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Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans.

Kluth O, Stadion M, Gottmann P, Aga H, Jähnert M, Scherneck S, Vogel H, Krus U, Seelig A, Ling C, Gerdes J, Schürmann A.

Cell Rep. 2019 Mar 12;26(11):3027-3036.e3. doi: 10.1016/j.celrep.2019.02.056.


Single- and multiple-dose pharmacokinetics and total removal of colistin in critically ill patients with acute kidney injury undergoing prolonged intermittent renal replacement therapy.

Schmidt JJ, Strunk AK, David S, Bode-Böger SM, Martens-Lobenhoffer J, Knitsch W, Scherneck S, Welte T, Kielstein JT.

J Antimicrob Chemother. 2019 Apr 1;74(4):997-1002. doi: 10.1093/jac/dky511.


Pregnancy outcome after first-trimester exposure to metformin: A prospective cohort study.

Scherneck S, Schlinke N, Beck E, Grupe K, Weber-Schoendorfer C, Schaefer C.

Reprod Toxicol. 2018 Oct;81:79-83. doi: 10.1016/j.reprotox.2018.07.004. Epub 2018 Jul 11.


[Hot rods in the ICU : What is the antibiotic mileage of your renal replacement therapy?]

Kielstein JT, Kruse AK, Anderson N, Vaitiekunas H, Scherneck S.

Med Klin Intensivmed Notfmed. 2019 Mar;114(2):139-145. doi: 10.1007/s00063-017-0303-z. Epub 2017 May 8. Review. German.


A vast genomic deletion in the C56BL/6 genome affects different genes within the Ifi200 cluster on chromosome 1 and mediates obesity and insulin resistance.

Vogel H, Jähnert M, Stadion M, Matzke D, Scherneck S, Schürmann A.

BMC Genomics. 2017 Feb 15;18(1):172. doi: 10.1186/s12864-017-3552-6.


Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation.

Kluth O, Matzke D, Kamitz A, Jähnert M, Vogel H, Scherneck S, Schulze M, Staiger H, Machicao F, Häring HU, Joost HG, Schürmann A.

PLoS Genet. 2015 Sep 8;11(9):e1005506. doi: 10.1371/journal.pgen.1005506. eCollection 2015 Sep.


Reversible oligohydramnios in the second trimester of pregnancy in two patients with long-term diclofenac exposure.

Scherneck S, Schöpa FL, Entezami M, Kayser A, Weber-Schoendorfer C, Schaefer C.

Reprod Toxicol. 2015 Dec;58:61-4. doi: 10.1016/j.reprotox.2015.08.002. Epub 2015 Aug 28.


The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice.

Chung B, Stadion M, Schulz N, Jain D, Scherneck S, Joost HG, Schürmann A.

Diabetologia. 2015 Oct;58(10):2403-13. doi: 10.1007/s00125-015-3703-8. Epub 2015 Aug 1.


Molecular links between Obesity and Diabetes: “Diabesity”.

Chadt A, Scherneck S, Joost HG, Al-Hasani H.

In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA):, Inc.; 2000-.
2018 Jan 23.


An interval of the obesity QTL Nob3.38 within a QTL hotspot on chromosome 1 modulates behavioral phenotypes.

Vogel H, Montag D, Kanzleiter T, Jonas W, Matzke D, Scherneck S, Chadt A, Töle J, Kluge R, Joost HG, Schürmann A.

PLoS One. 2013;8(1):e53025. doi: 10.1371/journal.pone.0053025. Epub 2013 Jan 4.


Pathophysiology and genetics of obesity and diabetes in the New Zealand obese mouse: a model of the human metabolic syndrome.

Kluge R, Scherneck S, Schürmann A, Joost HG.

Methods Mol Biol. 2012;933:59-73. doi: 10.1007/978-1-62703-068-7_5.


Loss of function of Ifi202b by a microdeletion on chromosome 1 of C57BL/6J mice suppresses 11β-hydroxysteroid dehydrogenase type 1 expression and development of obesity.

Vogel H, Scherneck S, Kanzleiter T, Benz V, Kluge R, Stadion M, Kryvych S, Blüher M, Klöting N, Joost HG, Schürmann A.

Hum Mol Genet. 2012 Sep 1;21(17):3845-57. doi: 10.1093/hmg/dds213. Epub 2012 Jun 12.


Non-invasive quantification of white and brown adipose tissues and liver fat content by computed tomography in mice.

Lubura M, Hesse D, Neumann N, Scherneck S, Wiedmer P, Schürmann A.

PLoS One. 2012;7(5):e37026. doi: 10.1371/journal.pone.0037026. Epub 2012 May 16.


Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion.

Gorboulev V, Schürmann A, Vallon V, Kipp H, Jaschke A, Klessen D, Friedrich A, Scherneck S, Rieg T, Cunard R, Veyhl-Wichmann M, Srinivasan A, Balen D, Breljak D, Rexhepaj R, Parker HE, Gribble FM, Reimann F, Lang F, Wiese S, Sabolic I, Sendtner M, Koepsell H.

Diabetes. 2012 Jan;61(1):187-96. doi: 10.2337/db11-1029. Epub 2011 Nov 28.


Role of medium- and short-chain L-3-hydroxyacyl-CoA dehydrogenase in the regulation of body weight and thermogenesis.

Schulz N, Himmelbauer H, Rath M, van Weeghel M, Houten S, Kulik W, Suhre K, Scherneck S, Vogel H, Kluge R, Wiedmer P, Joost HG, Schürmann A.

Endocrinology. 2011 Dec;152(12):4641-51. doi: 10.1210/en.2011-1547. Epub 2011 Oct 11.


Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure.

Kluth O, Mirhashemi F, Scherneck S, Kaiser D, Kluge R, Neschen S, Joost HG, Schürmann A.

Diabetologia. 2011 Mar;54(3):605-16. doi: 10.1007/s00125-010-1973-8. Epub 2010 Nov 24.


Role of zinc finger transcription factor zfp69 in body fat storage and diabetes susceptibility of mice.

Scherneck S, Vogel H, Nestler M, Kluge R, Schürmann A, Joost HG.

Results Probl Cell Differ. 2010;52:57-68. doi: 10.1007/978-3-642-14426-4_6. Review.


Diet dependence of diabetes in the New Zealand Obese (NZO) mouse: total fat, but not fat quality or sucrose accelerates and aggravates diabetes.

Mirhashemi F, Scherneck S, Kluth O, Kaiser D, Vogel H, Kluge R, Schürmann A, Neschen S, Joost HG.

Exp Clin Endocrinol Diabetes. 2011 Mar;119(3):167-71. doi: 10.1055/s-0030-1263127. Epub 2010 Sep 8.


Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL.

Scherneck S, Nestler M, Vogel H, Blüher M, Block MD, Berriel Diaz M, Herzig S, Schulz N, Teichert M, Tischer S, Al-Hasani H, Kluge R, Schürmann A, Joost HG.

PLoS Genet. 2009 Jul;5(7):e1000541. doi: 10.1371/journal.pgen.1000541. Epub 2009 Jul 3.


Characterization of Nob3, a major quantitative trait locus for obesity and hyperglycemia on mouse chromosome 1.

Vogel H, Nestler M, Rüschendorf F, Block MD, Tischer S, Kluge R, Schürmann A, Joost HG, Scherneck S.

Physiol Genomics. 2009 Jul 9;38(2):226-32. doi: 10.1152/physiolgenomics.00011.2009. Epub 2009 May 26.


Angiogenesis in the New Zealand obese mouse model fed with high fat diet.

Balwierz A, Polus A, Razny U, Wator L, Dyduch G, Tomaszewska R, Scherneck S, Joost H, Dembinska-Kiec A.

Lipids Health Dis. 2009 Apr 6;8:13. doi: 10.1186/1476-511X-8-13.


Identification of brain- and bone-specific breast cancer metastasis genes.

Klein A, Olendrowitz C, Schmutzler R, Hampl J, Schlag PM, Maass N, Arnold N, Wessel R, Ramser J, Meindl A, Scherneck S, Seitz S.

Cancer Lett. 2009 Apr 18;276(2):212-20. doi: 10.1016/j.canlet.2008.11.017. Epub 2008 Dec 27.


Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity.

Chadt A, Leicht K, Deshmukh A, Jiang LQ, Scherneck S, Bernhardt U, Dreja T, Vogel H, Schmolz K, Kluge R, Zierath JR, Hultschig C, Hoeben RC, Schürmann A, Joost HG, Al-Hasani H.

Nat Genet. 2008 Nov;40(11):1354-9. doi: 10.1038/ng.244. Epub 2008 Oct 19.


Neuronal functions, feeding behavior, and energy balance in Slc2a3+/- mice.

Schmidt S, Richter M, Montag D, Sartorius T, Gawlik V, Hennige AM, Scherneck S, Himmelbauer H, Lutz SZ, Augustin R, Kluge R, Ruth P, Joost HG, Schürmann A.

Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1084-94. doi: 10.1152/ajpendo.90491.2008. Epub 2008 Sep 9.


Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo.

Neschen S, Katterle Y, Richter J, Augustin R, Scherneck S, Mirhashemi F, Schürmann A, Joost HG, Klaus S.

Physiol Genomics. 2008 May 13;33(3):333-40. doi: 10.1152/physiolgenomics.00226.2007. Epub 2008 Mar 18.


High-fat, carbohydrate-free diet markedly aggravates obesity but prevents beta-cell loss and diabetes in the obese, diabetes-susceptible db/db strain.

Mirhashemi F, Kluth O, Scherneck S, Vogel H, Kluge R, Schurmann A, Joost HG, Neschen S.

Obes Facts. 2008;1(6):292-7. doi: 10.1159/000176064. Epub 2008 Dec 2.


Suppression of polyploidy by the BRCA2 protein.

Sagulenko E, Savelyeva L, Ehemann V, Sagulenko V, Hofmann W, Arnold K, Claas A, Scherneck S, Schwab M.

Cancer Lett. 2007 Nov 8;257(1):65-72. Epub 2007 Aug 7.


Expression of the protein phosphatase 1 inhibitor KEPI is downregulated in breast cancer cell lines and tissues and involved in the regulation of the tumor suppressor EGR1 via the MEK-ERK pathway.

Wenzel K, Daskalow K, Herse F, Seitz S, Zacharias U, Schenk JA, Schulz H, Hubner N, Micheel B, Schlag PM, Osterziel KJ, Ozcelik C, Scherneck S, Jandrig B.

Biol Chem. 2007 May;388(5):489-95.


Development of diabetes in obese, insulin-resistant mice: essential role of dietary carbohydrate in beta cell destruction.

Jürgens HS, Neschen S, Ortmann S, Scherneck S, Schmolz K, Schüler G, Schmidt S, Blüher M, Klaus S, Perez-Tilve D, Tschöp MH, Schürmann A, Joost HG.

Diabetologia. 2007 Jul;50(7):1481-9. Epub 2007 Apr 17.


Comparison of gene expression data from human and mouse breast cancers: identification of a conserved breast tumor gene set.

Klein A, Wessel R, Graessmann M, Jürgens M, Petersen I, Schmutzler R, Niederacher D, Arnold N, Meindl A, Scherneck S, Seitz S, Graessmann A.

Int J Cancer. 2007 Aug 1;121(3):683-8.


Hamster polyomavirus-derived virus-like particles are able to transfer in vitro encapsidated plasmid DNA to mammalian cells.

Voronkova T, Kazaks A, Ose V, Ozel M, Scherneck S, Pumpens P, Ulrich R.

Virus Genes. 2007 Jun;34(3):303-14. Epub 2006 Aug 22.


Genetic background of different cancer cell lines influences the gene set involved in chromosome 8 mediated breast tumor suppression.

Seitz S, Korsching E, Weimer J, Jacobsen A, Arnold N, Meindl A, Arnold W, Gustavus D, Klebig C, Petersen I, Scherneck S.

Genes Chromosomes Cancer. 2006 Jun;45(6):612-27.


Profile of differentially expressed genes after transfer of chromosome 17 into the breast cancer cell line CAL51.

Klebig C, Seitz S, Korsching E, Kristiansen G, Gustavus D, Scherneck S, Petersen I.

Genes Chromosomes Cancer. 2005 Nov;44(3):233-46.


Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype.

Lakhani SR, Reis-Filho JS, Fulford L, Penault-Llorca F, van der Vijver M, Parry S, Bishop T, Benitez J, Rivas C, Bignon YJ, Chang-Claude J, Hamann U, Cornelisse CJ, Devilee P, Beckmann MW, Nestle-Krämling C, Daly PA, Haites N, Varley J, Lalloo F, Evans G, Maugard C, Meijers-Heijboer H, Klijn JG, Olah E, Gusterson BA, Pilotti S, Radice P, Scherneck S, Sobol H, Jacquemier J, Wagner T, Peto J, Stratton MR, McGuffog L, Easton DF; Breast Cancer Linkage Consortium.

Clin Cancer Res. 2005 Jul 15;11(14):5175-80.


Mutation analysis of BRCA1 and BRCA2 genes in Iranian high risk breast cancer families.

Pietschmann A, Mehdipour P, Mehdipour P, Atri M, Hofmann W, Hosseini-Asl SS, Scherneck S, Mundlos S, Peters H.

J Cancer Res Clin Oncol. 2005 Aug;131(8):552-8. Epub 2005 May 26.


Characterization of {gamma}-aminobutyric acid type A receptor-associated protein, a novel tumor suppressor, showing reduced expression in breast cancer.

Klebig C, Seitz S, Arnold W, Deutschmann N, Pacyna-Gengelbach M, Scherneck S, Petersen I.

Cancer Res. 2005 Jan 15;65(2):394-400.


A network of clinically and functionally relevant genes is involved in the reversion of the tumorigenic phenotype of MDA-MB-231 breast cancer cells after transfer of human chromosome 8.

Seitz S, Frege R, Jacobsen A, Weimer J, Arnold W, von Haefen C, Niederacher D, Schmutzler R, Arnold N, Scherneck S.

Oncogene. 2005 Jan 27;24(5):869-79.


ST18 is a breast cancer tumor suppressor gene at human chromosome 8q11.2.

Jandrig B, Seitz S, Hinzmann B, Arnold W, Micheel B, Koelble K, Siebert R, Schwartz A, Ruecker K, Schlag PM, Scherneck S, Rosenthal A.

Oncogene. 2004 Dec 9;23(57):9295-302.


Limited relevance of the CHEK2 gene in hereditary breast cancer.

Dufault MR, Betz B, Wappenschmidt B, Hofmann W, Bandick K, Golla A, Pietschmann A, Nestle-Krämling C, Rhiem K, Hüttner C, von Lindern C, Dall P, Kiechle M, Untch M, Jonat W, Meindl A, Scherneck S, Niederacher D, Schmutzler RK, Arnold N.

Int J Cancer. 2004 Jun 20;110(3):320-5.


Tumor suppressor activity of profilin requires a functional actin binding site.

Wittenmayer N, Jandrig B, Rothkegel M, Schlüter K, Arnold W, Haensch W, Scherneck S, Jockusch BM.

Mol Biol Cell. 2004 Apr;15(4):1600-8. Epub 2004 Feb 6.


[PTEN/MMAC1 is apparently not a relevant tumor suppressor gene in development of hereditary breast carcinoma].

Estévez-Schwarz L, Grasmo-Wendler UH, Jandrig B, Scherneck S, Schlag PM.

Langenbecks Arch Chir Suppl Kongressbd. 1998;115(Suppl I):273-5. German.


Identification and characterization of KAT, a novel gene preferentially expressed in several human cancer cell lines.

Wenzel K, Felix SB, Flachmeier C, Heere P, Schulze W, Grunewald I, Pankow H, Hewelt A, Scherneck S, Bauer D, Hoehe MR.

Biol Chem. 2003 May;384(5):763-75.


Screening for large rearrangements of the BRCA1 gene in German breast or ovarian cancer families using semi-quantitative multiplex PCR method.

Hofmann W, Görgens H, John A, Horn D, Hüttner C, Arnold N, Scherneck S, Schackert HK.

Hum Mutat. 2003 Jul;22(1):103-4.


SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer.

Zeller C, Hinzmann B, Seitz S, Prokoph H, Burkhard-Goettges E, Fischer J, Jandrig B, Schwarz LE, Rosenthal A, Scherneck S.

Oncogene. 2003 May 15;22(19):2972-83.


Analysis of DLC-1 expression in human breast cancer.

Plaumann M, Seitz S, Frege R, Estevez-Schwarz L, Scherneck S.

J Cancer Res Clin Oncol. 2003 Jun;129(6):349-54. Epub 2003 May 21.


Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines.

Seitz S, Wassmuth P, Plaschke J, Schackert HK, Karsten U, Santibanez-Koref MF, Schlag PM, Scherneck S.

Genes Chromosomes Cancer. 2003 May;37(1):29-35.


The BRCA2 variant 8204G>A is a splicing mutation and results in an in frame deletion of the gene.

Hofmann W, Horn D, Hüttner C, Classen E, Scherneck S.

J Med Genet. 2003 Mar;40(3):e23. No abstract available.


Chimeric bacteriophage fr virus-like particles harboring the immunodominant C-terminal region of hamster polyomavirus VP1 induce a strong VP1-specific antibody response in rabbits and mice.

Voronkova T, Grosch A, Kazaks A, Ose V, Skrastina D, Sasnauskas K, Jandrig B, Arnold W, Scherneck S, Pumpens P, Ulrich R.

Viral Immunol. 2002;15(4):627-43.


Mutation analysis and mRNA expression of trail-receptors in human breast cancer.

Seitz S, Wassmuth P, Fischer J, Nothnagel A, Jandrig B, Schlag PM, Scherneck S.

Int J Cancer. 2002 Nov 10;102(2):117-28.


Polyomavirus infection in hamsters and trichoepitheliomas/cutaneous adnexal tumours.

Foster AP, Brown PJ, Jandrig B, Grosch A, Voronkova T, Scherneck S, Ulrich R.

Vet Rec. 2002 Jul 6;151(1):13-7.


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