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Items: 1 to 50 of 304

1.

Correction: An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer.

Bhakta S, Crocker LM, Chen Y, Hazen M, Schutten MM, Li D, Kuijl C, Ohri R, Zhong F, Poon KA, Go MAT, Cheng E, Piskol R, Firestein R, Fourie-O'Donohue A, Kozak KR, Raab H, Hongo JA, Sampath D, Dennis MS, Scheller RH, Polakis P, Junutula JR.

Mol Cancer Ther. 2019 Nov;18(11):2182. doi: 10.1158/1535-7163.MCT-19-0749. No abstract available.

PMID:
31676543
2.

Toward mechanistic models for genotype-phenotype correlations in phenylketonuria using protein stability calculations.

Scheller R, Stein A, Nielsen SV, Marin FI, Gerdes AM, Di Marco M, Papaleo E, Lindorff-Larsen K, Hartmann-Petersen R.

Hum Mutat. 2019 Apr;40(4):444-457. doi: 10.1002/humu.23707. Epub 2019 Jan 25.

PMID:
30648773
3.

Addressing the accuracy of direct-to-consumer genetic testing.

Wu S, Pollard J, Chowdry A, Scheller R, Gentleman R.

Genet Med. 2019 Mar;21(3):758-759. doi: 10.1038/s41436-018-0094-5. Epub 2018 Jun 29. No abstract available.

PMID:
29955106
4.

The effects of the Nepal community forestry program on biodiversity conservation and carbon storage.

Luintel H, Bluffstone RA, Scheller RM.

PLoS One. 2018 Jun 26;13(6):e0199526. doi: 10.1371/journal.pone.0199526. eCollection 2018.

5.

Effect of meditation on psychological distress and brain functioning: A randomized controlled study.

Travis F, Valosek L, Konrad A 4th, Link J, Salerno J, Scheller R, Nidich S.

Brain Cogn. 2018 Aug;125:100-105. doi: 10.1016/j.bandc.2018.03.011. Epub 2018 Jun 21.

PMID:
29936408
6.

Validation of a novel image-weighed technique for monitoring food intake and estimation of portion size in hospital settings: a pilot study.

Ofei KT, Mikkelsen BE, Scheller RA.

Public Health Nutr. 2019 May;22(7):1203-1208. doi: 10.1017/S1368980018001064. Epub 2018 May 15.

PMID:
29759093
7.

Disequilibrium of fire-prone forests sets the stage for a rapid decline in conifer dominance during the 21st century.

Serra-Diaz JM, Maxwell C, Lucash MS, Scheller RM, Laflower DM, Miller AD, Tepley AJ, Epstein HE, Anderson-Teixeira KJ, Thompson JR.

Sci Rep. 2018 Apr 30;8(1):6749. doi: 10.1038/s41598-018-24642-2.

8.

Transient plasma cobalamin elevation in patients with pneumonia - two case reports.

Rahbek MT, Scheller R, Nybo M, Ryg J.

Scand J Clin Lab Invest. 2018 Jul;78(4):333-334. doi: 10.1080/00365513.2018.1447143. Epub 2018 Mar 7.

PMID:
29513048
9.

An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer.

Bhakta S, Crocker LM, Chen Y, Hazen M, Schutten MM, Li D, Kuijl C, Ohri R, Zhong F, Poon KA, Go MAT, Cheng E, Piskol R, Firestein R, Fourie-O'Donohue A, Kozak KR, Raab H, Hongo JA, Sampath D, Dennis MS, Scheller RH, Polakis P, Junutula JR.

Mol Cancer Ther. 2018 Mar;17(3):638-649. doi: 10.1158/1535-7163.MCT-17-0813. Epub 2017 Dec 27. Erratum in: Mol Cancer Ther. 2019 Nov;18(11):2182.

10.

Prioritizing forest fuels treatments based on the probability of high-severity fire restores adaptive capacity in Sierran forests.

Krofcheck DJ, Hurteau MD, Scheller RM, Loudermilk EL.

Glob Chang Biol. 2018 Feb;24(2):729-737. doi: 10.1111/gcb.13913. Epub 2017 Oct 11.

PMID:
28940527
11.

How to measure energy and protein intake in a geriatric department - A comparison of three visual methods.

Husted MM, Fournaise A, Matzen L, Scheller RA.

Clin Nutr ESPEN. 2017 Feb;17:110-113. doi: 10.1016/j.clnesp.2016.10.002. Epub 2016 Oct 27.

PMID:
28361741
12.

Sudden Collapse of a Preschool-Aged Child on the Playground.

Scheller RL, Johnson LH, Caruso MC, Lorts A.

Pediatr Emerg Care. 2017 Feb;33(2):116-119. doi: 10.1097/PEC.0000000000000547.

PMID:
28146440
13.

Forest management scenarios in a changing climate: trade-offs between carbon, timber, and old forest.

Creutzburg MK, Scheller RM, Lucash MS, LeDuc SD, Johnson MG.

Ecol Appl. 2017 Mar;27(2):503-518. doi: 10.1002/eap.1460. Epub 2017 Feb 17.

PMID:
27767233
14.

Sudden Cardiac Arrest in Pediatrics.

Scheller RL, Johnson L, Lorts A, Ryan TD.

Pediatr Emerg Care. 2016 Sep;32(9):630-6. doi: 10.1097/PEC.0000000000000895. Review.

PMID:
27585126
15.

Utility of Pediatric Appendicitis Score in Female Adolescent Patients.

Scheller RL, Depinet HE, Ho ML, Hornung RW, Reed JL.

Acad Emerg Med. 2016 May;23(5):610-5. doi: 10.1111/acem.12916. Epub 2016 Apr 13.

16.
17.

Site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity through linker and antibody engineering.

Pillow TH, Tien J, Parsons-Reponte KL, Bhakta S, Li H, Staben LR, Li G, Chuh J, Fourie-O'Donohue A, Darwish M, Yip V, Liu L, Leipold DD, Su D, Wu E, Spencer SD, Shen BQ, Xu K, Kozak KR, Raab H, Vandlen R, Lewis Phillips GD, Scheller RH, Polakis P, Sliwkowski MX, Flygare JA, Junutula JR.

J Med Chem. 2014 Oct 9;57(19):7890-9. doi: 10.1021/jm500552c. Epub 2014 Sep 18.

PMID:
25191794
18.

Predicted effects of gypsy moth defoliation and climate change on forest carbon dynamics in the New Jersey pine barrens.

Kretchun AM, Scheller RM, Lucash MS, Clark KL, Hom J, Van Tuyl S.

PLoS One. 2014 Aug 13;9(8):e102531. doi: 10.1371/journal.pone.0102531. eCollection 2014.

19.

QnAs with Richard Scheller. Interview by Prashant Nair.

Scheller R.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):19973. doi: 10.1073/pnas.1319727110. Epub 2013 Nov 5. No abstract available.

20.

An improved and robust DNA immunization method to develop antibodies against extracellular loops of multi-transmembrane proteins.

Hazen M, Bhakta S, Vij R, Randle S, Kallop D, Chiang V, Hötzel I, Jaiswal BS, Ervin KE, Li B, Weimer RM, Polakis P, Scheller RH, Junutula JR, Hongo JA.

MAbs. 2014 Jan-Feb;6(1):95-107.

21.

In search of the molecular mechanism of intracellular membrane fusion and neurotransmitter release.

Scheller RH.

Nat Med. 2013 Oct;19(10):1232-5. doi: 10.1038/nm.3339. No abstract available.

PMID:
24100993
22.

Carbon dynamics in the future forest: the importance of long-term successional legacy and climate-fire interactions.

Loudermilk EL, Scheller RM, Weisberg PJ, Yang J, Dilts TE, Karam SL, Skinner C.

Glob Chang Biol. 2013 Nov;19(11):3502-15. doi: 10.1111/gcb.12310. Epub 2013 Sep 11.

PMID:
23821586
23.

Rac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria.

Kuijl C, Pilli M, Alahari SK, Janssen H, Khoo PS, Ervin KE, Calero M, Jonnalagadda S, Scheller RH, Neefjes J, Junutula JR.

EMBO J. 2013 Mar 6;32(5):713-27. doi: 10.1038/emboj.2013.10. Epub 2013 Feb 5.

24.

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.

Shen BQ, Xu K, Liu L, Raab H, Bhakta S, Kenrick M, Parsons-Reponte KL, Tien J, Yu SF, Mai E, Li D, Tibbitts J, Baudys J, Saad OM, Scales SJ, McDonald PJ, Hass PE, Eigenbrot C, Nguyen T, Solis WA, Fuji RN, Flagella KM, Patel D, Spencer SD, Khawli LA, Ebens A, Wong WL, Vandlen R, Kaur S, Sliwkowski MX, Scheller RH, Polakis P, Junutula JR.

Nat Biotechnol. 2012 Jan 22;30(2):184-9. doi: 10.1038/nbt.2108.

PMID:
22267010
25.

The influence of land use and climate change on forest biomass and composition in Massachusetts, USA.

Thompson JR, Foster DR, Scheller R, Kittredge D.

Ecol Appl. 2011 Oct;21(7):2425-44.

PMID:
22073633
26.

Fungal contamination of paraffin wax blocks in a pathology archive.

Müller K, Ellenberger C, Aupperle H, Schmäschke R, Scheller R, Wittenbrink MM, Schoon HA.

J Comp Pathol. 2011 Aug-Oct;145(2-3):214-9. doi: 10.1016/j.jcpa.2010.12.017. Epub 2011 Feb 18.

PMID:
21333307
27.

Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome.

Westlake CJ, Baye LM, Nachury MV, Wright KJ, Ervin KE, Phu L, Chalouni C, Beck JS, Kirkpatrick DS, Slusarski DC, Sheffield VC, Scheller RH, Jackson PK.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2759-64. doi: 10.1073/pnas.1018823108. Epub 2011 Jan 27.

28.

An interview with the Kavli prize winners. Interview by Claudia Wiedemann.

Rothman J, Scheller R, Südhof T.

Nat Rev Neurosci. 2010 Oct;11(10):669-73. No abstract available.

PMID:
21080540
29.

Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer.

Junutula JR, Flagella KM, Graham RA, Parsons KL, Ha E, Raab H, Bhakta S, Nguyen T, Dugger DL, Li G, Mai E, Lewis Phillips GD, Hiraragi H, Fuji RN, Tibbitts J, Vandlen R, Spencer SD, Scheller RH, Polakis P, Sliwkowski MX.

Clin Cancer Res. 2010 Oct 1;16(19):4769-78. doi: 10.1158/1078-0432.CCR-10-0987. Epub 2010 Aug 30.

30.

Evidence for a recent increase in forest growth is questionable.

Foster JR, Burton JI, Forrester JA, Liu F, Muss JD, Sabatini FM, Scheller RM, Mladenoff DJ.

Proc Natl Acad Sci U S A. 2010 May 25;107(21):E86-7; author reply E88-9. doi: 10.1073/pnas.1002725107. Epub 2010 May 3. No abstract available.

31.

Predicting global change effects on forest biomass and composition in south-central Siberia.

Gustafson EJ, Shvidenko AZ, Sturtevant BR, Scheller RM.

Ecol Appl. 2010 Apr;20(3):700-15.

PMID:
20437957
32.

Forest restoration in a mixed-ownership landscape under climate change.

Ravenscroft C, Scheller RM, Mladenoff DJ, White MA.

Ecol Appl. 2010 Mar;20(2):327-46.

PMID:
20405791
33.

Newsmaker interview. Defying skeptics, Richard Scheller thinks Genentech will thrive. Interview by Greg Miller.

Scheller R.

Science. 2009 May 1;324(5927):583. doi: 10.1126/science.324_583. No abstract available.

PMID:
19407174
34.

Birth prevalence and mutation spectrum in danish patients with autosomal recessive albinism.

Grønskov K, Ek J, Sand A, Scheller R, Bygum A, Brixen K, Brondum-Nielsen K, Rosenberg T.

Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1058-64. doi: 10.1167/iovs.08-2639. Epub 2008 Dec 5.

PMID:
19060277
35.

Isolation and characterization of a Drosophila neuropeptide gene.

Scheller RH, Nambu JR.

Neuron. 2008 Nov 6;60(3):400-1. doi: 10.1016/j.neuron.2008.10.029. No abstract available.

36.

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.

Junutula JR, Raab H, Clark S, Bhakta S, Leipold DD, Weir S, Chen Y, Simpson M, Tsai SP, Dennis MS, Lu Y, Meng YG, Ng C, Yang J, Lee CC, Duenas E, Gorrell J, Katta V, Kim A, McDorman K, Flagella K, Venook R, Ross S, Spencer SD, Lee Wong W, Lowman HB, Vandlen R, Sliwkowski MX, Scheller RH, Polakis P, Mallet W.

Nat Biotechnol. 2008 Aug;26(8):925-32. doi: 10.1038/nbt.1480. Epub 2008 Jul 20.

PMID:
18641636
37.

Chronic endometritis in an Asian elephant (Elephas maximus).

Aupperle H, Reischauer A, Bach F, Hildebrandt T, Göritz F, Jäger K, Scheller R, Klaue HJ, Schoon HA.

J Zoo Wildl Med. 2008 Mar;39(1):107-10.

PMID:
18432104
38.

Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs.

Junutula JR, Bhakta S, Raab H, Ervin KE, Eigenbrot C, Vandlen R, Scheller RH, Lowman HB.

J Immunol Methods. 2008 Mar 20;332(1-2):41-52. doi: 10.1016/j.jim.2007.12.011. Epub 2008 Jan 14.

PMID:
18230399
39.

Why Cabilly must stand.

Scheller RH.

Nat Biotechnol. 2007 Oct;25(10):1088-9. No abstract available.

PMID:
17921986
40.

A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.

Nachury MV, Loktev AV, Zhang Q, Westlake CJ, Peränen J, Merdes A, Slusarski DC, Scheller RH, Bazan JF, Sheffield VC, Jackson PK.

Cell. 2007 Jun 15;129(6):1201-13.

41.

Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene.

Westlake CJ, Junutula JR, Simon GC, Pilli M, Prekeris R, Scheller RH, Jackson PK, Eldridge AG.

Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1236-41. Epub 2007 Jan 17.

42.

SNAREs--engines for membrane fusion.

Jahn R, Scheller RH.

Nat Rev Mol Cell Biol. 2006 Sep;7(9):631-43. Epub 2006 Aug 16. Review.

PMID:
16912714
43.

Death-receptor activation halts clathrin-dependent endocytosis.

Austin CD, Lawrence DA, Peden AA, Varfolomeev EE, Totpal K, De Mazière AM, Klumperman J, Arnott D, Pham V, Scheller RH, Ashkenazi A.

Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10283-10288. doi: 10.1073/pnas.0604044103. Epub 2006 Jun 26. Erratum in: Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13560.

44.

[Picture of the month: cutaneous manifestations of vitamin C deficiency].

Bygum A, Clemmensen OJ, Scheller RA.

Ugeskr Laeger. 2006 Jan 16;168(3):287. Danish. No abstract available.

PMID:
16430815
45.

Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody-drug conjugates.

Austin CD, Wen X, Gazzard L, Nelson C, Scheller RH, Scales SJ.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17987-92. Epub 2005 Dec 1.

46.

Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase.

Jin R, Junutula JR, Matern HT, Ervin KE, Scheller RH, Brunger AT.

EMBO J. 2005 Jun 15;24(12):2064-74. Epub 2005 May 26.

47.

Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin.

Austin CD, De Mazière AM, Pisacane PI, van Dijk SM, Eigenbrot C, Sliwkowski MX, Klumperman J, Scheller RH.

Mol Biol Cell. 2004 Dec;15(12):5268-82. Epub 2004 Sep 22.

48.

The RCP-Rab11 complex regulates endocytic protein sorting.

Peden AA, Schonteich E, Chun J, Junutula JR, Scheller RH, Prekeris R.

Mol Biol Cell. 2004 Aug;15(8):3530-41. Epub 2004 Jun 4.

49.

Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins.

Junutula JR, Schonteich E, Wilson GM, Peden AA, Scheller RH, Prekeris R.

J Biol Chem. 2004 Aug 6;279(32):33430-7. Epub 2004 Jun 1.

50.

Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins.

Peden AA, Oorschot V, Hesser BA, Austin CD, Scheller RH, Klumperman J.

J Cell Biol. 2004 Mar 29;164(7):1065-76.

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