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Items: 1 to 50 of 258

1.

An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer.

Bhakta S, Crocker LM, Chen Y, Hazen M, Schutten MM, Li D, Kuijl C, Ohri R, Zhong F, Poon KA, Go MAT, Cheng E, Piskol R, Firestein R, Fourie-O'Donohue A, Kozak KR, Raab H, Hongo JA, Sampath D, Dennis MS, Scheller RH, Polakis P, Junutula JR.

Mol Cancer Ther. 2018 Mar;17(3):638-649. doi: 10.1158/1535-7163.MCT-17-0813. Epub 2017 Dec 27.

2.

Site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity through linker and antibody engineering.

Pillow TH, Tien J, Parsons-Reponte KL, Bhakta S, Li H, Staben LR, Li G, Chuh J, Fourie-O'Donohue A, Darwish M, Yip V, Liu L, Leipold DD, Su D, Wu E, Spencer SD, Shen BQ, Xu K, Kozak KR, Raab H, Vandlen R, Lewis Phillips GD, Scheller RH, Polakis P, Sliwkowski MX, Flygare JA, Junutula JR.

J Med Chem. 2014 Oct 9;57(19):7890-9. doi: 10.1021/jm500552c. Epub 2014 Sep 18.

PMID:
25191794
3.

An improved and robust DNA immunization method to develop antibodies against extracellular loops of multi-transmembrane proteins.

Hazen M, Bhakta S, Vij R, Randle S, Kallop D, Chiang V, Hötzel I, Jaiswal BS, Ervin KE, Li B, Weimer RM, Polakis P, Scheller RH, Junutula JR, Hongo JA.

MAbs. 2014 Jan-Feb;6(1):95-107.

4.

In search of the molecular mechanism of intracellular membrane fusion and neurotransmitter release.

Scheller RH.

Nat Med. 2013 Oct;19(10):1232-5. doi: 10.1038/nm.3339. No abstract available.

PMID:
24100993
5.

Rac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria.

Kuijl C, Pilli M, Alahari SK, Janssen H, Khoo PS, Ervin KE, Calero M, Jonnalagadda S, Scheller RH, Neefjes J, Junutula JR.

EMBO J. 2013 Mar 6;32(5):713-27. doi: 10.1038/emboj.2013.10. Epub 2013 Feb 5.

6.

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.

Shen BQ, Xu K, Liu L, Raab H, Bhakta S, Kenrick M, Parsons-Reponte KL, Tien J, Yu SF, Mai E, Li D, Tibbitts J, Baudys J, Saad OM, Scales SJ, McDonald PJ, Hass PE, Eigenbrot C, Nguyen T, Solis WA, Fuji RN, Flagella KM, Patel D, Spencer SD, Khawli LA, Ebens A, Wong WL, Vandlen R, Kaur S, Sliwkowski MX, Scheller RH, Polakis P, Junutula JR.

Nat Biotechnol. 2012 Jan 22;30(2):184-9. doi: 10.1038/nbt.2108.

PMID:
22267010
7.

Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome.

Westlake CJ, Baye LM, Nachury MV, Wright KJ, Ervin KE, Phu L, Chalouni C, Beck JS, Kirkpatrick DS, Slusarski DC, Sheffield VC, Scheller RH, Jackson PK.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2759-64. doi: 10.1073/pnas.1018823108. Epub 2011 Jan 27.

8.

Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer.

Junutula JR, Flagella KM, Graham RA, Parsons KL, Ha E, Raab H, Bhakta S, Nguyen T, Dugger DL, Li G, Mai E, Lewis Phillips GD, Hiraragi H, Fuji RN, Tibbitts J, Vandlen R, Spencer SD, Scheller RH, Polakis P, Sliwkowski MX.

Clin Cancer Res. 2010 Oct 1;16(19):4769-78. doi: 10.1158/1078-0432.CCR-10-0987. Epub 2010 Aug 30.

9.

Isolation and characterization of a Drosophila neuropeptide gene.

Scheller RH, Nambu JR.

Neuron. 2008 Nov 6;60(3):400-1. doi: 10.1016/j.neuron.2008.10.029. No abstract available.

10.

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.

Junutula JR, Raab H, Clark S, Bhakta S, Leipold DD, Weir S, Chen Y, Simpson M, Tsai SP, Dennis MS, Lu Y, Meng YG, Ng C, Yang J, Lee CC, Duenas E, Gorrell J, Katta V, Kim A, McDorman K, Flagella K, Venook R, Ross S, Spencer SD, Lee Wong W, Lowman HB, Vandlen R, Sliwkowski MX, Scheller RH, Polakis P, Mallet W.

Nat Biotechnol. 2008 Aug;26(8):925-32. doi: 10.1038/nbt.1480. Epub 2008 Jul 20.

PMID:
18641636
11.

Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs.

Junutula JR, Bhakta S, Raab H, Ervin KE, Eigenbrot C, Vandlen R, Scheller RH, Lowman HB.

J Immunol Methods. 2008 Mar 20;332(1-2):41-52. doi: 10.1016/j.jim.2007.12.011. Epub 2008 Jan 14.

PMID:
18230399
12.

Why Cabilly must stand.

Scheller RH.

Nat Biotechnol. 2007 Oct;25(10):1088-9. No abstract available.

PMID:
17921986
13.

A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.

Nachury MV, Loktev AV, Zhang Q, Westlake CJ, Peränen J, Merdes A, Slusarski DC, Scheller RH, Bazan JF, Sheffield VC, Jackson PK.

Cell. 2007 Jun 15;129(6):1201-13.

14.

Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene.

Westlake CJ, Junutula JR, Simon GC, Pilli M, Prekeris R, Scheller RH, Jackson PK, Eldridge AG.

Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1236-41. Epub 2007 Jan 17.

15.

SNAREs--engines for membrane fusion.

Jahn R, Scheller RH.

Nat Rev Mol Cell Biol. 2006 Sep;7(9):631-43. Epub 2006 Aug 16. Review.

PMID:
16912714
16.

Death-receptor activation halts clathrin-dependent endocytosis.

Austin CD, Lawrence DA, Peden AA, Varfolomeev EE, Totpal K, De Mazière AM, Klumperman J, Arnott D, Pham V, Scheller RH, Ashkenazi A.

Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10283-10288. doi: 10.1073/pnas.0604044103. Epub 2006 Jun 26. Erratum in: Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13560.

17.

Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody-drug conjugates.

Austin CD, Wen X, Gazzard L, Nelson C, Scheller RH, Scales SJ.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17987-92. Epub 2005 Dec 1.

18.

Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase.

Jin R, Junutula JR, Matern HT, Ervin KE, Scheller RH, Brunger AT.

EMBO J. 2005 Jun 15;24(12):2064-74. Epub 2005 May 26.

19.

Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin.

Austin CD, De Mazière AM, Pisacane PI, van Dijk SM, Eigenbrot C, Sliwkowski MX, Klumperman J, Scheller RH.

Mol Biol Cell. 2004 Dec;15(12):5268-82. Epub 2004 Sep 22.

20.

The RCP-Rab11 complex regulates endocytic protein sorting.

Peden AA, Schonteich E, Chun J, Junutula JR, Scheller RH, Prekeris R.

Mol Biol Cell. 2004 Aug;15(8):3530-41. Epub 2004 Jun 4.

21.

Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins.

Junutula JR, Schonteich E, Wilson GM, Peden AA, Scheller RH, Prekeris R.

J Biol Chem. 2004 Aug 6;279(32):33430-7. Epub 2004 Jun 1.

22.

Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins.

Peden AA, Oorschot V, Hesser BA, Austin CD, Scheller RH, Klumperman J.

J Cell Biol. 2004 Mar 29;164(7):1065-76.

23.

Rab14 is involved in membrane trafficking between the Golgi complex and endosomes.

Junutula JR, De Maziére AM, Peden AA, Ervin KE, Advani RJ, van Dijk SM, Klumperman J, Scheller RH.

Mol Biol Cell. 2004 May;15(5):2218-29. Epub 2004 Mar 5.

24.
25.

SNAP-25 Ser187 does not mediate phorbol ester enhancement of hippocampal synaptic transmission.

Finley MF, Scheller RH, Madison DV.

Neuropharmacology. 2003 Nov;45(6):857-62.

PMID:
14529723
26.

Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex.

Fukai S, Matern HT, Jagath JR, Scheller RH, Brunger AT.

EMBO J. 2003 Jul 1;22(13):3267-78.

27.

Sharing publication-related data and materials: responsibilities of authorship in the life sciences.

Cech TR, Eddy SR, Eisenberg D, Hersey K, Holtzman SH, Poste GH, Raikhel NV, Scheller RH, Singer DB, Waltham MC; National Academics Committee on Responsibilities of Authorship in the Biological Sciences.

Plant Physiol. 2003 May;132(1):19-24. No abstract available.

28.
29.

Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly.

Scales SJ, Hesser BA, Masuda ES, Scheller RH.

J Biol Chem. 2002 Aug 2;277(31):28271-9. Epub 2002 May 24.

30.

Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog.

Misura KM, Bock JB, Gonzalez LC Jr, Scheller RH, Weis WI.

Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9184-9. Epub 2002 Jun 24.

31.
32.

The ionic layer is required for efficient dissociation of the SNARE complex by alpha-SNAP and NSF.

Scales SJ, Yoo BY, Scheller RH.

Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14262-7.

33.

Cell biology. Fusion without SNAREs?

Scales SJ, Finley MF, Scheller RH.

Science. 2001 Nov 2;294(5544):1015-6.

PMID:
11691976
34.

The Di-leucine motif of vesicle-associated membrane protein 4 is required for its localization and AP-1 binding.

Peden AA, Park GY, Scheller RH.

J Biol Chem. 2001 Dec 28;276(52):49183-7. Epub 2001 Oct 11.

35.

Crystal structure and biophysical properties of a complex between the N-terminal SNARE region of SNAP25 and syntaxin 1a.

Misura KM, Gonzalez LC Jr, May AP, Scheller RH, Weis WI.

J Biol Chem. 2001 Nov 2;276(44):41301-9. Epub 2001 Aug 30.

36.

The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells.

Matern HT, Yeaman C, Nelson WJ, Scheller RH.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9648-53. Epub 2001 Aug 7.

37.

Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins.

Prekeris R, Davies JM, Scheller RH.

J Biol Chem. 2001 Oct 19;276(42):38966-70. Epub 2001 Jul 31.

38.

Physiological modulation of rabphilin phosphorylation.

Foletti DL, Blitzer JT, Scheller RH.

J Neurosci. 2001 Aug 1;21(15):5473-83.

39.

Developmental regulation and specific brain distribution of phosphorabphilin.

Foletti DL, Scheller RH.

J Neurosci. 2001 Aug 1;21(15):5461-72.

40.

Three SNARE complexes cooperate to mediate membrane fusion.

Hua Y, Scheller RH.

Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):8065-70. Epub 2001 Jun 26.

41.

A discontinuous SNAP-25 C-terminal coil supports exocytosis.

Chen YA, Scales SJ, Jagath JR, Scheller RH.

J Biol Chem. 2001 Jul 27;276(30):28503-8. Epub 2001 May 23.

42.

Calcium regulation of exocytosis in PC12 cells.

Chen YA, Scales SJ, Duvvuri V, Murthy M, Patel SM, Schulman H, Scheller RH.

J Biol Chem. 2001 Jul 13;276(28):26680-7. Epub 2001 May 18.

43.

Sequential SNARE assembly underlies priming and triggering of exocytosis.

Chen YA, Scales SJ, Scheller RH.

Neuron. 2001 Apr;30(1):161-70.

44.

A novel snare N-terminal domain revealed by the crystal structure of Sec22b.

Gonzalez LC Jr, Weis WI, Scheller RH.

J Biol Chem. 2001 Jun 29;276(26):24203-11. Epub 2001 Apr 17.

45.

SNARE-mediated membrane fusion.

Chen YA, Scheller RH.

Nat Rev Mol Cell Biol. 2001 Feb;2(2):98-106. Review.

PMID:
11252968
46.

A genomic perspective on membrane compartment organization.

Bock JB, Matern HT, Peden AA, Scheller RH.

Nature. 2001 Feb 15;409(6822):839-41.

PMID:
11237004
47.

SNARE protein trafficking in polarized MDCK cells.

Steegmaier M, Lee KC, Prekeris R, Scheller RH.

Traffic. 2000 Jul;1(7):553-60.

48.

A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes.

Prekeris R, Klumperman J, Scheller RH.

Mol Cell. 2000 Dec;6(6):1437-48.

49.

Syntaxin 11 is an atypical SNARE abundant in the immune system.

Prekeris R, Klumperman J, Scheller RH.

Eur J Cell Biol. 2000 Nov;79(11):771-80.

PMID:
11139139
50.

Self-association of the H3 region of syntaxin 1A. Implications for intermediates in SNARE complex assembly.

Misura KM, Scheller RH, Weis WI.

J Biol Chem. 2001 Apr 20;276(16):13273-82. Epub 2000 Dec 15.

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