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Nonconvulsive Seizures in Abusive Head Trauma.

Scheller J.

J Child Neurol. 2019 Sep 25:883073819876136. doi: 10.1177/0883073819876136. [Epub ahead of print]


Comparative Study on Hyaluronic Acid Binding to Murine SAA1.1 and SAA2.2.

Jin L, Syrovets T, Scheller JS, Zhang X, Simmet T.

ACS Omega. 2019 Aug 6;4(8):13388-13399. doi: 10.1021/acsomega.9b01590. eCollection 2019 Aug 20.


A Novel Role for IL-6 Receptor Classic Signaling: Induction of RORγt+Foxp3+ Tregs with Enhanced Suppressive Capacity.

Hagenstein J, Melderis S, Nosko A, Warkotsch MT, Richter JV, Ramcke T, Herrnstadt GR, Scheller J, Yan I, Mittrücker HW, Kluger MA, Steinmetz OM.

J Am Soc Nephrol. 2019 Aug;30(8):1439-1453. doi: 10.1681/ASN.2019020118. Epub 2019 Jul 16.


Naturally occurring and synthetic constitutive-active cytokine receptors in disease and therapy.

Floss DM, Scheller J.

Cytokine Growth Factor Rev. 2019 Jun;47:1-20. doi: 10.1016/j.cytogfr.2019.05.007. Epub 2019 May 21. Review.


IL-6 Trans-signaling Controls Liver Regeneration After Partial Hepatectomy.

Fazel Modares N, Polz R, Haghighi F, Lamertz L, Behnke K, Zhuang Y, Kordes C, Häussinger D, Sorg UR, Pfeffer K, Floss DM, Moll JM, Piekorz RP, Ahmadian MR, Lang PA, Scheller J.

Hepatology. 2019 May 17. doi: 10.1002/hep.30774. [Epub ahead of print]


A2bR-dependent signaling alters immune cell composition and enhances IL-6 formation in the ischemic heart.

Alter C, Ding Z, Flögel U, Scheller J, Schrader J.

Am J Physiol Heart Circ Physiol. 2019 Jul 1;317(1):H190-H200. doi: 10.1152/ajpheart.00029.2019. Epub 2019 May 3.



Behnke K, Zhuang Y, Xu HC, Sundaram B, Reich M, Shinde PV, Huang J, Modares NF, Tumanov AV, Polz R, Scheller J, Ware CF, Pfeffer K, Keitel V, Häussinger D, Pandyra AA, Lang KS, Lang PA.

Hepatology. 2019 Sep;70(3):1074-1075. doi: 10.1002/hep.30600. No abstract available.


Cell assay for the identification of amyloid inhibitors in systemic AA amyloidosis.

Puscalau-Girtu I, Scheller JS, Claus S, Fändrich M.

Amyloid. 2019 Mar;26(1):24-33. doi: 10.1080/13506129.2019.1568978. Epub 2019 Feb 9.


Immunoreceptor Engineering and Synthetic Cytokine Signaling for Therapeutics.

Scheller J, Engelowski E, Moll JM, Floss DM.

Trends Immunol. 2019 Mar;40(3):258-272. doi: 10.1016/ Epub 2019 Feb 6. Review.


IL-23R Signaling Plays No Role in Myocardial Infarction.

Engelowski E, Modares NF, Gorressen S, Bouvain P, Semmler D, Alter C, Ding Z, Flögel U, Schrader J, Xu H, Lang PA, Fischer J, Floss DM, Scheller J.

Sci Rep. 2018 Nov 20;8(1):17078. doi: 10.1038/s41598-018-35188-8.


Synthetic Cargo Internalization Receptor System for Nanoparticle Tracking of Individual Cell Populations by Fluorine Magnetic Resonance Imaging.

Temme S, Baran P, Bouvain P, Grapentin C, Krämer W, Knebel B, Al-Hasani H, Moll JM, Floss D, Schrader J, Schubert R, Flögel U, Scheller J.

ACS Nano. 2018 Nov 27;12(11):11178-11192. doi: 10.1021/acsnano.8b05698. Epub 2018 Nov 5.


Correction: SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy.

Lang A, Anand R, Altinoluk-Hambüchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, Böhler P, Hänsel J, Franke M, Stühler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP.

Aging (Albany NY). 2018 Sep 28;10(9):2536c. doi: 10.18632/aging.101570. No abstract available.


Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses.

Lamertz L, Rummel F, Polz R, Baran P, Hansen S, Waetzig GH, Moll JM, Floss DM, Scheller J.

Sci Signal. 2018 Oct 2;11(550). pii: eaar7388. doi: 10.1126/scisignal.aar7388.


Synthetic cytokine receptors transmit biological signals using artificial ligands.

Engelowski E, Schneider A, Franke M, Xu H, Clemen R, Lang A, Baran P, Binsch C, Knebel B, Al-Hasani H, Moll JM, Floß DM, Lang PA, Scheller J.

Nat Commun. 2018 May 23;9(1):2034. doi: 10.1038/s41467-018-04454-8.


B Cell-Mediated Maintenance of Cluster of Differentiation 169-Positive Cells Is Critical for Liver Regeneration.

Behnke K, Zhuang Y, Xu HC, Sundaram B, Reich M, Shinde PV, Huang J, Modares NF, Tumanov AV, Polz R, Scheller J, Ware CF, Pfeffer K, Keitel V, Häussinger D, Pandyra AA, Lang KS, Lang PA.

Hepatology. 2018 Dec;68(6):2348-2361. doi: 10.1002/hep.30088. Epub 2018 Nov 5.


The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling.

Baran P, Hansen S, Waetzig GH, Akbarzadeh M, Lamertz L, Huber HJ, Ahmadian MR, Moll JM, Scheller J.

J Biol Chem. 2018 May 4;293(18):6762-6775. doi: 10.1074/jbc.RA117.001163. Epub 2018 Mar 20.


Unravelling the mechanistic details of metal binding to mammalian metallothioneins from stoichiometric, kinetic, and binding affinity data.

Scheller JS, Irvine GW, Stillman MJ.

Dalton Trans. 2018 Mar 12;47(11):3613-3637. doi: 10.1039/c7dt03319b. Review.


Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis.

Schmok E, Abad Dar M, Behrends J, Erdmann H, Rückerl D, Endermann T, Heitmann L, Hessmann M, Yoshimura A, Rose-John S, Scheller J, Schaible UE, Ehlers S, Lang R, Hölscher C.

Front Immunol. 2017 Nov 10;8:1537. doi: 10.3389/fimmu.2017.01537. eCollection 2017.


Split2 Protein-Ligation Generates Active IL-6-Type Hyper-Cytokines from Inactive Precursors.

Moll JM, Wehmöller M, Frank NC, Homey L, Baran P, Garbers C, Lamertz L, Axelrod JH, Galun E, Mootz HD, Scheller J.

ACS Synth Biol. 2017 Dec 15;6(12):2260-2272. doi: 10.1021/acssynbio.7b00208. Epub 2017 Nov 29.


IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular Domains Reveals Canonical STAT Activation via Synthetic IL-35 and IL-39 Signaling.

Floss DM, Schönberg M, Franke M, Horstmeier FC, Engelowski E, Schneider A, Rosenfeldt EM, Scheller J.

Sci Rep. 2017 Nov 9;7(1):15172. doi: 10.1038/s41598-017-15173-3.


SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy.

Lang A, Anand R, Altinoluk-Hambüchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, Böhler P, Hänsel J, Franke M, Stühler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP.

Aging (Albany NY). 2017 Oct 29;9(10):2163-2189. doi: 10.18632/aging.101307. Erratum in: Aging (Albany NY). 2018 Sep 28;10(9):2536c.


An Unexpected Cause of Bilateral Retinal Hemorrhages in a Four-Month-Old Boy.

Scheller J.

Pediatr Neurol. 2018 Jan;78:79. doi: 10.1016/j.pediatrneurol.2017.07.015. Epub 2017 Aug 9. No abstract available.


Infantile retinal haemorrhages in the absence of brain and bodily injury.

Scheller J.

Acta Paediatr. 2017 Dec;106(12):1902-1904. doi: 10.1111/apa.14043. Epub 2017 Sep 12. No abstract available.


Synthetic Deletion of the Interleukin 23 Receptor (IL-23R) Stalk Region Led to Autonomous IL-23R Homodimerization and Activation.

Hummel TM, Ackfeld T, Schönberg M, Ciupka G, Schulz F, Oberdoerster A, Grötzinger J, Scheller J, Floss DM.

Mol Cell Biol. 2017 Aug 11;37(17). pii: e00014-17. doi: 10.1128/MCB.00014-17. Print 2017 Sep 1.


Stepwise copper(i) binding to metallothionein: a mixed cooperative and non-cooperative mechanism for all 20 copper ions.

Scheller JS, Irvine GW, Wong DL, Hartwig A, Stillman MJ.

Metallomics. 2017 May 24;9(5):447-462. doi: 10.1039/c7mt00041c.


CD73-derived adenosine and tenascin-C control cytokine production by epicardium-derived cells formed after myocardial infarction.

Hesse J, Leberling S, Boden E, Friebe D, Schmidt T, Ding Z, Dieterich P, Deussen A, Roderigo C, Rose CR, Floss DM, Scheller J, Schrader J.

FASEB J. 2017 Jul;31(7):3040-3053. doi: 10.1096/fj.201601307R. Epub 2017 Mar 31.


Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.

Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, Tholey A, Rabe B, Scheller J, Lucius R, Garbers C, Rose-John S, Becker-Pauly C.

Sci Rep. 2017 Mar 9;7:44053. doi: 10.1038/srep44053.


Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair.

Aden K, Breuer A, Rehman A, Geese H, Tran F, Sommer J, Waetzig GH, Reinheimer TM, Schreiber S, Rose-John S, Scheller J, Rosenstiel P.

Oncogenesis. 2016 Nov 21;5(11):e270. doi: 10.1038/oncsis.2016.71.


Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation.

Schumacher N, Schmidt S, Schwarz J, Dohr D, Lokau J, Scheller J, Garbers C, Chalaris A, Rose-John S, Rabe B.

J Immunol. 2016 Nov 1;197(9):3705-3715. Epub 2016 Oct 3.


Titin-Based Cardiac Myocyte Stiffening Contributes to Early Adaptive Ventricular Remodeling After Myocardial Infarction.

Kötter S, Kazmierowska M, Andresen C, Bottermann K, Grandoch M, Gorressen S, Heinen A, Moll JM, Scheller J, Gödecke A, Fischer JW, Schmitt JP, Krüger M.

Circ Res. 2016 Oct 14;119(9):1017-1029. Epub 2016 Sep 20.


Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor.

Monhasery N, Moll J, Cuman C, Franke M, Lamertz L, Nitz R, Görg B, Häussinger D, Lokau J, Floss DM, Piekorz R, Dimitriadis E, Garbers C, Scheller J.

Cell Rep. 2016 Jul 26;16(4):1067-1081. doi: 10.1016/j.celrep.2016.06.062. Epub 2016 Jul 14.


Defining the functional binding sites of interleukin 12 receptor β1 and interleukin 23 receptor to Janus kinases.

Floss DM, Klöcker T, Schröder J, Lamertz L, Mrotzek S, Strobl B, Hermanns H, Scheller J.

Mol Biol Cell. 2016 Jul 15;27(14):2301-16. doi: 10.1091/mbc.E14-12-1645. Epub 2016 May 18.


A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1.

Geissler R, Simkin A, Floss D, Patel R, Fogarty EA, Scheller J, Grimson A.

Genes Dev. 2016 May 1;30(9):1070-85. doi: 10.1101/gad.277392.116.


Human and Murine Interleukin 23 Receptors Are Novel Substrates for A Disintegrin and Metalloproteases ADAM10 and ADAM17.

Franke M, Schröder J, Monhasery N, Ackfeld T, Hummel TM, Rabe B, Garbers C, Becker-Pauly C, Floss DM, Scheller J.

J Biol Chem. 2016 May 13;291(20):10551-61. doi: 10.1074/jbc.M115.710541. Epub 2016 Mar 9.


Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source.

Efimov GA, Kruglov AA, Khlopchatnikova ZV, Rozov FN, Mokhonov VV, Rose-John S, Scheller J, Gordon S, Stacey M, Drutskaya MS, Tillib SV, Nedospasov SA.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3006-11. doi: 10.1073/pnas.1520175113. Epub 2016 Mar 2.


The Role of Embryonic Stem Cell-expressed RAS (ERAS) in the Maintenance of Quiescent Hepatic Stellate Cells.

Nakhaei-Rad S, Nakhaeizadeh H, Götze S, Kordes C, Sawitza I, Hoffmann MJ, Franke M, Schulz WA, Scheller J, Piekorz RP, Häussinger D, Ahmadian MR.

J Biol Chem. 2016 Apr 15;291(16):8399-413. doi: 10.1074/jbc.M115.700088. Epub 2016 Feb 16.


Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.

Lokau J, Nitz R, Agthe M, Monhasery N, Aparicio-Siegmund S, Schumacher N, Wolf J, Möller-Hackbarth K, Waetzig GH, Grötzinger J, Müller-Newen G, Rose-John S, Scheller J, Garbers C.

Cell Rep. 2016 Feb 23;14(7):1761-1773. doi: 10.1016/j.celrep.2016.01.053. Epub 2016 Feb 11.


A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing.

Wolf J, Waetzig GH, Reinheimer TM, Scheller J, Rose-John S, Garbers C.

Biochem Biophys Res Commun. 2016 Feb 19;470(4):870-6. doi: 10.1016/j.bbrc.2016.01.127. Epub 2016 Jan 22.


Modular organization of Interleukin-6 and Interleukin-11 α-receptors.

Nitz R, Lokau J, Aparicio-Siegmund S, Scheller J, Garbers C.

Biochimie. 2015 Dec;119:175-82. doi: 10.1016/j.biochi.2015.11.005. Epub 2015 Nov 10.


Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.

Maney SK, McIlwain DR, Polz R, Pandyra AA, Sundaram B, Wolff D, Ohishi K, Maretzky T, Brooke MA, Evers A, Vasudevan AA, Aghaeepour N, Scheller J, Münk C, Häussinger D, Mak TW, Nolan GP, Kelsell DP, Blobel CP, Lang KS, Lang PA.

Sci Signal. 2015 Nov 3;8(401):ra109. doi: 10.1126/scisignal.aac5356.


Anti-interleukin-6 therapy through application of a monogenic protein inhibitor via gene delivery.

Görtz D, Braun GS, Maruta Y, Djudjaj S, van Roeyen CR, Martin IV, Küster A, Schmitz-Van de Leur H, Scheller J, Ostendorf T, Floege J, Müller-Newen G.

Sci Rep. 2015 Oct 1;5:14685. doi: 10.1038/srep14685.


Novel Insights into Interleukin 6 (IL-6) Cis- and Trans-signaling Pathways by Differentially Manipulating the Assembly of the IL-6 Signaling Complex.

Lacroix M, Rousseau F, Guilhot F, Malinge P, Magistrelli G, Herren S, Jones SA, Jones GW, Scheller J, Lissilaa R, Kosco-Vilbois M, Johnson Z, Buatois V, Ferlin W.

J Biol Chem. 2015 Nov 6;290(45):26943-53. doi: 10.1074/jbc.M115.682138. Epub 2015 Sep 11.


"Family reunion"--A structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines.

Rose-John S, Scheller J, Schaper F.

Cytokine Growth Factor Rev. 2015 Oct;26(5):471-4. doi: 10.1016/j.cytogfr.2015.07.011. Epub 2015 Jul 6. No abstract available.


Insights into IL-23 biology: From structure to function.

Floss DM, Schröder J, Franke M, Scheller J.

Cytokine Growth Factor Rev. 2015 Oct;26(5):569-78. doi: 10.1016/j.cytogfr.2015.07.005. Epub 2015 Jul 11. Review.


Functional outcomes in Rett syndrome.

Pidcock FS, Salorio C, Bibat G, Swain J, Scheller J, Shore W, Naidu S.

Brain Dev. 2016 Jan;38(1):76-81. doi: 10.1016/j.braindev.2015.06.005. Epub 2015 Jul 11.


Peripheral and central blockade of interleukin-6 trans-signaling differentially affects sleep architecture.

Oyanedel CN, Kelemen E, Scheller J, Born J, Rose-John S.

Brain Behav Immun. 2015 Nov;50:178-185. doi: 10.1016/j.bbi.2015.07.001. Epub 2015 Jul 2.


Ruptured Aneurysm and Terson Syndrome in a 1-Month-Old Infant.

Scheller J, Doroslovacki P.

Pediatr Neurol. 2015 Jun;52(6):653-4. doi: 10.1016/j.pediatrneurol.2015.02.012. Epub 2015 Mar 13. No abstract available.


Retinal hemorrhages in nonaccidental trauma: look at susceptibility-weighted imaging on pediatric MRI.

Polan RM, Poretti A, Scheller JM, Huisman TA, Bosemani T.

Pediatr Neurol. 2015 Apr;52(4):464-5. doi: 10.1016/j.pediatrneurol.2015.01.005. Epub 2015 Jan 16. No abstract available.


Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN.

Luig M, Kluger MA, Goerke B, Meyer M, Nosko A, Yan I, Scheller J, Mittrücker HW, Rose-John S, Stahl RA, Panzer U, Steinmetz OM.

J Am Soc Nephrol. 2015 Jul;26(7):1597-607. doi: 10.1681/ASN.2014060620. Epub 2015 Feb 5.

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