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Items: 11


Scc2 counteracts a Wapl-independent mechanism that releases cohesin from chromosomes during G1.

Srinivasan M, Petela NJ, Scheinost JC, Collier J, Voulgaris M, B Roig M, Beckouët F, Hu B, Nasmyth KA.

Elife. 2019 Jun 21;8. pii: e44736. doi: 10.7554/eLife.44736.


Sister DNA Entrapment between Juxtaposed Smc Heads and Kleisin of the Cohesin Complex.

Chapard C, Jones R, van Oepen T, Scheinost JC, Nasmyth K.

Mol Cell. 2019 Jul 25;75(2):224-237.e5. doi: 10.1016/j.molcel.2019.05.023. Epub 2019 Jun 11.


The Cohesin Ring Uses Its Hinge to Organize DNA Using Non-topological as well as Topological Mechanisms.

Srinivasan M, Scheinost JC, Petela NJ, Gligoris TG, Wissler M, Ogushi S, Collier JE, Voulgaris M, Kurze A, Chan KL, Hu B, Costanzo V, Nasmyth KA.

Cell. 2018 May 31;173(6):1508-1519.e18. doi: 10.1016/j.cell.2018.04.015. Epub 2018 May 10.


Structurally Guided In Vivo Crosslinking.

Scheinost JC, Gligoris TG.

Methods Mol Biol. 2018;1764:123-132. doi: 10.1007/978-1-4939-7759-8_8.


Releasing Activity Disengages Cohesin's Smc3/Scc1 Interface in a Process Blocked by Acetylation.

Beckouët F, Srinivasan M, Roig MB, Chan KL, Scheinost JC, Batty P, Hu B, Petela N, Gligoris T, Smith AC, Strmecki L, Rowland BD, Nasmyth K.

Mol Cell. 2016 Feb 18;61(4):563-574. doi: 10.1016/j.molcel.2016.01.026.


Closing the cohesin ring: structure and function of its Smc3-kleisin interface.

Gligoris TG, Scheinost JC, Bürmann F, Petela N, Chan KL, Uluocak P, Beckouët F, Gruber S, Nasmyth K, Löwe J.

Science. 2014 Nov 21;346(6212):963-7. doi: 10.1126/science.1256917.


The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein.

Whitfield T, Miles AJ, Scheinost JC, Offer J, Wentworth P Jr, Dwek RA, Wallace BA, Biggin PC, Zitzmann N.

Mol Membr Biol. 2011 Aug;28(5):254-64. doi: 10.3109/09687688.2011.581253. Epub 2011 May 23.


Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope.

Cygan NK, Scheinost JC, Butters TD, Wentworth P Jr.

Biochemistry. 2011 Mar 29;50(12):2092-100. doi: 10.1021/bi200109q. Epub 2011 Feb 28.


Cholesterol secosterol adduction inhibits the misfolding of a mutant prion protein fragment that induces neurodegeneration.

Scheinost JC, Witter DP, Boldt GE, Offer J, Wentworth P Jr.

Angew Chem Int Ed Engl. 2009;48(50):9469-72. doi: 10.1002/anie.200904524. No abstract available.


Cholesterol seco-sterol-induced aggregation of methylated amyloid-beta peptides--insights into aldehyde-initiated fibrillization of amyloid-beta.

Scheinost JC, Wang H, Boldt GE, Offer J, Wentworth P Jr.

Angew Chem Int Ed Engl. 2008;47(21):3919-22. doi: 10.1002/anie.200705922. No abstract available.


Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.

Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, Schofield CJ, Oppermann U.

Nature. 2007 Jul 5;448(7149):87-91. Epub 2007 Jun 24.


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