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Caveolin-1 as a possible target in treatment for acne.

Kruglikov IL, Scherer PE.

Exp Dermatol. 2019 Nov 26. doi: 10.1111/exd.14063. [Epub ahead of print]


Imaging Metabolically Active Fat: A Literature Review and Mechanistic Insights.

Frankl J, Sherwood A, Clegg DJ, Scherer PE, Öz OK.

Int J Mol Sci. 2019 Nov 5;20(21). pii: E5509. doi: 10.3390/ijms20215509. Review.


Renal tubular cell spliced X-box binding protein 1 (Xbp1s) has a unique role in sepsis-induced acute kidney injury and inflammation.

Ferrè S, Deng Y, Huen SC, Lu CY, Scherer PE, Igarashi P, Moe OW.

Kidney Int. 2019 Dec;96(6):1359-1373. doi: 10.1016/j.kint.2019.06.023. Epub 2019 Aug 1.


Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue.

Song A, Dai W, Jang MJ, Medrano L, Li Z, Zhao H, Shao M, Tan J, Li A, Ning T, Miller MM, Armstrong B, Huss JM, Zhu Y, Liu Y, Gradinaru V, Wu X, Jiang L, Scherer PE, Wang QA.

J Clin Invest. 2019 Nov 25. pii: 129167. doi: 10.1172/JCI129167. [Epub ahead of print]


Cellular Origins of Beige Fat Cells Revisited.

Shao M, Wang QA, Song A, Vishvanath L, Busbuso NC, Scherer PE, Gupta RK.

Diabetes. 2019 Oct;68(10):1874-1885. doi: 10.2337/db19-0308.


Remodeling of Murine Mammary Adipose Tissue during Pregnancy, Lactation, and Involution.

Wang QA, Scherer PE.

J Mammary Gland Biol Neoplasia. 2019 Sep;24(3):207-212. doi: 10.1007/s10911-019-09434-2. Epub 2019 Sep 12. Review.


Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice.

Zhang Z, Shao M, Hepler C, Zi Z, Zhao S, An YA, Zhu Y, Ghaben AL, Wang MY, Li N, Onodera T, Joffin N, Crewe C, Zhu Q, Vishvanath L, Kumar A, Xing C, Wang QA, Gautron L, Deng Y, Gordillo R, Kruglikov I, Kusminski CM, Gupta RK, Scherer PE.

J Clin Invest. 2019 Dec 2;129(12):5327-5342. doi: 10.1172/JCI130239.


Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy.

Zhao S, Zhu Y, Schultz RD, Li N, He Z, Zhang Z, Caron A, Zhu Q, Sun K, Xiong W, Deng H, Sun J, Deng Y, Kim M, Lee CE, Gordillo R, Liu T, Odle AK, Childs GV, Zhang N, Kusminski CM, Elmquist JK, Williams KW, An Z, Scherer PE.

Cell Metab. 2019 Oct 1;30(4):706-719.e6. doi: 10.1016/j.cmet.2019.08.005. Epub 2019 Sep 5.


Caveolin-1 in skin aging - From innocent bystander to major contributor.

Kruglikov IL, Zhang Z, Scherer PE.

Ageing Res Rev. 2019 Nov;55:100959. doi: 10.1016/j.arr.2019.100959. Epub 2019 Sep 4. Review.


Obesity dysregulates fasting-induced changes in glucagon secretion.

Stern JH, Smith G, Chen S, Unger R, Klein S, Scherer PE.

J Endocrinol. 2019 Aug 1. pii: JOE-19-0201.R1. doi: 10.1530/JOE-19-0201. [Epub ahead of print]


Lowering ceramides to overcome diabetes.

Kusminski CM, Scherer PE.

Science. 2019 Jul 26;365(6451):319-320. doi: 10.1126/science.aax6594. No abstract available.


SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1.

Crewe C, Zhu Y, Paschoal VA, Joffin N, Ghaben AL, Gordillo R, Oh DY, Liang G, Horton JD, Scherer PE.

JCI Insight. 2019 Jul 16;5. pii: 129397. doi: 10.1172/jci.insight.129397.


Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis.

Caron A, Reynolds RP, Castorena CM, Michael NJ, Lee CE, Lee S, Berdeaux R, Scherer PE, Elmquist JK.

Mol Metab. 2019 Sep;27:11-21. doi: 10.1016/j.molmet.2019.06.019. Epub 2019 Jun 22.


Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication.

Funcke JB, Scherer PE.

J Lipid Res. 2019 Oct;60(10):1648-1684. doi: 10.1194/jlr.R094060. Epub 2019 Jun 17. Review.


Spliced X-box Binding Protein 1 Stimulates Adaptive Growth Through Activation of mTOR.

Wang X, Deng Y, Zhang G, Li C, Ding G, May HI, Tran DH, Luo X, Jiang DS, Li DL, Wei X, Xu L, Ferdous A, Gillette TG, Scherer PE, Jiang X, Wang ZV.

Circulation. 2019 Aug 13;140(7):566-579. doi: 10.1161/CIRCULATIONAHA.118.038924. Epub 2019 Jun 10.


Critical lipids link breastfeeding to healthy adipose tissue in infancy and adulthood.

Gliniak CM, Scherer PE.

J Clin Invest. 2019 May 13;129(6):2198-2200. doi: 10.1172/JCI128830. eCollection 2019 May 13.


Caveolin-1 as a target in prevention and treatment of hypertrophic scarring.

Kruglikov IL, Scherer PE.

NPJ Regen Med. 2019 Apr 26;4:9. doi: 10.1038/s41536-019-0071-x. eCollection 2019. Review.


XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in Idiopathic Pulmonary Fibrosis Airway Epithelia.

Chen G, Ribeiro CMP, Sun L, Okuda K, Kato T, Gilmore RC, Martino MB, Dang H, Abzhanova A, Lin JM, Hull-Ryde EA, Volmer AS, Randell SH, Livraghi-Butrico A, Deng Y, Scherer PE, Stripp BR, O'Neal WK, Boucher RC.

Am J Respir Crit Care Med. 2019 Jul 15;200(2):220-234. doi: 10.1164/rccm.201810-1972OC. Erratum in: Am J Respir Crit Care Med. 2019 Oct 15;200(8):1074.


Human endotrophin as a driver of malignant tumor growth.

Bu D, Crewe C, Kusminski CM, Gordillo R, Ghaben AL, Kim M, Park J, Deng H, Xiong W, Liu XZ, Lønning PE, Halberg N, Rios A, Chang Y, Gonzalez A, Zhang N, An Z, Scherer PE.

JCI Insight. 2019 Mar 21;5. pii: 125094. doi: 10.1172/jci.insight.125094.


Vascular Endothelial Growth Factor-D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity.

Chakraborty A, Barajas S, Lammoglia GM, Reyna AJ, Morley TS, Johnson JA, Scherer PE, Rutkowski JM.

Am J Pathol. 2019 Apr;189(4):924-939. doi: 10.1016/j.ajpath.2018.12.008. Epub 2019 Mar 13.


Adiponectin Moderates Antidepressant Treatment Outcome in the Combining Medications to Enhance Depression Outcomes Randomized Clinical Trial.

Furman JL, Soyombo A, Czysz AH, Jha MK, Carmody TJ, Mason BL, Scherer PE, Trivedi MH.

Pers Med Psychiatry. 2018 Aug-Sep;9-10:1-7. doi: 10.1016/j.pmip.2018.05.001. Epub 2018 Jun 21.


Lipotoxicity and β Cell Maintenance in Obesity and Type 2 Diabetes.

Ye R, Onodera T, Scherer PE.

J Endocr Soc. 2019 Feb 4;3(3):617-631. doi: 10.1210/js.2018-00372. eCollection 2019 Mar 1. Review.


The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice.

Beaudry JL, Kaur KD, Varin EM, Baggio LL, Cao X, Mulvihill EE, Stern JH, Campbell JE, Scherer PE, Drucker DJ.

Mol Metab. 2019 Apr;22:37-48. doi: 10.1016/j.molmet.2019.01.011. Epub 2019 Feb 5.


Caveolin-1 as a pathophysiological factor and target in psoriasis.

Kruglikov IL, Scherer PE.

NPJ Aging Mech Dis. 2019 Feb 5;5:4. doi: 10.1038/s41514-019-0034-x. eCollection 2019. Review.


β1 Syntrophin Supports Autophagy Initiation and Protects against Cerulein-Induced Acute Pancreatitis.

Ye R, Onodera T, Blanchard PG, Kusminski CM, Esser V, Brekken RA, Scherer PE.

Am J Pathol. 2019 Apr;189(4):813-825. doi: 10.1016/j.ajpath.2019.01.002. Epub 2019 Jan 14.


High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice.

Peri-Okonny P, Baskin KK, Iwamoto G, Mitchell JH, Smith SA, Kim HK, Szweda LI, Bassel-Duby R, Fujikawa T, Castorena CM, Richardson J, Shelton JM, Ayers C, Berry JD, Malladi VS, Hu MC, Moe OW, Scherer PE, Vongpatanasin W.

Circulation. 2019 Mar 12;139(11):1422-1434. doi: 10.1161/CIRCULATIONAHA.118.037550.


Adipogenesis and metabolic health.

Ghaben AL, Scherer PE.

Nat Rev Mol Cell Biol. 2019 Apr;20(4):242-258. doi: 10.1038/s41580-018-0093-z. Review.


The Role of Immature and Mature Adipocytes in Hair Cycling.

Kruglikov IL, Zhang Z, Scherer PE.

Trends Endocrinol Metab. 2019 Feb;30(2):93-105. doi: 10.1016/j.tem.2018.11.004. Epub 2018 Dec 14. Review.


Fasting and Glucose-Stimulated Changes in Plasma Glucagon in Pancreatic Cancer: Potential Biomarkers for Detection?

Stern JH, Arriaga Y, Gupta A, Verma U, Karri S, Syed S, Khosama L, Mansour J, Meyer J, Scherer PE, Beg MS.

Pancreas. 2019 Jan;48(1):e1-e3. doi: 10.1097/MPA.0000000000001208. No abstract available.


Reduced oxygen consumption by fat cells improves metabolic defects.

Joffin N, Scherer PE.

Nature. 2018 Dec;564(7734):47-48. doi: 10.1038/d41586-018-07248-6. No abstract available.


The many secret lives of adipocytes: implications for diabetes.

Scherer PE.

Diabetologia. 2019 Feb;62(2):223-232. doi: 10.1007/s00125-018-4777-x. Epub 2018 Nov 21. Review.


An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State.

Crewe C, Joffin N, Rutkowski JM, Kim M, Zhang F, Towler DA, Gordillo R, Scherer PE.

Cell. 2018 Oct 18;175(3):695-708.e13. doi: 10.1016/j.cell.2018.09.005. Epub 2018 Oct 4.


COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease.

Lee C, Kim M, Lee JH, Oh J, Shin HH, Lee SM, Scherer PE, Kwon HM, Choi JH, Park J.

J Pathol. 2019 Jan;247(1):99-109. doi: 10.1002/path.5172. Epub 2018 Nov 27.


Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study.

Neeland IJ, Singh S, McGuire DK, Vega GL, Roddy T, Reilly DF, Castro-Perez J, Kozlitina J, Scherer PE.

Diabetologia. 2018 Dec;61(12):2570-2579. doi: 10.1007/s00125-018-4720-1. Epub 2018 Aug 29.


HDAC11 suppresses the thermogenic program of adipose tissue via BRD2.

Bagchi RA, Ferguson BS, Stratton MS, Hu T, Cavasin MA, Sun L, Lin YH, Liu D, Londono P, Song K, Pino MF, Sparks LM, Smith SR, Scherer PE, Collins S, Seto E, McKinsey TA.

JCI Insight. 2018 Aug 9;3(15). pii: 120159. doi: 10.1172/jci.insight.120159. eCollection 2018 Aug 9.


Adiponectin modulates ventral tegmental area dopamine neuron activity and anxiety-related behavior through AdipoR1.

Sun F, Lei Y, You J, Li C, Sun L, Garza J, Zhang D, Guo M, Scherer PE, Lodge D, Lu XY.

Mol Psychiatry. 2019 Jan;24(1):126-144. doi: 10.1038/s41380-018-0102-9. Epub 2018 Jul 9.


Skin aging as a mechanical phenomenon: The main weak links.

Kruglikov IL, Scherer PE.

Nutr Healthy Aging. 2018 Jun 15;4(4):291-307. doi: 10.3233/NHA-170037.


Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction.

Cruz VH, Arner EN, Wynne KW, Scherer PE, Brekken RA.

Mol Metab. 2018 Oct;16:139-149. doi: 10.1016/j.molmet.2018.06.007. Epub 2018 Jun 11.


Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation.

Wang QA, Song A, Chen W, Schwalie PC, Zhang F, Vishvanath L, Jiang L, Ye R, Shao M, Tao C, Gupta RK, Deplancke B, Scherer PE.

Cell Metab. 2018 Aug 7;28(2):282-288.e3. doi: 10.1016/j.cmet.2018.05.022. Epub 2018 Jun 14.


Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease.

Jia L, Chang X, Qian S, Liu C, Lord CC, Ahmed N, Lee CE, Lee S, Gautron L, Mitchell MC, Horton JD, Scherer PE, Elmquist JK.

Mol Metab. 2018 Aug;14:121-129. doi: 10.1016/j.molmet.2018.05.015. Epub 2018 May 23.


Glucose-regulated protein 78 is essential for cardiac myocyte survival.

Wang X, Bi X, Zhang G, Deng Y, Luo X, Xu L, Scherer PE, Ferdous A, Fu G, Gillette TG, Lee AS, Jiang X, Wang ZV.

Cell Death Differ. 2018 Dec;25(12):2181-2194. doi: 10.1038/s41418-018-0109-4. Epub 2018 Apr 17.


Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis.

Zhang Z, Zi Z, Lee EE, Zhao J, Contreras DC, South AP, Abel ED, Chong BF, Vandergriff T, Hosler GA, Scherer PE, Mettlen M, Rathmell JC, DeBerardinis RJ, Wang RC.

Nat Med. 2018 May;24(5):617-627. doi: 10.1038/s41591-018-0003-0. Epub 2018 Apr 16.


New zoning laws enforced by glucagon.

Kusminski CM, Scherer PE.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4308-4310. doi: 10.1073/pnas.1804203115. Epub 2018 Apr 9. No abstract available.


Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis.

Apostolopoulou M, Gordillo R, Koliaki C, Gancheva S, Jelenik T, De Filippo E, Herder C, Markgraf D, Jankowiak F, Esposito I, Schlensak M, Scherer PE, Roden M.

Diabetes Care. 2018 Jun;41(6):1235-1243. doi: 10.2337/dc17-1318. Epub 2018 Mar 30.


Adipocyte Xbp1s overexpression drives uridine production and reduces obesity.

Deng Y, Wang ZV, Gordillo R, Zhu Y, Ali A, Zhang C, Wang X, Shao M, Zhang Z, Iyengar P, Gupta RK, Horton JD, Hill JA, Scherer PE.

Mol Metab. 2018 May;11:1-17. doi: 10.1016/j.molmet.2018.02.013. Epub 2018 Mar 2.


Peroxisome Proliferator-Activated Receptor γ and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization.

Wang QA, Zhang F, Jiang L, Ye R, An Y, Shao M, Tao C, Gupta RK, Scherer PE.

Mol Cell Biol. 2018 Apr 30;38(10). pii: e00677-17. doi: 10.1128/MCB.00677-17. Print 2018 May 15.


Hyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism.

Zhu Y, Kruglikov IL, Akgul Y, Scherer PE.

Matrix Biol. 2019 May;78-79:284-291. doi: 10.1016/j.matbio.2018.02.012. Epub 2018 Feb 16. Review.


Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity.

Ye R, Gordillo R, Shao M, Onodera T, Chen Z, Chen S, Lin X, SoRelle JA, Li X, Tang M, Keller MP, Kuliawat R, Attie AD, Gupta RK, Holland WL, Beutler B, Herz J, Scherer PE.

J Clin Invest. 2018 Mar 1;128(3):1178-1189. doi: 10.1172/JCI97702. Epub 2018 Feb 19.


An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents.

Zhang F, Hao G, Shao M, Nham K, An Y, Wang Q, Zhu Y, Kusminski CM, Hassan G, Gupta RK, Zhai Q, Sun X, Scherer PE, Oz OK.

Cell Metab. 2018 Jan 9;27(1):252-262.e3. doi: 10.1016/j.cmet.2017.12.004.


Adipose tissue: The dysfunctional adipocyte - a cancer cell's best friend.

Zhang Z, Scherer PE.

Nat Rev Endocrinol. 2018 Mar;14(3):132-134. doi: 10.1038/nrendo.2017.174. Epub 2018 Jan 5. No abstract available.


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