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Items: 1 to 50 of 239

1.

The binding mode of an ADP analog to a metallohydrolase mimics the likely transition state.

Feder D, Gahan L, McGeary R, Guddat L, Schenk G.

Chembiochem. 2019 Feb 4. doi: 10.1002/cbic.201900077. [Epub ahead of print]

PMID:
30719821
2.

Expansin assisted bio-affinity immobilization of endoxylanase from Bacillus subtilis onto corncob residue: Characterization and efficient production of xylooligosaccharides.

Wu B, Yu Q, Chang S, Pedroso MM, Gao Z, He B, Schenk G.

Food Chem. 2019 Jun 1;282:101-108. doi: 10.1016/j.foodchem.2019.01.004. Epub 2019 Jan 6.

PMID:
30711093
3.

Structural network topology relates to tissue properties in multiple sclerosis.

Kiljan S, Meijer KA, Steenwijk MD, Pouwels PJW, Schoonheim MM, Schenk GJ, Geurts JJG, Douw L.

J Neurol. 2019 Jan;266(1):212-222. doi: 10.1007/s00415-018-9130-2. Epub 2018 Nov 22.

4.

A New Mixed-Valence Mn(II)Mn(III) Compound With Catalase and Superoxide Dismutase Activities.

Costa RO, Ferreira SS, Pereira CA, Harmer JR, Noble CJ, Schenk G, Franco RWA, Resende JALC, Comba P, Roberts AE, Fernandes C, Horn A Jr.

Front Chem. 2018 Nov 5;6:491. doi: 10.3389/fchem.2018.00491. eCollection 2018.

5.

Synthesis, Magnetic Properties, and Catalytic Properties of a Nickel(II)-Dependent Biomimetic of Metallohydrolases.

Horn A Jr, Englert D, Roberts AE, Comba P, Schenk G, Krenske EH, Gahan LR.

Front Chem. 2018 Sep 25;6:441. doi: 10.3389/fchem.2018.00441. eCollection 2018.

6.

Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics.

Hussein WM, Feder D, Schenk G, Guddat LW, McGeary RP.

Eur J Med Chem. 2018 Sep 5;157:462-479. doi: 10.1016/j.ejmech.2018.08.004. Epub 2018 Aug 3.

PMID:
30107365
7.

Oscillatory brain activity associates with neuroligin-3 expression and predicts progression free survival in patients with diffuse glioma.

Derks J, Wesseling P, Carbo EWS, Hillebrand A, van Dellen E, de Witt Hamer PC, Klein M, Schenk GJ, Geurts JJG, Reijneveld JC, Douw L.

J Neurooncol. 2018 Nov;140(2):403-412. doi: 10.1007/s11060-018-2967-5. Epub 2018 Aug 9.

8.

Relative catalytic efficiencies and transcript levels of three d- and two l-lactate dehydrogenases for optically pure d-lactate production in Sporolactobacillus inulinus.

Wu B, Yu Q, Zheng S, Pedroso MM, Guddat LW, He B, Schenk G.

Microbiologyopen. 2018 Aug 1:e00704. doi: 10.1002/mbo3.704. [Epub ahead of print]

9.

The effectiveness of Dutch Cell Dogs in correctional facilities in the Netherlands: a study protocol of a quasi-experimental trial.

Schenk G, Duindam HM, Creemers HE, Hoeve M, Stams GJJM, Asscher JJ.

BMC Psychiatry. 2018 Jul 5;18(1):218. doi: 10.1186/s12888-018-1797-5.

10.

Formation of Catalytically Active Binuclear Center of Glycerophosphodiesterase: A Molecular Dynamics Study.

Paul TJ, Schenk G, Prabhakar R.

J Phys Chem B. 2018 Jun 7;122(22):5797-5808. doi: 10.1021/acs.jpcb.8b02046. Epub 2018 May 24.

PMID:
29723477
11.

Lipid biochemical changes detected in normal appearing white matter of chronic multiple sclerosis by spectral coherent Raman imaging.

Poon KWC, Brideau C, Klaver R, Schenk GJ, Geurts JJ, Stys PK.

Chem Sci. 2018 Jan 2;9(6):1586-1595. doi: 10.1039/c7sc03992a. eCollection 2018 Feb 14.

12.

Reduced risk of venous thromboembolism with the use of intermittent pneumatic compression after craniotomy: a randomized controlled prospective study.

Prell J, Schenk G, Taute BM, Scheller C, Marquart C, Strauss C, Rampp S.

J Neurosurg. 2018 Mar 1:1-7. doi: 10.3171/2017.9.JNS17533. [Epub ahead of print]

PMID:
29600912
13.

Insights into the Mechanisms That May Clarify Obesity as a Risk Factor for Multiple Sclerosis.

Huitema MJD, Schenk GJ.

Curr Neurol Neurosci Rep. 2018 Mar 10;18(4):18. doi: 10.1007/s11910-018-0827-5. Review.

14.

The use of SWATH to analyse the dynamic changes of bacterial proteome of carbapanemase-producing Escherichia coli under antibiotic pressure.

Sidjabat HE, Gien J, Kvaskoff D, Ashman K, Vaswani K, Reed S, McGeary RP, Paterson DL, Bordin A, Schenk G.

Sci Rep. 2018 Mar 1;8(1):3871. doi: 10.1038/s41598-018-21984-9.

15.

Processivity and enzymatic mechanism of a multifunctional family 5 endoglucanase from Bacillus subtilis BS-5 with potential applications in the saccharification of cellulosic substrates.

Wu B, Zheng S, Pedroso MM, Guddat LW, Chang S, He B, Schenk G.

Biotechnol Biofuels. 2018 Jan 29;11:20. doi: 10.1186/s13068-018-1022-2. eCollection 2018.

16.

Second-Sphere Effects in Dinuclear FeIIIZnII Hydrolase Biomimetics: Tuning Binding and Reactivity Properties.

Camargo TP, Neves A, Peralta RA, Chaves C, Maia ECP, Lizarazo-Jaimes EH, Gomes DA, Bortolotto T, Norberto DR, Terenzi H, Tierney DL, Schenk G.

Inorg Chem. 2018 Jan 2;57(1):187-203. doi: 10.1021/acs.inorgchem.7b02384. Epub 2017 Dec 13.

PMID:
29235857
17.

Metabolic strategies for the degradation of the neuromodulator agmatine in mammals.

Benítez J, García D, Romero N, González A, Martínez-Oyanedel J, Figueroa M, Salas M, López V, García-Robles M, Dodd PR, Schenk G, Carvajal N, Uribe E.

Metabolism. 2018 Apr;81:35-44. doi: 10.1016/j.metabol.2017.11.005. Epub 2017 Nov 21. Review.

PMID:
29162499
18.

Copper Ions and Coordination Complexes as Novel Carbapenem Adjuvants.

Djoko KY, Achard MES, Phan MD, Lo AW, Miraula M, Prombhul S, Hancock SJ, Peters KM, Sidjabat HE, Harris PN, Mitić N, Walsh TR, Anderson GJ, Shafer WM, Paterson DL, Schenk G, McEwan AG, Schembri MA.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e02280-17. doi: 10.1128/AAC.02280-17. Print 2018 Feb.

19.

Crystal Structures of Staphylococcus aureus Ketol-Acid Reductoisomerase in Complex with Two Transition State Analogues that Have Biocidal Activity.

Patel KM, Teran D, Zheng S, Kandale A, Garcia M, Lv Y, Schembri MA, McGeary RP, Schenk G, Guddat LW.

Chemistry. 2017 Dec 22;23(72):18289-18295. doi: 10.1002/chem.201704481. Epub 2017 Nov 30.

PMID:
28975665
20.

Deacidification of grass silage press juice by continuous production of acetoin from its lactate via an immobilized enzymatic reaction cascade.

Hohagen H, Schwarz D, Schenk G, Guddat LW, Schieder D, Carsten J, Sieber V.

Bioresour Technol. 2017 Dec;245(Pt A):1084-1092. doi: 10.1016/j.biortech.2017.08.203. Epub 2017 Sep 1.

PMID:
28946391
21.

Characterization of a highly efficient antibiotic-degrading metallo-β-lactamase obtained from an uncultured member of a permafrost community.

Pedroso MM, Selleck C, Enculescu C, Harmer JR, Mitić N, Craig WR, Helweh W, Hugenholtz P, Tyson GW, Tierney DL, Larrabee JA, Schenk G.

Metallomics. 2017 Aug 16;9(8):1157-1168. doi: 10.1039/c7mt00195a.

PMID:
28749495
22.

High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolase.

Selleck C, Guddat LW, Ollis DL, Schenk G, Pedroso MM.

J Inorg Biochem. 2017 Dec;177:287-290. doi: 10.1016/j.jinorgbio.2017.06.013. Epub 2017 Jun 27.

PMID:
28673485
23.

Structure-activity relationship study and optimisation of 2-aminopyrrole-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile as a broad spectrum metallo-β-lactamase inhibitor.

McGeary RP, Tan DTC, Selleck C, Monteiro Pedroso M, Sidjabat HE, Schenk G.

Eur J Med Chem. 2017 Sep 8;137:351-364. doi: 10.1016/j.ejmech.2017.05.061. Epub 2017 Jun 3.

PMID:
28614759
24.

Reaction mechanism of the metallohydrolase CpsB from Streptococcus pneumoniae, a promising target for novel antimicrobial agents.

Monteiro Pedroso M, Selleck C, Bilyj J, Harmer JR, Gahan LR, Mitić N, Standish AJ, Tierney DL, Larrabee JA, Schenk G.

Dalton Trans. 2017 Oct 10;46(39):13194-13201. doi: 10.1039/c7dt01350g.

PMID:
28573276
25.

Mechanistic Insight from Calorimetric Measurements of the Assembly of the Binuclear Metal Active Site of Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes.

Pedroso MM, Ely F, Carpenter MC, Mitić N, Gahan LR, Ollis DL, Wilcox DE, Schenk G.

Biochemistry. 2017 Jul 5;56(26):3328-3336. doi: 10.1021/acs.biochem.6b01200. Epub 2017 Jun 22.

PMID:
28562023
26.

Progress toward inhibitors of metallo-β-lactamases.

McGeary RP, Tan DT, Schenk G.

Future Med Chem. 2017 May;9(7):673-691. doi: 10.4155/fmc-2017-0007. Epub 2017 May 15. Review.

PMID:
28504895
27.

Is CuII Coordinated to Patellamides inside Prochloron Cells?

Comba P, Eisenschmidt A, Gahan LR, Herten DP, Nette G, Schenk G, Seefeld M.

Chemistry. 2017 Sep 7;23(50):12264-12274. doi: 10.1002/chem.201700895. Epub 2017 Apr 26.

PMID:
28339125
28.

Unique spectral signatures of the nucleic acid dye acridine orange can distinguish cell death by apoptosis and necroptosis.

Plemel JR, Caprariello AV, Keough MB, Henry TJ, Tsutsui S, Chu TH, Schenk GJ, Klaver R, Yong VW, Stys PK.

J Cell Biol. 2017 Apr 3;216(4):1163-1181. doi: 10.1083/jcb.201602028. Epub 2017 Mar 6.

29.

Visualization of the Reaction Trajectory and Transition State in a Hydrolytic Reaction Catalyzed by a Metalloenzyme.

Selleck C, Clayton D, Gahan LR, Mitić N, McGeary RP, Pedroso MM, Guddat LW, Schenk G.

Chemistry. 2017 Apr 6;23(20):4778-4781. doi: 10.1002/chem.201700866. Epub 2017 Mar 23.

PMID:
28261912
30.

Structural basis of the interaction between the putative adhesion-involved and iron-regulated FrpD and FrpC proteins of Neisseria meningitidis.

Sviridova E, Rezacova P, Bondar A, Veverka V, Novak P, Schenk G, Svergun DI, Kuta Smatanova I, Bumba L.

Sci Rep. 2017 Jan 13;7:40408. doi: 10.1038/srep40408.

31.

Insights into an evolutionary strategy leading to antibiotic resistance.

Hou CD, Liu JW, Collyer C, Mitić N, Pedroso MM, Schenk G, Ollis DL.

Sci Rep. 2017 Jan 11;7:40357. doi: 10.1038/srep40357.

32.

Altered blood-brain barrier transport in neuro-inflammatory disorders.

Schenk GJ, de Vries HE.

Drug Discov Today Technol. 2016 Jun;20:5-11. doi: 10.1016/j.ddtec.2016.07.002. Epub 2016 Oct 17. Review.

PMID:
27986224
33.

Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies.

Möhler JS, Kolmar T, Synnatschke K, Hergert M, Wilson LA, Ramu S, Elliott AG, Blaskovich MA, Sidjabat HE, Paterson DL, Schenk G, Cooper MA, Ziora ZM.

J Inorg Biochem. 2017 Feb;167:134-141. doi: 10.1016/j.jinorgbio.2016.11.028. Epub 2016 Nov 24.

PMID:
27984786
34.

Product release is rate-limiting for catalytic processing by the Dengue virus protease.

Shannon AE, Pedroso MM, Chappell KJ, Watterson D, Liebscher S, Kok WM, Fairlie DP, Schenk G, Young PR.

Sci Rep. 2016 Nov 29;6:37539. doi: 10.1038/srep37539.

35.

Mammalian agmatinases constitute unusual members in the family of Mn2+-dependent ureahydrolases.

Romero N, Benítez J, Garcia D, González A, Bennun L, García-Robles MA, López V, Wilson LA, Schenk G, Carvajal N, Uribe E.

J Inorg Biochem. 2017 Jan;166:122-125. doi: 10.1016/j.jinorgbio.2016.11.015. Epub 2016 Nov 9.

PMID:
27846445
36.

Angular correlations of photons from solution diffraction at a free-electron laser encode molecular structure.

Mendez D, Watkins H, Qiao S, Raines KS, Lane TJ, Schenk G, Nelson G, Subramanian G, Tono K, Joti Y, Yabashi M, Ratner D, Doniach S.

IUCrJ. 2016 Sep 26;3(Pt 6):420-429. eCollection 2016 Nov 1.

37.

Preface.

Gahan L, Comba P, Schenk G, Daumann L, Hambley T, Berners-Price S.

J Inorg Biochem. 2016 Sep;162:162-163. doi: 10.1016/j.jinorgbio.2016.09.011. No abstract available.

PMID:
27816087
38.

Metallohydrolase biomimetics with catalytic and structural flexibility.

Mendes LL, Englert D, Fernandes C, Gahan LR, Schenk G, Horn A.

Dalton Trans. 2016 Nov 22;45(46):18510-18521.

PMID:
27805706
39.

AIM-1: An Antibiotic-Degrading Metallohydrolase That Displays Mechanistic Flexibility.

Selleck C, Larrabee JA, Harmer J, Guddat LW, Mitić N, Helweh W, Ollis DL, Craig WR, Tierney DL, Monteiro Pedroso M, Schenk G.

Chemistry. 2016 Dec 5;22(49):17704-17714. doi: 10.1002/chem.201602762. Epub 2016 Oct 25.

PMID:
27778387
40.

Metal Ions Play an Essential Catalytic Role in the Mechanism of Ketol-Acid Reductoisomerase.

Tadrowski S, Pedroso MM, Sieber V, Larrabee JA, Guddat LW, Schenk G.

Chemistry. 2016 May 23;22(22):7427-36. doi: 10.1002/chem.201600620. Epub 2016 May 2.

PMID:
27136273
41.

Potential for measurement of the distribution of DNA folds in complex environments using Correlated X-ray Scattering.

Schenk G, Krajina B, Spakowitz A, Doniach S.

Mod Phys Lett B. 2016 Mar 30;30(8). pii: 1650117. Epub 2015 Dec 29.

42.

Demyelination induces transport of ribosome-containing vesicles from glia to axons: evidence from animal models and MS patient brains.

Shakhbazau A, Schenk GJ, Hay C, Kawasoe J, Klaver R, Yong VW, Geurts JJ, van Minnen J.

Mol Biol Rep. 2016 Jun;43(6):495-507. doi: 10.1007/s11033-016-3990-2. Epub 2016 Apr 26.

PMID:
27115494
43.

Design, synthesis, and in vitro and biological evaluation of potent amino acid-derived thiol inhibitors of the metallo-β-lactamase IMP-1.

Arjomandi OK, Hussein WM, Vella P, Yusof Y, Sidjabat HE, Schenk G, McGeary RP.

Eur J Med Chem. 2016 May 23;114:318-27. doi: 10.1016/j.ejmech.2016.03.017. Epub 2016 Mar 9.

PMID:
27017264
44.

Investigation of the identity of the nucleophile initiating the hydrolysis of phosphate esters catalyzed by dinuclear mimics of metallohydrolases.

Brown JJ, Gahan LR, Schöffler A, Krenske EH, Schenk G.

J Inorg Biochem. 2016 Sep;162:356-365. doi: 10.1016/j.jinorgbio.2016.02.008. Epub 2016 Feb 13.

PMID:
26947012
45.

Captopril analogues as metallo-β-lactamase inhibitors.

Yusof Y, Tan DTC, Arjomandi OK, Schenk G, McGeary RP.

Bioorg Med Chem Lett. 2016 Mar 15;26(6):1589-1593. doi: 10.1016/j.bmcl.2016.02.007. Epub 2016 Feb 4.

PMID:
26883147
46.

Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution - a potential target for anti-tuberculosis drug discovery.

Lv Y, Kandale A, Wun SJ, McGeary RP, Williams SJ, Kobe B, Sieber V, Schembri MA, Schenk G, Guddat LW.

FEBS J. 2016 Apr;283(7):1184-96. doi: 10.1111/febs.13672. Epub 2016 Feb 18.

47.

Asymmetric mono- and dinuclear GaIII and ZnII complexes as models for purple acid phosphatases.

Bosch S, Comba P, Gahan LR, Schenk G.

J Inorg Biochem. 2016 Sep;162:343-355. doi: 10.1016/j.jinorgbio.2015.12.028. Epub 2015 Dec 30.

PMID:
26874376
48.

Promiscuous metallo-β-lactamases: MIM-1 and MIM-2 may play an essential role in quorum sensing networks.

Miraula M, Schenk G, Mitić N.

J Inorg Biochem. 2016 Sep;162:366-375. doi: 10.1016/j.jinorgbio.2015.12.014. Epub 2015 Dec 24.

PMID:
26775612
49.

Ca(II) Binding Regulates and Dominates the Reactivity of a Transition-Metal-Ion-Dependent Diesterase from Mycobacterium tuberculosis.

Pedroso MM, Larrabee JA, Ely F, Gwee SE, Mitić N, Ollis DL, Gahan LR, Schenk G.

Chemistry. 2016 Jan 18;22(3):999-1009. doi: 10.1002/chem.201504001. Epub 2015 Dec 14.

PMID:
26662456
50.

Heavy Water as a Probe of the Free Radical Nature and Electrical Conductivity of Melanin.

Rienecker SB, Mostert AB, Schenk G, Hanson GR, Meredith P.

J Phys Chem B. 2015 Dec 3;119(48):14994-5000. doi: 10.1021/acs.jpcb.5b08970. Epub 2015 Nov 18.

PMID:
26580677

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