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Items: 1 to 50 of 174


Distributed Plasticity Drives Visual Habituation Learning in Larval Zebrafish.

Randlett O, Haesemeyer M, Forkin G, Shoenhard H, Schier AF, Engert F, Granato M.

Curr Biol. 2019 Apr 22;29(8):1337-1345.e4. doi: 10.1016/j.cub.2019.02.039. Epub 2019 Apr 4.


Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions.

Thyme SB, Pieper LM, Li EH, Pandey S, Wang Y, Morris NS, Sha C, Choi JW, Herrera KJ, Soucy ER, Zimmerman S, Randlett O, Greenwood J, McCarroll SA, Schier AF.

Cell. 2019 Apr 4;177(2):478-491.e20. doi: 10.1016/j.cell.2019.01.048. Epub 2019 Mar 28.


Individual long non-coding RNAs have no overt functions in zebrafish embryogenesis, viability and fertility.

Goudarzi M, Berg K, Pieper LM, Schier AF.

Elife. 2019 Jan 8;8. pii: e40815. doi: 10.7554/eLife.40815.


Conserved regulation of Nodal-mediated left-right patterning in zebrafish and mouse.

Montague TG, Gagnon JA, Schier AF.

Development. 2018 Dec 10;145(24). pii: dev171090. doi: 10.1242/dev.171090.


Large-scale reconstruction of cell lineages using single-cell readout of transcriptomes and CRISPR-Cas9 barcodes by scGESTALT.

Raj B, Gagnon JA, Schier AF.

Nat Protoc. 2018 Nov;13(11):2685-2713. doi: 10.1038/s41596-018-0058-x.


Scale-invariant patterning by size-dependent inhibition of Nodal signalling.

Almuedo-Castillo M, Bläßle A, Mörsdorf D, Marcon L, Soh GH, Rogers KW, Schier AF, Müller P.

Nat Cell Biol. 2018 Sep;20(9):1032-1042. doi: 10.1038/s41556-018-0155-7. Epub 2018 Jul 30.


A Brain-wide Circuit Model of Heat-Evoked Swimming Behavior in Larval Zebrafish.

Haesemeyer M, Robson DN, Li JM, Schier AF, Engert F.

Neuron. 2018 May 16;98(4):817-831.e6. doi: 10.1016/j.neuron.2018.04.013. Epub 2018 May 3.


A Massively Parallel Reporter Assay of 3' UTR Sequences Identifies In Vivo Rules for mRNA Degradation.

Rabani M, Pieper L, Chew GL, Schier AF.

Mol Cell. 2018 May 3;70(3):565. doi: 10.1016/j.molcel.2018.04.013. No abstract available.


Single-cell reconstruction of developmental trajectories during zebrafish embryogenesis.

Farrell JA, Wang Y, Riesenfeld SJ, Shekhar K, Regev A, Schier AF.

Science. 2018 Jun 1;360(6392). pii: eaar3131. doi: 10.1126/science.aar3131. Epub 2018 Apr 26.


Simultaneous single-cell profiling of lineages and cell types in the vertebrate brain.

Raj B, Wagner DE, McKenna A, Pandey S, Klein AM, Shendure J, Gagnon JA, Schier AF.

Nat Biotechnol. 2018 Jun;36(5):442-450. doi: 10.1038/nbt.4103. Epub 2018 Mar 28.


Comprehensive Identification and Spatial Mapping of Habenular Neuronal Types Using Single-Cell RNA-Seq.

Pandey S, Shekhar K, Regev A, Schier AF.

Curr Biol. 2018 Apr 2;28(7):1052-1065.e7. doi: 10.1016/j.cub.2018.02.040. Epub 2018 Mar 22.


A Massively Parallel Reporter Assay of 3' UTR Sequences Identifies In Vivo Rules for mRNA Degradation.

Rabani M, Pieper L, Chew GL, Schier AF.

Mol Cell. 2017 Dec 21;68(6):1083-1094.e5. doi: 10.1016/j.molcel.2017.11.014. Epub 2017 Dec 7. Erratum in: Mol Cell. 2018 May 3;70(3):565.


Nodal patterning without Lefty inhibitory feedback is functional but fragile.

Rogers KW, Lord ND, Gagnon JA, Pauli A, Zimmerman S, Aksel DC, Reyon D, Tsai SQ, Joung JK, Schier AF.

Elife. 2017 Dec 7;6. pii: e28785. doi: 10.7554/eLife.28785.


The primary role of zebrafish nanog is in extra-embryonic tissue.

Gagnon JA, Obbad K, Schier AF.

Development. 2018 Jan 9;145(1). pii: dev147793. doi: 10.1242/dev.147793.


Vg1-Nodal heterodimers are the endogenous inducers of mesendoderm.

Montague TG, Schier AF.

Elife. 2017 Nov 15;6. pii: e28183. doi: 10.7554/eLife.28183.


Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling.

Norris ML, Pauli A, Gagnon JA, Lord ND, Rogers KW, Mosimann C, Zon LI, Schier AF.

Elife. 2017 Nov 9;6. pii: e22626. doi: 10.7554/eLife.22626.


Kctd13 deletion reduces synaptic transmission via increased RhoA.

Escamilla CO, Filonova I, Walker AK, Xuan ZX, Holehonnur R, Espinosa F, Liu S, Thyme SB, López-García IA, Mendoza DB, Usui N, Ellegood J, Eisch AJ, Konopka G, Lerch JP, Schier AF, Speed HE, Powell CM.

Nature. 2017 Nov 9;551(7679):227-231. doi: 10.1038/nature24470. Epub 2017 Nov 1.


Gaze-Stabilizing Central Vestibular Neurons Project Asymmetrically to Extraocular Motoneuron Pools.

Schoppik D, Bianco IH, Prober DA, Douglass AD, Robson DN, Li JMB, Greenwood JSF, Soucy E, Engert F, Schier AF.

J Neurosci. 2017 Nov 22;37(47):11353-11365. doi: 10.1523/JNEUROSCI.1711-17.2017. Epub 2017 Sep 29.


Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.

Freyer L, Hsu CW, Nowotschin S, Pauli A, Ishida J, Kuba K, Fukamizu A, Schier AF, Hoodless PA, Dickinson ME, Hadjantonakis AK.

Cell Rep. 2017 Aug 29;20(9):2116-2130. doi: 10.1016/j.celrep.2017.08.014.


Whole-brain serial-section electron microscopy in larval zebrafish.

Hildebrand DGC, Cicconet M, Torres RM, Choi W, Quan TM, Moon J, Wetzel AW, Scott Champion A, Graham BJ, Randlett O, Plummer GS, Portugues R, Bianco IH, Saalfeld S, Baden AD, Lillaney K, Burns R, Vogelstein JT, Schier AF, Lee WA, Jeong WK, Lichtman JW, Engert F.

Nature. 2017 May 18;545(7654):345-349. doi: 10.1038/nature22356. Epub 2017 May 10.


Internal guide RNA interactions interfere with Cas9-mediated cleavage.

Thyme SB, Akhmetova L, Montague TG, Valen E, Schier AF.

Nat Commun. 2016 Jun 10;7:11750. doi: 10.1038/ncomms11750.


Whole-organism lineage tracing by combinatorial and cumulative genome editing.

McKenna A, Findlay GM, Gagnon JA, Horwitz MS, Schier AF, Shendure J.

Science. 2016 Jul 29;353(6298):aaf7907. doi: 10.1126/science.aaf7907. Epub 2016 May 26.


Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish.

Chew GL, Pauli A, Schier AF.

Nat Commun. 2016 May 24;7:11663. doi: 10.1038/ncomms11663.


Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development.

Thyme SB, Schier AF.

Cell Rep. 2016 May 17;15(7):1611-1613. doi: 10.1016/j.celrep.2016.04.089. Epub 2016 May 21. No abstract available.


Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development.

Thyme SB, Schier AF.

Cell Rep. 2016 Apr 26;15(4):707-714. doi: 10.1016/j.celrep.2016.03.072. Epub 2016 Apr 14. Erratum in: Cell Rep. 2016 May 17;15(7):1611-1613.


Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis.

Li-Villarreal N, Forbes MM, Loza AJ, Chen J, Ma T, Helde K, Moens CB, Shin J, Sawada A, Hindes AE, Dubrulle J, Schier AF, Longmore GD, Marlow FL, Solnica-Krezel L.

Development. 2016 May 15;143(10):1832. doi: 10.1242/dev.138859. Epub 2016 Apr 28. No abstract available.


Brain-wide mapping of neural activity controlling zebrafish exploratory locomotion.

Dunn TW, Mu Y, Narayan S, Randlett O, Naumann EA, Yang CT, Schier AF, Freeman J, Engert F, Ahrens MB.

Elife. 2016 Mar 22;5:e12741. doi: 10.7554/eLife.12741.


A Zebrafish Genetic Screen Identifies Neuromedin U as a Regulator of Sleep/Wake States.

Chiu CN, Rihel J, Lee DA, Singh C, Mosser EA, Chen S, Sapin V, Pham U, Engle J, Niles BJ, Montz CJ, Chakravarthy S, Zimmerman S, Salehi-Ashtiani K, Vidal M, Schier AF, Prober DA.

Neuron. 2016 Feb 17;89(4):842-56. doi: 10.1016/j.neuron.2016.01.007.


Whole-brain activity mapping onto a zebrafish brain atlas.

Randlett O, Wee CL, Naumann EA, Nnaemeka O, Schoppik D, Fitzgerald JE, Portugues R, Lacoste AM, Riegler C, Engert F, Schier AF.

Nat Methods. 2015 Nov;12(11):1039-46.


The structure and timescales of heat perception in larval zebrafish.

Haesemeyer M, Robson DN, Li JM, Schier AF, Engert F.

Cell Syst. 2015 Nov 25;1(5):338-348.


Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish.

Pauli A, Montague TG, Lennox KA, Behlke MA, Schier AF.

PLoS One. 2015 Oct 5;10(10):e0139504. doi: 10.1371/journal.pone.0139504. eCollection 2015.


Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis.

Li-Villarreal N, Forbes MM, Loza AJ, Chen J, Ma T, Helde K, Moens CB, Shin J, Sawada A, Hindes AE, Dubrulle J, Schier AF, Longmore GD, Marlow FL, Solnica-Krezel L.

Development. 2015 Aug 1;142(15):2704-18. doi: 10.1242/dev.119800. Epub 2015 Jul 9. Erratum in: Development. 2016 May 15;143(10 ):1832.


A convergent and essential interneuron pathway for Mauthner-cell-mediated escapes.

Lacoste AM, Schoppik D, Robson DN, Haesemeyer M, Portugues R, Li JM, Randlett O, Wee CL, Engert F, Schier AF.

Curr Biol. 2015 Jun 1;25(11):1526-34. doi: 10.1016/j.cub.2015.04.025. Epub 2015 May 7.


Efficient CRISPR-Cas9-mediated generation of knockin human pluripotent stem cells lacking undesired mutations at the targeted locus.

Merkle FT, Neuhausser WM, Santos D, Valen E, Gagnon JA, Maas K, Sandoe J, Schier AF, Eggan K.

Cell Rep. 2015 May 12;11(6):875-883. doi: 10.1016/j.celrep.2015.04.007. Epub 2015 Apr 30.


Response to Nodal morphogen gradient is determined by the kinetics of target gene induction.

Dubrulle J, Jordan BM, Akhmetova L, Farrell JA, Kim SH, Solnica-Krezel L, Schier AF.

Elife. 2015 Apr 14;4. doi: 10.7554/eLife.05042.


Spatial reconstruction of single-cell gene expression data.

Satija R, Farrell JA, Gennert D, Schier AF, Regev A.

Nat Biotechnol. 2015 May;33(5):495-502. doi: 10.1038/nbt.3192. Epub 2015 Apr 13.


Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9.

Liu J, Merkle FT, Gandhi AV, Gagnon JA, Woods IG, Chiu CN, Shimogori T, Schier AF, Prober DA.

Development. 2015 Mar 15;142(6):1113-24. doi: 10.1242/dev.117424. Epub 2015 Feb 27.


Vesicular stomatitis virus enables gene transfer and transsynaptic tracing in a wide range of organisms.

Mundell NA, Beier KT, Pan YA, Lapan SW, Göz Aytürk D, Berezovskii VK, Wark AR, Drokhlyansky E, Bielecki J, Born RT, Schier AF, Cepko CL.

J Comp Neurol. 2015 Aug 1;523(11):1639-63. doi: 10.1002/cne.23761. Epub 2015 Apr 2.


Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells.

Merkle FT, Maroof A, Wataya T, Sasai Y, Studer L, Eggan K, Schier AF.

Development. 2015 Feb 15;142(4):633-43. doi: 10.1242/dev.117978.


Measuring protein stability in living zebrafish embryos using fluorescence decay after photoconversion (FDAP).

Rogers KW, Blässle A, Schier AF, Müller P.

J Vis Exp. 2015 Jan 28;(95):52266. doi: 10.3791/52266.


The study of psychiatric disease genes and drugs in zebrafish.

Haesemeyer M, Schier AF.

Curr Opin Neurobiol. 2015 Feb;30:122-30. doi: 10.1016/j.conb.2014.12.002. Epub 2014 Dec 16. Review.


High-resolution sequencing and modeling identifies distinct dynamic RNA regulatory strategies.

Rabani M, Raychowdhury R, Jovanovic M, Rooney M, Stumpo DJ, Pauli A, Hacohen N, Schier AF, Blackshear PJ, Friedman N, Amit I, Regev A.

Cell. 2014 Dec 18;159(7):1698-710. doi: 10.1016/j.cell.2014.11.015. Epub 2014 Dec 11.


Identifying (non-)coding RNAs and small peptides: challenges and opportunities.

Pauli A, Valen E, Schier AF.

Bioessays. 2015 Jan;37(1):103-12. doi: 10.1002/bies.201400103. Epub 2014 Oct 24. Review.


Obituary: Walter J. Gehring (1939-2014).

Schier AF.

Development. 2014 Sep;141(17):3289-91. doi: 10.1242/dev.115402. Epub 2014 Aug 1.


Neuropeptidergic control of sleep and wakefulness.

Richter C, Woods IG, Schier AF.

Annu Rev Neurosci. 2014;37:503-31. doi: 10.1146/annurev-neuro-062111-150447. Review.


Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs.

Gagnon JA, Valen E, Thyme SB, Huang P, Akhmetova L, Pauli A, Montague TG, Zimmerman S, Richter C, Schier AF.

PLoS One. 2014 May 29;9(5):e98186. doi: 10.1371/journal.pone.0098186. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e106396. Ahkmetova, Laila [corrected to Akhmetova, Laila].


Neuropeptidergic signaling partitions arousal behaviors in zebrafish.

Woods IG, Schoppik D, Shi VJ, Zimmerman S, Coleman HA, Greenwood J, Soucy ER, Schier AF.

J Neurosci. 2014 Feb 26;34(9):3142-60. doi: 10.1523/JNEUROSCI.3529-13.2014.


Toddler: an embryonic signal that promotes cell movement via Apelin receptors.

Pauli A, Norris ML, Valen E, Chew GL, Gagnon JA, Zimmerman S, Mitchell A, Ma J, Dubrulle J, Reyon D, Tsai SQ, Joung JK, Saghatelian A, Schier AF.

Science. 2014 Feb 14;343(6172):1248636. doi: 10.1126/science.1248636. Epub 2014 Jan 9.


Canonical nucleosome organization at promoters forms during genome activation.

Zhang Y, Vastenhouw NL, Feng J, Fu K, Wang C, Ge Y, Pauli A, van Hummelen P, Schier AF, Liu XS.

Genome Res. 2014 Feb;24(2):260-6. doi: 10.1101/gr.157750.113. Epub 2013 Nov 27.


Should I stay or should I go: neuromodulators of behavioral states.

Schier AF.

Cell. 2013 Aug 29;154(5):955-956. doi: 10.1016/j.cell.2013.08.017.

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