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Items: 1 to 50 of 88

1.

Host-Microbe Interplay in the Cardiometabolic Benefits of Dietary Polyphenols.

Anhê FF, Choi BSY, Dyck JRB, Schertzer JD, Marette A.

Trends Endocrinol Metab. 2019 Jun;30(6):384-395. doi: 10.1016/j.tem.2019.04.002. Epub 2019 May 7. Review.

PMID:
31076221
2.

Statins Promote IL-1β-Dependent Adipocyte Insulin Resistance via Lower Prenylation not Cholesterol.

Henriksbo BD, Tamrakar AK, Xu J, Duggan BM, Cavallari JF, Phulka J, Stampfli MR, Ashkar AA, Schertzer JD.

Diabetes. 2019 Apr 22. pii: db180999. doi: 10.2337/db18-0999. [Epub ahead of print]

PMID:
31010959
3.

Immunometabolism Sentinels: Gut Surface T-Cells Regulate GLP-1 Availability.

Barra NG, Anhê FF, Schertzer JD.

Endocrinology. 2019 May 1;160(5):1177-1178. doi: 10.1210/en.2019-00215. No abstract available.

PMID:
30958533
4.

TNF, but not hyperinsulinemia or hyperglycemia, is a key driver of obesity-induced monocytosis revealing that inflammatory monocytes correlate with insulin in obese male mice.

Breznik JA, Naidoo A, Foley KP, Schulz C, Lau TC, Loukov D, Sloboda DM, Bowdish DME, Schertzer JD.

Physiol Rep. 2018 Dec;6(23):e13937. doi: 10.14814/phy2.13937.

5.

Targeting macrophage scavenger receptor 1 promotes insulin resistance in obese male mice.

Cavallari JF, Anhê FF, Foley KP, Denou E, Chan RW, Bowdish DME, Schertzer JD.

Physiol Rep. 2018 Nov;6(22):e13930. doi: 10.14814/phy2.13930.

6.

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity.

Yao Y, Jeyanathan M, Haddadi S, Barra NG, Vaseghi-Shanjani M, Damjanovic D, Lai R, Afkhami S, Chen Y, Dvorkin-Gheva A, Robbins CS, Schertzer JD, Xing Z.

Cell. 2018 Nov 29;175(6):1634-1650.e17. doi: 10.1016/j.cell.2018.09.042. Epub 2018 Oct 25.

PMID:
30433869
7.

Long term but not short term exposure to obesity related microbiota promotes host insulin resistance.

Foley KP, Zlitni S, Denou E, Duggan BM, Chan RW, Stearns JC, Schertzer JD.

Nat Commun. 2018 Nov 8;9(1):4681. doi: 10.1038/s41467-018-07146-5.

8.

Nod1-mediated lipolysis promotes diacylglycerol accumulation and successive inflammation via PKCδ-IRAK axis in adipocytes.

Sharma A, Maurya CK, Arha D, Rai AK, Singh S, Varshney S, Schertzer JD, Tamrakar AK.

Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):136-146. doi: 10.1016/j.bbadis.2018.10.036. Epub 2018 Nov 2.

PMID:
30391544
9.

Immunometabolism of T cells and NK cells: metabolic control of effector and regulatory function.

Poznanski SM, Barra NG, Ashkar AA, Schertzer JD.

Inflamm Res. 2018 Oct;67(10):813-828. doi: 10.1007/s00011-018-1174-3. Epub 2018 Jul 31. Review.

PMID:
30066126
10.

Fecal transplant from resveratrol-fed donors improves glycaemia and cardiovascular features of the metabolic syndrome in mice.

Kim TT, Parajuli N, Sung MM, Bairwa SC, Levasseur J, Soltys CM, Wishart DS, Madsen K, Schertzer JD, Dyck JRB.

Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E511-E519. doi: 10.1152/ajpendo.00471.2017. Epub 2018 Jun 5.

PMID:
29870676
11.

Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction.

Thevaranjan N, Puchta A, Schulz C, Naidoo A, Szamosi JC, Verschoor CP, Loukov D, Schenck LP, Jury J, Foley KP, Schertzer JD, Larché MJ, Davidson DJ, Verdú EF, Surette MG, Bowdish DME.

Cell Host Microbe. 2018 Apr 11;23(4):570. doi: 10.1016/j.chom.2018.03.006. No abstract available.

12.

Statin Therapy Negatively Impacts Skeletal Muscle Regeneration and Cutaneous Wound Repair in Type 1 Diabetic Mice.

Rebalka IA, Cao AW, Raleigh MJ, Henriksbo BD, Coleman SK, Schertzer JD, Hawke TJ.

Front Physiol. 2017 Dec 19;8:1088. doi: 10.3389/fphys.2017.01088. eCollection 2017.

13.

Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants.

Stearns JC, Simioni J, Gunn E, McDonald H, Holloway AC, Thabane L, Mousseau A, Schertzer JD, Ratcliffe EM, Rossi L, Surette MG, Morrison KM, Hutton EK.

Sci Rep. 2017 Nov 28;7(1):16527. doi: 10.1038/s41598-017-16606-9.

14.

Intestinal Microbiota Contributes to Energy Balance, Metabolic Inflammation, and Insulin Resistance in Obesity.

Cavallari JF, Schertzer JD.

J Obes Metab Syndr. 2017 Sep;26(3):161-171. doi: 10.7570/jomes.2017.26.3.161. Epub 2017 Sep 30. Review.

15.

The Gut Microbiota as a Mediator of Metabolic Benefits after Bariatric Surgery.

Anhê FF, Varin TV, Schertzer JD, Marette A.

Can J Diabetes. 2017 Aug;41(4):439-447. doi: 10.1016/j.jcjd.2017.02.002. Epub 2017 May 25. Review.

PMID:
28552651
16.

The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice.

McBride MJ, Foley KP, D'Souza DM, Li YE, Lau TC, Hawke TJ, Schertzer JD.

Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E222-E232. doi: 10.1152/ajpendo.00060.2017. Epub 2017 May 23.

17.

Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia.

Duggan BM, Foley KP, Henriksbo BD, Cavallari JF, Tamrakar AK, Schertzer JD.

Sci Rep. 2017 May 8;7(1):1578. doi: 10.1038/s41598-017-01822-0.

18.

Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4.

Cavallari JF, Fullerton MD, Duggan BM, Foley KP, Denou E, Smith BK, Desjardins EM, Henriksbo BD, Kim KJ, Tuinema BR, Stearns JC, Prescott D, Rosenstiel P, Coombes BK, Steinberg GR, Schertzer JD.

Cell Metab. 2017 May 2;25(5):1063-1074.e3. doi: 10.1016/j.cmet.2017.03.021. Epub 2017 Apr 20.

19.

Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction.

Thevaranjan N, Puchta A, Schulz C, Naidoo A, Szamosi JC, Verschoor CP, Loukov D, Schenck LP, Jury J, Foley KP, Schertzer JD, Larché MJ, Davidson DJ, Verdú EF, Surette MG, Bowdish DME.

Cell Host Microbe. 2017 Apr 12;21(4):455-466.e4. doi: 10.1016/j.chom.2017.03.002. Erratum in: Cell Host Microbe. 2018 Apr 11;23 (4):570.

20.

Resveratrol improves exercise performance and skeletal muscle oxidative capacity in heart failure.

Sung MM, Byrne NJ, Robertson IM, Kim TT, Samokhvalov V, Levasseur J, Soltys CL, Fung D, Tyreman N, Denou E, Jones KE, Seubert JM, Schertzer JD, Dyck JR.

Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H842-H853. doi: 10.1152/ajpheart.00455.2016. Epub 2017 Feb 3.

21.

Improved Glucose Homeostasis in Obese Mice Treated With Resveratrol Is Associated With Alterations in the Gut Microbiome.

Sung MM, Kim TT, Denou E, Soltys CM, Hamza SM, Byrne NJ, Masson G, Park H, Wishart DS, Madsen KL, Schertzer JD, Dyck JR.

Diabetes. 2017 Feb;66(2):418-425. doi: 10.2337/db16-0680. Epub 2016 Nov 30.

22.

A comparison of intestinal microbiota in a population of low-risk infants exposed and not exposed to intrapartum antibiotics: The Baby & Microbiota of the Intestine cohort study protocol.

Simioni J, Hutton EK, Gunn E, Holloway AC, Stearns JC, McDonald H, Mousseau A, Schertzer JD, Ratcliffe EM, Thabane L, Surette MG, Morrison KM.

BMC Pediatr. 2016 Nov 10;16(1):183.

23.

Statin Therapy Alters Lipid Storage in Diabetic Skeletal Muscle.

Rebalka IA, Raleigh MJ, Snook LA, Rebalka AN, MacPherson RE, Wright DC, Schertzer JD, Hawke TJ.

Front Endocrinol (Lausanne). 2016 Jul 19;7:95. doi: 10.3389/fendo.2016.00095. eCollection 2016.

24.

High-intensity exercise training increases the diversity and metabolic capacity of the mouse distal gut microbiota during diet-induced obesity.

Denou E, Marcinko K, Surette MG, Steinberg GR, Schertzer JD.

Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E982-93. doi: 10.1152/ajpendo.00537.2015. Epub 2016 Apr 26.

25.

Different Th17 immunity in gut, liver, and adipose tissues during obesity: the role of diet, genetics, and microbes.

Cavallari JF, Denou E, Foley KP, Khan WI, Schertzer JD.

Gut Microbes. 2016;7(1):82-9. doi: 10.1080/19490976.2015.1127481.

26.

New Role of Nod Proteins in Regulation of Intestinal Goblet Cell Response in the Context of Innate Host Defense in an Enteric Parasite Infection.

Wang H, Kim JJ, Denou E, Gallagher A, Thornton DJ, Shajib MS, Xia L, Schertzer JD, Grencis RK, Philpott DJ, Khan WI.

Infect Immun. 2015 Nov 2;84(1):275-85. doi: 10.1128/IAI.01187-15. Print 2016 Jan.

27.

Immunometabolism of obesity and diabetes: microbiota link compartmentalized immunity in the gut to metabolic tissue inflammation.

McPhee JB, Schertzer JD.

Clin Sci (Lond). 2015 Dec;129(12):1083-96. doi: 10.1042/CS20150431. Review.

PMID:
26464517
28.

Is immunity a mechanism contributing to statin-induced diabetes?

Henriksbo BD, Schertzer JD.

Adipocyte. 2015 Apr 20;4(4):232-8. doi: 10.1080/21623945.2015.1024394. eCollection 2015 Oct-Dec. Review.

29.

Pregnancy-related changes in the maternal gut microbiota are dependent upon the mother's periconceptional diet.

Gohir W, Whelan FJ, Surette MG, Moore C, Schertzer JD, Sloboda DM.

Gut Microbes. 2015;6(5):310-20. doi: 10.1080/19490976.2015.1086056.

30.

AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging.

Bujak AL, Crane JD, Lally JS, Ford RJ, Kang SJ, Rebalka IA, Green AE, Kemp BE, Hawke TJ, Schertzer JD, Steinberg GR.

Cell Metab. 2015 Jun 2;21(6):883-90. doi: 10.1016/j.cmet.2015.05.016.

31.

Salicylate improves macrophage cholesterol homeostasis via activation of Ampk.

Fullerton MD, Ford RJ, McGregor CP, LeBlond ND, Snider SA, Stypa SA, Day EA, Lhoták Š, Schertzer JD, Austin RC, Kemp BE, Steinberg GR.

J Lipid Res. 2015 May;56(5):1025-33. doi: 10.1194/jlr.M058875. Epub 2015 Mar 15.

32.

Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance.

Denou E, Lolmède K, Garidou L, Pomie C, Chabo C, Lau TC, Fullerton MD, Nigro G, Zakaroff-Girard A, Luche E, Garret C, Serino M, Amar J, Courtney M, Cavallari JF, Henriksbo BD, Barra NG, Foley KP, McPhee JB, Duggan BM, O'Neill HM, Lee AJ, Sansonetti P, Ashkar AA, Khan WI, Surette MG, Bouloumié A, Steinberg GR, Burcelin R, Schertzer JD.

EMBO Mol Med. 2015 Mar;7(3):259-74. doi: 10.15252/emmm.201404169.

33.

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis.

Crane JD, Palanivel R, Mottillo EP, Bujak AL, Wang H, Ford RJ, Collins A, Blümer RM, Fullerton MD, Yabut JM, Kim JJ, Ghia JE, Hamza SM, Morrison KM, Schertzer JD, Dyck JR, Khan WI, Steinberg GR.

Nat Med. 2015 Feb;21(2):166-72. doi: 10.1038/nm.3766. Epub 2014 Dec 8.

34.

Fluvastatin causes NLRP3 inflammasome-mediated adipose insulin resistance.

Henriksbo BD, Lau TC, Cavallari JF, Denou E, Chi W, Lally JS, Crane JD, Duggan BM, Foley KP, Fullerton MD, Tarnopolsky MA, Steinberg GR, Schertzer JD.

Diabetes. 2014 Nov;63(11):3742-7. doi: 10.2337/db13-1398. Epub 2014 Jun 10.

35.

Bacterial peptidoglycan stimulates adipocyte lipolysis via NOD1.

Chi W, Dao D, Lau TC, Henriksbo BD, Cavallari JF, Foley KP, Schertzer JD.

PLoS One. 2014 May 14;9(5):e97675. doi: 10.1371/journal.pone.0097675. eCollection 2014.

36.

AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease.

Steinberg GR, Schertzer JD.

Immunol Cell Biol. 2014 Apr;92(4):340-5. doi: 10.1038/icb.2014.11. Epub 2014 Mar 18. Review.

PMID:
24638063
37.

Immunometabolism: the interface of immune and metabolic responses in disease.

Schertzer JD, Steinberg GR.

Immunol Cell Biol. 2014 Apr;92(4):303. doi: 10.1038/icb.2014.12. Epub 2014 Mar 11. No abstract available.

PMID:
24613974
38.

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

Fullerton MD, Galic S, Marcinko K, Sikkema S, Pulinilkunnil T, Chen ZP, O'Neill HM, Ford RJ, Palanivel R, O'Brien M, Hardie DG, Macaulay SL, Schertzer JD, Dyck JR, van Denderen BJ, Kemp BE, Steinberg GR.

Nat Med. 2013 Dec;19(12):1649-54. doi: 10.1038/nm.3372. Epub 2013 Nov 3.

39.

IL-6 is not essential for exercise-induced increases in glucose uptake.

O'Neill HM, Palanivel R, Wright DC, MacDonald T, Lally JS, Schertzer JD, Steinberg GR.

J Appl Physiol (1985). 2013 May;114(9):1151-7. doi: 10.1152/japplphysiol.00946.2012. Epub 2013 Feb 28.

40.

Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity.

Jorgensen SB, O'Neill HM, Sylow L, Honeyman J, Hewitt KA, Palanivel R, Fullerton MD, Öberg L, Balendran A, Galic S, van der Poel C, Trounce IA, Lynch GS, Schertzer JD, Steinberg GR.

Diabetes. 2013 Jan;62(1):56-64. doi: 10.2337/db12-0443. Epub 2012 Sep 6.

41.

The ancient drug salicylate directly activates AMP-activated protein kinase.

Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, Peggie MW, Zibrova D, Green KA, Mustard KJ, Kemp BE, Sakamoto K, Steinberg GR, Hardie DG.

Science. 2012 May 18;336(6083):918-22. doi: 10.1126/science.1215327. Epub 2012 Apr 19.

42.

Hsp72 preserves muscle function and slows progression of severe muscular dystrophy.

Gehrig SM, van der Poel C, Sayer TA, Schertzer JD, Henstridge DC, Church JE, Lamon S, Russell AP, Davies KE, Febbraio MA, Lynch GS.

Nature. 2012 Apr 4;484(7394):394-8. doi: 10.1038/nature10980.

PMID:
22495301
43.

Muscle cellular properties in the ice hockey player: a model for investigating overtraining?

Green HJ, Batada A, Cole B, Burnett ME, Kollias H, McKay S, Roy B, Schertzer JD, Smith IC, Tupling S.

Can J Physiol Pharmacol. 2012 May;90(5):567-78. doi: 10.1139/y2012-017. Epub 2012 Apr 3.

PMID:
22471993
44.

Immunometabolism of AMPK in insulin resistance and atherosclerosis.

Fullerton MD, Steinberg GR, Schertzer JD.

Mol Cell Endocrinol. 2013 Feb 25;366(2):224-34. doi: 10.1016/j.mce.2012.02.004. Epub 2012 Feb 14. Review.

PMID:
22361321
45.

Ageing prolongs inflammatory marker expression in regenerating rat skeletal muscles after injury.

van der Poel C, Gosselin LE, Schertzer JD, Ryall JG, Swiderski K, Wondemaghen M, Lynch GS.

J Inflamm (Lond). 2011 Dec 29;8(1):41. doi: 10.1186/1476-9255-8-41.

46.

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity.

Galic S, Fullerton MD, Schertzer JD, Sikkema S, Marcinko K, Walkley CR, Izon D, Honeyman J, Chen ZP, van Denderen BJ, Kemp BE, Steinberg GR.

J Clin Invest. 2011 Dec;121(12):4903-15. doi: 10.1172/JCI58577. Epub 2011 Nov 14.

47.

AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise.

O'Neill HM, Maarbjerg SJ, Crane JD, Jeppesen J, Jørgensen SB, Schertzer JD, Shyroka O, Kiens B, van Denderen BJ, Tarnopolsky MA, Kemp BE, Richter EA, Steinberg GR.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16092-7. doi: 10.1073/pnas.1105062108. Epub 2011 Sep 6.

48.

Give a NOD to insulin resistance.

Schertzer JD, Klip A.

Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E585-6. doi: 10.1152/ajpendo.00362.2011. Epub 2011 Jul 19. No abstract available.

49.

NOD1 activators link innate immunity to insulin resistance.

Schertzer JD, Tamrakar AK, Magalhães JG, Pereira S, Bilan PJ, Fullerton MD, Liu Z, Steinberg GR, Giacca A, Philpott DJ, Klip A.

Diabetes. 2011 Sep;60(9):2206-15. doi: 10.2337/db11-0004. Epub 2011 Jun 29.

50.

NOD2 activation induces muscle cell-autonomous innate immune responses and insulin resistance.

Tamrakar AK, Schertzer JD, Chiu TT, Foley KP, Bilan PJ, Philpott DJ, Klip A.

Endocrinology. 2010 Dec;151(12):5624-37. doi: 10.1210/en.2010-0437. Epub 2010 Oct 6.

PMID:
20926588

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