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Items: 1 to 50 of 107


The Organophosphorus Pesticide Chlorpyrifos Induces Sex-Specific Airway Hyperreactivity in Adult Rats.

Shaffo FC, Grodzki AC, Schelegle ES, Lein PJ.

Toxicol Sci. 2018 Sep 1;165(1):244-253. doi: 10.1093/toxsci/kfy158.


Ultrafine Particulate Matter Combined With Ozone Exacerbates Lung Injury in Mature Adult Rats With Cardiovascular Disease.

Wong EM, Walby WF, Wilson DW, Tablin F, Schelegle ES.

Toxicol Sci. 2018 May 1;163(1):140-151. doi: 10.1093/toxsci/kfy018.


Nonhuman Primate Models of Respiratory Disease: Past, Present, and Future.

Miller LA, Royer CM, Pinkerton KE, Schelegle ES.

ILAR J. 2017 Dec 1;58(2):269-280. doi: 10.1093/ilar/ilx030. Review.


Early life allergen and air pollutant exposures alter longitudinal blood immune profiles in infant rhesus monkeys.

Crowley CM, Fontaine JH, Gerriets JE, Schelegle ES, Hyde DM, Miller LA.

Toxicol Appl Pharmacol. 2017 Aug 1;328:60-69. doi: 10.1016/j.taap.2017.05.006. Epub 2017 May 18.


Early Life Wildfire Smoke Exposure Is Associated with Immune Dysregulation and Lung Function Decrements in Adolescence.

Black C, Gerriets JE, Fontaine JH, Harper RW, Kenyon NJ, Tablin F, Schelegle ES, Miller LA.

Am J Respir Cell Mol Biol. 2017 May;56(5):657-666. doi: 10.1165/rcmb.2016-0380OC.


SMAD Signaling in the Airways of Healthy Rhesus Macaques versus Rhesus Macaques with Asthma Highlights a Relationship Between Inflammation and Bone Morphogenetic Proteins.

Lynn TM, Molloy EL, Masterson JC, Glynn SF, Costello RW, Avdalovic MV, Schelegle ES, Miller LA, Hyde DM, O'Dea S.

Am J Respir Cell Mol Biol. 2016 Apr;54(4):562-73. doi: 10.1165/rcmb.2015-0210OC.


Exhaled volatile organic compounds in individuals with a history of high altitude pulmonary edema and varying hypoxia-induced responses.

Figueroa JA, Mansoor JK, Allen RP, Davis CE, Walby WF, Aksenov AA, Zhao W, Lewis WR, Schelegle ES.

J Breath Res. 2015 Apr 20;9(2):026004. doi: 10.1088/1752-7155/9/2/026004.


Early life exposure to allergen and ozone results in altered development in adolescent rhesus macaque lungs.

Herring MJ, Putney LF, St George JA, Avdalovic MV, Schelegle ES, Miller LA, Hyde DM.

Toxicol Appl Pharmacol. 2015 Feb 15;283(1):35-41. doi: 10.1016/j.taap.2014.12.006. Epub 2014 Dec 27.


Ozone-induced airway epithelial cell death, the neurokinin-1 receptor pathway, and the postnatal developing lung.

Murphy SR, Oslund KL, Hyde DM, Miller LA, Van Winkle LS, Schelegle ES.

Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15;307(6):L471-81. doi: 10.1152/ajplung.00324.2013. Epub 2014 Jul 25.


Diverse forms of pulmonary hypertension remodel the arterial tree to a high shear phenotype.

Allen RP, Schelegle ES, Bennett SH.

Am J Physiol Heart Circ Physiol. 2014 Aug 1;307(3):H405-17. doi: 10.1152/ajpheart.00144.2014. Epub 2014 May 23.


Analysis of volatile compounds in exhaled breath condensate in patients with severe pulmonary arterial hypertension.

Mansoor JK, Schelegle ES, Davis CE, Walby WF, Zhao W, Aksenov AA, Pasamontes A, Figueroa J, Allen R.

PLoS One. 2014 Apr 18;9(4):e95331. doi: 10.1371/journal.pone.0095331. eCollection 2014.


Persistence of serotonergic enhancement of airway response in a model of childhood asthma.

Moore BD, Hyde DM, Miller LA, Wong EM, Schelegle ES.

Am J Respir Cell Mol Biol. 2014 Jul;51(1):77-85. doi: 10.1165/rcmb.2013-0387OC.


Behavioral inhibition in rhesus monkeys (Macaca mulatta) is related to the airways response, but not immune measures, commonly associated with asthma.

Chun K, Miller LA, Schelegle ES, Hyde DM, Capitanio JP.

PLoS One. 2013 Aug 9;8(8):e71575. doi: 10.1371/journal.pone.0071575. eCollection 2013. Erratum in: PLoS One. 2013;8(8). doi:10.1371/annotation/aade3c83-f488-446e-8b02-bca381d2fe60.


Ozone exposure alters serotonin and serotonin receptor expression in the developing lung.

Murphy SR, Schelegle ES, Miller LA, Hyde DM, Van Winkle LS.

Toxicol Sci. 2013 Jul;134(1):168-79. doi: 10.1093/toxsci/kft090. Epub 2013 Apr 9.


Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy.

Davis BB, Zeki AA, Bratt JM, Wang L, Filosto S, Walby WF, Kenyon NJ, Goldkorn T, Schelegle ES, Pinkerton KE.

Eur Respir J. 2013 Aug;42(2):350-61. doi: 10.1183/09031936.00042512. Epub 2012 Nov 22.


Postnatal exposure history and airways: oxidant stress responses in airway explants.

Murphy SR, Schelegle ES, Edwards PC, Miller LA, Hyde DM, Van Winkle LS.

Am J Respir Cell Mol Biol. 2012 Dec;47(6):815-23. doi: 10.1165/rcmb.2012-0110OC. Epub 2012 Sep 6.


Prediction of lung function response for populations exposed to a wide range of ozone conditions.

McDonnell WF, Stewart PW, Smith MV, Kim CS, Schelegle ES.

Inhal Toxicol. 2012 Aug;24(10):619-33. doi: 10.3109/08958378.2012.705919.


Ozone exposure during the early postnatal period alters the timing and pattern of alveolar growth and development in nonhuman primates.

Avdalovic MV, Tyler NK, Putney L, Nishio SJ, Quesenberry S, Singh PJ, Miller LA, Schelegle ES, Plopper CG, Vu T, Hyde DM.

Anat Rec (Hoboken). 2012 Oct;295(10):1707-16. doi: 10.1002/ar.22545. Epub 2012 Aug 13.


Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma.

Plopper CG, Joad JP, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdalovic MV, Evans MJ, Lasley WL, Buckpitt AR, Pinkerton KE, Tarkington BK, Davis S, Nishio SJ, Gershwin LJ, Wu R, Hyde DM.

Clin Exp Allergy. 2012 Jul;42(7):1104-18. doi: 10.1111/j.1365-2222.2012.04005.x.


Modelling of individual subject ozone exposure response kinetics.

Schelegle ES, Adams WC, Walby WF, Marion MS.

Inhal Toxicol. 2012 Jun;24(7):401-15. doi: 10.3109/08958378.2012.683891.


Vagal afferents contribute to exacerbated airway responses following ozone and allergen challenge.

Schelegle ES, Walby WF.

Respir Physiol Neurobiol. 2012 May 31;181(3):277-85. doi: 10.1016/j.resp.2012.04.003. Epub 2012 Apr 12.


Allergen and ozone exacerbate serotonin-induced increases in airway smooth muscle contraction in a model of childhood asthma.

Moore BD, Hyde D, Miller L, Wong E, Frelinger J, Schelegle ES.

Respiration. 2012;83(6):529-42. doi: 10.1159/000336835. Epub 2012 Apr 13.


Increased CCL24/eotaxin-2 with postnatal ozone exposure in allergen-sensitized infant monkeys is not associated with recruitment of eosinophils to airway mucosa.

Chou DL, Gerriets JE, Schelegle ES, Hyde DM, Miller LA.

Toxicol Appl Pharmacol. 2011 Dec 15;257(3):309-18. doi: 10.1016/j.taap.2011.09.001. Epub 2011 Sep 12.


Lung gene expression in a rhesus allergic asthma model correlates with physiologic parameters of disease and exhibits common and distinct pathways with human asthma and a mouse asthma model.

Abbas AR, Jackman JK, Bullens SL, Davis SM, Choy DF, Fedorowicz G, Tan M, Truong BT, Gloria Meng Y, Diehl L, Miller LA, Schelegle ES, Hyde DM, Clark HF, Modrusan Z, Arron JR, Wu LC.

Am J Pathol. 2011 Oct;179(4):1667-80. doi: 10.1016/j.ajpath.2011.06.009. Epub 2011 Aug 3.


Behavioral inhibition is associated with airway hyperresponsiveness but not atopy in a monkey model of asthma.

Capitanio JP, Miller LA, Schelegle ES, Mendoza SP, Mason WA, Hyde DM.

Psychosom Med. 2011 May;73(4):288-94. doi: 10.1097/PSY.0b013e3182155c83. Epub 2011 May 2.


Small particles disrupt postnatal airway development.

Lee D, Wallis C, Wexler AS, Schelegle ES, Van Winkle LS, Plopper CG, Fanucchi MV, Kumfer B, Kennedy IM, Chan JK.

J Appl Physiol (1985). 2010 Oct;109(4):1115-24. doi: 10.1152/japplphysiol.00295.2010. Epub 2010 Jul 15.


Airway mast cells in a rhesus model of childhood allergic airways disease.

Van Winkle LS, Baker GL, Chan JK, Schelegle ES, Plopper CG.

Toxicol Sci. 2010 Jul;116(1):313-22. doi: 10.1093/toxsci/kfq119. Epub 2010 Apr 19.


Activation of calcitonin gene-related peptide receptor during ozone inhalation contributes to airway epithelial injury and repair.

Oslund KL, Hyde DM, Putney LF, Alfaro MF, Walby WF, Tyler NK, Schelegle ES.

Toxicol Pathol. 2009 Oct;37(6):805-13. doi: 10.1177/0192623309345691. Epub 2009 Aug 21.


6.6-hour inhalation of ozone concentrations from 60 to 87 parts per billion in healthy humans.

Schelegle ES, Morales CA, Walby WF, Marion S, Allen RP.

Am J Respir Crit Care Med. 2009 Aug 1;180(3):265-72. doi: 10.1164/rccm.200809-1484OC. Epub 2009 May 15.


Ozone and allergen exposure during postnatal development alters the frequency and airway distribution of CD25+ cells in infant rhesus monkeys.

Miller LA, Gerriets JE, Tyler NK, Abel K, Schelegle ES, Plopper CG, Hyde DM.

Toxicol Appl Pharmacol. 2009 Apr 1;236(1):39-48. doi: 10.1016/j.taap.2008.12.031. Epub 2009 Feb 7.


Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair.

Oslund KL, Hyde DM, Putney LF, Alfaro MF, Walby WF, Tyler NK, Schelegle ES.

Am J Respir Cell Mol Biol. 2008 Sep;39(3):279-88. doi: 10.1165/rcmb.2008-0009OC. Epub 2008 Apr 3.


In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation.

Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl L, Austin CD, Meng YG, Tan M, Bullens SL, Seeber S, Fuentes ME, Labrijn AF, Graus YM, Miller LA, Schelegle ES, Hyde DM, Wu LC, Hymowitz SG, Martin F.

J Clin Invest. 2007 Dec;117(12):3868-78.


The effects of inhaled corticosteroids on intrinsic responsiveness and histology of airways from infant monkeys exposed to house dust mite allergen and ozone.

Joad JP, Kott KS, Bric JM, Schelegle ES, Gershwin LJ, Plopper CG, Peake JL, Pinkerton KE.

Toxicol Appl Pharmacol. 2008 Jan 15;226(2):153-60. Epub 2007 Sep 16.


Asthma/allergic airways disease: does postnatal exposure to environmental toxicants promote airway pathobiology?

Plopper CG, Smiley-Jewell SM, Miller LA, Fanucchi MV, Evans MJ, Buckpitt AR, Avdalovic M, Gershwin LJ, Joad JP, Kajekar R, Larson S, Pinkerton KE, Van Winkle LS, Schelegle ES, Pieczarka EM, Wu R, Hyde DM.

Toxicol Pathol. 2007 Jan;35(1):97-110.


Time course of ozone-induced changes in breathing pattern in healthy exercising humans.

Schelegle ES, Walby WF, Adams WC.

J Appl Physiol (1985). 2007 Feb;102(2):688-97. Epub 2006 Nov 2.


Influence of pirfenidone on airway hyperresponsiveness and inflammation in a Brown-Norway rat model of asthma.

Mansoor JK, Decile KC, Giri SN, Pinkerton KE, Walby WF, Bratt JM, Grewal H, Margolin SB, Schelegle ES.

Pulm Pharmacol Ther. 2007;20(6):660-8. Epub 2006 Sep 15.


Vascular remodeling is airway generation-specific in a primate model of chronic asthma.

Avdalovic MV, Putney LF, Schelegle ES, Miller L, Usachenko JL, Tyler NK, Plopper CG, Gershwin LJ, Hyde DM.

Am J Respir Crit Care Med. 2006 Nov 15;174(10):1069-76. Epub 2006 Aug 24.


Cyclic exposure to ozone alters distal airway development in infant rhesus monkeys.

Fanucchi MV, Plopper CG, Evans MJ, Hyde DM, Van Winkle LS, Gershwin LJ, Schelegle ES.

Am J Physiol Lung Cell Mol Physiol. 2006 Oct;291(4):L644-50. Epub 2006 Apr 28.


Early postnatal exposure to allergen and ozone leads to hyperinnervation of the pulmonary epithelium.

Kajekar R, Pieczarka EM, Smiley-Jewell SM, Schelegle ES, Fanucchi MV, Plopper CG.

Respir Physiol Neurobiol. 2007 Jan 15;155(1):55-63. Epub 2006 Apr 17.


Deep-breath frequency in bronchoconstricted monkeys (Macaca fascicularis).

Dybas JM, Andresen CJ, Schelegle ES, McCue RW, Callender NN, Jackson AC.

J Appl Physiol (1985). 2006 Mar;100(3):786-91.


Structural and functional localization of airway effects from episodic exposure of infant monkeys to allergen and/or ozone.

Joad JP, Kott KS, Bric JM, Peake JL, Plopper CG, Schelegle ES, Gershwin LJ, Pinkerton KE.

Toxicol Appl Pharmacol. 2006 Aug 1;214(3):237-43. Epub 2006 Feb 7.


L-arginine supplementation enhances exhaled NO, breath condensate VEGF, and headache at 4,342 m.

Mansoor JK, Morrissey BM, Walby WF, Yoneda KY, Juarez M, Kajekar R, Severinghaus JW, Eldridge MW, Schelegle ES.

High Alt Med Biol. 2005 Winter;6(4):289-300.


Rush immunotherapy in an experimental model of feline allergic asthma.

Reinero CR, Byerly JR, Berghaus RD, Berghaus LJ, Schelegle ES, Hyde DM, Gershwin LJ.

Vet Immunol Immunopathol. 2006 Mar 15;110(1-2):141-53. Epub 2005 Dec 2.


Effects of drug treatment on inflammation and hyperreactivity of airways and on immune variables in cats with experimentally induced asthma.

Reinero CR, Decile KC, Byerly JR, Berghaus RD, Walby WE, Berghaus LJ, Hyde DM, Schelegle ES, Gershwin LJ.

Am J Vet Res. 2005 Jul;66(7):1121-7.


Airway generation-specific differences in the spatial distribution of immune cells and cytokines in allergen-challenged rhesus monkeys.

Miller LA, Hurst SD, Coffman RL, Tyler NK, Stovall MY, Chou DL, Putney LF, Gershwin LJ, Schelegle ES, Plopper CG, Hyde DM.

Clin Exp Allergy. 2005 Jul;35(7):894-906.


Chronic aeroallergen during infancy enhances eotaxin-3 expression in airway epithelium and nerves.

Chou DL, Daugherty BL, McKenna EK, Hsu WM, Tyler NK, Plopper CG, Hyde DM, Schelegle ES, Gershwin LJ, Miller LA.

Am J Respir Cell Mol Biol. 2005 Jul;33(1):1-8. Epub 2005 Apr 15.


Smooth muscle hypertrophy in distal airways of sensitized infant rhesus monkeys exposed to house dust mite allergen.

Tran MU, Weir AJ, Fanucchi MV, Rodriguez AE, Pantle LM, Smiley-Jewell SM, Van Winkle LS, Evans MJ, Miller LA, Schelegle ES, Gershwin LJ, Hyde DM, Plopper CG.

Clin Exp Allergy. 2004 Oct;34(10):1627-33.


Smooth muscle development during postnatal growth of distal bronchioles in infant rhesus monkeys.

Tran MU, Weir AJ, Fanucchi MV, Murphy AE, Van Winkle LS, Evans MJ, Smiley-Jewell SM, Miller L, Schelegle ES, Gershwin LJ, Hyde DM, Plopper CG.

J Appl Physiol (1985). 2004 Dec;97(6):2364-71; discussion 2354. Epub 2004 Sep 3.


An experimental model of allergic asthma in cats sensitized to house dust mite or bermuda grass allergen.

Norris Reinero CR, Decile KC, Berghaus RD, Williams KJ, Leutenegger CM, Walby WF, Schelegle ES, Hyde DM, Gershwin LJ.

Int Arch Allergy Immunol. 2004 Oct;135(2):117-31. Epub 2004 Sep 2.


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