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Effect of fluconazole prophylaxis on Candida fluconazole susceptibility in premature infants.

Autmizguine J, Smith PB, Prather K, Bendel C, Natarajan G, Bidegain M, Kaufman DA, Burchfield DJ, Ross AS, Pandit P, Schell WA, Gao J, Benjamin DK Jr; Fluconazole Prophylaxis Study Team.

J Antimicrob Chemother. 2018 Dec 1;73(12):3482-3487. doi: 10.1093/jac/dky353.


Pulmonary blastomycosis presenting as primary lung cancer.

Hussaini SMQ, Madut D, Tong BC, Pavlisko EN, Schell WA, Perfect JR, Thielman NM.

BMC Infect Dis. 2018 Jul 18;18(1):336. doi: 10.1186/s12879-018-3244-0.


In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus.

Shaw KJ, Schell WA, Covel J, Duboc G, Giamberardino C, Kapoor M, Moloney M, Soltow QA, Tenor JL, Toffaletti DL, Trzoss M, Webb P, Perfect JR.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00523-18. doi: 10.1128/AAC.00523-18. Print 2018 Aug.


Genomic characterization of recurrent mold infections in thoracic transplant recipients.

Messina JA, Wolfe CR, Hemmersbach-Miller M, Milano C, Todd JL, Reynolds J, Alexander BD, Schell WA, Cuomo CA, Perfect JR.

Transpl Infect Dis. 2018 Oct;20(5):e12935. doi: 10.1111/tid.12935. Epub 2018 Jun 19.


Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species.

Schell WA, Jones AM, Borroto-Esoda K, Alexander BD.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01102-17. doi: 10.1128/AAC.01102-17. Print 2017 Nov.


Diagnostic difficulty identifying Apophysomyces trapeziformis septic arthritis in a patient with multiple myeloma.

Bertumen JB, Schell WA, Joyce M, Alley C, Woods CW.

JMM Case Rep. 2016 Dec 19;3(6):e005075. doi: 10.1099/jmmcr.0.005075. eCollection 2016 Dec.


Fungal CYP51 Inhibitors VT-1161 and VT-1129 Exhibit Strong In Vitro Activity against Candida glabrata and C. krusei Isolates Clinically Resistant to Azole and Echinocandin Antifungal Compounds.

Schell WA, Jones AM, Garvey EP, Hoekstra WJ, Schotzinger RJ, Alexander BD.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e01817-16. doi: 10.1128/AAC.01817-16. Print 2017 Mar.


Simple Strategy for Taming Membrane-Disrupting Antibiotics.

Yu Y, Sabulski MJ, Schell WA, Pires MM, Perfect JR, Regen SL.

Bioconjug Chem. 2016 Dec 21;27(12):2850-2853. doi: 10.1021/acs.bioconjchem.6b00629. Epub 2016 Nov 9.


Taming Amphotericin B.

Janout V, Schell WA, Thévenin D, Yu Y, Perfect JR, Regen SL.

Bioconjug Chem. 2015 Oct 21;26(10):2021-4. doi: 10.1021/acs.bioconjchem.5b00463. Epub 2015 Sep 10.


Characterization of alpha-toxin hla gene variants, alpha-toxin expression levels, and levels of antibody to alpha-toxin in hemodialysis and postsurgical patients with Staphylococcus aureus bacteremia.

Sharma-Kuinkel BK, Wu Y, Tabor DE, Mok H, Sellman BR, Jenkins A, Yu L, Jafri HS, Rude TH, Ruffin F, Schell WA, Park LP, Yan Q, Thaden JT, Messina JA, Fowler VG Jr, Esser MT.

J Clin Microbiol. 2015 Jan;53(1):227-36. doi: 10.1128/JCM.02023-14. Epub 2014 Nov 12.


Outbreak of bacteremia due to Burkholderia contaminans linked to intravenous fentanyl from an institutional compounding pharmacy.

Moehring RW, Lewis SS, Isaacs PJ, Schell WA, Thomann WR, Althaus MM, Hazen KC, Dicks KV, Lipuma JJ, Chen LF, Sexton DJ.

JAMA Intern Med. 2014 Apr;174(4):606-12. doi: 10.1001/jamainternmed.2013.13768.


Impact of surfactant protein D, interleukin-5, and eosinophilia on Cryptococcosis.

Holmer SM, Evans KS, Asfaw YG, Saini D, Schell WA, Ledford JG, Frothingham R, Wright JR, Sempowski GD, Perfect JR.

Infect Immun. 2014 Feb;82(2):683-93. doi: 10.1128/IAI.00855-13. Epub 2013 Nov 25.


Quantitative models of the dose-response and time course of inhalational anthrax in humans.

Toth DJ, Gundlapalli AV, Schell WA, Bulmahn K, Walton TE, Woods CW, Coghill C, Gallegos F, Samore MH, Adler FR.

PLoS Pathog. 2013 Aug;9(8):e1003555. doi: 10.1371/journal.ppat.1003555. Epub 2013 Aug 15.


Dematiaceous fungi mimicking a conjunctival melanoma.

Moss HB, Fowler WC, Schell WA, Perfect JR, Zedek DC.

Ophthalmic Plast Reconstr Surg. 2013 Mar-Apr;29(2):e65-6. doi: 10.1097/IOP.0b013e31826c2fd7.


Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for fluconazole, itraconazole, posaconazole, and voriconazole.

Espinel-Ingroff A, Aller AI, Canton E, Castañón-Olivares LR, Chowdhary A, Cordoba S, Cuenca-Estrella M, Fothergill A, Fuller J, Govender N, Hagen F, Illnait-Zaragozi MT, Johnson E, Kidd S, Lass-Flörl C, Lockhart SR, Martins MA, Meis JF, Melhem MS, Ostrosky-Zeichner L, Pelaez T, Pfaller MA, Schell WA, St-Germain G, Trilles L, Turnidge J.

Antimicrob Agents Chemother. 2012 Nov;56(11):5898-906. doi: 10.1128/AAC.01115-12. Epub 2012 Sep 4.


Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine.

Espinel-Ingroff A, Chowdhary A, Cuenca-Estrella M, Fothergill A, Fuller J, Hagen F, Govender N, Guarro J, Johnson E, Lass-Flörl C, Lockhart SR, Martins MA, Meis JF, Melhem MS, Ostrosky-Zeichner L, Pelaez T, Pfaller MA, Schell WA, Trilles L, Kidd S, Turnidge J.

Antimicrob Agents Chemother. 2012 Jun;56(6):3107-13. doi: 10.1128/AAC.06252-11. Epub 2012 Mar 5.


Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood.

Schell WA, Benton JL, Smith PB, Poore M, Rouse JL, Boles DJ, Johnson MD, Alexander BD, Pamula VK, Eckhardt AE, Pollack MG, Benjamin DK Jr, Perfect JR, Mitchell TG.

Eur J Clin Microbiol Infect Dis. 2012 Sep;31(9):2237-45. doi: 10.1007/s10096-012-1561-6. Epub 2012 Feb 11.


Quantitation of Candida CFU in initial positive blood cultures.

Pfeiffer CD, Samsa GP, Schell WA, Reller LB, Perfect JR, Alexander BD.

J Clin Microbiol. 2011 Aug;49(8):2879-83. doi: 10.1128/JCM.00609-11. Epub 2011 Jun 15.


A new lineage in Pucciniomycotina: class Tritirachiomycetes, order Tritirachiales, family Tritirachiaceae.

Schell WA, Lee AG, Aime MC.

Mycologia. 2011 Nov-Dec;103(6):1331-40. doi: 10.3852/10-333. Epub 2011 Jun 3.


Heterothallic mating in Mucor irregularis and first isolate of the species outside of Asia.

Schell WA, O'Donnell K, Alspaugh JA.

Med Mycol. 2011 Oct;49(7):714-23. doi: 10.3109/13693786.2011.568975. Epub 2011 Apr 1. Erratum in: Med Mycol. 2011 Oct;49(7):723.


Fatal Apophysomyces elegans infection transmitted by deceased donor renal allografts.

Alexander BD, Schell WA, Siston AM, Rao CY, Bower WA, Balajee SA, Howell DN, Moore ZS, Noble-Wang J, Rhyne JA, Fleischauer AT, Maillard JM, Kuehnert M, Vikraman D, Collins BH, Marroquin CE, Park BJ.

Am J Transplant. 2010 Sep;10(9):2161-7. doi: 10.1111/j.1600-6143.2010.03216.x. Epub 2010 Aug 25.


PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90.

LaFayette SL, Collins C, Zaas AK, Schell WA, Betancourt-Quiroz M, Gunatilaka AA, Perfect JR, Cowen LE.

PLoS Pathog. 2010 Aug 26;6(8):e1001069. doi: 10.1371/journal.ppat.1001069.


Microfluidic platform versus conventional real-time polymerase chain reaction for the detection of Mycoplasma pneumoniae in respiratory specimens.

Wulff-Burchfield E, Schell WA, Eckhardt AE, Pollack MG, Hua Z, Rouse JL, Pamula VK, Srinivasan V, Benton JL, Alexander BD, Wilfret DA, Kraft M, Cairns CB, Perfect JR, Mitchell TG.

Diagn Microbiol Infect Dis. 2010 May;67(1):22-9. doi: 10.1016/j.diagmicrobio.2009.12.020. Epub 2010 Mar 12.


Multiplexed real-time polymerase chain reaction on a digital microfluidic platform.

Hua Z, Rouse JL, Eckhardt AE, Srinivasan V, Pamula VK, Schell WA, Benton JL, Mitchell TG, Pollack MG.

Anal Chem. 2010 Mar 15;82(6):2310-6. doi: 10.1021/ac902510u.


Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin.

Singh SD, Robbins N, Zaas AK, Schell WA, Perfect JR, Cowen LE.

PLoS Pathog. 2009 Jul;5(7):e1000532. doi: 10.1371/journal.ppat.1000532. Epub 2009 Jul 31.


Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.

Cowen LE, Singh SD, Köhler JR, Collins C, Zaas AK, Schell WA, Aziz H, Mylonakis E, Perfect JR, Whitesell L, Lindquist S.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2818-23. doi: 10.1073/pnas.0813394106. Epub 2009 Feb 5.


Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model.

Onyewu C, Eads E, Schell WA, Perfect JR, Ullmann Y, Kaufman G, Horwitz BA, Berdicevsky I, Heitman J.

Antimicrob Agents Chemother. 2007 Oct;51(10):3743-6. Epub 2007 Jul 30.


Caspofungin for the treatment of azole resistant candidemia in a premature infant.

Smith PB, Steinbach WJ, Cotten CM, Schell WA, Perfect JR, Walsh TJ, Benjamin DK Jr.

J Perinatol. 2007 Feb;27(2):127-9.


Sinusitis caused by the fungus Xylaria enteroleuca in a lung transplant recipient.

Guarro J, Severo LC, Gené J, de Mattos Oliveira F, Cano J, Franche G, Cantarelli VV, Schell WA.

Diagn Microbiol Infect Dis. 2006 Oct;56(2):207-12. Epub 2006 Jul 28.


Candida glabrata fungemia in transplant patients receiving voriconazole after fluconazole.

Alexander BD, Schell WA, Miller JL, Long GD, Perfect JR.

Transplantation. 2005 Sep 27;80(6):868-71.


Novel use of a swimming pool biocide in the treatment of a rare fungal mastoiditis.

Chang CY, Schell WA, Perfect JR, Hulka GF.

Laryngoscope. 2005 Jun;115(6):1065-9.


In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients.

Steinbach WJ, Singh N, Miller JL, Benjamin DK Jr, Schell WA, Heitman J, Perfect JR.

Antimicrob Agents Chemother. 2004 Dec;48(12):4922-5.


Value of an inhalational model of invasive aspergillosis.

Steinbach WJ, Benjamin DK Jr, Trasi SA, Miller JL, Schell WA, Zaas AK, Foster WM, Perfect JR.

Med Mycol. 2004 Oct;42(5):417-25.


Native valve endocarditis due to Candida glabrata treated without valvular replacement: a potential role for caspofungin in the induction and maintenance treatment.

Jiménez-Expósito MJ, Torres G, Baraldés A, Benito N, Marco F, Paré JC, Moreno A, Claramonte X, Mestres CA, Almela M, García de la María C, Pérez N, Schell WA, Corey GR, Perfect J, Jiménez de Anta MT, Gatell JM, Miró JM.

Clin Infect Dis. 2004 Oct 1;39(7):e70-3. Epub 2004 Sep 8.


In vitro analyses, animal models, and 60 clinical cases of invasive Aspergillus terreus infection.

Steinbach WJ, Perfect JR, Schell WA, Walsh TJ, Benjamin DK Jr.

Antimicrob Agents Chemother. 2004 Sep;48(9):3217-25. Review. No abstract available.


Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans.

Miwa T, Takagi Y, Shinozaki M, Yun CW, Schell WA, Perfect JR, Kumagai H, Tamaki H.

Eukaryot Cell. 2004 Aug;3(4):919-31.


Interlaboratory comparison of results of susceptibility testing with caspofungin against Candida and Aspergillus species.

Odds FC, Motyl M, Andrade R, Bille J, Cantón E, Cuenca-Estrella M, Davidson A, Durussel C, Ellis D, Foraker E, Fothergill AW, Ghannoum MA, Giacobbe RA, Gobernado M, Handke R, Laverdière M, Lee-Yang W, Merz WG, Ostrosky-Zeichner L, Pemán J, Perea S, Perfect JR, Pfaller MA, Proia L, Rex JH, Rinaldi MG, Rodriguez-Tudela JL, Schell WA, Shields C, Sutton DA, Verweij PE, Warnock DW.

J Clin Microbiol. 2004 Aug;42(8):3475-82.


Allergic fungal rhinosinusitis: a report of 8 cases.

Taj-Aldeen SJ, Hilal AA, Schell WA.

Am J Otolaryngol. 2004 May-Jun;25(3):213-8.


In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus.

Steinbach WJ, Schell WA, Blankenship JR, Onyewu C, Heitman J, Perfect JR.

Antimicrob Agents Chemother. 2004 May;48(5):1664-9.


In vitro and in vivo efficacies of the new triazole albaconazole against Cryptococcus neoformans.

Miller JL, Schell WA, Wills EA, Toffaletti DL, Boyce M, Benjamin DK Jr, Bartroli J, Perfect JR.

Antimicrob Agents Chemother. 2004 Feb;48(2):384-7.


Status of medical mycology education.

Steinbach WJ, Mitchell TG, Schell WA, Espinel-Ingroff A, Coico RF, Walsh TJ, Perfect JR.

Med Mycol. 2003 Dec;41(6):457-67. Review.


Cerebral phaeohyphomycosis in an immunodeficient child treated medically with combination antifungal therapy.

Trinh JV, Steinbach WJ, Schell WA, Kurtzberg J, Giles SS, Perfect JR.

Med Mycol. 2003 Aug;41(4):339-45.


Candidemia in women with breast carcinoma treated with high-dose chemotherapy and autologous bone marrow transplantation.

Gottfredsson M, Vredenburgh JJ, Xu J, Schell WA, Perfect JR.

Cancer. 2003 Jul 1;98(1):24-30.


Calcineurin is essential for Candida albicans survival in serum and virulence.

Blankenship JR, Wormley FL, Boyce MK, Schell WA, Filler SG, Perfect JR, Heitman J.

Eukaryot Cell. 2003 Jun;2(3):422-30.


Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents.

Stephens CE, Tanious F, Kim S, Wilson WD, Schell WA, Perfect JR, Franzblau SG, Boykin DW.

J Med Chem. 2001 May 24;44(11):1741-8.


Unusual fungal pathogens in fungal rhinosinusitis.

Schell WA.

Otolaryngol Clin North Am. 2000 Apr;33(2):367-73. Review.


Histopathology of fungal rhinosinusitis.

Schell WA.

Otolaryngol Clin North Am. 2000 Apr;33(2):251-76. Review.


In vitro and in vivo efficacy of the triazole TAK-187 against Cryptococcus neoformans.

Schell WA, De Almeida GM, Dodge RK, Okonogi K, Perfect JR.

Antimicrob Agents Chemother. 1998 Oct;42(10):2630-2.

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