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Elevated Lipoprotein(a) in Perinatally HIV-Infected Children Compared With Healthy Ethnicity-Matched Controls.

Van den Hof M, Klein Haneveld MJ, Blokhuis C, Scherpbier HJ, Jansen HPG, Kootstra NA, Dallinga-Thie GM, Van Deventer SJH, Tsimikas S, Pajkrt D; NOVICE study group .

Open Forum Infect Dis. 2019 Sep 2;6(9):ofz301. doi: 10.1093/ofid/ofz301. eCollection 2019 Sep.


Systemic and intrathecal immune activation in association with cerebral and cognitive outcomes in paediatric HIV.

Blokhuis C, Peeters CFW, Cohen S, Scherpbier HJ, Kuijpers TW, Reiss P, Kootstra NA, Teunissen CE, Pajkrt D.

Sci Rep. 2019 May 29;9(1):8004. doi: 10.1038/s41598-019-44198-z.


Neurocognitive development in perinatally HIV-infected adolescents on long-term treatment compared to healthy matched controls: a longitudinal study.

Van den Hof M, Ter Haar AM, Scherpbier HJ, van der Lee JH, Reiss P, Wit FWNM, Oostrom KJ, Pajkrt D.

Clin Infect Dis. 2019 May 18. pii: ciz386. doi: 10.1093/cid/ciz386. [Epub ahead of print]


Correction: Long-Term Changes of Subcutaneous Fat Mass in HIV-Infected Children on Antiretroviral Therapy: A Retrospective Analysis of Longitudinal Data from Two Pediatric HIV-Cohorts.

Cohen S, Innes S, Geelen SPM, Wells JCK, Smit C, Wolfs TFW, van Eck-Smit BLF, Kuijpers TW, Reiss P, Scherpbier HJ, Pajkrt D, Bunders MJ.

PLoS One. 2018 Jan 2;13(1):e0190726. doi: 10.1371/journal.pone.0190726. eCollection 2018.


Inflammatory and Neuronal Biomarkers Associated With Retinal Thinning in Pediatric HIV.

Blokhuis C, Doeleman S, Cohen S, Demirkaya N, Scherpbier HJ, Kootstra NA, Kuhle J, Teunissen CE, Verbraak FD, Pajkrt D.

Invest Ophthalmol Vis Sci. 2017 Nov 1;58(13):5985-5992. doi: 10.1167/iovs.17-22252.


CNS penetration of ART in HIV-infected children.

Van den Hof M, Blokhuis C, Cohen S, Scherpbier HJ, Wit FWNM, Pistorius MCM, Kootstra NA, Teunissen CE, Mathot RAA, Pajkrt D.

J Antimicrob Chemother. 2018 Feb 1;73(2):484-489. doi: 10.1093/jac/dkx396.


Fetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants.

Schoeman JC, Moutloatse GP, Harms AC, Vreeken RJ, Scherpbier HJ, Van Leeuwen L, Kuijpers TW, Reinecke CJ, Berger R, Hankemeier T, Bunders MJ.

J Infect Dis. 2017 Aug 15;216(4):436-446. doi: 10.1093/infdis/jix291.


Higher subcortical and white matter cerebral blood flow in perinatally HIV-infected children.

Blokhuis C, Mutsaerts HJ, Cohen S, Scherpbier HJ, Caan MW, Majoie CB, Kuijpers TW, Reiss P, Wit FW, Pajkrt D.

Medicine (Baltimore). 2017 Feb;96(7):e5891. doi: 10.1097/MD.0000000000005891.


In-utero exposure to tenofovir is associated with impaired fetal and infant growth: need for follow-up studies in combination antiretroviral therapy/HIV-exposed infants: author's reply.

Denneman L, Cohen S, Godfried MH, van Leeuwen E, Nellen JF, Kuijpers TW, Pajkrt D, van de Plas A, Smit C, Weijsenfeld AM, Scherpbier HJ, Bunders MJ.

AIDS. 2017 Feb 20;31(4):596-598. doi: 10.1097/QAD.0000000000001364. No abstract available.


Immunisation practices in centres caring for children with perinatally acquired HIV: A call for harmonisation.

Bamford A, Manno EC, Mellado MJ, Spoulou V, Marques L, Scherpbier HJ, Niehues T, Oldakowska A, Rossi P, Palma P; PENTA-vac Group.

Vaccine. 2016 Nov 4;34(46):5587-5594. doi: 10.1016/j.vaccine.2016.09.035. Epub 2016 Oct 7.


In-utero exposure to tenofovir is associated with impaired fetal and infant growth: need for follow-up studies in combination antiretroviral therapy/HIV-exposed infants.

Denneman L, Cohen S, Godfried MH, van Leeuwen E, Nellen JF, Kuijpers TW, Pajkrt D, van de Plas A, Smit C, Weijsenfeld AM, Scherpbier HJ, Bunders MJ.

AIDS. 2016 Aug 24;30(13):2135-7. doi: 10.1097/QAD.0000000000001156. No abstract available.


The Eye as a Window to the Brain: Neuroretinal Thickness Is Associated With Microstructural White Matter Injury in HIV-Infected Children.

Blokhuis C, Demirkaya N, Cohen S, Wit FW, Scherpbier HJ, Reiss P, Abramoff MD, Caan MW, Majoie CB, Verbraak FD, Pajkrt D.

Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3864-71. doi: 10.1167/iovs.16-19716.


Virological and Social Outcomes of HIV-Infected Adolescents and Young Adults in The Netherlands Before and After Transition to Adult Care.

Weijsenfeld AM, Smit C, Cohen S, Wit FWNM, Mutschelknauss M, van der Knaap LC, van Zonneveld LM, Zomer BJ, Nauta N, Patist JC, Kuipers-Jansen MHJ, Smit EP, Blokhuis C, Pajkrt D; Dutch HIV Adolescents and Young Adults (AYA) Study Group, Weijsenfeld AM, Cohen S, Blokhuis C, van der Plas A, Scherpbier HJ, Mutschelknauss M, Nellen FJB, Prins JM, Pajkrt D, Smit C, Wit FWNM, Reiss P, van der Knaap L, Visser E, van Zonneveld LM, Vriesde ME, Bassant NY, van der Ende ME, van Rossum AMC, Driessen GJA, Fraaij PLA, Smit JV, Smit EP, Kastelijns MPW, den Hollander JG, Pogány K, Moons C, Kroon FP, Oude Geerdink E, van der Meche IB, Schouten WEM, Brinkman K, Ter Beest G, Gisolf EH, Richter C, Zomer BJ, Strik-Albers R, van der Flier M, Henriet SS, Koopmans PP, Patist JC, Nauta N, Geelen SPM, Wolfs TFW, Hoepelman IM, Mudrikova T, van der Meulen PA, de Jonge H, Scholvink EH, Bierman WFW, van den Berg JF, Bouwhuis JW, Faber S, van Vonderen M, Schippers JA, Lowe SH, Kuipers-Jansen MHJ, van Kasteren MEE, Brouwer AE, Pronk DC, Kortmann W.

Clin Infect Dis. 2016 Oct 15;63(8):1105-1112. doi: 10.1093/cid/ciw487. Epub 2016 Jul 20.


Tuberculids: cutaneous indicator diseases of Mycobacterium tuberculosis infection in young patients.

Hallensleben ND, de Vries HJ, Lettinga KD, Scherpbier HJ.

J Eur Acad Dermatol Venereol. 2016 Sep;30(9):1590-3. doi: 10.1111/jdv.13723. Epub 2016 May 26.


Noncirrhotic Portal Hypertension in Perinatally HIV-infected Adolescents Treated With Didanosine-containing Antiretroviral Regimens in Childhood.

Scherpbier HJ, Terpstra V, Pajkrt D, Puthakanit T, Ananworanich J, Foster C, van den Bergh Weerman M, Deurloo EE, van der Valk M, Kuijpers TW, Koot BG.

Pediatr Infect Dis J. 2016 Aug;35(8):e248-52. doi: 10.1097/INF.0000000000001202.


Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children.

Van Dalen YW, Blokhuis C, Cohen S, Ter Stege JA, Teunissen CE, Kuhle J, Kootstra NA, Scherpbier HJ, Kuijpers TW, Reiss P, Majoie CB, Caan MW, Pajkrt D.

Medicine (Baltimore). 2016 Mar;95(12):e3093. doi: 10.1097/MD.0000000000003093.


Cerebral injury in perinatally HIV-infected children compared to matched healthy controls.

Cohen S, Caan MW, Mutsaerts HJ, Scherpbier HJ, Kuijpers TW, Reiss P, Majoie CB, Pajkrt D.

Neurology. 2016 Jan 5;86(1):19-27. doi: 10.1212/WNL.0000000000002209. Epub 2015 Nov 11.


Health-related quality of life in perinatally HIV-infected children in the Netherlands.

Cohen S, ter Stege JA, Weijsenfeld AM, van der Plas A, Kuijpers TW, Reiss P, Scherpbier HJ, Haverman L, Pajkrt D.

AIDS Care. 2015;27(10):1279-88. doi: 10.1080/09540121.2015.1050986. Epub 2015 Aug 14.


Long-Term Changes of Subcutaneous Fat Mass in HIV-Infected Children on Antiretroviral Therapy: A Retrospective Analysis of Longitudinal Data from Two Pediatric HIV-Cohorts.

Cohen S, Innes S, Geelen SP, Wells JC, Smit C, Wolfs TF, van Eck-Smit BL, Kuijpers TW, Reiss P, Scherpbier HJ, Pajkrt D, Bunders MJ.

PLoS One. 2015 Jul 6;10(7):e0120927. doi: 10.1371/journal.pone.0120927. eCollection 2015. Erratum in: PLoS One. 2018 Jan 2;13(1):e0190726.


The effect of malnutrition on the pharmacokinetics and virologic outcomes of lopinavir, efavirenz and nevirapine in food insecure HIV-infected children in Tororo, Uganda.

Bartelink IH, Savic RM, Dorsey G, Ruel T, Gingrich D, Scherpbier HJ, Capparelli E, Jullien V, Young SL, Achan J, Plenty A, Charlebois E, Kamya M, Havlir D, Aweeka F.

Pediatr Infect Dis J. 2015 Mar;34(3):e63-70. doi: 10.1097/INF.0000000000000603.


Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV-1 infection 2015: optimizing health in preparation for adult life.

Bamford A, Turkova A, Lyall H, Foster C, Klein N, Bastiaans D, Burger D, Bernadi S, Butler K, Chiappini E, Clayden P, Della Negra M, Giacomet V, Giaquinto C, Gibb D, Galli L, Hainaut M, Koros M, Marques L, Nastouli E, Niehues T, Noguera-Julian A, Rojo P, Rudin C, Scherpbier HJ, Tudor-Williams G, Welch SB; (PENTA Steering Committee).

HIV Med. 2018 Jan;19(1):e1-e42. doi: 10.1111/hiv.12217. Epub 2015 Feb 3.


Poorer cognitive performance in perinatally HIV-infected children versus healthy socioeconomically matched controls.

Cohen S, Ter Stege JA, Geurtsen GJ, Scherpbier HJ, Kuijpers TW, Reiss P, Schmand B, Pajkrt D.

Clin Infect Dis. 2015 Apr 1;60(7):1111-9. doi: 10.1093/cid/ciu1144. Epub 2014 Dec 16.


Country of birth does not influence long-term clinical, virologic, and immunological outcome of HIV-infected children living in the Netherlands: a cohort study comparing children born in the Netherlands with children born in Sub-Saharan Africa.

Cohen S, van Bilsen WP, Smit C, Fraaij PL, Warris A, Kuijpers TW, Geelen SP, Wolfs TF, Scherpbier HJ, van Rossum AM, Pajkrt D.

J Acquir Immune Defic Syndr. 2015 Feb 1;68(2):178-85. doi: 10.1097/QAI.0000000000000431.


Long-term response to combination antiretroviral therapy in HIV-infected children in the Netherlands registered from 1996 to 2012.

Cohen S, Smit C, van Rossum AM, Fraaij PL, Wolfs TF, Geelen SP, Schölvinck EH, Warris A, Scherpbier HJ, Pajkrt D; Dutch Paediatric HIV Study Group.

AIDS. 2013 Oct 23;27(16):2567-75. doi: 10.1097/01.aids.0000432451.75980.1b.


Neurologic abnormalities in HIV-1 infected children in the era of combination antiretroviral therapy.

van Arnhem LA, Bunders MJ, Scherpbier HJ, Majoie CB, Reneman L, Frinking O, Poll-The BT, Kuijpers TW, Pajkrt D.

PLoS One. 2013 May 15;8(5):e64398. doi: 10.1371/journal.pone.0064398. Print 2013.


Bone mineral density increases in HIV-infected children treated with long-term combination antiretroviral therapy.

Bunders MJ, Frinking O, Scherpbier HJ, van Arnhem LA, van Eck-Smit BL, Kuijpers TW, Zwinderman AH, Reiss P, Pajkrt D.

Clin Infect Dis. 2013 Feb;56(4):583-6. doi: 10.1093/cid/cis917. Epub 2012 Oct 24.


Mannose-binding lectin and the risk of HIV transmission and disease progression in children: a systematic review.

Israëls J, Scherpbier HJ, Frakking FN, van de Wetering MD, Kremer LC, Kuijpers TW.

Pediatr Infect Dis J. 2012 Dec;31(12):1272-8. doi: 10.1097/INF.0b013e3182678bc4. Review.


Guidance on vaccination of HIV-infected children in Europe.

Menson EN, Mellado MJ, Bamford A, Castelli G, Duiculescu D, Marczyńska M, Navarro M, Scherpbier HJ, Heath PT; Paediatric European Network for Treatment of AIDS (PENTA) Vaccines Group; PENTA Steering Committee; Children's HIV Association (CHIVA).

HIV Med. 2012 Jul;13(6):333-6; e1-14. doi: 10.1111/j.1468-1293.2011.00982.x. Epub 2012 Feb 2. No abstract available.


Multi-National, Multi-Institutional Analysis of Clinical Decision Support Data Needs to Inform Development of the HL7 Virtual Medical Record Standard.

Kawamoto K, Del Fiol G, Strasberg HR, Hulse N, Curtis C, Cimino JJ, Rocha BH, Maviglia S, Fry E, Scherpbier HJ, Huser V, Redington PK, Vawdrey DK, Dufour JC, Price M, Weber JH, White T, Hughes KS, McClay JC, Wood C, Eckert K, Bolte S, Shields D, Tattam PR, Scott P, Liu Z, McIntyre AK.

AMIA Annu Symp Proc. 2010 Nov 13;2010:377-81.


A pharmacokinetic and pharmacogenetic study of efavirenz in children: dosing guidelines can result in subtherapeutic concentrations.

ter Heine R, Scherpbier HJ, Crommentuyn KM, Bekker V, Beijnen JH, Kuijpers TW, Huitema AD.

Antivir Ther. 2008;13(6):779-87.


Once-daily highly active antiretroviral therapy for HIV-infected children: safety and efficacy of an efavirenz-containing regimen.

Scherpbier HJ, Bekker V, Pajkrt D, Jurriaans S, Lange JM, Kuijpers TW.

Pediatrics. 2007 Mar;119(3):e705-15. Epub 2007 Feb 16.


Population pharmacokinetics and pharmacodynamics of nelfinavir and its active metabolite M8 in HIV-1-infected children.

Crommentuyn KM, Scherpbier HJ, Kuijpers TW, Mathôt RA, Huitema AD, Beijnen JH.

Pediatr Infect Dis J. 2006 Jun;25(6):538-43.


Long-term experience with combination antiretroviral therapy that contains nelfinavir for up to 7 years in a pediatric cohort.

Scherpbier HJ, Bekker V, van Leth F, Jurriaans S, Lange JM, Kuijpers TW.

Pediatrics. 2006 Mar;117(3):e528-36. Epub 2006 Feb 15.


Viral dynamics after starting first-line HAART in HIV-1-infected children.

Bekker V, Scherpbier HJ, Steingrover R, Jurriaans S, Lange JM, Wolthers KC, Kuijpers TW.

AIDS. 2006 Feb 28;20(4):517-23.


Haematological parameters of HIV-1-uninfected infants born to HIV-1-infected mothers.

Bunders MJ, Bekker V, Scherpbier HJ, Boer K, Godfried M, Kuijpers TW.

Acta Paediatr. 2005 Nov;94(11):1571-7.


Cytomegalovirus rather than HIV triggers the outgrowth of effector CD8+CD45RA+CD27- T cells in HIV-1-infected children.

Bekker V, Bronke C, Scherpbier HJ, Weel JF, Jurriaans S, Wertheim-van Dillen PM, van Leth F, Lange JM, Tesselaar K, van Baarle D, Kuijpers TW.

AIDS. 2005 Jul 1;19(10):1025-34.


A neonate with macrosomia, cardiomyopathy and hepatomegaly born to an HIV-infected mother.

Godfried MH, Boer K, Beuger S, Scherpbier HJ, Kuijpers TW.

Eur J Pediatr. 2005 Mar;164(3):190-2. Epub 2005 Jan 12. No abstract available.


[Treatment of HIV-1 infected pregnant women].

Nellen JF, Godfried MH, Kreijenbroek ME, Scherpbier HJ, Prins JM, Boer K.

Ned Tijdschr Geneeskd. 2004 Oct 9;148(41):2005-8. Dutch.


Establishment of the CD4+ T-cell pool in healthy children and untreated children infected with HIV-1.

Hazenberg MD, Otto SA, van Rossum AM, Scherpbier HJ, de Groot R, Kuijpers TW, Lange JM, Hamann D, de Boer RJ, Borghans JA, Miedema F.

Blood. 2004 Dec 1;104(12):3513-9. Epub 2004 Aug 5.


Liver failure in a child receiving highly active antiretroviral therapy and voriconazole.

Scherpbier HJ, Hilhorst MI, Kuijpers TW.

Clin Infect Dis. 2003 Sep 15;37(6):828-30. Epub 2003 Aug 26.


The pharmacokinetics of nelfinavir in HIV-1-infected children.

van Heeswijk RP, Scherpbier HJ, de Koning LA, Heymans HS, Lange JM, Beijnen JH, Hoetelmans RM.

Ther Drug Monit. 2002 Aug;24(4):487-91.


[Reduction of vertical transmission by means of perinatal prophylaxis in the case of children exposed to HIV-1 and born in the Netherlands during the period 1995-1999].

van Rossum AM, Kuiper IE, Rodrigues PR, Scherpbier HJ, Wolfs TF, de Groot R.

Ned Tijdschr Geneeskd. 2002 Jul 6;146(27):1277-81. Dutch.


Results of 2 years of treatment with protease-inhibitor--containing antiretroviral therapy in dutch children infected with human immunodeficiency virus type 1.

van Rossum AM, Geelen SP, Hartwig NG, Wolfs TF, Weemaes CM, Scherpbier HJ, van Lochem EG, Hop WC, Schutten M, Osterhaus AD, Burger DM, de Groot R.

Clin Infect Dis. 2002 Apr 1;34(7):1008-16. Epub 2002 Mar 4.


Treatment with highly active antiretroviral therapy in human immunodeficiency virus type 1-infected children is associated with a sustained effect on growth.

Verweel G, van Rossum AM, Hartwig NG, Wolfs TF, Scherpbier HJ, de Groot R.

Pediatrics. 2002 Feb;109(2):E25.


Therapeutic immune reconstitution in HIV-1-infected children is independent of their age and pretreatment immune status.

van Rossum AM, Scherpbier HJ, van Lochem EG, Pakker NG, Slieker WA, Wolthers KC, Roos MT, Kuijpers JH, Hooijkaas H, Hartwig NG, Geelen SP, Wolfs TF, Lange JM, Miedema F, de Groot R; Dutch Study Group for Children with HIV Infections.

AIDS. 2001 Nov 23;15(17):2267-75.


Pharmacokinetics of the protease inhibitor indinavir in human immunodeficiency virus type 1-infected children.

Burger DM, van Rossum AM, Hugen PW, Suur MH, Hartwig NG, Geelen SP, Scherpbier HJ, Hoetelmans RM, Vulto AG, de Groot R; Dutch Study Group for Children with HIV-1 Infection.

Antimicrob Agents Chemother. 2001 Mar;45(3):701-5.


Clinical and virologic response to combination treatment with indinavir, zidovudine, and lamivudine in children with human immunodeficiency virus-1 infection: a multicenter study in the Netherlands. On behalf of the Dutch Study Group for Children with HIV-1 infections.

van Rossum AM, Niesters HG, Geelen SP, Scherpbier HJ, Hartwig NG, Weemaes CM, Veerman AJ, Suur MH, de Graeff-Meeder ER, Slieker WA, Hop WC, Osterhaus AD, Burger DM, De Groot R.

J Pediatr. 2000 Jun;136(6):780-8.


Myelodysplastic syndrome in an HIV-1-infected infant.

van den Berg H, Scherpbier HJ, Kroes W.

Med Pediatr Oncol. 1999 May;32(5):385. No abstract available.


Early recovery of CD4+ T lymphocytes in children on highly active antiretroviral therapy. Dutch study group for children with HIV infections.

Cohen Stuart JW, Slieker WA, Rijkers GT, Noest A, Boucher CA, Suur MH, de Boer R, Geelen SP, Scherpbier HJ, Hartwig NG, Hooijkaas H, Roos MT, de Graeff-Meeder B, de Groot R.

AIDS. 1998 Nov 12;12(16):2155-9.


Computerized pharmacokinetics on an institutional clinical information system.

Chrymko MM, Scherpbier HJ.

Pharm Pract Manag Q. 1995 Oct;15(3):36-43.


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