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Items: 1 to 50 of 182

1.

Synthetic cytokine receptors transmit biological signals using artificial ligands.

Engelowski E, Schneider A, Franke M, Xu H, Clemen R, Lang A, Baran P, Binsch C, Knebel B, Al-Hasani H, Moll JM, Floß DM, Lang PA, Scheller J.

Nat Commun. 2018 May 23;9(1):2034. doi: 10.1038/s41467-018-04454-8.

2.

Combined deletion of the fibronectin-type III domains and the stalk region results in ligand-independent, constitutive activation of the Interleukin 6 signal-transducing receptor gp130.

Lamertz L, Floss DM, Scheller J.

Cytokine. 2018 May 19. pii: S1043-4666(18)30210-2. doi: 10.1016/j.cyto.2018.05.011. [Epub ahead of print]

PMID:
29789201
3.

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration.

Behnke K, Zhuang Y, Xu HC, Sundaram B, Reich M, Shinde PV, Huang J, Modares NF, Tumanov AV, Polz R, Scheller J, Ware CF, Pfeffer K, Keitel V, Häussinger D, Pandyra AA, Lang KS, Lang PA.

Hepatology. 2018 May 9. doi: 10.1002/hep.30088. [Epub ahead of print]

PMID:
29742809
4.

The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling.

Baran P, Hansen S, Waetzig GH, Akbarzadeh M, Lamertz L, Huber HJ, Ahmadian MR, Moll JM, Scheller J.

J Biol Chem. 2018 May 4;293(18):6762-6775. doi: 10.1074/jbc.RA117.001163. Epub 2018 Mar 20.

PMID:
29559558
5.

Unravelling the mechanistic details of metal binding to mammalian metallothioneins from stoichiometric, kinetic, and binding affinity data.

Scheller JS, Irvine GW, Stillman MJ.

Dalton Trans. 2018 Mar 12;47(11):3613-3637. doi: 10.1039/c7dt03319b.

PMID:
29431781
6.

Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis.

Schmok E, Abad Dar M, Behrends J, Erdmann H, Rückerl D, Endermann T, Heitmann L, Hessmann M, Yoshimura A, Rose-John S, Scheller J, Schaible UE, Ehlers S, Lang R, Hölscher C.

Front Immunol. 2017 Nov 10;8:1537. doi: 10.3389/fimmu.2017.01537. eCollection 2017.

7.

Split2 Protein-Ligation Generates Active IL-6-Type Hyper-Cytokines from Inactive Precursors.

Moll JM, Wehmöller M, Frank NC, Homey L, Baran P, Garbers C, Lamertz L, Axelrod JH, Galun E, Mootz HD, Scheller J.

ACS Synth Biol. 2017 Dec 15;6(12):2260-2272. doi: 10.1021/acssynbio.7b00208. Epub 2017 Nov 29.

PMID:
29136368
8.

IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular Domains Reveals Canonical STAT Activation via Synthetic IL-35 and IL-39 Signaling.

Floss DM, Schönberg M, Franke M, Horstmeier FC, Engelowski E, Schneider A, Rosenfeldt EM, Scheller J.

Sci Rep. 2017 Nov 9;7(1):15172. doi: 10.1038/s41598-017-15173-3.

9.

SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy.

Lang A, Anand R, Altinoluk-Hambüchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, Böhler P, Hänsel J, Franke M, Stühler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP.

Aging (Albany NY). 2017 Oct 29;9(10):2163-2189. doi: 10.18632/aging.101307.

10.

An Unexpected Cause of Bilateral Retinal Hemorrhages in a Four-Month-Old Boy.

Scheller J.

Pediatr Neurol. 2018 Jan;78:79. doi: 10.1016/j.pediatrneurol.2017.07.015. Epub 2017 Aug 9. No abstract available.

PMID:
28927674
11.

Infantile retinal haemorrhages in the absence of brain and bodily injury.

Scheller J.

Acta Paediatr. 2017 Dec;106(12):1902-1904. doi: 10.1111/apa.14043. Epub 2017 Sep 12. No abstract available.

PMID:
28833451
12.

Synthetic Deletion of the Interleukin 23 Receptor (IL-23R) Stalk Region Led to Autonomous IL-23R Homodimerization and Activation.

Hummel TM, Ackfeld T, Schönberg M, Ciupka G, Schulz F, Oberdoerster A, Grötzinger J, Scheller J, Floss DM.

Mol Cell Biol. 2017 Aug 11;37(17). pii: e00014-17. doi: 10.1128/MCB.00014-17. Print 2017 Sep 1.

13.

Stepwise copper(i) binding to metallothionein: a mixed cooperative and non-cooperative mechanism for all 20 copper ions.

Scheller JS, Irvine GW, Wong DL, Hartwig A, Stillman MJ.

Metallomics. 2017 May 24;9(5):447-462. doi: 10.1039/c7mt00041c.

PMID:
28466911
14.

CD73-derived adenosine and tenascin-C control cytokine production by epicardium-derived cells formed after myocardial infarction.

Hesse J, Leberling S, Boden E, Friebe D, Schmidt T, Ding Z, Dieterich P, Deussen A, Roderigo C, Rose CR, Floss DM, Scheller J, Schrader J.

FASEB J. 2017 Jul;31(7):3040-3053. doi: 10.1096/fj.201601307R. Epub 2017 Mar 31.

PMID:
28363952
15.

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.

Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, Tholey A, Rabe B, Scheller J, Lucius R, Garbers C, Rose-John S, Becker-Pauly C.

Sci Rep. 2017 Mar 9;7:44053. doi: 10.1038/srep44053.

16.

Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair.

Aden K, Breuer A, Rehman A, Geese H, Tran F, Sommer J, Waetzig GH, Reinheimer TM, Schreiber S, Rose-John S, Scheller J, Rosenstiel P.

Oncogenesis. 2016 Nov 21;5(11):e270. doi: 10.1038/oncsis.2016.71.

17.

Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation.

Schumacher N, Schmidt S, Schwarz J, Dohr D, Lokau J, Scheller J, Garbers C, Chalaris A, Rose-John S, Rabe B.

J Immunol. 2016 Nov 1;197(9):3705-3715. Epub 2016 Oct 3.

18.

Titin-Based Cardiac Myocyte Stiffening Contributes to Early Adaptive Ventricular Remodeling After Myocardial Infarction.

Kötter S, Kazmierowska M, Andresen C, Bottermann K, Grandoch M, Gorressen S, Heinen A, Moll JM, Scheller J, Gödecke A, Fischer JW, Schmitt JP, Krüger M.

Circ Res. 2016 Oct 14;119(9):1017-1029. Epub 2016 Sep 20.

19.

Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor.

Monhasery N, Moll J, Cuman C, Franke M, Lamertz L, Nitz R, Görg B, Häussinger D, Lokau J, Floss DM, Piekorz R, Dimitriadis E, Garbers C, Scheller J.

Cell Rep. 2016 Jul 26;16(4):1067-1081. doi: 10.1016/j.celrep.2016.06.062. Epub 2016 Jul 14.

20.

Defining the functional binding sites of interleukin 12 receptor β1 and interleukin 23 receptor to Janus kinases.

Floss DM, Klöcker T, Schröder J, Lamertz L, Mrotzek S, Strobl B, Hermanns H, Scheller J.

Mol Biol Cell. 2016 Jul 15;27(14):2301-16. doi: 10.1091/mbc.E14-12-1645. Epub 2016 May 18.

21.

A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1.

Geissler R, Simkin A, Floss D, Patel R, Fogarty EA, Scheller J, Grimson A.

Genes Dev. 2016 May 1;30(9):1070-85. doi: 10.1101/gad.277392.116.

22.

Human and Murine Interleukin 23 Receptors Are Novel Substrates for A Disintegrin and Metalloproteases ADAM10 and ADAM17.

Franke M, Schröder J, Monhasery N, Ackfeld T, Hummel TM, Rabe B, Garbers C, Becker-Pauly C, Floss DM, Scheller J.

J Biol Chem. 2016 May 13;291(20):10551-61. doi: 10.1074/jbc.M115.710541. Epub 2016 Mar 9.

23.

Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source.

Efimov GA, Kruglov AA, Khlopchatnikova ZV, Rozov FN, Mokhonov VV, Rose-John S, Scheller J, Gordon S, Stacey M, Drutskaya MS, Tillib SV, Nedospasov SA.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3006-11. doi: 10.1073/pnas.1520175113. Epub 2016 Mar 2.

24.

The Role of Embryonic Stem Cell-expressed RAS (ERAS) in the Maintenance of Quiescent Hepatic Stellate Cells.

Nakhaei-Rad S, Nakhaeizadeh H, Götze S, Kordes C, Sawitza I, Hoffmann MJ, Franke M, Schulz WA, Scheller J, Piekorz RP, Häussinger D, Ahmadian MR.

J Biol Chem. 2016 Apr 15;291(16):8399-413. doi: 10.1074/jbc.M115.700088. Epub 2016 Feb 16.

25.

Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.

Lokau J, Nitz R, Agthe M, Monhasery N, Aparicio-Siegmund S, Schumacher N, Wolf J, Möller-Hackbarth K, Waetzig GH, Grötzinger J, Müller-Newen G, Rose-John S, Scheller J, Garbers C.

Cell Rep. 2016 Feb 23;14(7):1761-1773. doi: 10.1016/j.celrep.2016.01.053. Epub 2016 Feb 11.

26.

A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing.

Wolf J, Waetzig GH, Reinheimer TM, Scheller J, Rose-John S, Garbers C.

Biochem Biophys Res Commun. 2016 Feb 19;470(4):870-6. doi: 10.1016/j.bbrc.2016.01.127. Epub 2016 Jan 22.

PMID:
26809098
27.

Modular organization of Interleukin-6 and Interleukin-11 α-receptors.

Nitz R, Lokau J, Aparicio-Siegmund S, Scheller J, Garbers C.

Biochimie. 2015 Dec;119:175-82. doi: 10.1016/j.biochi.2015.11.005. Epub 2015 Nov 10.

PMID:
26551279
28.

Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.

Maney SK, McIlwain DR, Polz R, Pandyra AA, Sundaram B, Wolff D, Ohishi K, Maretzky T, Brooke MA, Evers A, Vasudevan AA, Aghaeepour N, Scheller J, Münk C, Häussinger D, Mak TW, Nolan GP, Kelsell DP, Blobel CP, Lang KS, Lang PA.

Sci Signal. 2015 Nov 3;8(401):ra109. doi: 10.1126/scisignal.aac5356.

PMID:
26535007
29.

Anti-interleukin-6 therapy through application of a monogenic protein inhibitor via gene delivery.

Görtz D, Braun GS, Maruta Y, Djudjaj S, van Roeyen CR, Martin IV, Küster A, Schmitz-Van de Leur H, Scheller J, Ostendorf T, Floege J, Müller-Newen G.

Sci Rep. 2015 Oct 1;5:14685. doi: 10.1038/srep14685.

30.

Novel Insights into Interleukin 6 (IL-6) Cis- and Trans-signaling Pathways by Differentially Manipulating the Assembly of the IL-6 Signaling Complex.

Lacroix M, Rousseau F, Guilhot F, Malinge P, Magistrelli G, Herren S, Jones SA, Jones GW, Scheller J, Lissilaa R, Kosco-Vilbois M, Johnson Z, Buatois V, Ferlin W.

J Biol Chem. 2015 Nov 6;290(45):26943-53. doi: 10.1074/jbc.M115.682138. Epub 2015 Sep 11.

31.

"Family reunion"--A structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines.

Rose-John S, Scheller J, Schaper F.

Cytokine Growth Factor Rev. 2015 Oct;26(5):471-4. doi: 10.1016/j.cytogfr.2015.07.011. Epub 2015 Jul 6. No abstract available.

PMID:
26235233
32.

Insights into IL-23 biology: From structure to function.

Floss DM, Schröder J, Franke M, Scheller J.

Cytokine Growth Factor Rev. 2015 Oct;26(5):569-78. doi: 10.1016/j.cytogfr.2015.07.005. Epub 2015 Jul 11. Review.

PMID:
26195433
33.

Functional outcomes in Rett syndrome.

Pidcock FS, Salorio C, Bibat G, Swain J, Scheller J, Shore W, Naidu S.

Brain Dev. 2016 Jan;38(1):76-81. doi: 10.1016/j.braindev.2015.06.005. Epub 2015 Jul 11.

34.

Peripheral and central blockade of interleukin-6 trans-signaling differentially affects sleep architecture.

Oyanedel CN, Kelemen E, Scheller J, Born J, Rose-John S.

Brain Behav Immun. 2015 Nov;50:178-185. doi: 10.1016/j.bbi.2015.07.001. Epub 2015 Jul 2.

35.

Ruptured Aneurysm and Terson Syndrome in a 1-Month-Old Infant.

Scheller J, Doroslovacki P.

Pediatr Neurol. 2015 Jun;52(6):653-4. doi: 10.1016/j.pediatrneurol.2015.02.012. Epub 2015 Mar 13. No abstract available.

PMID:
26002054
36.

Retinal hemorrhages in nonaccidental trauma: look at susceptibility-weighted imaging on pediatric MRI.

Polan RM, Poretti A, Scheller JM, Huisman TA, Bosemani T.

Pediatr Neurol. 2015 Apr;52(4):464-5. doi: 10.1016/j.pediatrneurol.2015.01.005. Epub 2015 Jan 16. No abstract available.

PMID:
25682484
37.

Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN.

Luig M, Kluger MA, Goerke B, Meyer M, Nosko A, Yan I, Scheller J, Mittrücker HW, Rose-John S, Stahl RA, Panzer U, Steinmetz OM.

J Am Soc Nephrol. 2015 Jul;26(7):1597-607. doi: 10.1681/ASN.2014060620. Epub 2015 Feb 5.

38.

Non-canonical interleukin 23 receptor complex assembly: p40 protein recruits interleukin 12 receptor β1 via site II and induces p19/interleukin 23 receptor interaction via site III.

Schröder J, Moll JM, Baran P, Grötzinger J, Scheller J, Floss DM.

J Biol Chem. 2015 Jan 2;290(1):359-70. doi: 10.1074/jbc.M114.617597. Epub 2014 Nov 4.

39.

Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease.

Karbach S, Croxford AL, Oelze M, Schüler R, Minwegen D, Wegner J, Koukes L, Yogev N, Nikolaev A, Reißig S, Ullmann A, Knorr M, Waldner M, Neurath MF, Li H, Wu Z, Brochhausen C, Scheller J, Rose-John S, Piotrowski C, Bechmann I, Radsak M, Wild P, Daiber A, von Stebut E, Wenzel P, Waisman A, Münzel T.

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2658-68. doi: 10.1161/ATVBAHA.114.304108. Epub 2014 Oct 23.

40.

Moderate Bilateral Retinal Hemorrhages in an Infant Following a Short Fall.

Scheller J, Huisman TA.

Clin Pediatr (Phila). 2015 Sep;54(10):999-1002. doi: 10.1177/0009922814554501. Epub 2014 Oct 13. No abstract available.

PMID:
25316220
41.

Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35.

Aparicio-Siegmund S, Moll JM, Lokau J, Grusdat M, Schröder J, Plöhn S, Rose-John S, Grötzinger J, Lang PA, Scheller J, Garbers C.

PLoS One. 2014 Sep 26;9(9):e107990. doi: 10.1371/journal.pone.0107990. eCollection 2014.

42.

Interleukin-6-dependent phenotypic modulation of cardiac fibroblasts after acute myocardial infarction.

Müller J, Gorressen S, Grandoch M, Feldmann K, Kretschmer I, Lehr S, Ding Z, Schmitt JP, Schrader J, Garbers C, Heusch G, Kelm M, Scheller J, Fischer JW.

Basic Res Cardiol. 2014;109(6):440. doi: 10.1007/s00395-014-0440-y. Epub 2014 Sep 19.

PMID:
25236954
43.

The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses.

Marczynska J, Ozga A, Wlodarczyk A, Majchrzak-Gorecka M, Kulig P, Banas M, Michalczyk-Wetula D, Majewski P, Hutloff A, Schwarz J, Chalaris A, Scheller J, Rose-John S, Cichy J.

J Immunol. 2014 Sep 15;193(6):2753-63. doi: 10.4049/jimmunol.1302893. Epub 2014 Aug 8.

44.

Pivotal role of phospholipase D1 in tumor necrosis factor-α-mediated inflammation and scar formation after myocardial ischemia and reperfusion in mice.

Schönberger T, Jürgens T, Müller J, Armbruster N, Niermann C, Gorressen S, Sommer J, Tian H, di Paolo G, Scheller J, Fischer JW, Gawaz M, Elvers M.

Am J Pathol. 2014 Sep;184(9):2450-64. doi: 10.1016/j.ajpath.2014.06.005. Epub 2014 Jul 18.

PMID:
25046692
45.

Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis.

Sommer J, Engelowski E, Baran P, Garbers C, Floss DM, Scheller J.

Int J Mol Med. 2014 Sep;34(3):651-60. doi: 10.3892/ijmm.2014.1825. Epub 2014 Jun 27.

46.

Alternative intronic polyadenylation generates the interleukin-6 trans-signaling inhibitor sgp130-E10.

Sommer J, Garbers C, Wolf J, Trad A, Moll JM, Sack M, Fischer R, Grötzinger J, Waetzig GH, Floss DM, Scheller J.

J Biol Chem. 2014 Aug 8;289(32):22140-50. doi: 10.1074/jbc.M114.560938. Epub 2014 Jun 27.

47.

The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.

Garbers C, Monhasery N, Aparicio-Siegmund S, Lokau J, Baran P, Nowell MA, Jones SA, Rose-John S, Scheller J.

Biochim Biophys Acta. 2014 Sep;1842(9):1485-94. doi: 10.1016/j.bbadis.2014.05.018. Epub 2014 May 27.

48.

The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR).

Wagener EM, Aurich M, Aparicio-Siegmund S, Floss DM, Garbers C, Breusing K, Rabe B, Schwanbeck R, Grötzinger J, Rose-John S, Scheller J.

J Biol Chem. 2014 Jun 27;289(26):18442-50. doi: 10.1074/jbc.M114.568857. Epub 2014 May 6.

49.

A disintegrin and metalloprotease 17 dynamic interaction sequence, the sweet tooth for the human interleukin 6 receptor.

Düsterhöft S, Höbel K, Oldefest M, Lokau J, Waetzig GH, Chalaris A, Garbers C, Scheller J, Rose-John S, Lorenzen I, Grötzinger J.

J Biol Chem. 2014 Jun 6;289(23):16336-48. doi: 10.1074/jbc.M114.557322. Epub 2014 Apr 30.

50.

Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation.

Aparicio-Siegmund S, Sommer J, Monhasery N, Schwanbeck R, Keil E, Finkenstädt D, Pfeffer K, Rose-John S, Scheller J, Garbers C.

Oncotarget. 2014 Apr 30;5(8):2131-48.

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