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Amelioration of elastase-induced lung emphysema and reversal of pulmonary hypertension by pharmacological iNOS inhibition in mice.

Fysikopoulos A, Seimetz M, Hadzic S, Knoepp F, Wu CY, Malkmus K, Wilhelm J, Pichl A, Bednorz M, Tadele Roxlau E, Ghofrani HA, Sommer N, Gierhardt M, Schermuly RT, Seeger W, Grimminger F, Weissmann N, Kraut S.

Br J Pharmacol. 2020 Mar 22. doi: 10.1111/bph.15057. [Epub ahead of print]


Yarsagumba is a Promising Therapeutic Option for Treatment of Pulmonary Hypertension due to the Potent Anti-Proliferative and Vasorelaxant Properties.

Luitel H, Novoyatleva T, Sydykov A, Petrovic A, Mamazhakypov A, Devkota B, Wygrecka M, Ghofrani HA, Avdeev S, Schermuly RT, Kosanovic D.

Medicina (Kaunas). 2020 Mar 16;56(3). pii: E131. doi: 10.3390/medicina56030131.


Lung developmental arrest caused by PDGF-A deletion: consequences for the adult mouse lung.

Gouveia L, Kraut S, Hadzic S, Vazquéz-Liébanas E, Kojonazarov B, Wu CY, Veith C, He L, Mermelekas G, Schermuly RT, Weissmann N, Betsholtz C, Andrae J.

Am J Physiol Lung Cell Mol Physiol. 2020 Apr 1;318(4):L831-L843. doi: 10.1152/ajplung.00295.2019. Epub 2020 Mar 18.


Cardioprotection in right heart failure.

Boengler K, Schlüter KD, Schermuly RT, Schulz R.

Br J Pharmacol. 2020 Jan 29. doi: 10.1111/bph.14992. [Epub ahead of print] Review.


FHL-1 is not involved in pressure overload-induced maladaptive right ventricular remodeling and dysfunction.

Veith C, Neghabian D, Luitel H, Wilhelm J, Egemnazarov B, Muntanjohl C, Fischer JH, Dahal BK, Schermuly RT, Ghofrani HA, Grimminger F, Fink L, Kwapiszewska G, Weissmann N, Sydykov A.

Basic Res Cardiol. 2020 Jan 24;115(2):17. doi: 10.1007/s00395-019-0767-5.


Profiling of human lymphocytes reveals a specific network of protein kinases modulated by endurance training status.

Alack K, Weiss A, Krüger K, Höret M, Schermuly R, Frech T, Eggert M, Mooren FC.

Sci Rep. 2020 Jan 21;10(1):888. doi: 10.1038/s41598-020-57676-6.


Lung epithelium damage in COPD - An unstoppable pathological event?

Hadzic S, Wu CY, Avdeev S, Weissmann N, Schermuly RT, Kosanovic D.

Cell Signal. 2020 Jan 15;68:109540. doi: 10.1016/j.cellsig.2020.109540. [Epub ahead of print]


Orotracheal treprostinil administration attenuates bleomycin-induced lung injury, vascular remodeling, and fibrosis in mice.

Nikitopoulou I, Manitsopoulos N, Kotanidou A, Tian X, Petrovic A, Magkou C, Ninou I, Aidinis V, Schermuly RT, Kosanovic D, Orfanos SE.

Pulm Circ. 2019 Nov 15;9(4):2045894019881954. doi: 10.1177/2045894019881954. eCollection 2019 Oct-Dec.


Kinases as potential targets for treatment of pulmonary hypertension and right ventricular dysfunction.

Weiss A, Boehm M, Egemnazarov B, Grimminger F, Savai Pullamsetti S, Kwapiszewska G, Schermuly RT.

Br J Pharmacol. 2019 Nov 10. doi: 10.1111/bph.14919. [Epub ahead of print] Review.


Depletion of Bone Marrow-Derived Fibrocytes Attenuates TAA-Induced Liver Fibrosis in Mice.

Hempel F, Roderfeld M, Savai R, Sydykov A, Irungbam K, Schermuly R, Voswinckel R, Köhler K, Churin Y, Kiss L, Bier J, Pons-Kühnemann J, Roeb E.

Cells. 2019 Oct 7;8(10). pii: E1210. doi: 10.3390/cells8101210.


Is PKM2 Phosphorylation a Prerequisite for Oligomer Disassembly in Pulmonary Arterial Hypertension?

Novoyatleva T, Rai N, Weissmann N, Grimminger F, Ghofrani HA, Seeger W, Gall H, Schermuly RT.

Am J Respir Crit Care Med. 2019 Dec 15;200(12):1550-1554. doi: 10.1164/rccm.201904-0782LE. No abstract available.


Pulmonary Vascular Pressure Response to Acute Cold Exposure in Kyrgyz Highlanders.

Sydykov A, Maripov A, Muratali Uulu K, Kushubakova N, Petrovic A, Vroom C, Cholponbaeva M, Duishobaev M, Satybaldyev S, Satieva N, Mamazhakypov A, Sartmyrzaeva M, Omurzakova N, Kerimbekova Z, Baktybek N, Pak O, Zhao L, Weissmann N, Sarybaev A, Avdeev S, Ghofrani HA, Schermuly RT, Kosanovic D.

High Alt Med Biol. 2019 Dec;20(4):375-382. doi: 10.1089/ham.2019.0046. Epub 2019 Aug 29.


Reply to Bogaard et al.: Emphysema Is-at the Most-Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension.

Kojonazarov B, Hadzic S, Ghofrani HA, Grimminger F, Seeger W, Weissmann N, Schermuly RT.

Am J Respir Crit Care Med. 2019 Dec 1;200(11):1450-1452. doi: 10.1164/rccm.201907-1367LE. No abstract available.


The role of chemokines and chemokine receptors in pulmonary arterial hypertension.

Mamazhakypov A, Viswanathan G, Lawrie A, Schermuly RT, Rajagopal S.

Br J Pharmacol. 2019 Aug 10. doi: 10.1111/bph.14826. [Epub ahead of print] Review.


Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis.

Kheirollahi V, Wasnick RM, Biasin V, Vazquez-Armendariz AI, Chu X, Moiseenko A, Weiss A, Wilhelm J, Zhang JS, Kwapiszewska G, Herold S, Schermuly RT, Mari B, Li X, Seeger W, Günther A, Bellusci S, El Agha E.

Nat Commun. 2019 Jul 5;10(1):2987. doi: 10.1038/s41467-019-10839-0.


[Hemodynamic Definition of Pulmonary Hypertension: Commentary on the Proposed Change by the 6th World Symposium on Pulmonary Hypertension].

Rosenkranz S, Diller GP, Dumitrescu D, Ewert R, Ghofrani HA, Grünig E, Halank M, Held M, Kaemmerer H, Klose H, Kovacs G, Konstantinides S, Lang IM, Lange TJ, Leuchte H, Mayer E, Olschewski A, Olschewski H, Olsson KM, Opitz C, Schermuly RT, Seeger W, Wilkens H, Hoeper MM.

Dtsch Med Wochenschr. 2019 Sep;144(19):1367-1372. doi: 10.1055/a-0918-3772. Epub 2019 Jul 5. German.


Enhanced circulating levels of CD3 cells-derived extracellular vesicles in different forms of pulmonary hypertension.

Kosanovic D, Deo U, Gall H, Selvakumar B, Herold S, Weiss A, Petrovic A, Sydykov A, Ghofrani HA, Schermuly RT.

Pulm Circ. 2019 Jul-Sep;9(3):2045894019864357. doi: 10.1177/2045894019864357.


Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension.

Rudyk O, Rowan A, Prysyazhna O, Krasemann S, Hartmann K, Zhang M, Shah AM, Ruppert C, Weiss A, Schermuly RT, Ida T, Akaike T, Zhao L, Eaton P.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13016-13025. doi: 10.1073/pnas.1904064116. Epub 2019 Jun 11.


Right ventricular function in pulmonary (arterial) hypertension.

Tello K, Gall H, Richter M, Ghofrani A, Schermuly R.

Herz. 2019 Sep;44(6):509-516. doi: 10.1007/s00059-019-4815-6. Review.


Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension.

Weiss A, Neubauer MC, Yerabolu D, Kojonazarov B, Schlueter BC, Neubert L, Jonigk D, Baal N, Ruppert C, Dorfmuller P, Pullamsetti SS, Weissmann N, Ghofrani HA, Grimminger F, Seeger W, Schermuly RT.

Nat Commun. 2019 May 17;10(1):2204. doi: 10.1038/s41467-019-10135-x.


Severe Emphysema in the SU5416/Hypoxia Rat Model of Pulmonary Hypertension.

Kojonazarov B, Hadzic S, Ghofrani HA, Grimminger F, Seeger W, Weissmann N, Schermuly RT.

Am J Respir Crit Care Med. 2019 Aug 15;200(4):515-518. doi: 10.1164/rccm.201902-0390LE. No abstract available.


Altered proteasome function in right ventricular hypertrophy.

Heitmeier T, Sydykov A, Lukas C, Vroom C, Korfei M, Petrovic A, Klingel K, Günther A, Eickelberg O, Weissmann N, Ghofrani HA, Seeger W, Grimminger F, Schermuly RT, Meiners S, Kosanovic D.

Cardiovasc Res. 2020 Feb 1;116(2):406-415. doi: 10.1093/cvr/cvz103.


Lipids - two sides of the same coin in lung fibrosis.

Mamazhakypov A, Schermuly RT, Schaefer L, Wygrecka M.

Cell Signal. 2019 Aug;60:65-80. doi: 10.1016/j.cellsig.2019.04.007. Epub 2019 Apr 15. Review.


Riociguat for treatment of pulmonary hypertension in COPD: a translational study.

Pichl A, Sommer N, Bednorz M, Seimetz M, Hadzic S, Kuhnert S, Kraut S, Roxlau ET, Kojonazarov B, Wilhelm J, Gredic M, Gall H, Tello K, Richter MJ, Pak O, Petrovic A, Hecker M, Schermuly RT, Grimminger F, Seeger W, Ghofrani HA, Weissmann N.

Eur Respir J. 2019 Jun 27;53(6). pii: 1802445. doi: 10.1183/13993003.02445-2018. Print 2019 Jun.


LRP1 promotes synthetic phenotype of pulmonary artery smooth muscle cells in pulmonary hypertension.

Zucker MM, Wujak L, Gungl A, Didiasova M, Kosanovic D, Petrovic A, Klepetko W, Schermuly RT, Kwapiszewska G, Schaefer L, Wygrecka M.

Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1604-1616. doi: 10.1016/j.bbadis.2019.03.012. Epub 2019 Mar 22.


Protection against pressure overload-induced right heart failure by uncoupling protein 2 silencing.

Esfandiary A, Kutsche HS, Schreckenberg R, Weber M, Pak O, Kojonazarov B, Sydykov A, Hirschhäuser C, Wolf A, Haag D, Hecker M, Fink L, Seeger W, Ghofrani HA, Schermuly RT, Weißmann N, Schulz R, Rohrbach S, Li L, Sommer N, Schlüter KD.

Cardiovasc Res. 2019 Jun 1;115(7):1217-1227. doi: 10.1093/cvr/cvz049.


Circulating Apoptotic Signals During Acute and Chronic Exposure to High Altitude in Kyrgyz Population.

Kosanovic D, Platzek SM, Petrovic A, Sydykov A, Maripov A, Mamazhakypov A, Sartmyrzaeva M, Muratali Uulu K, Cholponbaeva M, Toktosunova A, Omurzakova N, Duishobaev M, Vroom C, Pak O, Weissmann N, Ghofrani HA, Sarybaev A, Schermuly RT.

Front Physiol. 2019 Feb 5;10:54. doi: 10.3389/fphys.2019.00054. eCollection 2019.


Aerobic endurance training status affects lymphocyte apoptosis sensitivity by induction of molecular genetic adaptations.

Alack K, Krüger K, Weiss A, Schermuly R, Frech T, Eggert M, Mooren FC.

Brain Behav Immun. 2019 Jan;75:251-257. doi: 10.1016/j.bbi.2018.10.001. Epub 2018 Oct 25.


Response to: Comment on "Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding".

Rai N, Veeroju S, Schymura Y, Janssen W, Wietelmann A, Kojonazarov B, Weissmann N, Stasch JP, Ghofrani HA, Seeger W, Schermuly RT, Novoyatleva T.

Biomed Res Int. 2018 Dec 16;2018:7491284. doi: 10.1155/2018/7491284. eCollection 2018. No abstract available.


The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension.

Viswanathan G, Mamazhakypov A, Schermuly RT, Rajagopal S.

Front Cardiovasc Med. 2018 Dec 17;5:179. doi: 10.3389/fcvm.2018.00179. eCollection 2018. Review.


Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia.

Chao CM, Moiseenko A, Kosanovic D, Rivetti S, El Agha E, Wilhelm J, Kampschulte M, Yahya F, Ehrhardt H, Zimmer KP, Barreto G, Rizvanov AA, Schermuly RT, Reiss I, Morty RE, Rottier RJ, Bellusci S, Zhang JS.

Hum Mol Genet. 2019 May 1;28(9):1429-1444. doi: 10.1093/hmg/ddy439.


Evidence for the Fucoidan/P-Selectin Axis as a Therapeutic Target in Hypoxia-induced Pulmonary Hypertension.

Novoyatleva T, Kojonazarov B, Owczarek A, Veeroju S, Rai N, Henneke I, Böhm M, Grimminger F, Ghofrani HA, Seeger W, Weissmann N, Schermuly RT.

Am J Respir Crit Care Med. 2019 Jun 1;199(11):1407-1420. doi: 10.1164/rccm.201806-1170OC.


Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives.

Humbert M, Guignabert C, Bonnet S, Dorfmüller P, Klinger JR, Nicolls MR, Olschewski AJ, Pullamsetti SS, Schermuly RT, Stenmark KR, Rabinovitch M.

Eur Respir J. 2019 Jan 24;53(1). pii: 1801887. doi: 10.1183/13993003.01887-2018. Print 2019 Jan.


Evaluating Systolic and Diastolic Cardiac Function in Rodents Using Microscopic Computed Tomography.

Kojonazarov B, Belenkov A, Shinomiya S, Wilchelm J, Kampschulte M, Mizuno S, Ghofrani HA, Grimminger F, Weissmann N, Seeger W, Schermuly RT.

Circ Cardiovasc Imaging. 2018 Dec;11(12):e007653. doi: 10.1161/CIRCIMAGING.118.007653.


Pathobiology, pathology and genetics of pulmonary hypertension: Update from the Cologne Consensus Conference 2018.

Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kuebler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT.

Int J Cardiol. 2018 Dec 1;272S:4-10. doi: 10.1016/j.ijcard.2018.09.070. Epub 2018 Sep 20. Review.


Nitric Oxide Synthase 2 Induction Promotes Right Ventricular Fibrosis.

Boehm M, Novoyatleva T, Kojonazarov B, Veit F, Weissmann N, Ghofrani HA, Seeger W, Schermuly RT.

Am J Respir Cell Mol Biol. 2019 Mar;60(3):346-356. doi: 10.1165/rcmb.2018-0069OC.


Transcriptome profiling reveals the complexity of pirfenidone effects in idiopathic pulmonary fibrosis.

Kwapiszewska G, Gungl A, Wilhelm J, Marsh LM, Thekkekara Puthenparampil H, Sinn K, Didiasova M, Klepetko W, Kosanovic D, Schermuly RT, Wujak L, Weiss B, Schaefer L, Schneider M, Kreuter M, Olschewski A, Seeger W, Olschewski H, Wygrecka M.

Eur Respir J. 2018 Nov 22;52(5). pii: 1800564. doi: 10.1183/13993003.00564-2018. Print 2018 Nov.


Hypoxic pulmonary vasoconstriction in isolated mouse pulmonary arterial vessels.

Strielkov I, Krause NC, Sommer N, Schermuly RT, Ghofrani HA, Grimminger F, Gudermann T, Dietrich A, Weissmann N.

Exp Physiol. 2018 Sep;103(9):1185-1191. doi: 10.1113/EP087117. Epub 2018 Jul 6.


Inflammatory Mediators Drive Adverse Right Ventricular Remodeling and Dysfunction and Serve as Potential Biomarkers.

Sydykov A, Mamazhakypov A, Petrovic A, Kosanovic D, Sarybaev AS, Weissmann N, Ghofrani HA, Schermuly RT.

Front Physiol. 2018 May 23;9:609. doi: 10.3389/fphys.2018.00609. eCollection 2018. Review.


Myeloperoxidase aggravates pulmonary arterial hypertension by activation of vascular Rho-kinase.

Klinke A, Berghausen E, Friedrichs K, Molz S, Lau D, Remane L, Berlin M, Kaltwasser C, Adam M, Mehrkens D, Mollenhauer M, Manchanda K, Ravekes T, Heresi GA, Aytekin M, Dweik RA, Hennigs JK, Kubala L, Michaëlsson E, Rosenkranz S, Rudolph TK, Hazen SL, Klose H, Schermuly RT, Rudolph V, Baldus S.

JCI Insight. 2018 Jun 7;3(11). pii: 97530. doi: 10.1172/jci.insight.97530. eCollection 2018 Jun 7.


Natural plant products in treatment of pulmonary arterial hypertension.

Xiang L, Li Y, Deng X, Kosanovic D, Schermuly RT, Li X.

Pulm Circ. 2018 Jul-Sep;8(3):2045894018784033. doi: 10.1177/2045894018784033. Epub 2018 Jun 5.


JDP2 overexpression provokes cardiac dysfunction in mice.

Heger J, Bornbaum J, Würfel A, Hill C, Brockmann N, Gáspár R, Pálóczi J, Varga ZV, Sárközy M, Bencsik P, Csont T, Török S, Kojonazarov B, Schermuly RT, Böngler K, Parahuleva M, Ferdinandy P, Schulz R, Euler G.

Sci Rep. 2018 May 16;8(1):7647. doi: 10.1038/s41598-018-26052-w.


Nintedanib in Severe Pulmonary Arterial Hypertension.

Richter MJ, Ewert J, Grimminger F, Ghofrani HA, Kojonazarov B, Petrovic A, Seeger W, Schermuly RT, Tello K, Gall H.

Am J Respir Crit Care Med. 2018 Sep 15;198(6):808-810. doi: 10.1164/rccm.201801-0195LE. No abstract available.


Is the fibroblast growth factor signaling pathway a victim of receptor tyrosine kinase inhibition in pulmonary parenchymal and vascular remodeling?

El Agha E, Schwind F, Ruppert C, Günther A, Bellusci S, Schermuly RT, Kosanovic D.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L248-L252. doi: 10.1152/ajplung.00140.2018. Epub 2018 May 3.


Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding.

Rai N, Veeroju S, Schymura Y, Janssen W, Wietelmann A, Kojonazarov B, Weissmann N, Stasch JP, Ghofrani HA, Seeger W, Schermuly RT, Novoyatleva T.

Biomed Res Int. 2018 Jan 3;2018:3293584. doi: 10.1155/2018/3293584. eCollection 2018.


Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension.

Boehm M, Arnold N, Braithwaite A, Pickworth J, Lu C, Novoyatleva T, Kiely DG, Grimminger F, Ghofrani HA, Weissmann N, Seeger W, Lawrie A, Schermuly RT, Kojonazarov B.

BMC Pulm Med. 2018 Mar 2;18(1):41. doi: 10.1186/s12890-018-0604-x.


Differential Alterations of the Mitochondrial Morphology and Respiratory Chain Complexes during Postnatal Development of the Mouse Lung.

El-Merhie N, Baumgart-Vogt E, Pilatz A, Pfreimer S, Pfeiffer B, Pak O, Kosanovic D, Seimetz M, Schermuly RT, Weissmann N, Karnati S.

Oxid Med Cell Longev. 2017;2017:9169146. doi: 10.1155/2017/9169146. Epub 2017 Dec 19.


Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension.

Pak O, Scheibe S, Esfandiary A, Gierhardt M, Sydykov A, Logan A, Fysikopoulos A, Veit F, Hecker M, Kroschel F, Quanz K, Erb A, Schäfer K, Fassbinder M, Alebrahimdehkordi N, Ghofrani HA, Schermuly RT, Brandes RP, Seeger W, Murphy MP, Weissmann N, Sommer N.

Eur Respir J. 2018 Feb 1. pii: 1701024. doi: 10.1183/13993003.01024-2017. [Epub ahead of print]


Lung cancer-associated pulmonary hypertension: Role of microenvironmental inflammation based on tumor cell-immune cell cross-talk.

Pullamsetti SS, Kojonazarov B, Storn S, Gall H, Salazar Y, Wolf J, Weigert A, El-Nikhely N, Ghofrani HA, Krombach GA, Fink L, Gattenlöhner S, Rapp UR, Schermuly RT, Grimminger F, Seeger W, Savai R.

Sci Transl Med. 2017 Nov 15;9(416). pii: eaai9048. doi: 10.1126/scitranslmed.aai9048.


Lung Ischaemia-Reperfusion Injury: The Role of Reactive Oxygen Species.

Pak O, Sydykov A, Kosanovic D, Schermuly RT, Dietrich A, Schröder K, Brandes RP, Gudermann T, Sommer N, Weissmann N.

Adv Exp Med Biol. 2017;967:195-225. doi: 10.1007/978-3-319-63245-2_12. Review.


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