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Items: 1 to 50 of 151

1.

Disruption of the RNA exosome reveals the hidden face of the malaria parasite transcriptome.

Droll D, Wei G, Guo G, Fan Y, Baumgarten S, Zhou Y, Xiao Y, Scherf A, Zhang Q.

RNA Biol. 2018;15(9):1206-1214. doi: 10.1080/15476286.2018.1517014. Epub 2018 Sep 20.

PMID:
30235972
2.

A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Zanghì G, Vembar SS, Baumgarten S, Ding S, Guizetti J, Bryant JM, Mattei D, Jensen ATR, Rénia L, Goh YS, Sauerwein R, Hermsen CC, Franetich JF, Bordessoulles M, Silvie O, Soulard V, Scatton O, Chen P, Mecheri S, Mazier D, Scherf A.

Cell Rep. 2018 Mar 13;22(11):2951-2963. doi: 10.1016/j.celrep.2018.02.075.

3.

De Novo Genome Assembly of a Plasmodium falciparum NF54 Clone Using Single-Molecule Real-Time Sequencing.

Bryant JM, Baumgarten S, Lorthiois A, Scheidig-Benatar C, Claës A, Scherf A.

Genome Announc. 2018 Feb 1;6(5). pii: e01479-17. doi: 10.1128/genomeA.01479-17.

4.

Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum.

Lubin AS, Rueda-Zubiaurre A, Matthews H, Baumann H, Fisher FR, Morales-Sanfrutos J, Hadavizadeh KS, Nardella F, Tate EW, Baum J, Scherf A, Fuchter MJ.

ACS Infect Dis. 2018 Apr 13;4(4):523-530. doi: 10.1021/acsinfecdis.7b00228. Epub 2018 Feb 5.

5.

Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity.

Sundriyal S, Chen PB, Lubin AS, Lueg GA, Li F, White AJP, Malmquist NA, Vedadi M, Scherf A, Fuchter MJ.

Medchemcomm. 2017 May 1;8(5):1069-1092. doi: 10.1039/c7md00052a. Epub 2017 Mar 15.

6.

Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites.

Sindikubwabo F, Ding S, Hussain T, Ortet P, Barakat M, Baumgarten S, Cannella D, Palencia A, Bougdour A, Belmudes L, Couté Y, Tardieux I, Botté CY, Scherf A, Hakimi MA.

Elife. 2017 Nov 4;6. pii: e29391. doi: 10.7554/eLife.29391.

7.

An ApiAP2 member regulates expression of clonally variant genes of the human malaria parasite Plasmodium falciparum.

Martins RM, Macpherson CR, Claes A, Scheidig-Benatar C, Sakamoto H, Yam XY, Preiser P, Goel S, Wahlgren M, Sismeiro O, Coppée JY, Scherf A.

Sci Rep. 2017 Oct 25;7(1):14042. doi: 10.1038/s41598-017-12578-y.

8.

Identification of the centromeres of Leishmania major: revealing the hidden pieces.

Garcia-Silva MR, Sollelis L, MacPherson CR, Stanojcic S, Kuk N, Crobu L, Bringaud F, Bastien P, Pagès M, Scherf A, Sterkers Y.

EMBO Rep. 2017 Nov;18(11):1968-1977. doi: 10.15252/embr.201744216. Epub 2017 Sep 21.

9.

CRISPR/Cas9 Genome Editing Reveals That the Intron Is Not Essential for var2csa Gene Activation or Silencing in Plasmodium falciparum.

Bryant JM, Regnault C, Scheidig-Benatar C, Baumgarten S, Guizetti J, Scherf A.

MBio. 2017 Jul 11;8(4). pii: e00729-17. doi: 10.1128/mBio.00729-17.

10.

Laser capture microdissection enables transcriptomic analysis of dividing and quiescent liver stages of Plasmodium relapsing species.

Cubi R, Vembar SS, Biton A, Franetich JF, Bordessoulles M, Sossau D, Zanghi G, Bosson-Vanga H, Benard M, Moreno A, Dereuddre-Bosquet N, Le Grand R, Scherf A, Mazier D.

Cell Microbiol. 2017 Aug;19(8). doi: 10.1111/cmi.12735. Epub 2017 Mar 13.

11.

Trans-acting GC-rich non-coding RNA at var expression site modulates gene counting in malaria parasite.

Guizetti J, Barcons-Simon A, Scherf A.

Nucleic Acids Res. 2016 Nov 16;44(20):9710-9718. Epub 2016 Jul 27.

12.

Complete telomere-to-telomere de novo assembly of the Plasmodium falciparum genome through long-read (>11 kb), single molecule, real-time sequencing.

Vembar SS, Seetin M, Lambert C, Nattestad M, Schatz MC, Baybayan P, Scherf A, Smith ML.

DNA Res. 2016 Aug;23(4):339-51. doi: 10.1093/dnares/dsw022. Epub 2016 Jun 26.

13.

Translational regulation in blood stages of the malaria parasite Plasmodium spp.: systems-wide studies pave the way.

Vembar SS, Droll D, Scherf A.

Wiley Interdiscip Rev RNA. 2016 Nov;7(6):772-792. doi: 10.1002/wrna.1365. Epub 2016 May 26. Review.

14.

Orientation relationship of eutectoid FeAl and FeAl2.

Scherf A, Kauffmann A, Kauffmann-Weiss S, Scherer T, Li X, Stein F, Heilmaier M.

J Appl Crystallogr. 2016 Feb 24;49(Pt 2):442-449. eCollection 2016 Apr 1.

15.

Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites.

Chen PB, Ding S, Zanghì G, Soulard V, DiMaggio PA, Fuchter MJ, Mecheri S, Mazier D, Scherf A, Malmquist NA.

Sci Rep. 2016 Feb 23;6:21802. doi: 10.1038/srep21802.

16.

The PfAlba1 RNA-binding protein is an important regulator of translational timing in Plasmodium falciparum blood stages.

Vembar SS, Macpherson CR, Sismeiro O, Coppée JY, Scherf A.

Genome Biol. 2015 Sep 28;16:212. doi: 10.1186/s13059-015-0771-5.

17.

Flexible guide-RNA design for CRISPR applications using Protospacer Workbench.

MacPherson CR, Scherf A.

Nat Biotechnol. 2015 Aug;33(8):805-6. doi: 10.1038/nbt.3291. Epub 2015 Jun 29. No abstract available.

PMID:
26121414
18.

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).

Lucas-Hourani M, Munier-Lehmann H, El Mazouni F, Malmquist NA, Harpon J, Coutant EP, Guillou S, Helynck O, Noel A, Scherf A, Phillips MA, Tangy F, Vidalain PO, Janin YL.

J Med Chem. 2015 Jul 23;58(14):5579-98. doi: 10.1021/acs.jmedchem.5b00606. Epub 2015 Jun 30.

19.

First efficient CRISPR-Cas9-mediated genome editing in Leishmania parasites.

Sollelis L, Ghorbal M, MacPherson CR, Martins RM, Kuk N, Crobu L, Bastien P, Scherf A, Lopez-Rubio JJ, Sterkers Y.

Cell Microbiol. 2015 Oct;17(10):1405-12. doi: 10.1111/cmi.12456. Epub 2015 Jun 19.

PMID:
25939677
20.

RNase II: A new player enters the game.

Zhang Q, Scherf A.

RNA Biol. 2015;12(6):586-9. doi: 10.1080/15476286.2015.1038013.

21.

Post-translational protein modifications in malaria parasites.

Doerig C, Rayner JC, Scherf A, Tobin AB.

Nat Rev Microbiol. 2015 Mar;13(3):160-72. doi: 10.1038/nrmicro3402. Epub 2015 Feb 9. Review.

PMID:
25659318
22.

Cellular microbiology editorial letter.

Scherf A, Grinstein S.

Cell Microbiol. 2015 Jan;17(1):1. doi: 10.1111/cmi.12402. No abstract available.

PMID:
25523229
23.

Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans.

Malmquist NA, Sundriyal S, Caron J, Chen P, Witkowski B, Menard D, Suwanarusk R, Renia L, Nosten F, Jiménez-Díaz MB, Angulo-Barturen I, Santos Martínez M, Ferrer S, Sanz LM, Gamo FJ, Wittlin S, Duffy S, Avery VM, Ruecker A, Delves MJ, Sinden RE, Fuchter MJ, Scherf A.

Antimicrob Agents Chemother. 2015 Feb;59(2):950-9. doi: 10.1128/AAC.04419-14. Epub 2014 Nov 24.

24.

P. berghei telomerase subunit TERT is essential for parasite survival.

Religa AA, Ramesar J, Janse CJ, Scherf A, Waters AP.

PLoS One. 2014 Oct 2;9(9):e108930. doi: 10.1371/journal.pone.0108930. eCollection 2014.

25.

Development of diaminoquinazoline histone lysine methyltransferase inhibitors as potent blood-stage antimalarial compounds.

Sundriyal S, Malmquist NA, Caron J, Blundell S, Liu F, Chen X, Srimongkolpithak N, Jin J, Charman SA, Scherf A, Fuchter MJ.

ChemMedChem. 2014 Oct;9(10):2360-2373. doi: 10.1002/cmdc.201402098. Epub 2014 Jul 9.

26.

Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria.

Zhang Q, Siegel TN, Martins RM, Wang F, Cao J, Gao Q, Cheng X, Jiang L, Hon CC, Scheidig-Benatar C, Sakamoto H, Turner L, Jensen AT, Claes A, Guizetti J, Malmquist NA, Scherf A.

Nature. 2014 Sep 18;513(7518):431-5. doi: 10.1038/nature13468. Epub 2014 Jun 29.

PMID:
25043062
27.

Noncoding RNAs as emerging regulators of Plasmodium falciparum virulence gene expression.

Vembar SS, Scherf A, Siegel TN.

Curr Opin Microbiol. 2014 Aug;20:153-61. doi: 10.1016/j.mib.2014.06.013. Epub 2014 Jul 12. Review.

28.

Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system.

Ghorbal M, Gorman M, Macpherson CR, Martins RM, Scherf A, Lopez-Rubio JJ.

Nat Biotechnol. 2014 Aug;32(8):819-21. doi: 10.1038/nbt.2925. Epub 2014 Jun 1.

PMID:
24880488
29.

Biology of the malaria parasite--on the special issue for the 10th BioMalPar conference.

Frischknecht F, Mota M, Scherf A, Waters A.

Cell Microbiol. 2014 May;16(5):599-601. doi: 10.1111/cmi.12295. No abstract available.

PMID:
24735376
30.

Strand-specific RNA-Seq reveals widespread and developmentally regulated transcription of natural antisense transcripts in Plasmodium falciparum.

Siegel TN, Hon CC, Zhang Q, Lopez-Rubio JJ, Scheidig-Benatar C, Martins RM, Sismeiro O, Coppée JY, Scherf A.

BMC Genomics. 2014 Feb 22;15:150. doi: 10.1186/1471-2164-15-150.

31.

Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures.

Dembélé L, Franetich JF, Lorthiois A, Gego A, Zeeman AM, Kocken CH, Le Grand R, Dereuddre-Bosquet N, van Gemert GJ, Sauerwein R, Vaillant JC, Hannoun L, Fuchter MJ, Diagana TT, Malmquist NA, Scherf A, Snounou G, Mazier D.

Nat Med. 2014 Mar;20(3):307-12. doi: 10.1038/nm.3461. Epub 2014 Feb 9.

PMID:
24509527
32.

PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum.

Jiang L, Mu J, Zhang Q, Ni T, Srinivasan P, Rayavara K, Yang W, Turner L, Lavstsen T, Theander TG, Peng W, Wei G, Jing Q, Wakabayashi Y, Bansal A, Luo Y, Ribeiro JM, Scherf A, Aravind L, Zhu J, Zhao K, Miller LH.

Nature. 2013 Jul 11;499(7457):223-7. doi: 10.1038/nature12361. Epub 2013 Jul 3.

33.

Nuclear pores and perinuclear expression sites of var and ribosomal DNA genes correspond to physically distinct regions in Plasmodium falciparum.

Guizetti J, Martins RM, Guadagnini S, Claes A, Scherf A.

Eukaryot Cell. 2013 May;12(5):697-702. doi: 10.1128/EC.00023-13. Epub 2013 Mar 8.

34.

Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum.

Mancio-Silva L, Lopez-Rubio JJ, Claes A, Scherf A.

Nat Commun. 2013;4:1530. doi: 10.1038/ncomms2539.

35.

Silence, activate, poise and switch! Mechanisms of antigenic variation in Plasmodium falciparum.

Guizetti J, Scherf A.

Cell Microbiol. 2013 May;15(5):718-26. doi: 10.1111/cmi.12115. Epub 2013 Feb 21. Review.

36.

Comprehensive histone phosphorylation analysis and identification of Pf14-3-3 protein as a histone H3 phosphorylation reader in malaria parasites.

Dastidar EG, Dzeyk K, Krijgsveld J, Malmquist NA, Doerig C, Scherf A, Lopez-Rubio JJ.

PLoS One. 2013;8(1):e53179. doi: 10.1371/journal.pone.0053179. Epub 2013 Jan 7.

37.

Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria.

Fried M, Avril M, Chaturvedi R, Fernandez P, Lograsso J, Narum D, Nielsen MA, Oleinikov AV, Resende M, Salanti A, Saveria T, Williamson K, Dicko A, Scherf A, Smith JD, Theander TG, Duffy PE.

Infect Immun. 2013 Feb;81(2):487-95. doi: 10.1128/IAI.01106-12. Epub 2012 Dec 3.

38.

Initial characterization of the Pf-Int recombinase from the malaria parasite Plasmodium falciparum.

Ghorbal M, Scheidig-Benatar C, Bouizem S, Thomas C, Paisley G, Faltermeier C, Liu M, Scherf A, Lopez-Rubio JJ, Gopaul DN.

PLoS One. 2012;7(10):e46507. doi: 10.1371/journal.pone.0046507. Epub 2012 Oct 8.

39.

Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum.

Malmquist NA, Moss TA, Mecheri S, Scherf A, Fuchter MJ.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16708-13. doi: 10.1073/pnas.1205414109. Epub 2012 Sep 24.

40.
41.

Genome-wide chromatin immunoprecipitation-sequencing in Plasmodium.

Lopez-Rubio JJ, Siegel TN, Scherf A.

Methods Mol Biol. 2013;923:321-33.

PMID:
22990789
42.

Two long non-coding RNAs generated from subtelomeric regions accumulate in a novel perinuclear compartment in Plasmodium falciparum.

Sierra-Miranda M, Delgadillo DM, Mancio-Silva L, Vargas M, Villegas-Sepulveda N, Martínez-Calvillo S, Scherf A, Hernandez-Rivas R.

Mol Biochem Parasitol. 2012 Sep;185(1):36-47. doi: 10.1016/j.molbiopara.2012.06.005. Epub 2012 Jun 18.

PMID:
22721695
43.

Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway.

Dastidar EG, Dayer G, Holland ZM, Dorin-Semblat D, Claes A, Chêne A, Sharma A, Hamelin R, Moniatte M, Lopez-Rubio JJ, Scherf A, Doerig C.

BMC Biol. 2012 Jan 31;10:5. doi: 10.1186/1741-7007-10-5.

44.

Clag9 is not essential for PfEMP1 surface expression in non-cytoadherent Plasmodium falciparum parasites with a chromosome 9 deletion.

Nacer A, Roux E, Pomel S, Scheidig-Benatar C, Sakamoto H, Lafont F, Scherf A, Mattei D.

PLoS One. 2011;6(12):e29039. doi: 10.1371/journal.pone.0029039. Epub 2011 Dec 19.

45.

PfAlbas constitute a new eukaryotic DNA/RNA-binding protein family in malaria parasites.

Chêne A, Vembar SS, Rivière L, Lopez-Rubio JJ, Claes A, Siegel TN, Sakamoto H, Scheidig-Benatar C, Hernandez-Rivas R, Scherf A.

Nucleic Acids Res. 2012 Apr;40(7):3066-77. doi: 10.1093/nar/gkr1215. Epub 2011 Dec 13.

46.

A critical role of perinuclear filamentous actin in spatial repositioning and mutually exclusive expression of virulence genes in malaria parasites.

Zhang Q, Huang Y, Zhang Y, Fang X, Claes A, Duchateau M, Namane A, Lopez-Rubio JJ, Pan W, Scherf A.

Cell Host Microbe. 2011 Nov 17;10(5):451-63. doi: 10.1016/j.chom.2011.09.013.

47.

Strain-transcendent immune response to recombinant Var2CSA DBL5-ε domain block P. falciparum adhesion to placenta-derived BeWo cells under flow conditions.

Fernandez P, Petres S, Mécheri S, Gysin J, Scherf A.

PLoS One. 2010 Sep 3;5(9):e12558. doi: 10.1371/journal.pone.0012558.

48.

Clustering of dispersed ribosomal DNA and its role in gene regulation and chromosome-end associations in malaria parasites.

Mancio-Silva L, Zhang Q, Scheidig-Benatar C, Scherf A.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15117-22. doi: 10.1073/pnas.1001045107. Epub 2010 Aug 9.

49.

Plasmodium falciparum FIKK kinase members target distinct components of the erythrocyte membrane.

Nunes MC, Okada M, Scheidig-Benatar C, Cooke BM, Scherf A.

PLoS One. 2010 Jul 23;5(7):e11747. doi: 10.1371/journal.pone.0011747.

50.

Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA.

Srivastava A, Gangnard S, Round A, Dechavanne S, Juillerat A, Raynal B, Faure G, Baron B, Ramboarina S, Singh SK, Belrhali H, England P, Lewit-Bentley A, Scherf A, Bentley GA, Gamain B.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4884-9. doi: 10.1073/pnas.1000951107. Epub 2010 Mar 1.

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