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Items: 37

1.

Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists.

Schiano Moriello A, López Chinarro S, Novo Fernández O, Eras J, Amodeo P, Canela-Garayoa R, Vitale RM, Di Marzo V, De Petrocellis L.

J Med Chem. 2018 Sep 14. doi: 10.1021/acs.jmedchem.8b00734. [Epub ahead of print]

PMID:
30176215
2.

Iodine-mediated cyclization of cannabigerol (CBG) expands the cannabinoid biological and chemical space.

Lopatriello A, Caprioglio D, Minassi A, Schiano Moriello A, Formisano C, De Petrocellis L, Appendino G, Taglialatela-Scafati O.

Bioorg Med Chem. 2018 Aug 15;26(15):4532-4536. doi: 10.1016/j.bmc.2018.07.044. Epub 2018 Jul 27.

PMID:
30077611
3.

TRPA1 Modulating C14 Polyacetylenes from the Iranian Endemic Plant Echinophora platyloba.

Chianese G, Sirignano C, Shokoohinia Y, Mohammadi Z, Bazvandi L, Jafari F, Jalilian F, Schiano Moriello A, De Petrocellis L, Taglialatela-Scafati O, Rigano D.

Molecules. 2018 Jul 17;23(7). pii: E1750. doi: 10.3390/molecules23071750.

4.

Reprint of: Amorfrutin-type phytocannabinoids from Helichrysum umbraculigerum.

Pollastro F, De Petrocellis L, Schiano-Moriello A, Chianese G, Heyman H, Appendino G, Taglialatela-Scafati O.

Fitoterapia. 2018 Apr;126:35-39. doi: 10.1016/j.fitote.2018.04.002. Epub 2018 Apr 11. No abstract available.

PMID:
29655820
5.

Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect.

Petrosino S, Cordaro M, Verde R, Schiano Moriello A, Marcolongo G, Schievano C, Siracusa R, Piscitelli F, Peritore AF, Crupi R, Impellizzeri D, Esposito E, Cuzzocrea S, Di Marzo V.

Front Pharmacol. 2018 Mar 20;9:249. doi: 10.3389/fphar.2018.00249. eCollection 2018.

6.

Amorfrutin-type phytocannabinoids from Helichrysum umbraculigerum.

Pollastro F, De Petrocellis L, Schiano-Moriello A, Chianese G, Heyman H, Appendino G, Taglialatela-Scafati O.

Fitoterapia. 2017 Nov;123:13-17. doi: 10.1016/j.fitote.2017.09.010. Epub 2017 Sep 20. No abstract available. Corrected and republished in: Fitoterapia. 2018 Apr;126:35-39.

PMID:
28941742
7.

Effects of curcumin and curcumin analogues on TRP channels.

Nalli M, Ortar G, Schiano Moriello A, Di Marzo V, De Petrocellis L.

Fitoterapia. 2017 Oct;122:126-131. doi: 10.1016/j.fitote.2017.09.007. Epub 2017 Sep 10. Review.

PMID:
28903060
8.

Extracts and compounds active on TRP ion channels from Waldheimia glabra, a ritual medicinal plant from Himalaya.

Giorgi A, Bassoli A, Borgonovo G, Panseri S, Manzo A, Pentimalli D, Schiano Moriello A, De Petrocellis L.

Phytomedicine. 2017 Aug 15;32:80-87. doi: 10.1016/j.phymed.2017.04.012. Epub 2017 May 1.

PMID:
28732812
9.

Correction to Tetrahydroisoquinoline-Derived Urea and 2,5-Diketopiperazine Derivatives as Selective Antagonists of the Transient Receptor Potential Melastatin 8 (TRPM8) Channel Receptor and Antiprostate Cancer Agents.

De Petrocellis L, Arroyo FJ, Orlando P, Schiano Moriello A, Vitale RM, Amodeo P, Sánchez A, Roncero C, Bianchini G, Martín MA, López-Alvarado P, Menéndez JC.

J Med Chem. 2016 Aug 25;59(16):7697. doi: 10.1021/acs.jmedchem.6b01091. Epub 2016 Aug 3. No abstract available.

PMID:
27487560
10.

Neuroactive and Anti-inflammatory Frankincense Cembranes: A Structure-Activity Study.

Pollastro F, Golin S, Chianese G, Putra MY, Schiano Moriello A, De Petrocellis L, García V, Munoz E, Taglialatela-Scafati O, Appendino G.

J Nat Prod. 2016 Jul 22;79(7):1762-8. doi: 10.1021/acs.jnatprod.6b00141. Epub 2016 Jun 28.

PMID:
27352042
11.

Tetrahydroisoquinoline-Derived Urea and 2,5-Diketopiperazine Derivatives as Selective Antagonists of the Transient Receptor Potential Melastatin 8 (TRPM8) Channel Receptor and Antiprostate Cancer Agents.

De Petrocellis L, Arroyo FJ, Orlando P, Schiano Moriello A, Vitale RM, Amodeo P, Sánchez A, Roncero C, Bianchini G, Martín MA, López-Alvarado P, Menéndez JC.

J Med Chem. 2016 Jun 23;59(12):5661-83. doi: 10.1021/acs.jmedchem.5b01448. Epub 2016 Jun 14. Erratum in: J Med Chem. 2016 Aug 25;59(16):7697.

PMID:
27232526
12.

Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates.

Monti L, Stefanucci A, Pieretti S, Marzoli F, Fidanza L, Mollica A, Mirzaie S, Carradori S, De Petrocellis L, Schiano Moriello A, Benyhe S, Zádor F, Szűcs E, Ötvös F, Erdei AI, Samavati R, Dvorácskó S, Tömböly C, Novellino E.

J Enzyme Inhib Med Chem. 2016 Dec;31(6):1638-47. doi: 10.3109/14756366.2016.1160902. Epub 2016 Apr 11.

PMID:
27063555
13.

Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress.

Aiello F, Badolato M, Pessina F, Sticozzi C, Maestrini V, Aldinucci C, Luongo L, Guida F, Ligresti A, Artese A, Allarà M, Costa G, Frosini M, Schiano Moriello A, De Petrocellis L, Valacchi G, Alcaro S, Maione S, Di Marzo V, Corelli F, Brizzi A.

ACS Chem Neurosci. 2016 Jun 15;7(6):737-48. doi: 10.1021/acschemneuro.5b00333. Epub 2016 Mar 22.

PMID:
26942555
14.

Arylboronic acids as dual-action FAAH and TRPV1 ligands.

Morera E, Di Marzo V, Monti L, Allarà M, Schiano Moriello A, Nalli M, Ortar G, De Petrocellis L.

Bioorg Med Chem Lett. 2016 Mar 1;26(5):1401-5. doi: 10.1016/j.bmcl.2016.01.071. Epub 2016 Jan 25.

PMID:
26850005
15.

Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient receptor vanilloid type-1 (TRPV1) channel.

De Petrocellis L, Schiano Moriello A, Byun JS, Sohn JM, Lee JY, Vázquez-Romero A, Garrido M, Messeguer A, Zhang FX, Zamponi GW, Deplano A, Congiu C, Onnis V, Balboni G, Di Marzo V.

Pharmacol Res. 2015 Sep;99:362-9. doi: 10.1016/j.phrs.2015.07.009. Epub 2015 Jul 17.

PMID:
26192347
16.

TRPV1 modulators: Synthesis and in vitro evaluation of 1-heteroaryl piperidinecarboxamide and piperazinylurea derivatives.

Congiu C, Onnis V, Balboni G, Schiano-Moriello A, Di Marzo V, De Petrocellis L.

Eur J Med Chem. 2015 Jul 15;100:129-38. doi: 10.1016/j.ejmech.2015.05.041. Epub 2015 Jun 6.

PMID:
26079089
17.

Structure-activity relationships of the prototypical TRPM8 agonist icilin.

De Petrocellis L, Ortar G, Schiano Moriello A, Serum EM, Rusterholz DB.

Bioorg Med Chem Lett. 2015 Jun 1;25(11):2285-90. doi: 10.1016/j.bmcl.2015.04.032. Epub 2015 Apr 16.

PMID:
25935641
18.

Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands.

Del Prete D, Caprioglio D, Appendino G, Minassi A, Schiano-Moriello A, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2015 Mar 1;25(5):1009-11. doi: 10.1016/j.bmcl.2015.01.039. Epub 2015 Jan 28.

PMID:
25666822
19.

The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels.

Petrosino S, Schiano Moriello A, Cerrato S, Fusco M, Puigdemont A, De Petrocellis L, Di Marzo V.

Br J Pharmacol. 2016 Apr;173(7):1154-62. doi: 10.1111/bph.13084. Epub 2015 Mar 26.

20.

Effect of acyclic monoterpene alcohols and their derivatives on TRP channels.

Ortar G, Schiano Moriello A, Morera E, Nalli M, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2014 Dec 1;24(23):5507-11. doi: 10.1016/j.bmcl.2014.10.012. Epub 2014 Oct 12.

PMID:
25455494
21.

Electrophysiological variability in the SH-SY5Y cellular line.

Santillo S, Schiano Moriello A, Di Maio V.

Gen Physiol Biophys. 2014;33(1):121-9. doi: 10.4149/gpb_2013071. Epub 2014 Jan 22.

PMID:
24448369
22.

3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.

Ortar G, Schiano Moriello A, Morera E, Nalli M, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5614-8. doi: 10.1016/j.bmcl.2013.08.039. Epub 2013 Aug 14.

PMID:
23993334
23.

Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels.

De Petrocellis L, Schiano Moriello A, Fontana G, Sacchetti A, Passarella D, Appendino G, Di Marzo V.

Br J Pharmacol. 2014 May;171(10):2608-20. doi: 10.1111/bph.12320.

24.

Analogues of perillaketone as highly potent agonists of TRPA1 channel.

Bassoli A, Borgonovo G, Morini G, De Petrocellis L, Schiano Moriello A, Di Marzo V.

Food Chem. 2013 Dec 1;141(3):2044-51. doi: 10.1016/j.foodchem.2013.05.063. Epub 2013 May 24.

PMID:
23870926
25.

Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.

Ortar G, Morera E, De Petrocellis L, Ligresti A, Schiano Moriello A, Morera L, Nalli M, Ragno R, Pirolli A, Di Marzo V.

Eur J Med Chem. 2013 May;63:118-32. doi: 10.1016/j.ejmech.2013.02.005. Epub 2013 Feb 15.

PMID:
23474898
26.

2-Amino-4-arylthiazole compounds as TRPA1 antagonists (WO 2012085662): a patent evaluation.

De Petrocellis L, Schiano Moriello A.

Expert Opin Ther Pat. 2013 Jan;23(1):119-47. doi: 10.1517/13543776.2013.736496. Epub 2012 Nov 6.

PMID:
23126422
27.

A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons.

De Petrocellis L, Schiano Moriello A, Imperatore R, Cristino L, Starowicz K, Di Marzo V.

Br J Pharmacol. 2012 Dec;167(8):1643-51. doi: 10.1111/j.1476-5381.2012.02122.x.

28.

Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms.

De Petrocellis L, Ligresti A, Schiano Moriello A, Iappelli M, Verde R, Stott CG, Cristino L, Orlando P, Di Marzo V.

Br J Pharmacol. 2013 Jan;168(1):79-102. doi: 10.1111/j.1476-5381.2012.02027.x.

29.

New tetrazole-based selective anandamide uptake inhibitors.

Ortar G, Schiano Moriello A, Cascio MG, De Petrocellis L, Ligresti A, Morera E, Nalli M, Di Marzo V.

Bioorg Med Chem Lett. 2008 May 1;18(9):2820-4. doi: 10.1016/j.bmcl.2008.04.003. Epub 2008 Apr 4.

PMID:
18424134
30.

Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8.

De Petrocellis L, Vellani V, Schiano-Moriello A, Marini P, Magherini PC, Orlando P, Di Marzo V.

J Pharmacol Exp Ther. 2008 Jun;325(3):1007-15. doi: 10.1124/jpet.107.134809. Epub 2008 Mar 19.

31.

New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain.

Ortar G, Cascio MG, De Petrocellis L, Morera E, Rossi F, Schiano-Moriello A, Nalli M, de Novellis V, Woodward DF, Maione S, Di Marzo V.

J Med Chem. 2007 Dec 27;50(26):6554-69. Epub 2007 Nov 21.

PMID:
18027904
32.

Development of the first potential covalent inhibitors of anandamide cellular uptake.

Schiano Moriello A, Balas L, Ligresti A, Cascio MG, Durand T, Morera E, Ortar G, Di Marzo V.

J Med Chem. 2006 Apr 6;49(7):2320-32.

PMID:
16570928
33.

Iodinated N-acylvanillamines: potential "multiple-target" anti-inflammatory agents acting via the inhibition of t-cell activation and antagonism at vanilloid TRPV1 channels.

Márquez N, De Petrocellis L, Caballero FJ, Macho A, Schiano-Moriello A, Minassi A, Appendino G, Muñoz E, Di Marzo V.

Mol Pharmacol. 2006 Apr;69(4):1373-82. Epub 2006 Jan 4.

34.

Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels.

van der Stelt M, Trevisani M, Vellani V, De Petrocellis L, Schiano Moriello A, Campi B, McNaughton P, Geppetti P, Di Marzo V.

EMBO J. 2005 Sep 7;24(17):3026-37. Epub 2005 Aug 18. Erratum in: EMBO J. 2005 Oct 5;24(19):3517-8.

35.

Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain.

Bisogno T, Howell F, Williams G, Minassi A, Cascio MG, Ligresti A, Matias I, Schiano-Moriello A, Paul P, Williams EJ, Gangadharan U, Hobbs C, Di Marzo V, Doherty P.

J Cell Biol. 2003 Nov 10;163(3):463-8.

36.

Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists.

Appendino G, Harrison S, De Petrocellis L, Daddario N, Bianchi F, Schiano Moriello A, Trevisani M, Benvenuti F, Geppetti P, Di Marzo V.

Br J Pharmacol. 2003 Aug;139(8):1417-24. Erratum in: Br J Pharmacol. 2003 Nov;140(5):1008.

37.

Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response.

Hermann H, De Petrocellis L, Bisogno T, Schiano Moriello A, Lutz B, Di Marzo V.

Cell Mol Life Sci. 2003 Mar;60(3):607-16.

PMID:
12737320

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