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Items: 1 to 20 of 48


ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2.

Kee AJ, Bryce NS, Yang L, Polishchuk E, Schevzov G, Weigert R, Polishchuk R, Gunning PW, Hardeman EC.

Cytoskeleton (Hoboken). 2017 Oct;74(10):379-389. doi: 10.1002/cm.21405. Epub 2017 Aug 31.


Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling.

Jeong S, Lim S, Schevzov G, Gunning PW, Helfman DM.

Oncotarget. 2017 May 16;8(20):33544-33559. doi: 10.18632/oncotarget.16825.


Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.

Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltrán J, Aurbach K, Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT.

J Clin Invest. 2017 Mar 1;127(3):814-829. doi: 10.1172/JCI86154. Epub 2017 Jan 30.


Tropomyosin Promotes Lamellipodial Persistence by Collaborating with Arp2/3 at the Leading Edge.

Brayford S, Bryce NS, Schevzov G, Haynes EM, Bear JE, Hardeman EC, Gunning PW.

Curr Biol. 2016 May 23;26(10):1312-8. doi: 10.1016/j.cub.2016.03.028. Epub 2016 Apr 21.


Ras Transformation Overrides a Proliferation Defect Induced by Tpm3.1 Knockout.

Coombes JD, Schevzov G, Kan CY, Petti C, Maritz MF, Whittaker S, Mackenzie KL, Gunning PW.

Cell Mol Biol Lett. 2015 Dec;20(4):626-46. doi: 10.1515/cmble-2015-0037.


Stable incorporation of α-smooth muscle actin into stress fibers is dependent on specific tropomyosin isoforms.

Prunotto M, Bruschi M, Gunning P, Gabbiani G, Weibel F, Ghiggeri GM, Petretto A, Scaloni A, Bonello T, Schevzov G, Alieva I, Bochaton-Piallat ML, Candiano G, Dugina V, Chaponnier C.

Cytoskeleton (Hoboken). 2015 Jun;72(6):257-67. doi: 10.1002/cm.21230.


Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton.

Jalilian I, Heu C, Cheng H, Freittag H, Desouza M, Stehn JR, Bryce NS, Whan RM, Hardeman EC, Fath T, Schevzov G, Gunning PW.

PLoS One. 2015 May 15;10(5):e0126214. doi: 10.1371/journal.pone.0126214. eCollection 2015.


Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments.

Schevzov G, Kee AJ, Wang B, Sequeira VB, Hook J, Coombes JD, Lucas CA, Stehn JR, Musgrove EA, Cretu A, Assoian R, Fath T, Hanoch T, Seger R, Pleines I, Kile BT, Hardeman EC, Gunning PW.

Mol Biol Cell. 2015 Jul 1;26(13):2475-90. doi: 10.1091/mbc.E14-10-1453. Epub 2015 May 13.


Tropomyosins induce neuritogenesis and determine neurite branching patterns in B35 neuroblastoma cells.

Curthoys NM, Freittag H, Connor A, Desouza M, Brettle M, Poljak A, Hall A, Hardeman E, Schevzov G, Gunning PW, Fath T.

Mol Cell Neurosci. 2014 Jan;58:11-21. doi: 10.1016/j.mcn.2013.10.011. Epub 2013 Nov 6.


A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells.

Stehn JR, Haass NK, Bonello T, Desouza M, Kottyan G, Treutlein H, Zeng J, Nascimento PR, Sequeira VB, Butler TL, Allanson M, Fath T, Hill TA, McCluskey A, Schevzov G, Palmer SJ, Hardeman EC, Winlaw D, Reeve VE, Dixon I, Weninger W, Cripe TP, Gunning PW.

Cancer Res. 2013 Aug 15;73(16):5169-82. doi: 10.1158/0008-5472.CAN-12-4501. Erratum in: Cancer Res. 2013 Oct 1;73(19):6094.


Functional diversity of actin cytoskeleton in neurons and its regulation by tropomyosin.

Schevzov G, Curthoys NM, Gunning PW, Fath T.

Int Rev Cell Mol Biol. 2012;298:33-94. doi: 10.1016/B978-0-12-394309-5.00002-X. Review.


Tropomyosin isoforms and reagents.

Schevzov G, Whittaker SP, Fath T, Lin JJ, Gunning PW.

Bioarchitecture. 2011 Jul;1(4):135-164. Epub 2011 Jul 1.


A molecular pathway for myosin II recruitment to stress fibers.

Tojkander S, Gateva G, Schevzov G, Hotulainen P, Naumanen P, Martin C, Gunning PW, Lappalainen P.

Curr Biol. 2011 Apr 12;21(7):539-50. doi: 10.1016/j.cub.2011.03.007. Epub 2011 Mar 31.


Tropomyosin variants describe distinct functional subcellular domains in differentiated vascular smooth muscle cells.

Gallant C, Appel S, Graceffa P, Leavis P, Lin JJ, Gunning PW, Schevzov G, Chaponnier C, DeGnore J, Lehman W, Morgan KG.

Am J Physiol Cell Physiol. 2011 Jun;300(6):C1356-65. doi: 10.1152/ajpcell.00450.2010. Epub 2011 Feb 2.


Tropomyosin isoform modulation of focal adhesion structure and cell migration.

Bach CT, Schevzov G, Bryce NS, Gunning PW, O'Neill GM.

Cell Adh Migr. 2010 Apr-Jun;4(2):226-34. Epub 2010 Apr 7.


New aspects of tropomyosin-regulated neuritogenesis revealed by the deletion of Tm5NM1 and 2.

Fath T, Agnes Chan YK, Vrhovski B, Clarke H, Curthoys N, Hook J, Lemckert F, Schevzov G, Tam P, Watson CM, Khoo PL, Gunning P.

Eur J Cell Biol. 2010 Jul;89(7):489-98. doi: 10.1016/j.ejcb.2009.11.028. Epub 2010 Mar 12.


Alternatively spliced N-terminal exons in tropomyosin isoforms do not act as autonomous targeting signals.

Martin C, Schevzov G, Gunning P.

J Struct Biol. 2010 May;170(2):286-93. doi: 10.1016/j.jsb.2009.12.016. Epub 2009 Dec 22.


Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle.

Lee AS, Kahatapitiya P, Kramer B, Joya JE, Hook J, Liu R, Schevzov G, Alexander IE, McCowage G, Montarras D, Gunning PW, Hardeman EC.

Stem Cells. 2009 May;27(5):1098-108. doi: 10.1002/stem.28.


Tropomyosin gene expression in vivo and in vitro.

Schevzov G, O'Neill G.

Adv Exp Med Biol. 2008;644:43-59. Review.


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