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Items: 1 to 50 of 260

1.

Is PKM2 Phosphorylation Prerequisite for Oligomer Disassembly in Pulmonary Arterial Hypertension?

Novoyatleva T, Rai N, Weissmann N, Grimminger F, Ghofrani HA, Seeger W, Gall H, Schermuly RT.

Am J Respir Crit Care Med. 2019 Sep 5. doi: 10.1164/rccm.201904-0782LE. [Epub ahead of print] No abstract available.

PMID:
31486671
2.

Pulmonary Vascular Pressure Response to Acute Cold Exposure in Kyrgyz Highlanders.

Sydykov A, Maripov A, Muratali Uulu K, Kushubakova N, Petrovic A, Vroom C, Cholponbaeva M, Duishobaev M, Satybaldyev S, Satieva N, Mamazhakypov A, Sartmyrzaeva M, Omurzakova N, Kerimbekova Z, Baktybek N, Pak O, Zhao L, Weissmann N, Sarybaev A, Avdeev S, Ghofrani HA, Schermuly RT, Kosanovic D.

High Alt Med Biol. 2019 Aug 29. doi: 10.1089/ham.2019.0046. [Epub ahead of print]

PMID:
31464532
3.

Reply to: Emphysema is - at the most - only a Mild Phenotype in the Sugen-Hypoxia Rat Model of Pulmonary Arterial Hypertension.

Kojonazarov B, Hadzic S, Ghofrani HA, Grimminger F, Seeger W, Weissmann N, Schermuly RT.

Am J Respir Crit Care Med. 2019 Aug 22. doi: 10.1164/rccm.201907-1367LE. [Epub ahead of print] No abstract available.

PMID:
31437400
4.

The role of chemokines and chemokine receptors in pulmonary arterial hypertension.

Mamazhakypov A, Viswanathan G, Lawrie A, Schermuly RT, Rajagopal S.

Br J Pharmacol. 2019 Aug 10. doi: 10.1111/bph.14826. [Epub ahead of print] Review.

PMID:
31399998
5.

Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis.

Kheirollahi V, Wasnick RM, Biasin V, Vazquez-Armendariz AI, Chu X, Moiseenko A, Weiss A, Wilhelm J, Zhang JS, Kwapiszewska G, Herold S, Schermuly RT, Mari B, Li X, Seeger W, Günther A, Bellusci S, El Agha E.

Nat Commun. 2019 Jul 5;10(1):2987. doi: 10.1038/s41467-019-10839-0.

6.

[Hemodynamic Definition of Pulmonary Hypertension: Commentary on the Proposed Change by the 6th World Symposium on Pulmonary Hypertension].

Rosenkranz S, Diller GP, Dumitrescu D, Ewert R, Ghofrani HA, Grünig E, Halank M, Held M, Kaemmerer H, Klose H, Kovacs G, Konstantinides S, Lang IM, Lange TJ, Leuchte H, Mayer E, Olschewski A, Olschewski H, Olsson KM, Opitz C, Schermuly RT, Seeger W, Wilkens H, Hoeper MM.

Dtsch Med Wochenschr. 2019 Sep;144(19):1367-1372. doi: 10.1055/a-0918-3772. Epub 2019 Jul 5. German.

7.

Enhanced circulating levels of CD3 cells-derived extracellular vesicles in different forms of pulmonary hypertension.

Kosanovic D, Deo U, Gall H, Selvakumar B, Herold S, Weiss A, Petrovic A, Sydykov A, Ghofrani HA, Schermuly RT.

Pulm Circ. 2019 Jul-Sep;9(3):2045894019864357. doi: 10.1177/2045894019864357.

8.

Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension.

Rudyk O, Rowan A, Prysyazhna O, Krasemann S, Hartmann K, Zhang M, Shah AM, Ruppert C, Weiss A, Schermuly RT, Ida T, Akaike T, Zhao L, Eaton P.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13016-13025. doi: 10.1073/pnas.1904064116. Epub 2019 Jun 11.

9.

Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension.

Weiss A, Neubauer MC, Yerabolu D, Kojonazarov B, Schlueter BC, Neubert L, Jonigk D, Baal N, Ruppert C, Dorfmuller P, Pullamsetti SS, Weissmann N, Ghofrani HA, Grimminger F, Seeger W, Schermuly RT.

Nat Commun. 2019 May 17;10(1):2204. doi: 10.1038/s41467-019-10135-x.

10.

Severe Emphysema in the SU5416/Hypoxia Rat Model of Pulmonary Hypertension.

Kojonazarov B, Hadzic S, Ghofrani HA, Grimminger F, Seeger W, Weissmann N, Schermuly RT.

Am J Respir Crit Care Med. 2019 Aug 15;200(4):515-518. doi: 10.1164/rccm.201902-0390LE. No abstract available.

PMID:
31034778
11.

Altered proteasome function in right ventricular hypertrophy.

Heitmeier T, Sydykov A, Lukas C, Vroom C, Korfei M, Petrovic A, Klingel K, Günther A, Eickelberg O, Weissmann N, Ghofrani HA, Seeger W, Grimminger F, Schermuly RT, Meiners S, Kosanovic D.

Cardiovasc Res. 2019 Apr 24. pii: cvz103. doi: 10.1093/cvr/cvz103. [Epub ahead of print]

PMID:
31020333
12.

Lipids - two sides of the same coin in lung fibrosis.

Mamazhakypov A, Schermuly RT, Schaefer L, Wygrecka M.

Cell Signal. 2019 Aug;60:65-80. doi: 10.1016/j.cellsig.2019.04.007. Epub 2019 Apr 15. Review.

PMID:
30998969
13.

Riociguat for treatment of pulmonary hypertension in COPD: a translational study.

Pichl A, Sommer N, Bednorz M, Seimetz M, Hadzic S, Kuhnert S, Kraut S, Roxlau ET, Kojonazarov B, Wilhelm J, Gredic M, Gall H, Tello K, Richter MJ, Pak O, Petrovic A, Hecker M, Schermuly RT, Grimminger F, Seeger W, Ghofrani HA, Weissmann N.

Eur Respir J. 2019 Jun 27;53(6). pii: 1802445. doi: 10.1183/13993003.02445-2018. Print 2019 Jun.

PMID:
30956210
14.

LRP1 promotes synthetic phenotype of pulmonary artery smooth muscle cells in pulmonary hypertension.

Zucker MM, Wujak L, Gungl A, Didiasova M, Kosanovic D, Petrovic A, Klepetko W, Schermuly RT, Kwapiszewska G, Schaefer L, Wygrecka M.

Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1604-1616. doi: 10.1016/j.bbadis.2019.03.012. Epub 2019 Mar 22.

PMID:
30910704
15.

Protection against pressure overload-induced right heart failure by uncoupling protein 2 silencing.

Esfandiary A, Kutsche HS, Schreckenberg R, Weber M, Pak O, Kojonazarov B, Sydykov A, Hirschhäuser C, Wolf A, Haag D, Hecker M, Fink L, Seeger W, Ghofrani HA, Schermuly RT, Weißmann N, Schulz R, Rohrbach S, Li L, Sommer N, Schlüter KD.

Cardiovasc Res. 2019 Jun 1;115(7):1217-1227. doi: 10.1093/cvr/cvz049.

16.

Circulating Apoptotic Signals During Acute and Chronic Exposure to High Altitude in Kyrgyz Population.

Kosanovic D, Platzek SM, Petrovic A, Sydykov A, Maripov A, Mamazhakypov A, Sartmyrzaeva M, Muratali Uulu K, Cholponbaeva M, Toktosunova A, Omurzakova N, Duishobaev M, Vroom C, Pak O, Weissmann N, Ghofrani HA, Sarybaev A, Schermuly RT.

Front Physiol. 2019 Feb 5;10:54. doi: 10.3389/fphys.2019.00054. eCollection 2019.

17.

Response to: Comment on "Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding".

Rai N, Veeroju S, Schymura Y, Janssen W, Wietelmann A, Kojonazarov B, Weissmann N, Stasch JP, Ghofrani HA, Seeger W, Schermuly RT, Novoyatleva T.

Biomed Res Int. 2018 Dec 16;2018:7491284. doi: 10.1155/2018/7491284. eCollection 2018. No abstract available.

18.

The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension.

Viswanathan G, Mamazhakypov A, Schermuly RT, Rajagopal S.

Front Cardiovasc Med. 2018 Dec 17;5:179. doi: 10.3389/fcvm.2018.00179. eCollection 2018. Review.

19.

Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia.

Chao CM, Moiseenko A, Kosanovic D, Rivetti S, El Agha E, Wilhelm J, Kampschulte M, Yahya F, Ehrhardt H, Zimmer KP, Barreto G, Rizvanov AA, Schermuly RT, Reiss I, Morty RE, Rottier RJ, Bellusci S, Zhang JS.

Hum Mol Genet. 2019 May 1;28(9):1429-1444. doi: 10.1093/hmg/ddy439.

PMID:
30566624
20.

Evidence for the Fucoidan/P-Selectin Axis as a Therapeutic Target in Hypoxia-induced Pulmonary Hypertension.

Novoyatleva T, Kojonazarov B, Owczarek A, Veeroju S, Rai N, Henneke I, Böhm M, Grimminger F, Ghofrani HA, Seeger W, Weissmann N, Schermuly RT.

Am J Respir Crit Care Med. 2019 Jun 1;199(11):1407-1420. doi: 10.1164/rccm.201806-1170OC.

PMID:
30557519
21.

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives.

Humbert M, Guignabert C, Bonnet S, Dorfmüller P, Klinger JR, Nicolls MR, Olschewski AJ, Pullamsetti SS, Schermuly RT, Stenmark KR, Rabinovitch M.

Eur Respir J. 2019 Jan 24;53(1). pii: 1801887. doi: 10.1183/13993003.01887-2018. Print 2019 Jan.

22.

Evaluating Systolic and Diastolic Cardiac Function in Rodents Using Microscopic Computed Tomography.

Kojonazarov B, Belenkov A, Shinomiya S, Wilchelm J, Kampschulte M, Mizuno S, Ghofrani HA, Grimminger F, Weissmann N, Seeger W, Schermuly RT.

Circ Cardiovasc Imaging. 2018 Dec;11(12):e007653. doi: 10.1161/CIRCIMAGING.118.007653.

PMID:
30525986
23.

Pathobiology, pathology and genetics of pulmonary hypertension: Update from the Cologne Consensus Conference 2018.

Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kuebler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT.

Int J Cardiol. 2018 Dec 1;272S:4-10. doi: 10.1016/j.ijcard.2018.09.070. Epub 2018 Sep 20. Review.

PMID:
30314839
24.

Nitric Oxide Synthase 2 Induction Promotes Right Ventricular Fibrosis.

Boehm M, Novoyatleva T, Kojonazarov B, Veit F, Weissmann N, Ghofrani HA, Seeger W, Schermuly RT.

Am J Respir Cell Mol Biol. 2019 Mar;60(3):346-356. doi: 10.1165/rcmb.2018-0069OC.

PMID:
30277804
25.

Transcriptome profiling reveals the complexity of pirfenidone effects in idiopathic pulmonary fibrosis.

Kwapiszewska G, Gungl A, Wilhelm J, Marsh LM, Thekkekara Puthenparampil H, Sinn K, Didiasova M, Klepetko W, Kosanovic D, Schermuly RT, Wujak L, Weiss B, Schaefer L, Schneider M, Kreuter M, Olschewski A, Seeger W, Olschewski H, Wygrecka M.

Eur Respir J. 2018 Nov 22;52(5). pii: 1800564. doi: 10.1183/13993003.00564-2018. Print 2018 Nov.

26.

Hypoxic pulmonary vasoconstriction in isolated mouse pulmonary arterial vessels.

Strielkov I, Krause NC, Sommer N, Schermuly RT, Ghofrani HA, Grimminger F, Gudermann T, Dietrich A, Weissmann N.

Exp Physiol. 2018 Sep;103(9):1185-1191. doi: 10.1113/EP087117. Epub 2018 Jul 6.

PMID:
29917290
27.

Inflammatory Mediators Drive Adverse Right Ventricular Remodeling and Dysfunction and Serve as Potential Biomarkers.

Sydykov A, Mamazhakypov A, Petrovic A, Kosanovic D, Sarybaev AS, Weissmann N, Ghofrani HA, Schermuly RT.

Front Physiol. 2018 May 23;9:609. doi: 10.3389/fphys.2018.00609. eCollection 2018. Review.

28.

Myeloperoxidase aggravates pulmonary arterial hypertension by activation of vascular Rho-kinase.

Klinke A, Berghausen E, Friedrichs K, Molz S, Lau D, Remane L, Berlin M, Kaltwasser C, Adam M, Mehrkens D, Mollenhauer M, Manchanda K, Ravekes T, Heresi GA, Aytekin M, Dweik RA, Hennigs JK, Kubala L, Michaëlsson E, Rosenkranz S, Rudolph TK, Hazen SL, Klose H, Schermuly RT, Rudolph V, Baldus S.

JCI Insight. 2018 Jun 7;3(11). pii: 97530. doi: 10.1172/jci.insight.97530. eCollection 2018 Jun 7.

29.

Natural plant products in treatment of pulmonary arterial hypertension.

Xiang L, Li Y, Deng X, Kosanovic D, Schermuly RT, Li X.

Pulm Circ. 2018 Jul-Sep;8(3):2045894018784033. doi: 10.1177/2045894018784033. Epub 2018 Jun 5.

30.

JDP2 overexpression provokes cardiac dysfunction in mice.

Heger J, Bornbaum J, Würfel A, Hill C, Brockmann N, Gáspár R, Pálóczi J, Varga ZV, Sárközy M, Bencsik P, Csont T, Török S, Kojonazarov B, Schermuly RT, Böngler K, Parahuleva M, Ferdinandy P, Schulz R, Euler G.

Sci Rep. 2018 May 16;8(1):7647. doi: 10.1038/s41598-018-26052-w.

31.

Nintedanib in Severe Pulmonary Arterial Hypertension.

Richter MJ, Ewert J, Grimminger F, Ghofrani HA, Kojonazarov B, Petrovic A, Seeger W, Schermuly RT, Tello K, Gall H.

Am J Respir Crit Care Med. 2018 Sep 15;198(6):808-810. doi: 10.1164/rccm.201801-0195LE. No abstract available.

PMID:
29763335
32.

Is the fibroblast growth factor signaling pathway a victim of receptor tyrosine kinase inhibition in pulmonary parenchymal and vascular remodeling?

El Agha E, Schwind F, Ruppert C, Günther A, Bellusci S, Schermuly RT, Kosanovic D.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L248-L252. doi: 10.1152/ajplung.00140.2018. Epub 2018 May 3.

33.

Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding.

Rai N, Veeroju S, Schymura Y, Janssen W, Wietelmann A, Kojonazarov B, Weissmann N, Stasch JP, Ghofrani HA, Seeger W, Schermuly RT, Novoyatleva T.

Biomed Res Int. 2018 Jan 3;2018:3293584. doi: 10.1155/2018/3293584. eCollection 2018.

34.

Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension.

Boehm M, Arnold N, Braithwaite A, Pickworth J, Lu C, Novoyatleva T, Kiely DG, Grimminger F, Ghofrani HA, Weissmann N, Seeger W, Lawrie A, Schermuly RT, Kojonazarov B.

BMC Pulm Med. 2018 Mar 2;18(1):41. doi: 10.1186/s12890-018-0604-x.

35.

Differential Alterations of the Mitochondrial Morphology and Respiratory Chain Complexes during Postnatal Development of the Mouse Lung.

El-Merhie N, Baumgart-Vogt E, Pilatz A, Pfreimer S, Pfeiffer B, Pak O, Kosanovic D, Seimetz M, Schermuly RT, Weissmann N, Karnati S.

Oxid Med Cell Longev. 2017;2017:9169146. doi: 10.1155/2017/9169146. Epub 2017 Dec 19.

36.

Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension.

Pak O, Scheibe S, Esfandiary A, Gierhardt M, Sydykov A, Logan A, Fysikopoulos A, Veit F, Hecker M, Kroschel F, Quanz K, Erb A, Schäfer K, Fassbinder M, Alebrahimdehkordi N, Ghofrani HA, Schermuly RT, Brandes RP, Seeger W, Murphy MP, Weissmann N, Sommer N.

Eur Respir J. 2018 Feb 1. pii: 1701024. doi: 10.1183/13993003.01024-2017. [Epub ahead of print]

PMID:
29419444
37.

Lung cancer-associated pulmonary hypertension: Role of microenvironmental inflammation based on tumor cell-immune cell cross-talk.

Pullamsetti SS, Kojonazarov B, Storn S, Gall H, Salazar Y, Wolf J, Weigert A, El-Nikhely N, Ghofrani HA, Krombach GA, Fink L, Gattenlöhner S, Rapp UR, Schermuly RT, Grimminger F, Seeger W, Savai R.

Sci Transl Med. 2017 Nov 15;9(416). pii: eaai9048. doi: 10.1126/scitranslmed.aai9048.

PMID:
29141888
38.

Lung Ischaemia-Reperfusion Injury: The Role of Reactive Oxygen Species.

Pak O, Sydykov A, Kosanovic D, Schermuly RT, Dietrich A, Schröder K, Brandes RP, Gudermann T, Sommer N, Weissmann N.

Adv Exp Med Biol. 2017;967:195-225. doi: 10.1007/978-3-319-63245-2_12. Review.

PMID:
29047088
39.

ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension.

Budas GR, Boehm M, Kojonazarov B, Viswanathan G, Tian X, Veeroju S, Novoyatleva T, Grimminger F, Hinojosa-Kirschenbaum F, Ghofrani HA, Weissmann N, Seeger W, Liles JT, Schermuly RT.

Am J Respir Crit Care Med. 2018 Feb 1;197(3):373-385. doi: 10.1164/rccm.201703-0502OC.

PMID:
28910144
40.

Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4).

Lu S, Liu S, Wietelmann A, Kojonazarov B, Atzberger A, Tang C, Schermuly RT, Gröne HJ, Offermanns S.

PLoS One. 2017 Aug 14;12(8):e0183166. doi: 10.1371/journal.pone.0183166. eCollection 2017.

41.

Enhanced inflammatory cell profiles in schistosomiasis-induced pulmonary vascular remodeling.

Ali Z, Kosanovic D, Kolosionek E, Schermuly RT, Graham BB, Mathie A, Butrous G.

Pulm Circ. 2017 Apr 4;7(1):244-252. doi: 10.1086/690687. eCollection 2017 Mar.

42.

Oxidative injury of the pulmonary circulation in the perinatal period: Short- and long-term consequences for the human cardiopulmonary system.

de Wijs-Meijler DP, Duncker DJ, Tibboel D, Schermuly RT, Weissmann N, Merkus D, Reiss IKM.

Pulm Circ. 2017 Jan 1;7(1):55-66. doi: 10.1086/689748. eCollection 2017 Mar.

43.

The Role of Transient Receptor Potential Channel 6 Channels in the Pulmonary Vasculature.

Malczyk M, Erb A, Veith C, Ghofrani HA, Schermuly RT, Gudermann T, Dietrich A, Weissmann N, Sydykov A.

Front Immunol. 2017 Jun 16;8:707. doi: 10.3389/fimmu.2017.00707. eCollection 2017. Review.

44.

p38 MAPK Inhibition Improves Heart Function in Pressure-Loaded Right Ventricular Hypertrophy.

Kojonazarov B, Novoyatleva T, Boehm M, Happe C, Sibinska Z, Tian X, Sajjad A, Luitel H, Kriechling P, Posern G, Evans SM, Grimminger F, Ghofrani HA, Weissmann N, Bogaard HJ, Seeger W, Schermuly RT.

Am J Respir Cell Mol Biol. 2017 Nov;57(5):603-614. doi: 10.1165/rcmb.2016-0374OC.

PMID:
28657795
45.

Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study.

Rhodes CJ, Wharton J, Ghataorhe P, Watson G, Girerd B, Howard LS, Gibbs JSR, Condliffe R, Elliot CA, Kiely DG, Simonneau G, Montani D, Sitbon O, Gall H, Schermuly RT, Ghofrani HA, Lawrie A, Humbert M, Wilkins MR.

Lancet Respir Med. 2017 Sep;5(9):717-726. doi: 10.1016/S2213-2600(17)30161-3. Epub 2017 Jun 15.

46.

Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing.

Sommer N, Hüttemann M, Pak O, Scheibe S, Knoepp F, Sinkler C, Malczyk M, Gierhardt M, Esfandiary A, Kraut S, Jonas F, Veith C, Aras S, Sydykov A, Alebrahimdehkordi N, Giehl K, Hecker M, Brandes RP, Seeger W, Grimminger F, Ghofrani HA, Schermuly RT, Grossman LI, Weissmann N.

Circ Res. 2017 Aug 4;121(4):424-438. doi: 10.1161/CIRCRESAHA.116.310482. Epub 2017 Jun 15.

47.

Plasma MMP2/TIMP4 Ratio at Follow-up Assessment Predicts Disease Progression of Idiopathic Pulmonary Arterial Hypertension.

Wetzl V, Tiede SL, Faerber L, Weissmann N, Schermuly RT, Ghofrani HA, Gall H.

Lung. 2017 Aug;195(4):489-496. doi: 10.1007/s00408-017-0014-5. Epub 2017 May 17.

PMID:
28516393
48.

Farnesylation of RhoB: the cancer hypothesis of pulmonary hypertension revisited.

Merkus D, Schermuly RT.

Cardiovasc Res. 2017 Mar 1;113(3):249-250. doi: 10.1093/cvr/cvx010. No abstract available.

PMID:
28395024
49.

Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis.

El Agha E, Moiseenko A, Kheirollahi V, De Langhe S, Crnkovic S, Kwapiszewska G, Szibor M, Kosanovic D, Schwind F, Schermuly RT, Henneke I, MacKenzie B, Quantius J, Herold S, Ntokou A, Ahlbrecht K, Braun T, Morty RE, Günther A, Seeger W, Bellusci S.

Cell Stem Cell. 2017 Apr 6;20(4):571. doi: 10.1016/j.stem.2017.03.011. No abstract available.

50.

Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.

Leisegang MS, Fork C, Josipovic I, Richter FM, Preussner J, Hu J, Miller MJ, Epah J, Hofmann P, Günther S, Moll F, Valasarajan C, Heidler J, Ponomareva Y, Freiman TM, Maegdefessel L, Plate KH, Mittelbronn M, Uchida S, Künne C, Stellos K, Schermuly RT, Weissmann N, Devraj K, Wittig I, Boon RA, Dimmeler S, Pullamsetti SS, Looso M, Miller FJ Jr, Brandes RP.

Circulation. 2017 Jul 4;136(1):65-79. doi: 10.1161/CIRCULATIONAHA.116.026991. Epub 2017 Mar 28.

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