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Items: 41

1.

PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity.

Jang I, Pottekat A, Poothong J, Yong J, Lagunas-Acosta J, Charbono A, Chen Z, Scheuner DL, Liu M, Itkin-Ansari P, Arvan P, Kaufman RJ.

Elife. 2019 Jun 11;8. pii: e44528. doi: 10.7554/eLife.44528.

2.

Use of the PET ligand florbetapir for in vivo imaging of pancreatic islet amyloid deposits in hIAPP transgenic mice.

Templin AT, Meier DT, Willard JR, Wolden-Hanson T, Conway K, Lin YG, Gillespie PJ, Bokvist KB, Attardo G, Kahn SE, Scheuner D, Hull RL.

Diabetologia. 2018 Oct;61(10):2215-2224. doi: 10.1007/s00125-018-4695-y. Epub 2018 Jul 25.

3.

A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes.

Chen Y, Song M, Riley JP, Hu CC, Peng X, Scheuner D, Bokvist K, Maiti P, Kahl SD, Montrose-Rafizadeh C, Hamdouchi C, Miller AR.

Pharmacol Res Perspect. 2016 Nov 21;4(6):e00278. doi: 10.1002/prp2.278. eCollection 2016 Dec.

4.

The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells.

Hassler JR, Scheuner DL, Wang S, Han J, Kodali VK, Li P, Nguyen J, George JS, Davis C, Wu SP, Bai Y, Sartor M, Cavalcoli J, Malhi H, Baudouin G, Zhang Y, Yates JR III, Itkin-Ansari P, Volkmann N, Kaufman RJ.

PLoS Biol. 2015 Oct 15;13(10):e1002277. doi: 10.1371/journal.pbio.1002277. eCollection 2015 Oct.

5.

Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.

Muaddi H, Majumder M, Peidis P, Papadakis AI, Holcik M, Scheuner D, Kaufman RJ, Hatzoglou M, Koromilas AE.

Mol Biol Cell. 2010 Sep 15;21(18):3220-31. doi: 10.1091/mbc.E10-01-0023. Epub 2010 Jul 21.

6.

Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity.

Schulz O, Pichlmair A, Rehwinkel J, Rogers NC, Scheuner D, Kato H, Takeuchi O, Akira S, Kaufman RJ, Reis e Sousa C.

Cell Host Microbe. 2010 May 20;7(5):354-61. doi: 10.1016/j.chom.2010.04.007.

7.

eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress.

Bevilacqua E, Wang X, Majumder M, Gaccioli F, Yuan CL, Wang C, Zhu X, Jordan LE, Scheuner D, Kaufman RJ, Koromilas AE, Snider MD, Holcik M, Hatzoglou M.

J Biol Chem. 2010 May 28;285(22):17098-111. doi: 10.1074/jbc.M110.109439. Epub 2010 Mar 25.

8.

Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway.

Mounir Z, Krishnamoorthy JL, Robertson GP, Scheuner D, Kaufman RJ, Georgescu MM, Koromilas AE.

Sci Signal. 2009 Dec 22;2(102):ra85. doi: 10.1126/scisignal.2000389.

9.

Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells.

Back SH, Scheuner D, Han J, Song B, Ribick M, Wang J, Gildersleeve RD, Pennathur S, Kaufman RJ.

Cell Metab. 2009 Jul;10(1):13-26. doi: 10.1016/j.cmet.2009.06.002.

10.

Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress.

DuRose JB, Scheuner D, Kaufman RJ, Rothblum LI, Niwa M.

Mol Cell Biol. 2009 Aug;29(15):4295-307. doi: 10.1128/MCB.00260-09. Epub 2009 May 26.

11.

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development.

Harding HP, Zhang Y, Scheuner D, Chen JJ, Kaufman RJ, Ron D.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1832-7. doi: 10.1073/pnas.0809632106. Epub 2009 Jan 30.

12.

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.

Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ.

J Clin Invest. 2008 Oct;118(10):3378-89. doi: 10.1172/JCI34587.

13.

Novel function of PERK as a mediator of force-induced apoptosis.

Mak BC, Wang Q, Laschinger C, Lee W, Ron D, Harding HP, Kaufman RJ, Scheuner D, Austin RC, McCulloch CA.

J Biol Chem. 2008 Aug 22;283(34):23462-72. doi: 10.1074/jbc.M803194200. Epub 2008 Jun 11.

14.

The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes.

Scheuner D, Kaufman RJ.

Endocr Rev. 2008 May;29(3):317-33. doi: 10.1210/er.2007-0039. Epub 2008 Apr 24. Review. Erratum in: Endocr Rev. 2008 Aug;29(5):631.

15.

Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells.

Vander Mierde D, Scheuner D, Quintens R, Patel R, Song B, Tsukamoto K, Beullens M, Kaufman RJ, Bollen M, Schuit FC.

Endocrinology. 2007 Feb;148(2):609-17. Epub 2006 Nov 2.

PMID:
17082262
16.

Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis.

Scheuner D, Patel R, Wang F, Lee K, Kumar K, Wu J, Nilsson A, Karin M, Kaufman RJ.

J Biol Chem. 2006 Jul 28;281(30):21458-68. Epub 2006 May 22.

17.

Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression.

Harding HP, Zhang Y, Khersonsky S, Marciniak S, Scheuner D, Kaufman RJ, Javitt N, Chang YT, Ron D.

Cell Metab. 2005 Dec;2(6):361-71.

18.

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth.

Bi M, Naczki C, Koritzinsky M, Fels D, Blais J, Hu N, Harding H, Novoa I, Varia M, Raleigh J, Scheuner D, Kaufman RJ, Bell J, Ron D, Wouters BG, Koumenis C.

EMBO J. 2005 Oct 5;24(19):3470-81. Epub 2005 Sep 8.

19.

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis.

Scheuner D, Vander Mierde D, Song B, Flamez D, Creemers JW, Tsukamoto K, Ribick M, Schuit FC, Kaufman RJ.

Nat Med. 2005 Jul;11(7):757-64. Epub 2005 Jun 26.

PMID:
15980866
20.

Stress granules and processing bodies are dynamically linked sites of mRNP remodeling.

Kedersha N, Stoecklin G, Ayodele M, Yacono P, Lykke-Andersen J, Fritzler MJ, Scheuner D, Kaufman RJ, Golan DE, Anderson P.

J Cell Biol. 2005 Jun 20;169(6):871-84.

21.

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.

Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J.

Science. 2005 Feb 11;307(5711):935-9.

22.

The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.

Zhang K, Wong HN, Song B, Miller CN, Scheuner D, Kaufman RJ.

J Clin Invest. 2005 Feb;115(2):268-81.

23.

Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure.

McEwen E, Kedersha N, Song B, Scheuner D, Gilks N, Han A, Chen JJ, Anderson P, Kaufman RJ.

J Biol Chem. 2005 Apr 29;280(17):16925-33. Epub 2005 Jan 31.

24.

Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2.

Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, Sonenberg N, Harding HP, Ron D.

Mol Cell Biol. 2004 Dec;24(23):10161-8.

25.

Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis.

Wu S, Tan M, Hu Y, Wang JL, Scheuner D, Kaufman RJ.

J Biol Chem. 2004 Aug 13;279(33):34898-902. Epub 2004 Jun 7.

26.

Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2.

Lu PD, Jousse C, Marciniak SJ, Zhang Y, Novoa I, Scheuner D, Kaufman RJ, Ron D, Harding HP.

EMBO J. 2004 Jan 14;23(1):169-79. Epub 2004 Jan 8.

27.

The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis.

Scheuner D, Gromeier M, Davies MV, Dorner AJ, Song B, Patel RV, Wimmer EJ, McLendon RE, Kaufman RJ.

Virology. 2003 Dec 20;317(2):263-74.

28.

Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses.

Jiang HY, Wek SA, McGrath BC, Scheuner D, Kaufman RJ, Cavener DR, Wek RC.

Mol Cell Biol. 2003 Aug;23(16):5651-63.

29.

The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader.

Yaman I, Fernandez J, Liu H, Caprara M, Komar AA, Koromilas AE, Zhou L, Snider MD, Scheuner D, Kaufman RJ, Hatzoglou M.

Cell. 2003 May 16;113(4):519-31.

30.
31.

Activation of GCN2 in UV-irradiated cells inhibits translation.

Deng J, Harding HP, Raught B, Gingras AC, Berlanga JJ, Scheuner D, Kaufman RJ, Ron D, Sonenberg N.

Curr Biol. 2002 Aug 6;12(15):1279-86.

32.

The unfolded protein response in nutrient sensing and differentiation.

Kaufman RJ, Scheuner D, Schröder M, Shen X, Lee K, Liu CY, Arnold SM.

Nat Rev Mol Cell Biol. 2002 Jun;3(6):411-21. Review.

PMID:
12042763
33.

Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway.

Tallóczy Z, Jiang W, Virgin HW 4th, Leib DA, Scheuner D, Kaufman RJ, Eskelinen EL, Levine B.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):190-5. Epub 2001 Dec 26.

34.

Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis.

Scarim AL, Arnush M, Blair LA, Concepcion J, Heitmeier MR, Scheuner D, Kaufman RJ, Ryerse J, Buller RM, Corbett JA.

Am J Pathol. 2001 Jul;159(1):273-83.

35.

Translational control is required for the unfolded protein response and in vivo glucose homeostasis.

Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJ.

Mol Cell. 2001 Jun;7(6):1165-76.

36.

Potential role of PKR in double-stranded RNA-induced macrophage activation.

Maggi LB Jr, Heitmeier MR, Scheuner D, Kaufman RJ, Buller RM, Corbett JA.

EMBO J. 2000 Jul 17;19(14):3630-8.

37.

Eukaryotic initiation factor 2alpha kinase and phosphatase activity during postischemic brain reperfusion.

DeGracia DJ, Adamczyk S, Folbe AJ, Konkoly LL, Pittman JE, Neumar RW, Sullivan JM, Scheuner D, Kaufman RJ, White BC, Krause GS.

Exp Neurol. 1999 Feb;155(2):221-7.

PMID:
10072297
38.

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.

Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S.

Nat Med. 1996 Aug;2(8):864-70.

PMID:
8705854
40.

Bovine chromaffin granule membranes undergo Ca(2+)-regulated exocytosis in frog oocytes.

Scheuner D, Logsdon CD, Holz RW.

J Cell Biol. 1992 Jan;116(2):359-65.

41.

Nucleotide sequence of a cDNA for bovine cytochrome c oxidase subunit VIIa.

Seelan RS, Scheuner D, Lomax MI, Grossman LI.

Nucleic Acids Res. 1989 Aug 11;17(15):6410. No abstract available.

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