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Status of PCSK9 Monoclonal Antibodies in Australia.

Scherer DJ, Nelson AJ, O'Brien R, Kostner KM, Hare DL, Colquhoun DM, Barter PJ, Aylward P, Nicholls SJ, Watts GF.

Heart Lung Circ. 2019 May 8. pii: S1443-9506(19)30354-3. doi: 10.1016/j.hlc.2019.04.014. [Epub ahead of print] Review.


Profiling of gallbladder carcinoma reveals distinct miRNA profiles and activation of STAT1 by the tumor suppressive miRNA-145-5p.

Goeppert B, Truckenmueller F, Ori A, Fritz V, Albrecht T, Fraas A, Scherer D, Silos RG, Sticht C, Gretz N, Mehrabi A, Bewerunge-Hudler M, Pusch S, Bermejo JL, Dietrich P, Schirmacher P, Renner M, Roessler S.

Sci Rep. 2019 Mar 18;9(1):4796. doi: 10.1038/s41598-019-40857-3.


Optimal selection of genetic variants for adjustment of population stratification in European association studies.

Brinster R, Scherer D, Lorenzo Bermejo J.

Brief Bioinform. 2019 Mar 13. pii: bbz023. doi: 10.1093/bib/bbz023. [Epub ahead of print]


The ASAMET trial: a randomized, phase II, double-blind, placebo-controlled, multicenter, 2 × 2 factorial biomarker study of tertiary prevention with low-dose aspirin and metformin in stage I-III colorectal cancer patients.

Petrera M, Paleari L, Clavarezza M, Puntoni M, Caviglia S, Briata IM, Oppezzi M, Mislej EM, Stabuc B, Gnant M, Bachleitner-Hofmann T, Roth W, Scherer D, Haefeli WE, Ulrich CM, DeCensi A.

BMC Cancer. 2018 Dec 4;18(1):1210. doi: 10.1186/s12885-018-5126-7.


Quantification and evaluation of intra-urban heat-stress variability in Seoul, Korea.

Jänicke B, Holtmann A, Kim KR, Kang M, Fehrenbach U, Scherer D.

Int J Biometeorol. 2019 Jan;63(1):1-12. doi: 10.1007/s00484-018-1631-2. Epub 2018 Nov 20.


Effect of Evolocumab on Coronary Plaque Composition.

Nicholls SJ, Puri R, Anderson T, Ballantyne CM, Cho L, Kastelein JJP, Koenig W, Somaratne R, Kassahun H, Yang J, Wasserman SM, Honda S, Shishikura D, Scherer DJ, Borgman M, Brennan DM, Wolski K, Nissen SE.

J Am Coll Cardiol. 2018 Oct 23;72(17):2012-2021. doi: 10.1016/j.jacc.2018.06.078.


Body Fatness, Adipose Tissue Compartments, and Biomarkers of Inflammation and Angiogenesis in Colorectal Cancer: The ColoCare Study.

Himbert C, Ose J, Nattenmüller J, Warby CA, Holowatyj AN, Böhm J, Lin T, Haffa M, Gigic B, Hardikar S, Scherer D, Zielske L, Schrotz-King P, Kölsch T, Siegel EM, Shibata D, Ulrich A, Schneider M, Hursting SD, Kauczor HU, Ulrich CM.

Cancer Epidemiol Biomarkers Prev. 2019 Jan;28(1):76-82. doi: 10.1158/1055-9965.EPI-18-0654. Epub 2018 Oct 17.


Novel approach to discriminate left bundle branch block from nonspecific intraventricular conduction delay using pacing-induced functional left bundle branch block.

Scholz EP, Fischer P, Lugenbiel P, Xynogalos P, Schweizer PA, Scherer D, Thomas D, Katus HA, Zitron E.

J Interv Card Electrophysiol. 2018 Dec;53(3):347-355. doi: 10.1007/s10840-018-0449-5. Epub 2018 Sep 19.


Spin Waves in Detwinned BaFe_{2}As_{2}.

Lu X, Scherer DD, Tam DW, Zhang W, Zhang R, Luo H, Harriger LW, Walker HC, Adroja DT, Andersen BM, Dai P.

Phys Rev Lett. 2018 Aug 10;121(6):067002. doi: 10.1103/PhysRevLett.121.067002.


Spin-Orbit Coupling and Magnetic Anisotropy in Iron-Based Superconductors.

Scherer DD, Andersen BM.

Phys Rev Lett. 2018 Jul 20;121(3):037205. doi: 10.1103/PhysRevLett.121.037205.


Effect of Serial Infusions of CER-001, a Pre-β High-Density Lipoprotein Mimetic, on Coronary Atherosclerosis in Patients Following Acute Coronary Syndromes in the CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial: A Randomized Clinical Trial.

Nicholls SJ, Andrews J, Kastelein JJP, Merkely B, Nissen SE, Ray KK, Schwartz GG, Worthley SG, Keyserling C, Dasseux JL, Griffith L, Kim SW, Janssan A, Di Giovanni G, Pisaniello AD, Scherer DJ, Psaltis PJ, Butters J.

JAMA Cardiol. 2018 Sep 1;3(9):815-822. doi: 10.1001/jamacardio.2018.2121.


Pathway analysis of genetic variants in folate-mediated one-carbon metabolism-related genes and survival in a prospectively followed cohort of colorectal cancer patients.

Ose J, Botma A, Balavarca Y, Buck K, Scherer D, Habermann N, Beyerle J, Pfütze K, Seibold P, Kap EJ, Benner A, Jansen L, Butterbach K, Hoffmeister M, Brenner H, Ulrich A, Schneider M, Chang-Claude J, Burwinkel B, Ulrich CM.

Cancer Med. 2018 May 29. doi: 10.1002/cam4.1407. [Epub ahead of print]


Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles.

Klett H, Balavarca Y, Toth R, Gigic B, Habermann N, Scherer D, Schrotz-King P, Ulrich A, Schirmacher P, Herpel E, Brenner H, Ulrich CM, Michels KB, Busch H, Boerries M.

Epigenetics. 2018;13(4):386-397. doi: 10.1080/15592294.2018.1460034. Epub 2018 May 3.


High Accumulation of Metformin in Colonic Tissue of Subjects With Diabetes or the Metabolic Syndrome.

Paleari L, Burhenne J, Weiss J, Foersch S, Roth W, Parodi A, Gnant M, Bachleitner-Hofmann T, Scherer D, Ulrich CM, Stabuc B, Puntoni M, Coccia G, Petrera M, Haefeli WE, DeCensi A.

Gastroenterology. 2018 Apr;154(5):1543-1545. doi: 10.1053/j.gastro.2017.12.040. Epub 2018 Mar 8. No abstract available.


Pediatric Participation in Medical Decision Making: The Devil Is in the Details.

Scherer DG.

Am J Bioeth. 2018 Mar;18(3):16-18. doi: 10.1080/15265161.2017.1418924. No abstract available.


Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations.

Sheth H, Northwood E, Ulrich CM, Scherer D, Elliott F, Barrett JH, Forman D, Wolf CR, Smith G, Jackson MS, Santibanez-Koref M, Haile R, Casey G, Jenkins M, Win AK, Hopper JL, Marchand LL, Lindor NM, Thibodeau SN, Potter JD, Burn J, Bishop DT.

PLoS One. 2018 Feb 9;13(2):e0192223. doi: 10.1371/journal.pone.0192223. eCollection 2018.


Semifluorinated alkane based systems for enhanced corneal penetration of poorly soluble drugs.

Agarwal P, Scherer D, Günther B, Rupenthal ID.

Int J Pharm. 2018 Mar 1;538(1-2):119-129. doi: 10.1016/j.ijpharm.2018.01.019. Epub 2018 Jan 12.


Associations Between Dietary Patterns and Longitudinal Quality of Life Changes in Colorectal Cancer Patients: The ColoCare Study.

Gigic B, Boeing H, Toth R, Böhm J, Habermann N, Scherer D, Schrotz-King P, Abbenhardt-Martin C, Skender S, Brenner H, Chang-Claude J, Hoffmeister M, Syrjala K, Jacobsen PB, Schneider M, Ulrich A, Ulrich CM.

Nutr Cancer. 2018 Jan;70(1):51-60. doi: 10.1080/01635581.2018.1397707. Epub 2017 Dec 15.


A randomized study of a method for optimizing adolescent assent to biomedical research.

Annett RD, Brody JL, Scherer DG, Turner CW, Dalen J, Raissy H.

AJOB Empir Bioeth. 2017 Jul-Sep;8(3):189-197. doi: 10.1080/23294515.2016.1251507. Epub 2016 Oct 24.


Signals from the Adipose Microenvironment and the Obesity-Cancer Link-A Systematic Review.

Himbert C, Delphan M, Scherer D, Bowers LW, Hursting S, Ulrich CM.

Cancer Prev Res (Phila). 2017 Sep;10(9):494-506. doi: 10.1158/1940-6207.CAPR-16-0322. Review.


Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study.

Barrow TM, Klett H, Toth R, Böhm J, Gigic B, Habermann N, Scherer D, Schrotz-King P, Skender S, Abbenhardt-Martin C, Zielske L, Schneider M, Ulrich A, Schirmacher P, Herpel E, Brenner H, Busch H, Boerries M, Ulrich CM, Michels KB.

J Pathol. 2017 Nov;243(3):366-375. doi: 10.1002/path.4955. Epub 2017 Sep 29.


A Low Concentration of Tacrolimus/Semifluorinated Alkane (SFA) Eyedrop Suppresses Intraocular Inflammation in Experimental Models of Uveitis.

De Majumdar S, Subinya M, Korward J, Pettigrew A, Scherer D, Xu H.

Curr Mol Med. 2017;17(3):211-220. doi: 10.2174/1566524017666170807144009.


[More heat stress and air pollution for the lungs in view of climate change].

Witt C, Liebers U, Dostal V, Heinsohn JB, Hanisch M, Drozdek M, Schubert A, Scherer D.

MMW Fortschr Med. 2017 Jul;159(13):42-45. doi: 10.1007/s15006-017-9900-2. Review. German. No abstract available.


A Conceptual Model and Clinical Framework for Integrating Mindfulness into Family Therapy with Adolescents.

Brody JL, Scherer DG, Turner CW, Annett RD, Dalen J.

Fam Process. 2018 Jun;57(2):510-524. doi: 10.1111/famp.12298. Epub 2017 Jun 7.


PCSK9 Inhibitors in Hyperlipidemia: Current Status and Clinical Outlook.

Di Bartolo B, Scherer DJ, Brown A, Psaltis PJ, Nicholls SJ.

BioDrugs. 2017 Jun;31(3):167-174. doi: 10.1007/s40259-017-0220-y.


Targeting low-density lipoprotein cholesterol with PCSK9 inhibitors.

Scherer DJ, Nelson AJ, Psaltis PJ, Nicholls SJ.

Intern Med J. 2017 Aug;47(8):856-865. doi: 10.1111/imj.13451. Review.


Inhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference.

Scherer D, Schworm B, Seyler C, Xynogalos P, Scholz EP, Thomas D, Katus HA, Zitron E.

Naunyn Schmiedebergs Arch Pharmacol. 2017 Jul;390(7):701-710. doi: 10.1007/s00210-017-1372-5. Epub 2017 Apr 2.


Role of plasma membrane-associated AKAPs for the regulation of cardiac IK1 current by protein kinase A.

Seyler C, Scherer D, Köpple C, Kulzer M, Korkmaz S, Xynogalos P, Thomas D, Kaya Z, Scholz E, Backs J, Karle C, Katus HA, Zitron E.

Naunyn Schmiedebergs Arch Pharmacol. 2017 May;390(5):493-503. doi: 10.1007/s00210-017-1344-9. Epub 2017 Mar 22.


Dual Mechanism for Inhibition of Inwardly Rectifying Kir2.x Channels by Quinidine Involving Direct Pore Block and PIP2-interference.

Koepple C, Scherer D, Seyler C, Scholz E, Thomas D, Katus HA, Zitron E.

J Pharmacol Exp Ther. 2017 May;361(2):209-218. doi: 10.1124/jpet.116.238287. Epub 2017 Feb 10.


Effect of serial infusions of reconstituted high-density lipoprotein (CER-001) on coronary atherosclerosis: rationale and design of the CARAT study.

Andrews J, Janssan A, Nguyen T, Pisaniello AD, Scherer DJ, Kastelein JJ, Merkely B, Nissen SE, Ray K, Schwartz GG, Worthley SG, Keyserling C, Dasseux JL, Butters J, Girardi J, Miller R, Nicholls SJ.

Cardiovasc Diagn Ther. 2017 Feb;7(1):45-51. doi: 10.21037/cdt.2017.01.01.


Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium.

Toth R, Scherer D, Kelemen LE, Risch A, Hazra A, Balavarca Y, Issa JJ, Moreno V, Eeles RA, Ogino S, Wu X, Ye Y, Hung RJ, Goode EL, Ulrich CM; OCAC, CORECT, TRICL, ELLIPSE, DRIVE, and GAME-ON consortia.

Cancer Epidemiol Biomarkers Prev. 2017 Jun;26(6):816-825. doi: 10.1158/1055-9965.EPI-16-0728. Epub 2017 Jan 23.


Inducing apolipoprotein A-I synthesis to reduce cardiovascular risk: from ASSERT to SUSTAIN and beyond.

Di Bartolo BA, Scherer DJ, Nicholls SJ.

Arch Med Sci. 2016 Dec 1;12(6):1302-1307. Epub 2016 Oct 24.


Future imaging of atherosclerosis: molecular imaging of coronary atherosclerosis with (18)F positron emission tomography.

Scherer DJ, Psaltis PJ.

Cardiovasc Diagn Ther. 2016 Aug;6(4):354-67. doi: 10.21037/cdt.2015.12.02. Review.


Inhibition of Cardiac Kir Current (IK1) by Protein Kinase C Critically Depends on PKCβ and Kir2.2.

Scherer D, Seyler C, Xynogalos P, Scholz EP, Thomas D, Backs J, Andrassy M, Völkers M, Karle CA, Katus HA, Zitron E.

PLoS One. 2016 May 23;11(5):e0156181. doi: 10.1371/journal.pone.0156181. eCollection 2016.


Non-traumatic spinal intradural haematoma: a rare case of paralysis following abciximab for ST elevation acute coronary syndrome.

Wong GR, Scherer DJ, Nelson AJ, Worthley MI.

BMJ Case Rep. 2016 May 10;2016. pii: bcr2016215616. doi: 10.1136/bcr-2016-215616. No abstract available.


The Effects of Climate Change on Patients With Chronic Lung Disease. A Systematic Literature Review.

Witt C, Schubert AJ, Jehn M, Holzgreve A, Liebers U, Endlicher W, Scherer D.

Dtsch Arztebl Int. 2015 Dec 21;112(51-52):878-83. doi: 10.3238/arztebl.2015.0878. Review.


CT-based compartmental quantification of adipose tissue versus body metrics in colorectal cancer patients.

Nattenmueller J, Hoegenauer H, Boehm J, Scherer D, Paskow M, Gigic B, Schrotz-King P, Grenacher L, Ulrich C, Kauczor HU.

Eur Radiol. 2016 Nov;26(11):4131-4140. Epub 2016 Feb 6.


SNPs in transporter and metabolizing genes as predictive markers for oxaliplatin treatment in colorectal cancer patients.

Kap EJ, Seibold P, Scherer D, Habermann N, Balavarca Y, Jansen L, Zucknick M, Becker N, Hoffmeister M, Ulrich A, Benner A, Ulrich CM, Burwinkel B, Brenner H, Chang-Claude J.

Int J Cancer. 2016 Jun 15;138(12):2993-3001. doi: 10.1002/ijc.30026. Epub 2016 Feb 19.


Modification of Heat-Related Mortality in an Elderly Urban Population by Vegetation (Urban Green) and Proximity to Water (Urban Blue): Evidence from Lisbon, Portugal.

Burkart K, Meier F, Schneider A, Breitner S, Canário P, Alcoforado MJ, Scherer D, Endlicher W.

Environ Health Perspect. 2016 Jul;124(7):927-34. doi: 10.1289/ehp.1409529. Epub 2015 Nov 13.


Semifluorinated Alkane Eye Drops for Treatment of Dry Eye Disease--A Prospective, Multicenter Noninterventional Study.

Steven P, Scherer D, Krösser S, Beckert M, Cursiefen C, Kaercher T.

J Ocul Pharmacol Ther. 2015 Oct;31(8):498-503. doi: 10.1089/jop.2015.0048. Epub 2015 Aug 21.


Kounis syndrome and hypersensitivity myocarditis - One and the same? Insights from cardiac magnetic resonance imaging.

Baillie TJ, Scherer DJ, Wong DTL, Steele PM.

J Cardiol Cases. 2015 Jul 17;12(4):119-122. doi: 10.1016/j.jccase.2015.05.012. eCollection 2015 Oct.


Metabolomics and transcriptomics identify pathway differences between visceral and subcutaneous adipose tissue in colorectal cancer patients: the ColoCare study.

Liesenfeld DB, Grapov D, Fahrmann JF, Salou M, Scherer D, Toth R, Habermann N, Böhm J, Schrotz-King P, Gigic B, Schneider M, Ulrich A, Herpel E, Schirmacher P, Fiehn O, Lampe JW, Ulrich CM.

Am J Clin Nutr. 2015 Aug;102(2):433-43. doi: 10.3945/ajcn.114.103804. Epub 2015 Jul 8.


Decennial Analysis of Interventional Left Atrial Appendage Closure.

Schmidt B, Bordignon S, Fuernkranz A, Perrotta L, Scherer D, Chun KRJ.

J Cardiovasc Electrophysiol. 2015 Aug;26(8):840-844. doi: 10.1111/jce.12704. Epub 2015 Jun 16.


Lowering triglycerides to modify cardiovascular risk: will icosapent deliver?

Scherer DJ, Nicholls SJ.

Vasc Health Risk Manag. 2015 Mar 25;11:203-9. doi: 10.2147/VHRM.S40134. eCollection 2015. Review.


Genetic variants in DNA repair genes as potential predictive markers for oxaliplatin chemotherapy in colorectal cancer.

Kap EJ, Seibold P, Richter S, Scherer D, Habermann N, Balavarca Y, Jansen L, Becker N, Pfütze K, Popanda O, Hoffmeister M, Ulrich A, Benner A, Ulrich CM, Burwinkel B, Brenner H, Chang-Claude J.

Pharmacogenomics J. 2015 Dec;15(6):505-12. doi: 10.1038/tpj.2015.8. Epub 2015 Mar 17.


Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action.

Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP.

Drug Des Devel Ther. 2015 Feb 16;9:867-77. doi: 10.2147/DDDT.S72765. eCollection 2015.


Ongoing challenges for pharmacotherapy for dyslipidemia.

Pisaniello AD, Scherer DJ, Kataoka Y, Nicholls SJ.

Expert Opin Pharmacother. 2015 Feb;16(3):347-56. doi: 10.1517/14656566.2014.986094. Epub 2014 Dec 5. Review.


Inhibition of cardiac Kv1.5 potassium current by the anesthetic midazolam: mode of action.

Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP.

Drug Des Devel Ther. 2014 Nov 7;8:2263-71. doi: 10.2147/DDDT.S70461. eCollection 2014.


Class III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224.

Xynogalos P, Seyler C, Scherer D, Koepple C, Scholz EP, Thomas D, Katus HA, Zitron E.

Naunyn Schmiedebergs Arch Pharmacol. 2014 Dec;387(12):1153-61. doi: 10.1007/s00210-014-1045-6. Epub 2014 Sep 4.


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