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Items: 1 to 50 of 105

1.

The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells.

Ignarski M, Rill C, Kaiser RWJ, Kaldirim M, Neuhaus R, Esmaillie R, Li X, Klein C, Bohl K, Petersen M, Frese CK, Höhne M, Atanassov I, Rinschen MM, Höpker K, Schermer B, Benzing T, Dieterich C, Fabretti F, Müller RU.

J Am Soc Nephrol. 2019 Mar 13. pii: ASN.2018090914. doi: 10.1681/ASN.2018090914. [Epub ahead of print]

PMID:
30867249
2.

Inactivation of Apoptosis Antagonizing Transcription Factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis.

Jain M, Kaiser RWJ, Bohl K, Hoehne M, Göbel H, Bartram MP, Habbig S, Müller RU, Fogo AB, Benzing T, Schermer B, Höpker K, Slaats GG.

Kidney Int. 2019 Feb 12. pii: S0085-2538(18)30894-9. doi: 10.1016/j.kint.2018.10.034. [Epub ahead of print]

PMID:
30770218
3.

[Genome Editing with CRISPR/Cas9: First Steps Towards a new Era in Medicine?]

Schermer B, Benzing T.

Dtsch Med Wochenschr. 2019 Feb;144(4):276-281. doi: 10.1055/a-0759-7180. Epub 2019 Feb 13. German.

PMID:
30759475
4.

The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury.

Späth MR, Bartram MP, Palacio-Escat N, Hoyer KJR, Debes C, Demir F, Schroeter CB, Mandel AM, Grundmann F, Ciarimboli G, Beyer A, Kizhakkedathu JN, Brodesser S, Göbel H, Becker JU, Benzing T, Schermer B, Höhne M, Burst V, Saez-Rodriguez J, Huesgen PF, Müller RU, Rinschen MM.

Kidney Int. 2019 Feb;95(2):333-349. doi: 10.1016/j.kint.2018.08.037. Epub 2018 Dec 3.

PMID:
30522767
5.

Neph2/Kirrel3 regulates sensory input, motor coordination, and home-cage activity in rodents.

Völker LA, Maar BA, Pulido Guevara BA, Bilkei-Gorzo A, Zimmer A, Brönneke H, Dafinger C, Bertsch S, Wagener JR, Schweizer H, Schermer B, Benzing T, Hoehne M.

Genes Brain Behav. 2018 Nov;17(8):e12516. doi: 10.1111/gbb.12516. Epub 2018 Sep 14.

PMID:
30133126
6.

Urine-derived cells: a promising diagnostic tool in Fabry disease patients.

Slaats GG, Braun F, Hoehne M, Frech LE, Blomberg L, Benzing T, Schermer B, Rinschen MM, Kurschat CE.

Sci Rep. 2018 Jul 23;8(1):11042. doi: 10.1038/s41598-018-29240-w.

7.

Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.

Dafinger C, Rinschen MM, Borgal L, Ehrenberg C, Basten SG, Franke M, Höhne M, Rauh M, Göbel H, Bloch W, Wunderlich FT, Peters DJM, Tasche D, Mishra T, Habbig S, Dötsch J, Müller RU, Brüning JC, Persigehl T, Giles RH, Benzing T, Schermer B, Liebau MC.

Exp Mol Med. 2018 Jun 28;50(6):75. doi: 10.1038/s12276-018-0108-z.

8.

A Single-Cell Transcriptome Atlas of the Mouse Glomerulus.

Karaiskos N, Rahmatollahi M, Boltengagen A, Liu H, Hoehne M, Rinschen M, Schermer B, Benzing T, Rajewsky N, Kocks C, Kann M, Müller RU.

J Am Soc Nephrol. 2018 Aug;29(8):2060-2068. doi: 10.1681/ASN.2018030238. Epub 2018 May 24.

PMID:
29794128
9.

A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.

Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB.

Cell Rep. 2018 May 22;23(8):2495-2508. doi: 10.1016/j.celrep.2018.04.059.

10.

An optimized electroporation approach for efficient CRISPR/Cas9 genome editing in murine zygotes.

Tröder SE, Ebert LK, Butt L, Assenmacher S, Schermer B, Zevnik B.

PLoS One. 2018 May 3;13(5):e0196891. doi: 10.1371/journal.pone.0196891. eCollection 2018.

11.

Protein half-life determines expression of proteostatic networks in podocyte differentiation.

Schroeter CB, Koehler S, Kann M, Schermer B, Benzing T, Brinkkoetter PT, Rinschen MM.

FASEB J. 2018 Sep;32(9):4696-4713. doi: 10.1096/fj.201701307R. Epub 2018 Apr 25.

PMID:
29694247
12.

Preoperative Short-Term Calorie Restriction for Prevention of Acute Kidney Injury After Cardiac Surgery: A Randomized, Controlled, Open-Label, Pilot Trial.

Grundmann F, Müller RU, Reppenhorst A, Hülswitt L, Späth MR, Kubacki T, Scherner M, Faust M, Becker I, Wahlers T, Schermer B, Benzing T, Burst V.

J Am Heart Assoc. 2018 Mar 13;7(6). pii: e008181. doi: 10.1161/JAHA.117.008181.

13.

Single-nephron proteomes connect morphology and function in proteinuric kidney disease.

Höhne M, Frese CK, Grahammer F, Dafinger C, Ciarimboli G, Butt L, Binz J, Hackl MJ, Rahmatollahi M, Kann M, Schneider S, Altintas MM, Schermer B, Reinheckel T, Göbel H, Reiser J, Huber TB, Kramann R, Seeger-Nukpezah T, Liebau MC, Beck BB, Benzing T, Beyer A, Rinschen MM.

Kidney Int. 2018 Jun;93(6):1308-1319. doi: 10.1016/j.kint.2017.12.012. Epub 2018 Mar 9.

PMID:
29530281
14.

AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer.

Welcker D, Jain M, Khurshid S, Jokić M, Höhne M, Schmitt A, Frommolt P, Niessen CM, Spiro J, Persigehl T, Wittersheim M, Büttner R, Fanciulli M, Schermer B, Reinhardt HC, Benzing T, Höpker K.

Oncogene. 2018 Mar;37(11):1503-1518. doi: 10.1038/s41388-017-0054-6. Epub 2018 Jan 11.

PMID:
29321668
15.

Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression.

Hagmann H, Mangold N, Rinschen MM, Koenig T, Kunzelmann K, Schermer B, Benzing T, Brinkkoetter PT.

FASEB J. 2018 Jan;32(1):208-219. doi: 10.1096/fj.201700309R. Epub 2017 Sep 6.

16.

Magnetic resonance T2 mapping and diffusion-weighted imaging for early detection of cystogenesis and response to therapy in a mouse model of polycystic kidney disease.

Franke M, Baeßler B, Vechtel J, Dafinger C, Höhne M, Borgal L, Göbel H, Koerber F, Maintz D, Benzing T, Schermer B, Persigehl T.

Kidney Int. 2017 Dec;92(6):1544-1554. doi: 10.1016/j.kint.2017.05.024. Epub 2017 Jul 26.

PMID:
28754558
17.

N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton.

Rinschen MM, Hoppe AK, Grahammer F, Kann M, Völker LA, Schurek EM, Binz J, Höhne M, Demir F, Malisic M, Huber TB, Kurschat C, Kizhakkedathu JN, Schermer B, Huesgen PF, Benzing T.

J Am Soc Nephrol. 2017 Oct;28(10):2867-2878. doi: 10.1681/ASN.2016101119. Epub 2017 Jul 19.

18.

The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia.

Kohli P, Höhne M, Jüngst C, Bertsch S, Ebert LK, Schauss AC, Benzing T, Rinschen MM, Schermer B.

EMBO Rep. 2017 Sep;18(9):1521-1535. doi: 10.15252/embr.201643846. Epub 2017 Jul 14.

19.

Characterization of a splice-site mutation in the tumor suppressor gene FLCN associated with renal cancer.

Bartram MP, Mishra T, Reintjes N, Fabretti F, Gharbi H, Adam AC, Göbel H, Franke M, Schermer B, Haneder S, Benzing T, Beck BB, Müller RU.

BMC Med Genet. 2017 May 12;18(1):53. doi: 10.1186/s12881-017-0416-5.

20.

YAP-mediated mechanotransduction determines the podocyte's response to damage.

Rinschen MM, Grahammer F, Hoppe AK, Kohli P, Hagmann H, Kretz O, Bertsch S, Höhne M, Göbel H, Bartram MP, Gandhirajan RK, Krüger M, Brinkkoetter PT, Huber TB, Kann M, Wickström SA, Benzing T, Schermer B.

Sci Signal. 2017 Apr 11;10(474). pii: eaaf8165. doi: 10.1126/scisignal.aaf8165.

PMID:
28400537
21.

Challenges in establishing genotype-phenotype correlations in ARPKD: case report on a toddler with two severe PKHD1 mutations.

Ebner K, Dafinger C, Ortiz-Bruechle N, Koerber F, Schermer B, Benzing T, Dötsch J, Zerres K, Weber LT, Beck BB, Liebau MC.

Pediatr Nephrol. 2017 Jul;32(7):1269-1273. doi: 10.1007/s00467-017-3648-x. Epub 2017 Mar 31.

PMID:
28364132
22.

Construction of a viral T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes.

Koehler S, Brähler S, Braun F, Hagmann H, Rinschen MM, Späth MR, Höhne M, Wunderlich FT, Schermer B, Benzing T, Brinkkoetter PT.

Kidney Int. 2017 Jun;91(6):1510-1517. doi: 10.1016/j.kint.2016.12.011. Epub 2017 Feb 7.

PMID:
28187984
23.

Single and Transient Ca2+ Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion.

Koehler S, Brähler S, Kuczkowski A, Binz J, Hackl MJ, Hagmann H, Höhne M, Vogt MC, Wunderlich CM, Wunderlich FT, Schweda F, Schermer B, Benzing T, Brinkkoetter PT.

Sci Rep. 2016 Oct 19;6:35400. doi: 10.1038/srep35400.

24.

Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage.

Johnsen M, Späth MR, Denzel MS, Göbel H, Kubacki T, Hoyer KJ, Hinze Y, Benzing T, Schermer B, Antebi A, Burst V, Müller RU.

PLoS One. 2016 Aug 24;11(8):e0161315. doi: 10.1371/journal.pone.0161315. eCollection 2016.

25.

Quantitative deep mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation.

Rinschen MM, Schroeter CB, Koehler S, Ising C, Schermer B, Kann M, Benzing T, Brinkkoetter PT.

Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C404-17. doi: 10.1152/ajpcell.00121.2016. Epub 2016 Jun 29.

26.

Par3A is dispensable for the function of the glomerular filtration barrier of the kidney.

Koehler S, Tellkamp F, Niessen CM, Bloch W, Kerjaschki D, Schermer B, Benzing T, Brinkkoetter PT.

Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F112-9. doi: 10.1152/ajprenal.00171.2016. Epub 2016 Apr 27.

27.

Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier.

Ising C, Bharill P, Brinkkoetter S, Brähler S, Schroeter C, Koehler S, Hagmann H, Merkwirth C, Höhne M, Müller RU, Fabretti F, Schermer B, Bloch W, Kerjaschki D, Kurschat CE, Benzing T, Brinkkoetter PT.

Am J Pathol. 2016 May;186(5):1128-39. doi: 10.1016/j.ajpath.2015.12.018.

PMID:
27105734
28.

Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure.

Bartram MP, Amendola E, Benzing T, Schermer B, de Vita G, Müller RU.

BMC Mol Biol. 2016 Apr 18;17:11. doi: 10.1186/s12867-016-0064-x.

29.

Cysteine S-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ).

Gandhirajan RK, Jain M, Walla B, Johnsen M, Bartram MP, Huynh Anh M, Rinschen MM, Benzing T, Schermer B.

J Biol Chem. 2016 May 27;291(22):11596-607. doi: 10.1074/jbc.M115.712539. Epub 2016 Apr 5.

30.

Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.

Borgal L, Rinschen MM, Dafinger C, Liebrecht VI, Abken H, Benzing T, Schermer B.

Cell Cycle. 2016;15(8):1034-45. doi: 10.1080/15384101.2016.1152429.

31.

Altered lipid metabolism in the aging kidney identified by three layered omic analysis.

Braun F, Rinschen MM, Bartels V, Frommolt P, Habermann B, Hoeijmakers JH, Schumacher B, Dollé ME, Müller RU, Benzing T, Schermer B, Kurschat CE.

Aging (Albany NY). 2016 Mar;8(3):441-57.

32.

The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.

Rinschen MM, Bharill P, Wu X, Kohli P, Reinert MJ, Kretz O, Saez I, Schermer B, Höhne M, Bartram MP, Aravamudhan S, Brooks BR, Vilchez D, Huber TB, Müller RU, Krüger M, Benzing T.

Hum Mol Genet. 2016 Apr 1;25(7):1328-44. doi: 10.1093/hmg/ddw016. Epub 2016 Jan 19.

33.

Endothelial cilia protect against atherosclerosis.

Schermer B, Benzing T.

EMBO Rep. 2016 Feb;17(2):125-6. doi: 10.15252/embr.201541890. Epub 2016 Jan 14. No abstract available.

34.

Three-layered proteomic characterization of a novel ACTN4 mutation unravels its pathogenic potential in FSGS.

Bartram MP, Habbig S, Pahmeyer C, Höhne M, Weber LT, Thiele H, Altmüller J, Kottoor N, Wenzel A, Krueger M, Schermer B, Benzing T, Rinschen MM, Beck BB.

Hum Mol Genet. 2016 Mar 15;25(6):1152-64. doi: 10.1093/hmg/ddv638. Epub 2016 Jan 5.

PMID:
26740551
35.

The NF-κB essential modulator (NEMO) controls podocyte cytoskeletal dynamics independently of NF-κB.

Brähler S, Ising C, Barrera Aranda B, Höhne M, Schermer B, Benzing T, Brinkkoetter PT.

Am J Physiol Renal Physiol. 2015 Oct 1;309(7):F617-26. doi: 10.1152/ajprenal.00059.2015. Epub 2015 Aug 12.

36.

Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation.

Bartram MP, Dafinger C, Habbig S, Benzing T, Schermer B, Müller RU.

BMC Nephrol. 2015 Apr 14;16:55. doi: 10.1186/s12882-015-0053-1.

37.

WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals.

Kann M, Bae E, Lenz MO, Li L, Trannguyen B, Schumacher VA, Taglienti ME, Bordeianou L, Hartwig S, Rinschen MM, Schermer B, Benzing T, Fan CM, Kreidberg JA.

Development. 2015 Apr 1;142(7):1254-66. doi: 10.1242/dev.119735.

38.

Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure.

Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT.

EMBO Mol Med. 2015 Mar;7(3):275-87. doi: 10.15252/emmm.201404916.

39.

Genome-Wide Analysis of Wilms' Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms.

Kann M, Ettou S, Jung YL, Lenz MO, Taglienti ME, Park PJ, Schermer B, Benzing T, Kreidberg JA.

J Am Soc Nephrol. 2015 Sep;26(9):2097-104. doi: 10.1681/ASN.2014090940. Epub 2015 Jan 30.

40.

Comparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture.

Rinschen MM, Pahmeyer C, Pisitkun T, Schnell N, Wu X, Maaß M, Bartram MP, Lamkemeyer T, Schermer B, Benzing T, Brinkkoetter PT.

Proteomics. 2015 Apr;15(7):1326-31. doi: 10.1002/pmic.201400235. Epub 2015 Jan 19.

PMID:
25420462
41.

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage.

Mueller MM, Castells-Roca L, Babu V, Ermolaeva MA, Müller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, Schumacher B.

Nat Cell Biol. 2014 Dec;16(12):1168-1179. doi: 10.1038/ncb3071. Epub 2014 Nov 24.

42.

An approach to cystic kidney diseases: the clinician's view.

Kurschat CE, Müller RU, Franke M, Maintz D, Schermer B, Benzing T.

Nat Rev Nephrol. 2014 Dec;10(12):687-99. doi: 10.1038/nrneph.2014.173. Epub 2014 Sep 30. Review.

PMID:
25266212
43.

Casein kinase 1 α phosphorylates the Wnt regulator Jade-1 and modulates its activity.

Borgal L, Rinschen MM, Dafinger C, Hoff S, Reinert MJ, Lamkemeyer T, Lienkamp SS, Benzing T, Schermer B.

J Biol Chem. 2014 Sep 19;289(38):26344-56. doi: 10.1074/jbc.M114.562165. Epub 2014 Aug 6.

44.

A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (PHB) domain protein podocin.

Schurek EM, Völker LA, Tax J, Lamkemeyer T, Rinschen MM, Ungrue D, Kratz JE 3rd, Sirianant L, Kunzelmann K, Chalfie M, Schermer B, Benzing T, Höhne M.

J Biol Chem. 2014 Apr 18;289(16):11262-71. doi: 10.1074/jbc.M113.521773. Epub 2014 Mar 4.

45.

The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation.

Talbot JJ, Song X, Wang X, Rinschen MM, Doerr N, LaRiviere WB, Schermer B, Pei YP, Torres VE, Weimbs T.

J Am Soc Nephrol. 2014 Aug;25(8):1737-48. doi: 10.1681/ASN.2013091026. Epub 2014 Feb 27.

46.

Label-free quantitative proteomic analysis of the YAP/TAZ interactome.

Kohli P, Bartram MP, Habbig S, Pahmeyer C, Lamkemeyer T, Benzing T, Schermer B, Rinschen MM.

Am J Physiol Cell Physiol. 2014 May 1;306(9):C805-18. doi: 10.1152/ajpcell.00339.2013. Epub 2014 Feb 26.

47.

Vasopressin-2 receptor signaling and autosomal dominant polycystic kidney disease: from bench to bedside and back again.

Rinschen MM, Schermer B, Benzing T.

J Am Soc Nephrol. 2014 Jun;25(6):1140-7. doi: 10.1681/ASN.2013101037. Epub 2014 Feb 20. Review.

48.

Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier.

Rinschen MM, Wu X, König T, Pisitkun T, Hagmann H, Pahmeyer C, Lamkemeyer T, Kohli P, Schnell N, Schermer B, Dryer S, Brooks BR, Beltrao P, Krueger M, Brinkkoetter PT, Benzing T.

J Am Soc Nephrol. 2014 Jul;25(7):1509-22. doi: 10.1681/ASN.2013070760. Epub 2014 Feb 7.

49.

Low-molecular weight heparin increases circulating sFlt-1 levels and enhances urinary elimination.

Hagmann H, Bossung V, Belaidi AA, Fridman A, Karumanchi SA, Thadhani R, Schermer B, Mallmann P, Schwarz G, Benzing T, Brinkkoetter PT.

PLoS One. 2014 Jan 21;9(1):e85258. doi: 10.1371/journal.pone.0085258. eCollection 2014.

50.

Breaking the chain at the membrane: paraoxonase 2 counteracts lipid peroxidation at the plasma membrane.

Hagmann H, Kuczkowski A, Ruehl M, Lamkemeyer T, Brodesser S, Horke S, Dryer S, Schermer B, Benzing T, Brinkkoetter PT.

FASEB J. 2014 Apr;28(4):1769-79. doi: 10.1096/fj.13-240309. Epub 2014 Jan 13.

PMID:
24421402

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