.

Cold Spring Harb Perspect Med. 2018 Mar 12. pii: a030486. doi: 10.1101/cshperspect.a030486. [Epub ahead of print]

PMID:
29530944
3.

Response and Resistance to Paradox-Breaking BRAF Inhibitor in Melanomas In Vivo and Ex Vivo.

Hartsough EJ, Kugel CH 3rd, Vido MJ, Berger AC, Purwin TJ, Goldberg A, Davies MA, Schiewer MJ, Knudsen KE, Bollag G, Aplin AE.

Mol Cancer Ther. 2018 Jan;17(1):84-95. doi: 10.1158/1535-7163.MCT-17-0705. Epub 2017 Nov 13.

PMID:
29133617
4.

Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors.

Chand SN, Zarei M, Schiewer MJ, Kamath AR, Romeo C, Lal S, Cozzitorto JA, Nevler A, Scolaro L, Londin E, Jiang W, Meisner-Kober N, Pishvaian MJ, Knudsen KE, Yeo CJ, Pascal JM, Winter JM, Brody JR.

Cancer Res. 2017 Sep 15;77(18):5011-5025. doi: 10.1158/0008-5472.CAN-16-2704. Epub 2017 Jul 7.

PMID:
28687616
5.

Detection of Activating Estrogen Receptor Gene (ESR1) Mutations in Single Circulating Tumor Cells.

Paolillo C, Mu Z, Rossi G, Schiewer MJ, Nguyen T, Austin L, Capoluongo E, Knudsen K, Cristofanilli M, Fortina P.

Clin Cancer Res. 2017 Oct 15;23(20):6086-6093. doi: 10.1158/1078-0432.CCR-17-1173. Epub 2017 Jul 5.

PMID:
28679775
6.

PARP Inhibitors in Prostate Cancer.

Ramakrishnan Geethakumari P, Schiewer MJ, Knudsen KE, Kelly WK.

Curr Treat Options Oncol. 2017 Jun;18(6):37. doi: 10.1007/s11864-017-0480-2. Review.

PMID:
28540598
7.

Not So Fast: Cultivating miRs as Kinks in the Chain of the Cell Cycle.

Schiewer MJ, Knudsen KE.

Cancer Cell. 2017 Apr 10;31(4):471-473. doi: 10.1016/j.ccell.2017.03.012.

8.

Cell cycle-coupled expansion of AR activity promotes cancer progression.

McNair C, Urbanucci A, Comstock CE, Augello MA, Goodwin JF, Launchbury R, Zhao SG, Schiewer MJ, Ertel A, Karnes J, Davicioni E, Wang L, Wang Q, Mills IG, Feng FY, Li W, Carroll JS, Knudsen KE.

Oncogene. 2017 Mar 23;36(12):1655-1668. doi: 10.1038/onc.2016.334. Epub 2016 Sep 26.

9.

Linking DNA Damage and Hormone Signaling Pathways in Cancer.

Schiewer MJ, Knudsen KE.

Trends Endocrinol Metab. 2016 Apr;27(4):216-225. doi: 10.1016/j.tem.2016.02.004. Epub 2016 Mar 1. Review.

10.

Patient-Level DNA Damage and Repair Pathway Profiles and Prognosis After Prostatectomy for High-Risk Prostate Cancer.

Evans JR, Zhao SG, Chang SL, Tomlins SA, Erho N, Sboner A, Schiewer MJ, Spratt DE, Kothari V, Klein EA, Den RB, Dicker AP, Karnes RJ, Yu X, Nguyen PL, Rubin MA, de Bono J, Knudsen KE, Davicioni E, Feng FY.

JAMA Oncol. 2016 Apr;2(4):471-80. doi: 10.1001/jamaoncol.2015.4955.

11.

Downregulation of Critical Oncogenes by the Selective SK2 Inhibitor ABC294640 Hinders Prostate Cancer Progression.

Schrecengost RS, Keller SN, Schiewer MJ, Knudsen KE, Smith CD.

Mol Cancer Res. 2015 Dec;13(12):1591-601. doi: 10.1158/1541-7786.MCR-14-0626. Epub 2015 Aug 13.

12.

DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis.

Goodwin JF, Kothari V, Drake JM, Zhao S, Dylgjeri E, Dean JL, Schiewer MJ, McNair C, Jones JK, Aytes A, Magee MS, Snook AE, Zhu Z, Den RB, Birbe RC, Gomella LG, Graham NA, Vashisht AA, Wohlschlegel JA, Graeber TG, Karnes RJ, Takhar M, Davicioni E, Tomlins SA, Abate-Shen C, Sharifi N, Witte ON, Feng FY, Knudsen KE.

Cancer Cell. 2015 Jul 13;28(1):97-113. doi: 10.1016/j.ccell.2015.06.004.

13.

Consequence of the tumor-associated conversion to cyclin D1b.

Augello MA, Berman-Booty LD, Carr R 3rd, Yoshida A, Dean JL, Schiewer MJ, Feng FY, Tomlins SA, Gao E, Koch WJ, Benovic JL, Diehl JA, Knudsen KE.

EMBO Mol Med. 2015 May;7(5):628-47. doi: 10.15252/emmm.201404242.

14.

Novel actions of next-generation taxanes benefit advanced stages of prostate cancer.

de Leeuw R, Berman-Booty LD, Schiewer MJ, Ciment SJ, Den RB, Dicker AP, Kelly WK, Trabulsi EJ, Lallas CD, Gomella LG, Knudsen KE.

Clin Cancer Res. 2015 Feb 15;21(4):795-807. doi: 10.1158/1078-0432.CCR-14-1358.

15.

Transcriptional roles of PARP1 in cancer.

Schiewer MJ, Knudsen KE.

Mol Cancer Res. 2014 Aug;12(8):1069-80. doi: 10.1158/1541-7786.MCR-13-0672. Epub 2014 Jun 10. Review.

16.

Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells.

Dressing GE, Knutson TP, Schiewer MJ, Daniel AR, Hagan CR, Diep CH, Knudsen KE, Lange CA.

Mol Endocrinol. 2014 Apr;28(4):442-57. doi: 10.1210/me.2013-1196. Epub 2014 Feb 25.

17.

AMPed up to treat prostate cancer: novel AMPK activators emerge for cancer therapy.

Schiewer MJ, Knudsen KE.

EMBO Mol Med. 2014 Apr;6(4):439-41. doi: 10.1002/emmm.201303737. Epub 2014 Feb 20.

18.

USP22 regulates oncogenic signaling pathways to drive lethal cancer progression.

Schrecengost RS, Dean JL, Goodwin JF, Schiewer MJ, Urban MW, Stanek TJ, Sussman RT, Hicks JL, Birbe RC, Draganova-Tacheva RA, Visakorpi T, DeMarzo AM, McMahon SB, Knudsen KE.

Cancer Res. 2014 Jan 1;74(1):272-86. doi: 10.1158/0008-5472.CAN-13-1954. Epub 2013 Nov 6.

19.

Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

Steffen JD, Tholey RM, Langelier MF, Planck JL, Schiewer MJ, Lal S, Bildzukewicz NA, Yeo CJ, Knudsen KE, Brody JR, Pascal JM.

Cancer Res. 2014 Jan 1;74(1):31-7. doi: 10.1158/0008-5472.CAN-13-1701. Epub 2013 Nov 4.

20.

A hormone-DNA repair circuit governs the response to genotoxic insult.

Goodwin JF, Schiewer MJ, Dean JL, Schrecengost RS, de Leeuw R, Han S, Ma T, Den RB, Dicker AP, Feng FY, Knudsen KE.

Cancer Discov. 2013 Nov;3(11):1254-71. doi: 10.1158/2159-8290.CD-13-0108. Epub 2013 Sep 11.

21.

Targeting cell cycle and hormone receptor pathways in cancer.

Comstock CE, Augello MA, Goodwin JF, de Leeuw R, Schiewer MJ, Ostrander WF Jr, Burkhart RA, McClendon AK, McCue PA, Trabulsi EJ, Lallas CD, Gomella LG, Centenera MM, Brody JR, Butler LM, Tilley WD, Knudsen KE.

Oncogene. 2013 Nov 28;32(48):5481-91. doi: 10.1038/onc.2013.83. Epub 2013 May 27.

22.

Dual roles of PARP-1 promote cancer growth and progression.

Schiewer MJ, Goodwin JF, Han S, Brenner JC, Augello MA, Dean JL, Liu F, Planck JL, Ravindranathan P, Chinnaiyan AM, McCue P, Gomella LG, Raj GV, Dicker AP, Brody JR, Pascal JM, Centenera MM, Butler LM, Tilley WD, Feng FY, Knudsen KE.

Cancer Discov. 2012 Dec;2(12):1134-49. doi: 10.1158/2159-8290.CD-12-0120. Epub 2012 Sep 19.

23.

mTOR is a selective effector of the radiation therapy response in androgen receptor-positive prostate cancer.

Schiewer MJ, Den R, Hoang DT, Augello MA, Lawrence YR, Dicker AP, Knudsen KE.

Endocr Relat Cancer. 2012 Jan 9;19(1):1-12. doi: 10.1530/ERC-11-0072. Print 2012 Feb.

24.

The AR dependent cell cycle: mechanisms and cancer relevance.

Schiewer MJ, Augello MA, Knudsen KE.

Mol Cell Endocrinol. 2012 Apr 16;352(1-2):34-45. doi: 10.1016/j.mce.2011.06.033. Epub 2011 Jul 12. Review.

25.

Cyclin D1 is a selective modifier of androgen-dependent signaling and androgen receptor function.

Comstock CE, Augello MA, Schiewer MJ, Karch J, Burd CJ, Ertel A, Knudsen ES, Jessen WJ, Aronow BJ, Knudsen KE.

J Biol Chem. 2011 Mar 11;286(10):8117-27. doi: 10.1074/jbc.M110.170720. Epub 2011 Jan 5.

26.

Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene.

Olshavsky NA, Comstock CE, Schiewer MJ, Augello MA, Hyslop T, Sette C, Zhang J, Parysek LM, Knudsen KE.

Cancer Res. 2010 May 15;70(10):3975-84. doi: 10.1158/0008-5472.CAN-09-3468. Epub 2010 May 11.

27.

Cyclin D1 repressor domain mediates proliferation and survival in prostate cancer.

Schiewer MJ, Morey LM, Burd CJ, Liu Y, Merry DE, Ho SM, Knudsen KE.

Oncogene. 2009 Feb 19;28(7):1016-27. doi: 10.1038/onc.2008.446. Epub 2008 Dec 15.

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