Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 166

1.

Methyl-Cytosine-Driven Structural Changes Enhance Adduction Kinetics of an Exon 7 fragment of the p53 Gene.

Malla S, Kadimisetty K, Fu YJ, Choudhary D, Schenkman JB, Rusling JF.

Sci Rep. 2017 Jan 19;7:40890. doi: 10.1038/srep40890.

2.

CHEMICAL SELECTIVITY OF NUCLEOBASE ADDUCTION RELATIVE TO IN VIVO MUTATION SITES ON EXON 7 FRAGMENT OF P53 TUMOR SUPPRESSOR GENE.

Malla S, Kadimisetty K, Fu YJ, Choudhary D, Jansson I, Schenkman JB, Rusling JF.

Chem Sci. 2015 Oct 1;6(10):5554-5563. Epub 2015 Jun 24.

3.

Elucidating Organ-Specific Metabolic Toxicity Chemistry from Electrochemiluminescent Enzyme/DNA Arrays and Bioreactor Bead-LC-MS/MS.

Wasalathanthri DP, Li D, Song D, Zheng Z, Choudhary D, Jansson I, Lu X, Schenkman JB, Rusling JF.

Chem Sci. 2015;6(4):2457-2468.

4.

Thin multicomponent films for functional enzyme devices and bioreactor particles.

Rusling JF, Wasalathanthri DP, Schenkman JB.

Soft Matter. 2014 Nov 7;10(41):8145-56. doi: 10.1039/c4sm01679c. Review.

5.

Genotoxicity-related chemistry of human metabolites of benzo[ghi]perylene (B[ghi]P) investigated using electro-optical arrays and DNA/microsome biocolloid reactors with LC-MS/MS.

Pan S, Li D, Zhao L, Schenkman JB, Rusling JF.

Chem Res Toxicol. 2013 Aug 19;26(8):1229-39. doi: 10.1021/tx400147c. Epub 2013 Aug 8.

6.

Screening reactive metabolites bioactivated by multiple enzyme pathways using a multiplexed microfluidic system.

Wasalathanthri DP, Faria RC, Malla S, Joshi AA, Schenkman JB, Rusling JF.

Analyst. 2013 Jan 7;138(1):171-8. doi: 10.1039/c2an35993f. Epub 2012 Oct 25.

7.

Metabolic toxicity screening using electrochemiluminescence arrays coupled with enzyme-DNA biocolloid reactors and liquid chromatography-mass spectrometry.

Hvastkovs EG, Schenkman JB, Rusling JF.

Annu Rev Anal Chem (Palo Alto Calif). 2012;5:79-105. doi: 10.1146/annurev.anchem.111808.073659. Epub 2012 Apr 5. Review.

8.

Bioelectronic delivery of electrons to cytochrome P450 enzymes.

Krishnan S, Schenkman JB, Rusling JF.

J Phys Chem B. 2011 Jul 7;115(26):8371-80. doi: 10.1021/jp201235m. Epub 2011 May 17.

9.

Evaluation of electrochemiluminescent metabolic toxicity screening arrays using a multiple compound set.

Pan S, Zhao L, Schenkman JB, Rusling JF.

Anal Chem. 2011 Apr 1;83(7):2754-60. doi: 10.1021/ac200050n. Epub 2011 Mar 11.

10.

Efficient bioelectronic actuation of the natural catalytic pathway of human metabolic cytochrome P450s.

Krishnan S, Wasalathanthri D, Zhao L, Schenkman JB, Rusling JF.

J Am Chem Soc. 2011 Feb 9;133(5):1459-65. doi: 10.1021/ja108637s. Epub 2011 Jan 7.

11.

High-throughput metabolic toxicity screening using magnetic biocolloid reactors and LC-MS/MS.

Zhao L, Schenkman JB, Rusling JF.

Anal Chem. 2010 Dec 15;82(24):10172-8. doi: 10.1021/ac102317a. Epub 2010 Nov 19.

12.

Rapid LC-MS drug metabolite profiling using microsomal enzyme bioreactors in a parallel processing format.

Bajrami B, Zhao L, Schenkman JB, Rusling JF.

Anal Chem. 2009 Dec 15;81(24):9921-9. doi: 10.1021/ac9015853. Erratum in: Anal Chem. 2010 Jan 15;82(2):762.

13.

Control of electrochemical and ferryloxy formation kinetics of cyt P450s in polyion films by heme iron spin state and secondary structure.

Krishnan S, Abeykoon A, Schenkman JB, Rusling JF.

J Am Chem Soc. 2009 Nov 11;131(44):16215-24. doi: 10.1021/ja9065317.

14.

Screening for reactive metabolites using electro-optical arrays featuring human liver cytosol and microsomal enzyme sources and DNA.

Zhao L, Schenkman JB, Rusling JF.

Chem Commun (Camb). 2009 Sep 28;(36):5386-8. doi: 10.1039/b909372a. Epub 2009 Aug 17.

15.

CYP1B1, a developmental gene with a potential role in glaucoma therapy.

Choudhary D, Jansson I, Schenkman JB.

Xenobiotica. 2009 Aug;39(8):606-15. doi: 10.1080/00498250903000198. Review.

PMID:
19622003
16.

Differences in metabolite-mediated toxicity of tamoxifen in rodents versus humans elucidated with DNA/microsome electro-optical arrays and nanoreactors.

Zhao L, Krishnan S, Zhang Y, Schenkman JB, Rusling JF.

Chem Res Toxicol. 2009 Feb;22(2):341-7. doi: 10.1021/tx8004295.

17.

Human cyt P450 mediated metabolic toxicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) evaluated using electrochemiluminescent arrays.

Krishnan S, Hvastkovs EG, Bajrami B, Schenkman JB, Rusling JF.

Mol Biosyst. 2009 Feb;5(2):163-9. doi: 10.1039/b815910f. Epub 2008 Dec 12.

18.

Characterizing metabolic inhibition using electrochemical enzyme/DNA biosensors.

Hull DO, Bajrami B, Jansson I, Schenkman JB, Rusling JF.

Anal Chem. 2009 Jan 15;81(2):716-24. doi: 10.1021/ac802179s.

19.

Electrochemical biosensor featuring a two-enzyme pathway and DNA for screening toxic reactive metabolites of arylamines.

So M, Schenkman JB, Rusling JF.

Chem Commun (Camb). 2008 Sep 28;(36):4354-6. doi: 10.1039/b805447a. Epub 2008 Jul 18.

20.

Characterization of the biochemical and structural phenotypes of four CYP1B1 mutations observed in individuals with primary congenital glaucoma.

Choudhary D, Jansson I, Sarfarazi M, Schenkman JB.

Pharmacogenet Genomics. 2008 Aug;18(8):665-76. doi: 10.1097/FPC.0b013e3282ff5a36.

PMID:
18622259
21.

Synergistic metabolic toxicity screening using microsome/DNA electrochemiluminescent arrays and nanoreactors.

Krishnan S, Hvastkovs EG, Bajrami B, Choudhary D, Schenkman JB, Rusling JF.

Anal Chem. 2008 Jul 15;80(14):5279-85. doi: 10.1021/ac800763r. Epub 2008 Jun 19.

22.

Accurate DNA fragment sizing by capillary electrophoresis with laser-induced fluorescence array for detection of sequence specificity of DNA damage.

Fundador EV, Choudhary D, Schenkman JB, Rusling JF.

Anal Chem. 2008 Mar 15;80(6):2212-21. doi: 10.1021/ac702265b. Epub 2008 Feb 12.

23.

Enzyme-DNA biocolloids for DNA adduct and reactive metabolite detection by chromatography-mass spectrometry.

Bajrami B, Hvastkovs EG, Jensen GC, Schenkman JB, Rusling JF.

Anal Chem. 2008 Feb 15;80(4):922-32. doi: 10.1021/ac702025f. Epub 2008 Jan 25.

PMID:
18217727
24.

Electrochemical genotoxicity screening for arylamines bioactivated by N-acetyltransferase.

So M, Hvastkovs EG, Bajrami B, Schenkman JB, Rusling JF.

Anal Chem. 2008 Feb 15;80(4):1192-200. doi: 10.1021/ac701781y. Epub 2008 Jan 12.

PMID:
18189370
25.

Biochemical applications of ultrathin films of enzymes, polyions and DNA.

Rusling JF, Hvastkovs EG, Hull DO, Schenkman JB.

Chem Commun (Camb). 2008 Jan 14;(2):141-54. Epub 2007 Aug 30. Review.

26.

Electrochemiluminescent/voltammetric toxicity screening sensor using enzyme-generated DNA damage.

So M, Hvastkovs EG, Schenkman JB, Rusling JF.

Biosens Bioelectron. 2007 Nov 30;23(4):492-8. Epub 2007 Jul 28.

27.

Genotoxicity screening for N-nitroso compounds. Electrochemical and electrochemiluminescent detection of human enzyme-generated DNA damage from N-nitrosopyrrolidine.

Krishnan S, Hvastkovs EG, Bajrami B, Jansson I, Schenkman JB, Rusling JF.

Chem Commun (Camb). 2007 May 7;(17):1713-5. Epub 2007 Apr 3.

PMID:
17457417
28.

Cyp1b1 protein in the mouse eye during development: an immunohistochemical study.

Choudhary D, Jansson I, Rezaul K, Han DK, Sarfarazi M, Schenkman JB.

Drug Metab Dispos. 2007 Jun;35(6):987-94. Epub 2007 Feb 26.

PMID:
17325023
29.

Toxicity screening using biosensors that measure DNA damage.

Rusling JF, Hvastkovs EG, Schenkman JB.

Curr Opin Drug Discov Devel. 2007 Jan;10(1):67-73. Review.

PMID:
17265744
30.

Electrochemiluminescent arrays for cytochrome P450-activated genotoxicity screening. DNA damage from benzo[a]pyrene metabolites.

Hvastkovs EG, So M, Krishnan S, Bajrami B, Tarun M, Jansson I, Schenkman JB, Rusling JF.

Anal Chem. 2007 Mar 1;79(5):1897-906. Epub 2007 Jan 30. Erratum in: Anal Chem. 2008 Mar 15;80(6):2272.

31.

Spectral analyses of cytochromes P450.

Schenkman JB, Jansson I.

Methods Mol Biol. 2006;320:11-8.

PMID:
16719370
32.

Physiological significance and expression of P450s in the developing eye.

Choudhary D, Jansson I, Sarfarazi M, Schenkman JB.

Drug Metab Rev. 2006;38(1-2):337-52. Review.

PMID:
16684663
33.

David Kupfer at meetings and play.

Schenkman JB.

Drug Metab Rev. 2006;38(1-2):163-70.

PMID:
16684655
34.

Protein film electrochemistry of microsomes genetically enriched in human cytochrome p450 monooxygenases.

Sultana N, Schenkman JB, Rusling JF.

J Am Chem Soc. 2005 Oct 5;127(39):13460-1.

PMID:
16190685
35.

Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues.

Choudhary D, Jansson I, Stoilov I, Sarfarazi M, Schenkman JB.

Arch Biochem Biophys. 2005 Apr 1;436(1):50-61.

PMID:
15752708
36.

Evaluating enzymes that generate genotoxic benzo[a]pyrene metabolites using sensor arrays.

Wang B, Jansson I, Schenkman JB, Rusling JF.

Anal Chem. 2005 Mar 1;77(5):1361-7.

PMID:
15732919
37.

Xenobiotic-metabolizing cytochromes P450 in ontogeny: evolving perspective.

Choudhary D, Jansson I, Sarfarazi M, Schenkman JB.

Drug Metab Rev. 2004 Oct;36(3-4):549-68. Review.

PMID:
15554235
38.

Expression of cytochrome P4501b1 (Cyp1b1) during early murine development.

Stoilov I, Rezaie T, Jansson I, Schenkman JB, Sarfarazi M.

Mol Vis. 2004 Aug 30;10:629-36.

39.

Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1.

Choudhary D, Jansson I, Stoilov I, Sarfarazi M, Schenkman JB.

Drug Metab Dispos. 2004 Aug;32(8):840-7.

PMID:
15258110
40.

Genetics and biochemistry of primary congenital glaucoma.

Sarfarazi M, Stoilov I, Schenkman JB.

Ophthalmol Clin North Am. 2003 Dec;16(4):543-54, vi. Review.

PMID:
14740995
41.

Isolation and purification of constitutive forms of microsomal cytochrome P450.

Schenkman JB, Jansson I.

Methods Mol Biol. 1998;107:55-67. No abstract available.

PMID:
14577212
42.

Spectral analyses of cytochromes P450.

Schenkman JB, Jansson I.

Methods Mol Biol. 1998;107:25-33. No abstract available.

PMID:
14577210
43.

Epoxidation of styrene by human cyt P450 1A2 by thin film electrolysis and peroxide activation compared to solution reactions.

Estavillo C, Lu Z, Jansson I, Schenkman JB, Rusling JF.

Biophys Chem. 2003 May 1;104(1):291-6.

PMID:
12834847
44.

Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.

Choudhary D, Jansson I, Schenkman JB, Sarfarazi M, Stoilov I.

Arch Biochem Biophys. 2003 Jun 1;414(1):91-100.

PMID:
12745259
45.

The many roles of cytochrome b5.

Schenkman JB, Jansson I.

Pharmacol Ther. 2003 Feb;97(2):139-52. Review.

PMID:
12559387
46.

Toxicity screening by electrochemical detection of DNA damage by metabolites generated in situ in ultrathin DNA-enzyme films.

Zhou L, Yang J, Estavillo C, Stuart JD, Schenkman JB, Rusling JF.

J Am Chem Soc. 2003 Feb 5;125(5):1431-6.

PMID:
12553846
47.
48.

Measurement of cytochrome P-450.

Schenkman JB, Jansson I.

Curr Protoc Toxicol. 2002;Chapter 4:Unit4.1. doi: 10.1002/0471140856.tx0401s13.

PMID:
23045081
49.

Effect of two mutations of human CYP1B1, G61E and R469W, on stability and endogenous steroid substrate metabolism.

Jansson I, Stoilov I, Sarfarazi M, Schenkman JB.

Pharmacogenetics. 2001 Dec;11(9):793-801.

PMID:
11740343
50.

Roles of cytochrome p450 in development.

Stoilov I, Jansson I, Sarfarazi M, Schenkman JB.

Drug Metabol Drug Interact. 2001;18(1):33-55. Review.

PMID:
11522124

Supplemental Content

Loading ...
Support Center