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Items: 47

1.

A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism.

Pradas-Juni M, Hansmeier NR, Link JC, Schmidt E, Larsen BD, Klemm P, Meola N, Topel H, Loureiro R, Dhaouadi I, Kiefer CA, Schwarzer R, Khani S, Oliverio M, Awazawa M, Frommolt P, Heeren J, Scheja L, Heine M, Dieterich C, Büning H, Yang L, Cao H, Jesus DF, Kulkarni RN, Zevnik B, Tröder SE, Knippschild U, Edwards PA, Lee RG, Yamamoto M, Ulitsky I, Fernandez-Rebollo E, Vallim TQA, Kornfeld JW.

Nat Commun. 2020 Jan 31;11(1):644. doi: 10.1038/s41467-020-14323-y.

2.

The endocrine function of adipose tissues in health and cardiometabolic disease.

Scheja L, Heeren J.

Nat Rev Endocrinol. 2019 Sep;15(9):507-524. doi: 10.1038/s41574-019-0230-6. Epub 2019 Jul 11. Review.

PMID:
31296970
3.

PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles.

Fischer AW, Albers K, Schlein C, Sass F, Krott LM, Schmale H, Gordts PLSM, Scheja L, Heeren J.

Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1592-1603. doi: 10.1016/j.bbadis.2019.03.010. Epub 2019 Mar 21.

PMID:
30904610
4.

Development of the Metabolic Syndrome: Study Design and Baseline Data of the Lufthansa Prevention Study (LUPS), A Prospective Observational Cohort Survey.

Müller-Wieland D, Altenburg C, Becher H, Burchard J, Frisch A, Gebhard J, Haas J, Harth V, Heeren J, Hengelbrock J, von Karais M, Knebel B, Kotzka J, Löwe B, Marx N, Pinnschmidt H, Preisser A, Rose M, Sawitzky-Rose B, Scheja L, Terschüren C, Töller M, Vettorazzi E, Wegscheider K.

Exp Clin Endocrinol Diabetes. 2018 Nov 26. doi: 10.1055/a-0767-6361. [Epub ahead of print]

PMID:
30477037
5.

The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins.

Fischer AW, Albers K, Krott LM, Hoffzimmer B, Heine M, Schmale H, Scheja L, Gordts PLSM, Heeren J.

Mol Metab. 2018 Oct;16:88-99. doi: 10.1016/j.molmet.2018.07.010. Epub 2018 Jul 30.

6.

Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice.

Heine M, Fischer AW, Schlein C, Jung C, Straub LG, Gottschling K, Mangels N, Yuan Y, Nilsson SK, Liebscher G, Chen O, Schreiber R, Zechner R, Scheja L, Heeren J.

Cell Metab. 2018 Oct 2;28(4):644-655.e4. doi: 10.1016/j.cmet.2018.06.020. Epub 2018 Jul 19.

7.

Brown adipose tissue and lipid metabolism.

Heeren J, Scheja L.

Curr Opin Lipidol. 2018 Jun;29(3):180-185. doi: 10.1097/MOL.0000000000000504. Review.

PMID:
29718003
8.

Comparison of Fatty Acid and Gene Profiles in Skeletal Muscle in Normal and Obese C57BL/6J Mice before and after Blunt Muscle Injury.

Werner JU, Tödter K, Xu P, Lockhart L, Jähnert M, Gottmann P, Schürmann A, Scheja L, Wabitsch M, Knippschild U.

Front Physiol. 2018 Jan 30;9:19. doi: 10.3389/fphys.2018.00019. eCollection 2018.

9.

Introduction to the special issue on dietary control of immunometabolism.

Scheja L, Heeren J.

Semin Immunopathol. 2018 Feb;40(2):141-144. doi: 10.1007/s00281-017-0667-4. Epub 2017 Dec 8. No abstract available.

PMID:
29222582
10.

Regulation of immunometabolism in adipose tissue.

Kumari M, Heeren J, Scheja L.

Semin Immunopathol. 2018 Feb;40(2):189-202. doi: 10.1007/s00281-017-0668-3. Epub 2017 Dec 5. Review.

PMID:
29209828
11.

Quantification of Bone Fatty Acid Metabolism and Its Regulation by Adipocyte Lipoprotein Lipase.

Bartelt A, Koehne T, Tödter K, Reimer R, Müller B, Behler-Janbeck F, Heeren J, Scheja L, Niemeier A.

Int J Mol Sci. 2017 Jun 13;18(6). pii: E1264. doi: 10.3390/ijms18061264.

12.

Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis.

Worthmann A, John C, Rühlemann MC, Baguhl M, Heinsen FA, Schaltenberg N, Heine M, Schlein C, Evangelakos I, Mineo C, Fischer M, Dandri M, Kremoser C, Scheja L, Franke A, Shaul PW, Heeren J.

Nat Med. 2017 Jul;23(7):839-849. doi: 10.1038/nm.4357. Epub 2017 Jun 12.

PMID:
28604703
13.

Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport.

Bartelt A, John C, Schaltenberg N, Berbée JFP, Worthmann A, Cherradi ML, Schlein C, Piepenburg J, Boon MR, Rinninger F, Heine M, Toedter K, Niemeier A, Nilsson SK, Fischer M, Wijers SL, van Marken Lichtenbelt W, Scheja L, Rensen PCN, Heeren J.

Nat Commun. 2017 Apr 19;8:15010. doi: 10.1038/ncomms15010.

14.

An extended fatty liver index to predict non-alcoholic fatty liver disease.

Kantartzis K, Rettig I, Staiger H, Machann J, Schick F, Scheja L, Gastaldelli A, Bugianesi E, Peter A, Schulze MB, Fritsche A, Häring HU, Stefan N.

Diabetes Metab. 2017 Jun;43(3):229-239. doi: 10.1016/j.diabet.2016.11.006. Epub 2017 Jan 12.

15.

Novel Mouse Models of Methylmalonic Aciduria Recapitulate Phenotypic Traits with a Genetic Dosage Effect.

Forny P, Schumann A, Mustedanagic M, Mathis D, Wulf MA, Nägele N, Langhans CD, Zhakupova A, Heeren J, Scheja L, Fingerhut R, Peters HL, Hornemann T, Thony B, Kölker S, Burda P, Froese DS, Devuyst O, Baumgartner MR.

J Biol Chem. 2016 Sep 23;291(39):20563-73. doi: 10.1074/jbc.M116.747717. Epub 2016 Aug 12.

16.

Insulin Regulates Hepatic Triglyceride Secretion and Lipid Content via Signaling in the Brain.

Scherer T, Lindtner C, O'Hare J, Hackl M, Zielinski E, Freudenthaler A, Baumgartner-Parzer S, Tödter K, Heeren J, Krššák M, Scheja L, Fürnsinn C, Buettner C.

Diabetes. 2016 Jun;65(6):1511-20. doi: 10.2337/db15-1552. Epub 2016 Feb 9.

17.

FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues.

Schlein C, Talukdar S, Heine M, Fischer AW, Krott LM, Nilsson SK, Brenner MB, Heeren J, Scheja L.

Cell Metab. 2016 Mar 8;23(3):441-53. doi: 10.1016/j.cmet.2016.01.006. Epub 2016 Feb 4.

18.

Metabolic interplay between white, beige, brown adipocytes and the liver.

Scheja L, Heeren J.

J Hepatol. 2016 May;64(5):1176-1186. doi: 10.1016/j.jhep.2016.01.025. Epub 2016 Jan 30. Review.

PMID:
26829204
19.

Endocannabinoid regulation in white and brown adipose tissue following thermogenic activation.

Krott LM, Piscitelli F, Heine M, Borrino S, Scheja L, Silvestri C, Heeren J, Di Marzo V.

J Lipid Res. 2016 Mar;57(3):464-73. doi: 10.1194/jlr.M065227. Epub 2016 Jan 14.

20.

Diabetes prevalence in NZO females depends on estrogen action on liver fat content.

Lubura M, Hesse D, Kraemer M, Hallahan N, Schupp M, von Löffelholz C, Kriebel J, Rudovich N, Pfeiffer A, John C, Scheja L, Heeren J, Koliaki C, Roden M, Schürmann A.

Am J Physiol Endocrinol Metab. 2015 Dec 15;309(12):E968-80. doi: 10.1152/ajpendo.00338.2015. Epub 2015 Oct 20.

21.

Prevalence of non-alcoholic fatty liver disease in four different weight related patient groups: association with small bowel length and risk factors.

Hillenbrand A, Kiebler B, Schwab C, Scheja L, Xu P, Henne-Bruns D, Wolf AM, Knippschild U.

BMC Res Notes. 2015 Jul 3;8:290. doi: 10.1186/s13104-015-1224-7.

22.

Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue.

Hoffmann LS, Etzrodt J, Willkomm L, Sanyal A, Scheja L, Fischer AWC, Stasch JP, Bloch W, Friebe A, Heeren J, Pfeifer A.

Nat Commun. 2015 May 26;6:7235. doi: 10.1038/ncomms8235.

23.

Utilizing immunoaffinity chromatography (IAC) cross-reactivity in GC-MS/MS exemplified at the measurement of prostaglandin E1 in human plasma using prostaglandin E2-specific IAC columns.

Tsikas D, Suchy MT, Tödter K, Heeren J, Scheja L.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 May 15;1021:101-107. doi: 10.1016/j.jchromb.2015.04.026. Epub 2015 Apr 23.

PMID:
25944643
24.

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development.

Berbée JF, Boon MR, Khedoe PP, Bartelt A, Schlein C, Worthmann A, Kooijman S, Hoeke G, Mol IM, John C, Jung C, Vazirpanah N, Brouwers LP, Gordts PL, Esko JD, Hiemstra PS, Havekes LM, Scheja L, Heeren J, Rensen PC.

Nat Commun. 2015 Mar 10;6:6356. doi: 10.1038/ncomms7356.

25.

Determining the association between adipokine expression in multiple tissues and phenotypic features of non-alcoholic fatty liver disease in obesity.

Wolfs MG, Gruben N, Rensen SS, Verdam FJ, Greve JW, Driessen A, Wijmenga C, Buurman WA, Franke L, Scheja L, Koonen DP, Shiri-Sverdlov R, van Haeften TW, Hofker MH, Fu J.

Nutr Diabetes. 2015 Feb 9;5:e146. doi: 10.1038/nutd.2014.43.

26.

Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice.

Baumeier C, Kaiser D, Heeren J, Scheja L, John C, Weise C, Eravci M, Lagerpusch M, Schulze G, Joost HG, Schwenk RW, Schürmann A.

Biochim Biophys Acta. 2015 May;1851(5):566-76. doi: 10.1016/j.bbalip.2015.01.013. Epub 2015 Jan 31.

27.

A liquid chromatography-tandem mass spectrometry-based method for the simultaneous determination of hydroxy sterols and bile acids.

John C, Werner P, Worthmann A, Wegner K, Tödter K, Scheja L, Rohn S, Heeren J, Fischer M.

J Chromatogr A. 2014 Dec 5;1371:184-95. doi: 10.1016/j.chroma.2014.10.064. Epub 2014 Oct 29.

PMID:
25456597
28.

Arginine and NASH--do macrophages deliver the first hit?

Scheja L, Kluwe J.

J Hepatol. 2015 Feb;62(2):260-1. doi: 10.1016/j.jhep.2014.11.001. Epub 2014 Nov 8. No abstract available.

29.

Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.

Shin AC, Fasshauer M, Filatova N, Grundell LA, Zielinski E, Zhou JY, Scherer T, Lindtner C, White PJ, Lapworth AL, Ilkayeva O, Knippschild U, Wolf AM, Scheja L, Grove KL, Smith RD, Qian WJ, Lynch CJ, Newgard CB, Buettner C.

Cell Metab. 2014 Nov 4;20(5):898-909. doi: 10.1016/j.cmet.2014.09.003. Epub 2014 Oct 9.

30.

The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver.

Heine M, Bartelt A, Bruns OT, Bargheer D, Giemsa A, Freund B, Scheja L, Waurisch C, Eychmüller A, Reimer R, Weller H, Nielsen P, Heeren J.

Beilstein J Nanotechnol. 2014 Sep 2;5:1432-1440. doi: 10.3762/bjnano.5.155. eCollection 2014.

31.

Dichloroacetate prevents restenosis in preclinical animal models of vessel injury.

Deuse T, Hua X, Wang D, Maegdefessel L, Heeren J, Scheja L, Bolaños JP, Rakovic A, Spin JM, Stubbendorff M, Ikeno F, Länger F, Zeller T, Schulte-Uentrop L, Stoehr A, Itagaki R, Haddad F, Eschenhagen T, Blankenberg S, Kiefmann R, Reichenspurner H, Velden J, Klein C, Yeung A, Robbins RC, Tsao PS, Schrepfer S.

Nature. 2014 May 29;509(7502):641-4. doi: 10.1038/nature13232. Epub 2014 Apr 20.

32.

De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health.

Eissing L, Scherer T, Tödter K, Knippschild U, Greve JW, Buurman WA, Pinnschmidt HO, Rensen SS, Wolf AM, Bartelt A, Heeren J, Buettner C, Scheja L.

Nat Commun. 2013;4:1528. doi: 10.1038/ncomms2537.

33.

Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b.

Kornfeld JW, Baitzel C, Könner AC, Nicholls HT, Vogt MC, Herrmanns K, Scheja L, Haumaitre C, Wolf AM, Knippschild U, Seibler J, Cereghini S, Heeren J, Stoffel M, Brüning JC.

Nature. 2013 Feb 7;494(7435):111-5. doi: 10.1038/nature11793.

PMID:
23389544
34.

Effects of adipocyte lipoprotein lipase on de novo lipogenesis and white adipose tissue browning.

Bartelt A, Weigelt C, Cherradi ML, Niemeier A, Tödter K, Heeren J, Scheja L.

Biochim Biophys Acta. 2013 May;1831(5):934-42. doi: 10.1016/j.bbalip.2012.11.011. Epub 2012 Dec 8.

PMID:
23228690
35.

Platelet lysate suppresses the expression of lipocalin-type prostaglandin D2 synthase that positively controls adipogenic differentiation of human mesenchymal stromal cells.

Lange C, Brunswig-Spickenheier B, Eissing L, Scheja L.

Exp Cell Res. 2012 Nov 1;318(18):2284-96. doi: 10.1016/j.yexcr.2012.06.004. Epub 2012 Jun 12.

PMID:
22698646
36.

Altered endocannabinoid signalling after a high-fat diet in Apoe(-/-) mice: relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance.

Bartelt A, Orlando P, Mele C, Ligresti A, Toedter K, Scheja L, Heeren J, Di Marzo V.

Diabetologia. 2011 Nov;54(11):2900-10. doi: 10.1007/s00125-011-2274-6. Epub 2011 Aug 17.

PMID:
21847582
37.

Plasma triglycerides after oral glucose load specifically associate with metabolic risk markers in healthy type 2 diabetes offspring.

Vossen M, Tödter K, Altenburg C, Beisiegel U, Scheja L.

Atherosclerosis. 2011 Jul;217(1):214-9. doi: 10.1016/j.atherosclerosis.2011.03.013. Epub 2011 Mar 15.

PMID:
21474138
38.

Beneficial effects of IKKε-deficiency on body weight and insulin sensitivity are lost in high fat diet-induced obesity in mice.

Scheja L, Heese B, Seedorf K.

Biochem Biophys Res Commun. 2011 Apr 8;407(2):288-94. doi: 10.1016/j.bbrc.2011.02.137. Epub 2011 Mar 1.

PMID:
21371440
39.

Brain insulin controls adipose tissue lipolysis and lipogenesis.

Scherer T, O'Hare J, Diggs-Andrews K, Schweiger M, Cheng B, Lindtner C, Zielinski E, Vempati P, Su K, Dighe S, Milsom T, Puchowicz M, Scheja L, Zechner R, Fisher SJ, Previs SF, Buettner C.

Cell Metab. 2011 Feb 2;13(2):183-94. doi: 10.1016/j.cmet.2011.01.008.

40.

Liver TAG transiently decreases while PL n-3 and n-6 fatty acids are persistently elevated in insulin resistant mice.

Scheja L, Toedter K, Mohr R, Niederfellner G, Michael MD, Meissner A, Schoettler A, Pospisil H, Beisiegel U, Heeren J.

Lipids. 2008 Nov;43(11):1039-51. doi: 10.1007/s11745-008-3220-3. Epub 2008 Sep 2.

PMID:
18763007
41.

Acute-phase serum amyloid A as a marker of insulin resistance in mice.

Scheja L, Heese B, Zitzer H, Michael MD, Siesky AM, Pospisil H, Beisiegel U, Seedorf K.

Exp Diabetes Res. 2008;2008:230837. doi: 10.1155/2008/230837.

42.

Identification of a cis-acting element and a novel trans-acting factor of the glutamine synthetase gene in liver cells.

Gaunitz F, Weber S, Scheja L, Gebhardt R.

Biochem Biophys Res Commun. 2001 Jun 8;284(2):377-83.

PMID:
11394889
43.

Improved glucose and lipid metabolism in genetically obese mice lacking aP2.

Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GS.

Endocrinology. 2000 Sep;141(9):3388-96.

PMID:
10965911
44.

Characterisation of receptor-specific TNFalpha functions in adipocyte cell lines lacking type 1 and 2 TNF receptors.

Sethi JK, Xu H, Uysal KT, Wiesbrock SM, Scheja L, Hotamisligil GS.

FEBS Lett. 2000 Mar 3;469(1):77-82.

45.

Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice.

Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek DR, Meyers DS, Morgan M, Parker RA, Hotamisligil GS.

Diabetes. 1999 Oct;48(10):1987-94.

PMID:
10512363
46.

Treatment of cirrhotic rats with L-ornithine-L-aspartate enhances urea synthesis and lowers serum ammonia levels.

Gebhardt R, Beckers G, Gaunitz F, Haupt W, Jonitza D, Klein S, Scheja L.

J Pharmacol Exp Ther. 1997 Oct;283(1):1-6.

PMID:
9336301
47.

Heterogeneous expression of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase genes in the rat liver lobulus.

Twisk J, Hoekman MF, Mager WH, Moorman AF, de Boer PA, Scheja L, Princen HM, Gebhardt R.

J Clin Invest. 1995 Mar;95(3):1235-43.

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