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Items: 1 to 50 of 79

1.

Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25.

Schepetkin IA, Karpenko AS, Khlebnikov AI, Shibinska MO, Levandovskiy IA, Kirpotina LN, Danilenko NV, Quinn MT.

Eur J Med Chem. 2019 Dec 1;183:111719. doi: 10.1016/j.ejmech.2019.111719. Epub 2019 Sep 18.

PMID:
31563013
2.

A patenting perspective on human neutrophil elastase (HNE) inhibitors (2014-2018) and their therapeutic applications.

Crocetti L, Quinn MT, Schepetkin IA, Giovannoni MP.

Expert Opin Ther Pat. 2019 Jul;29(7):555-578. doi: 10.1080/13543776.2019.1630379. Epub 2019 Jun 16. Review.

PMID:
31204543
3.

Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds.

Schepetkin IA, Kirpotina LN, Khlebnikov AI, Balasubramanian N, Quinn MT.

Molecules. 2019 May 10;24(9). pii: E1809. doi: 10.3390/molecules24091809.

4.

Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats.

Plotnikov MB, Chernysheva GA, Aliev OI, Smol'iakova VI, Fomina TI, Osipenko AN, Rydchenko VS, Anfinogenova YJ, Khlebnikov AI, Schepetkin IA, Atochin DN.

Molecules. 2019 May 3;24(9). pii: E1722. doi: 10.3390/molecules24091722.

5.

Further modifications of 1H-pyrrolo[2,3-b]pyridine derivatives as inhibitors of human neutrophil elastase.

Giovannoni MP, Cantini N, Crocetti L, Guerrini G, Iacovone A, Schepetkin IA, Vergelli C, Khlebnikov AI, Quinn MT.

Drug Dev Res. 2019 Aug;80(5):617-628. doi: 10.1002/ddr.21539. Epub 2019 Apr 19.

PMID:
31002441
6.

Inhibition of T Cell Receptor Activation by Semi-Synthetic Sesquiterpene Lactone Derivatives and Molecular Modeling of Their Interaction with Glutathione and Tyrosine Kinase ZAP-70.

Khlebnikov AI, Schepetkin IA, Kishkentaeva AS, Shaimerdenova ZR, Atazhanova GA, Adekenov SM, Kirpotina LN, Quinn MT.

Molecules. 2019 Jan 19;24(2). pii: E350. doi: 10.3390/molecules24020350.

7.

1H-pyrrolo[2,3-b]pyridine: A new scaffold for human neutrophil elastase (HNE) inhibitors.

Crocetti L, Giovannoni MP, Schepetkin IA, Quinn MT, Khlebnikov AI, Cantini N, Guerrini G, Iacovone A, Teodori E, Vergelli C.

Bioorg Med Chem. 2018 Nov 15;26(21):5583-5595. doi: 10.1016/j.bmc.2018.09.034. Epub 2018 Sep 27.

PMID:
30385225
8.

Synthesis, biological evaluation, and molecular modeling of 11H-indeno[1,2-b]quinoxalin-11-one derivatives and tryptanthrin-6-oxime as c-Jun N-terminal kinase inhibitors.

Schepetkin IA, Khlebnikov AI, Potapov AS, Kovrizhina AR, Matveevskaya VV, Belyanin ML, Atochin DN, Zanoza SO, Gaidarzhy NM, Lyakhov SA, Kirpotina LN, Quinn MT.

Eur J Med Chem. 2019 Jan 1;161:179-191. doi: 10.1016/j.ejmech.2018.10.023. Epub 2018 Oct 12.

PMID:
30347329
9.

c-Jun N-Terminal Kinases (JNKs) in Myocardial and Cerebral Ischemia/Reperfusion Injury.

Shvedova M, Anfinogenova Y, Atochina-Vasserman EN, Schepetkin IA, Atochin DN.

Front Pharmacol. 2018 Jul 5;9:715. doi: 10.3389/fphar.2018.00715. eCollection 2018. Review.

10.

Chemical Composition and Antibacterial Activity of Essential Oils from Ferula L. Species against Methicillin-Resistant Staphylococcus aureus.

Utegenova GA, Pallister KB, Kushnarenko SV, Özek G, Özek T, Abidkulova KT, Kirpotina LN, Schepetkin IA, Quinn MT, Voyich JM.

Molecules. 2018 Jul 10;23(7). pii: E1679. doi: 10.3390/molecules23071679.

11.

Synthesis, biological evaluation, and molecular modelling studies of potent human neutrophil elastase (HNE) inhibitors.

Giovannoni MP, Schepetkin IA, Quinn MT, Cantini N, Crocetti L, Guerrini G, Iacovone A, Paoli P, Rossi P, Bartolucci G, Menicatti M, Vergelli C.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1108-1124. doi: 10.1080/14756366.2018.1480615.

12.

Physicochemical Characterization and Antioxidant Activity of Humic Acids Isolated from Peat of Various Origins.

Zykova MV, Schepetkin IA, Belousov MV, Krivoshchekov SV, Logvinova LA, Bratishko KA, Yusubov MS, Romanenko SV, Quinn MT.

Molecules. 2018 Mar 24;23(4). pii: E753. doi: 10.3390/molecules23040753.

13.

The natural sesquiterpene lactones arglabin, grosheimin, agracin, parthenolide, and estafiatin inhibit T cell receptor (TCR) activation.

Schepetkin IA, Kirpotina LN, Mitchell PT, Kishkentaeva АS, Shaimerdenova ZR, Atazhanova GA, Adekenov SM, Quinn MT.

Phytochemistry. 2018 Feb;146:36-46. doi: 10.1016/j.phytochem.2017.11.010. Epub 2017 Dec 22.

14.

Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors.

Crocetti L, Bartolucci G, Cilibrizzi A, Giovannoni MP, Guerrini G, Iacovone A, Menicatti M, Schepetkin IA, Khlebnikov AI, Quinn MT, Vergelli C.

Chem Cent J. 2017 Dec 6;11(1):127. doi: 10.1186/s13065-017-0358-1.

15.

Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation.

Stama ML, Ślusarczyk J, Lacivita E, Kirpotina LN, Schepetkin IA, Chamera K, Riganti C, Perrone R, Quinn MT, Basta-Kaim A, Leopoldo M.

Eur J Med Chem. 2017 Dec 1;141:703-720. doi: 10.1016/j.ejmech.2017.09.023. Epub 2017 Sep 18.

16.

Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress.

Stama ML, Lacivita E, Kirpotina LN, Niso M, Perrone R, Schepetkin IA, Quinn MT, Leopoldo M.

ChemMedChem. 2017 Nov 22;12(22):1839-1847. doi: 10.1002/cmdc.201700429. Epub 2017 Nov 7.

17.

4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-ones as N-formyl peptide receptor 1 (FPR1) antagonists.

Kirpotina LN, Schepetkin IA, Khlebnikov AI, Ruban OI, Ge Y, Ye RD, Kominsky DJ, Quinn MT.

Biochem Pharmacol. 2017 Oct 15;142:120-132. doi: 10.1016/j.bcp.2017.07.004. Epub 2017 Jul 8.

18.

Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors.

Vergelli C, Schepetkin IA, Crocetti L, Iacovone A, Giovannoni MP, Guerrini G, Khlebnikov AI, Ciattini S, Ciciani G, Quinn MT.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):821-831. doi: 10.1080/14756366.2017.1326915.

19.

Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils.

Özek G, Schepetkin IA, Utegenova GA, Kirpotina LN, Andrei SR, Özek T, Başer KHC, Abidkulova KT, Kushnarenko SV, Khlebnikov AI, Damron DS, Quinn MT.

J Leukoc Biol. 2017 Jun;101(6):1361-1371. doi: 10.1189/jlb.3A1216-518RR. Epub 2017 Mar 3.

20.

[JUN N-TERMINAL KINASES AND THEIR PHARMACOLOGICAL MODULATION OF ISCHE-MIC AND REPERFUSION INJURY OF THE BRAIN].

Shvedova MV, Anfinogenova YD, Schepetkin IA, Atochin DN.

Ross Fiziol Zh Im I M Sechenova. 2017 Mar;103(3):268-83. Review. Russian.

PMID:
30199207
21.

Synthesis of Five- and Six-Membered N-Phenylacetamido Substituted Heterocycles as Formyl Peptide Receptor Agonists.

Vergelli C, Schepetkin IA, Ciciani G, Cilibrizzi A, Crocetti L, Giovannoni MP, Guerrini G, Iacovone A, Kirpotina LN, Ye RD, Quinn MT.

Drug Dev Res. 2017 Feb;78(1):49-62. doi: 10.1002/ddr.21370. Epub 2016 Nov 18.

22.

Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents.

Schepetkin IA, Kushnarenko SV, Özek G, Kirpotina LN, Sinharoy P, Utegenova GA, Abidkulova KT, Özek T, Başer KH, Kovrizhina AR, Khlebnikov AI, Damron DS, Quinn MT.

J Agric Food Chem. 2016 Sep 28;64(38):7156-70. doi: 10.1021/acs.jafc.6b03205. Epub 2016 Sep 13.

23.

Synthesis and Pharmacological Evaluation of Indole Derivatives as Deaza Analogues of Potent Human Neutrophil Elastase Inhibitors.

Crocetti L, Schepetkin IA, Ciciani G, Giovannoni MP, Guerrini G, Iacovone A, Khlebnikov AI, Kirpotina LN, Quinn MT, Vergelli C.

Drug Dev Res. 2016 Sep;77(6):285-99. doi: 10.1002/ddr.21323. Epub 2016 Jul 30.

24.

Therapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed).

Schepetkin IA, Ramstead AG, Kirpotina LN, Voyich JM, Jutila MA, Quinn MT.

Phytother Res. 2016 Aug;30(8):1287-97. doi: 10.1002/ptr.5648. Epub 2016 May 24. Review.

25.

2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists.

Vergelli C, Schepetkin IA, Ciciani G, Cilibrizzi A, Crocetti L, Giovannoni MP, Guerrini G, Iacovone A, Kirpotina LN, Khlebnikov AI, Ye RD, Quinn MT.

Bioorg Med Chem. 2016 Apr 8. pii: S0968-0896(16)30253-X. doi: 10.1016/j.bmc.2016.04.019. [Epub ahead of print]

26.

A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice.

Atochin DN, Schepetkin IA, Khlebnikov AI, Seledtsov VI, Swanson H, Quinn MT, Huang PL.

Neurosci Lett. 2016 Apr 8;618:45-49. doi: 10.1016/j.neulet.2016.02.033. Epub 2016 Feb 26.

27.

Antagonism of human formyl peptide receptor 1 with natural compounds and their synthetic derivatives.

Schepetkin IA, Khlebnikov AI, Kirpotina LN, Quinn MT.

Int Immunopharmacol. 2016 Aug;37:43-58. doi: 10.1016/j.intimp.2015.08.036. Epub 2015 Sep 15. Review.

28.

Cinnoline derivatives as human neutrophil elastase inhibitors.

Giovannoni MP, Schepetkin IA, Crocetti L, Ciciani G, Cilibrizzi A, Guerrini G, Khlebnikov AI, Quinn MT, Vergelli C.

J Enzyme Inhib Med Chem. 2016 Aug;31(4):628-39. doi: 10.3109/14756366.2015.1057718. Epub 2015 Jul 21.

29.

Inhibition of Human Neutrophil Responses by the Essential Oil of Artemisia kotuchovii and Its Constituents.

Schepetkin IA, Kushnarenko SV, Özek G, Kirpotina LN, Utegenova GA, Kotukhov YA, Danilova AN, Özek T, Başer KH, Quinn MT.

J Agric Food Chem. 2015 May 27;63(20):4999-5007. doi: 10.1021/acs.jafc.5b01307. Epub 2015 May 19.

30.

Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B.

Ramstead AG, Schepetkin IA, Todd K, Loeffelholz J, Berardinelli JG, Quinn MT, Jutila MA.

Int Immunopharmacol. 2015 Jun;26(2):367-77. doi: 10.1016/j.intimp.2015.04.008. Epub 2015 Apr 15.

31.

Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor.

Schepetkin IA, Kirpotina LN, Hammaker D, Kochetkova I, Khlebnikov AI, Lyakhov SA, Firestein GS, Quinn MT.

J Pharmacol Exp Ther. 2015 Jun;353(3):505-16. doi: 10.1124/jpet.114.220251. Epub 2015 Mar 17.

32.

Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2.

Lacivita E, Schepetkin IA, Stama ML, Kirpotina LN, Colabufo NA, Perrone R, Khlebnikov AI, Quinn MT, Leopoldo M.

Bioorg Med Chem. 2015 Jul 15;23(14):3913-24. doi: 10.1016/j.bmc.2014.12.007. Epub 2014 Dec 13.

33.

Antagonism of human formyl peptide receptor 1 (FPR1) by chromones and related isoflavones.

Schepetkin IA, Kirpotina LN, Khlebnikov AI, Cheng N, Ye RD, Quinn MT.

Biochem Pharmacol. 2014 Dec 15;92(4):627-41. doi: 10.1016/j.bcp.2014.09.027. Epub 2014 Oct 17.

34.

Neutrophil isolation from nonhuman species.

Siemsen DW, Malachowa N, Schepetkin IA, Whitney AR, Kirpotina LN, Lei B, Deleo FR, Quinn MT.

Methods Mol Biol. 2014;1124:19-37. doi: 10.1007/978-1-62703-845-4_3.

35.

Development of small molecule non-peptide formyl peptide receptor (FPR) ligands and molecular modeling of their recognition.

Schepetkin IA, Khlebnikov AI, Giovannoni MP, Kirpotina LN, Cilibrizzi A, Quinn MT.

Curr Med Chem. 2014;21(13):1478-504. Review.

36.

Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase.

Crocetti L, Schepetkin IA, Cilibrizzi A, Graziano A, Vergelli C, Giomi D, Khlebnikov AI, Quinn MT, Giovannoni MP.

J Med Chem. 2013 Aug 8;56(15):6259-72. doi: 10.1021/jm400742j. Epub 2013 Jul 25.

37.

Immunomodulatory activity of polysaccharides isolated from Clerodendrum splendens: beneficial effects in experimental autoimmune encephalomyelitis.

Kouakou K, Schepetkin IA, Jun S, Kirpotina LN, Yapi A, Khramova DS, Pascual DW, Ovodov YS, Jutila MA, Quinn MT.

BMC Complement Altern Med. 2013 Jun 28;13:149. doi: 10.1186/1472-6882-13-149.

38.

Synthesis, HPLC enantioresolution, and X-ray analysis of a new series of C5-methyl pyridazines as N-formyl peptide receptor (FPR) agonists.

Cilibrizzi A, Crocetti L, Giovannoni MP, Graziano A, Vergelli C, Bartolucci G, Soldani G, Quinn MT, Schepetkin IA, Faggi C.

Chirality. 2013 Jul;25(7):400-8. doi: 10.1002/chir.22162. Epub 2013 Jun 6.

39.

Further studies on 2-arylacetamide pyridazin-3(2H)-ones: design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists.

Giovannoni MP, Schepetkin IA, Cilibrizzi A, Crocetti L, Khlebnikov AI, Dahlgren C, Graziano A, Dal Piaz V, Kirpotina LN, Zerbinati S, Vergelli C, Quinn MT.

Eur J Med Chem. 2013 Jun;64:512-28. doi: 10.1016/j.ejmech.2013.03.066. Epub 2013 Apr 8.

40.

Immunomodulatory and hemagglutinating activities of acidic polysaccharides isolated from Combretum racemosum.

Schepetkin IA, Kouakou K, Yapi A, Kirpotina LN, Jutila MA, Quinn MT.

Int Immunopharmacol. 2013 Mar;15(3):628-37. doi: 10.1016/j.intimp.2013.01.015. Epub 2013 Feb 1.

41.

Immunomodulatory activity of polysaccharides isolated from Alchornea cordifolia.

Kouakou K, Schepetkin IA, Yapi A, Kirpotina LN, Jutila MA, Quinn MT.

J Ethnopharmacol. 2013 Mar 7;146(1):232-42. doi: 10.1016/j.jep.2012.12.037. Epub 2013 Jan 2.

42.

Oenothein B, a cyclic dimeric ellagitannin isolated from Epilobium angustifolium, enhances IFNγ production by lymphocytes.

Ramstead AG, Schepetkin IA, Quinn MT, Jutila MA.

PLoS One. 2012;7(11):e50546. doi: 10.1371/journal.pone.0050546. Epub 2012 Nov 30.

43.

3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: molecular modeling of chiral recognition by FPR2.

Schepetkin IA, Kirpotina LN, Khlebnikov AI, Leopoldo M, Lucente E, Lacivita E, De Giorgio P, Quinn MT.

Biochem Pharmacol. 2013 Feb 1;85(3):404-16. doi: 10.1016/j.bcp.2012.11.015. Epub 2012 Dec 3.

44.

Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists.

Cilibrizzi A, Schepetkin IA, Bartolucci G, Crocetti L, Dal Piaz V, Giovannoni MP, Graziano A, Kirpotina LN, Quinn MT, Vergelli C.

Bioorg Med Chem. 2012 Jun 15;20(12):3781-92. doi: 10.1016/j.bmc.2012.04.043. Epub 2012 Apr 27.

45.

Nasal Acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei Infections.

Skyberg JA, Rollins MF, Holderness JS, Marlenee NL, Schepetkin IA, Goodyear A, Dow SW, Jutila MA, Pascual DW.

PLoS Pathog. 2012;8(3):e1002587. doi: 10.1371/journal.ppat.1002587. Epub 2012 Mar 15.

46.

Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors.

Schepetkin IA, Kirpotina LN, Khlebnikov AI, Hanks TS, Kochetkova I, Pascual DW, Jutila MA, Quinn MT.

Mol Pharmacol. 2012 Jun;81(6):832-45. doi: 10.1124/mol.111.077446. Epub 2012 Mar 20.

47.

Molecular docking of 2-(benzimidazol-2-ylthio)-N-phenylacetamide-derived small-molecule agonists of human formyl peptide receptor 1.

Khlebnikov AI, Schepetkin IA, Kirpotina LN, Brive L, Dahlgren C, Jutila MA, Quinn MT.

J Mol Model. 2012 Jun;18(6):2831-43. doi: 10.1007/s00894-011-1307-x. Epub 2011 Nov 30.

48.

Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase.

Crocetti L, Giovannoni MP, Schepetkin IA, Quinn MT, Khlebnikov AI, Cilibrizzi A, Piaz VD, Graziano A, Vergelli C.

Bioorg Med Chem. 2011 Aug 1;19(15):4460-72. doi: 10.1016/j.bmc.2011.06.036. Epub 2011 Jul 7.

49.

Polysaccharides isolated from Açaí fruit induce innate immune responses.

Holderness J, Schepetkin IA, Freedman B, Kirpotina LN, Quinn MT, Hedges JF, Jutila MA.

PLoS One. 2011 Feb 28;6(2):e17301. doi: 10.1371/journal.pone.0017301.

50.

Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors.

Schepetkin IA, Kirpotina LN, Khlebnikov AI, Jutila MA, Quinn MT.

Mol Pharmacol. 2011 Jan;79(1):77-90. doi: 10.1124/mol.110.068288. Epub 2010 Oct 13.

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