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Activity of eltrombopag in severe aplastic anemia.

Scheinberg P.

Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):450-456. doi: 10.1182/asheducation-2018.1.450. Review.


Activity of eltrombopag in severe aplastic anemia.

Scheinberg P.

Blood Adv. 2018 Nov 13;2(21):3054-3062. doi: 10.1182/bloodadvances.2018020248. Review.


Recent Advances and Long-Term Results of Medical Treatment of Acquired Aplastic Anemia: Are Patients Cured?

Scheinberg P.

Hematol Oncol Clin North Am. 2018 Aug;32(4):609-618. doi: 10.1016/j.hoc.2018.03.003. Epub 2018 May 18. Review.


Rabbit antithymocyte globulin dose does not affect response or survival as first-line therapy for acquired aplastic anemia: a multicenter retrospective study.

Clé DV, Atta EH, Dias DSP, Lima CBL, Bonduel M, Sciuccati G, Medeiros LA, de Oliveira MM, Blum Fonseca PB, Saad STO, Hamerschlak N, Salvino MA, Garanito MP, Pazin-Filho A, Scheinberg P, Calado RT.

Ann Hematol. 2018 Nov;97(11):2039-2046. doi: 10.1007/s00277-018-3416-4. Epub 2018 Jul 5.


Predictors of early mortality after rabbit antithymocyte globulin as first-line treatment in severe aplastic anemia.

Atta EH, Lima CBL, Dias DSP, Clé DV, Bonduel MM, Sciuccati GB, Medeiros LA, Oliveira MM, Salvino MA, Garanito MP, Blum Fonseca PB, Saad STO, Calado RT, Scheinberg P.

Ann Hematol. 2017 Nov;96(11):1907-1914. doi: 10.1007/s00277-017-3086-7. Epub 2017 Aug 16.


Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia.

Townsley DM, Scheinberg P, Winkler T, Desmond R, Dumitriu B, Rios O, Weinstein B, Valdez J, Lotter J, Feng X, Desierto M, Leuva H, Bevans M, Wu C, Larochelle A, Calvo KR, Dunbar CE, Young NS.

N Engl J Med. 2017 Apr 20;376(16):1540-1550. doi: 10.1056/NEJMoa1613878.


A plasma microRNA signature as a biomarker for acquired aplastic anemia.

Hosokawa K, Kajigaya S, Feng X, Desierto MJ, Fernandez Ibanez MD, Rios O, Weinstein B, Scheinberg P, Townsley DM, Young NS.

Haematologica. 2017 Jan;102(1):69-78. doi: 10.3324/haematol.2016.151076. Epub 2016 Sep 22.


How deep can you go into Tregs?

Scheinberg P.

Blood. 2016 Sep 1;128(9):1158-9. doi: 10.1182/blood-2016-07-722439. No abstract available.


Danazol Treatment for Telomere Diseases.

Townsley DM, Dumitriu B, Liu D, Biancotto A, Weinstein B, Chen C, Hardy N, Mihalek AD, Lingala S, Kim YJ, Yao J, Jones E, Gochuico BR, Heller T, Wu CO, Calado RT, Scheinberg P, Young NS.

N Engl J Med. 2016 May 19;374(20):1922-31. doi: 10.1056/NEJMoa1515319.


Alemtuzumab in T-cell large granular lymphocytic leukaemia: interim results from a single-arm, open-label, phase 2 study.

Dumitriu B, Ito S, Feng X, Stephens N, Yunce M, Kajigaya S, Melenhorst JJ, Rios O, Scheinberg P, Chinian F, Keyvanfar K, Battiwalla M, Wu CO, Maric I, Xi L, Raffeld M, Muranski P, Townsley DM, Young NS, Barrett AJ, Scheinberg P.

Lancet Haematol. 2016 Jan;3(1):e22-9. doi: 10.1016/S2352-3026(15)00227-6. Epub 2015 Dec 17.


Hematopoietic stem cell transplantation for cutaneous T-cell lymphoma: Summary of 11 cases from two facilities in Japan and Brazil.

Oka T, Sugaya M, Cury-Martins J, Vasconcelos-Berg R, Suga H, Miyagaki T, Scheinberg P, Fujita H, Izutsu K, Sato S, Sanches JA.

J Dermatol. 2016 Jun;43(6):638-42. doi: 10.1111/1346-8138.13199. Epub 2015 Nov 25.


Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.

Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S.

N Engl J Med. 2015 Jul 2;373(1):35-47. doi: 10.1056/NEJMoa1414799.


Answer to "Confounding effect of cyclosporine dosing when comparing horse and rabbit antithymocyte globulin in patients with severe aplastic anemia".

Feng X, Scheinberg P, Young NS.

Haematologica. 2015 May;100(5):e213. doi: 10.3324/haematol.2015.124446. No abstract available.


CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo.

Hanley PJ, Melenhorst JJ, Nikiforow S, Scheinberg P, Blaney JW, Demmler-Harrison G, Cruz CR, Lam S, Krance RA, Leung KS, Martinez CA, Liu H, Douek DC, Heslop HE, Rooney CM, Shpall EJ, Barrett AJ, Rodgers JR, Bollard CM.

Sci Transl Med. 2015 Apr 29;7(285):285ra63. doi: 10.1126/scitranslmed.aaa2546. Erratum in: Sci Transl Med. 2016 Jan 13;8(321):321er1.


Repeat course of rabbit antithymocyte globulin as salvage following initial therapy with rabbit antithymocyte globulin in acquired aplastic anemia.

Clé DV, Atta EH, Dias DS, Lima CB, Bonduel M, Sciuccati G, Medeiros LA, de Oliveira MM, Salvino MA, Garanito M, Saad ST, Calado RT, Scheinberg P.

Haematologica. 2015 Sep;100(9):e345-7. doi: 10.3324/haematol.2015.123760. Epub 2015 Apr 10. No abstract available.


CT screening for lung cancer: value of expert review of initial baseline screenings.

Xu DM, Lee IJ, Zhao S, Rowena Y, Farooqi A, Cheung EH, Connery CP, Frumiento C, Glassberg RM, Herzog G, Peeke J, Scheinberg P, Shah P, Taylor J, Welch L, Widmann M, Yoder M, Yankelevitz DF, Henschke CI.

AJR Am J Roentgenol. 2015 Feb;204(2):281-6. doi: 10.2214/AJR.14.12526. Epub 2014 Oct 28.


Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4.

Kuehn HS, Ouyang W, Lo B, Deenick EK, Niemela JE, Avery DT, Schickel JN, Tran DQ, Stoddard J, Zhang Y, Frucht DM, Dumitriu B, Scheinberg P, Folio LR, Frein CA, Price S, Koh C, Heller T, Seroogy CM, Huttenlocher A, Rao VK, Su HC, Kleiner D, Notarangelo LD, Rampertaap Y, Olivier KN, McElwee J, Hughes J, Pittaluga S, Oliveira JB, Meffre E, Fleisher TA, Holland SM, Lenardo MJ, Tangye SG, Uzel G.

Science. 2014 Sep 26;345(6204):1623-1627. doi: 10.1126/science.1255904. Epub 2014 Sep 11.


Moderate-dose cyclophosphamide for severe aplastic anemia has significant toxicity and does not prevent relapse and clonal evolution.

Scheinberg P, Townsley D, Dumitriu B, Scheinberg P, Weinstein B, Daphtary M, Rios O, Wu CO, Young NS.

Blood. 2014 Oct 30;124(18):2820-3. doi: 10.1182/blood-2014-05-573642. Epub 2014 Sep 3.


Prolonged cyclosporine administration after antithymocyte globulin delays but does not prevent relapse in severe aplastic anemia.

Scheinberg P, Rios O, Scheinberg P, Weinstein B, Wu CO, Young NS.

Am J Hematol. 2014 Jun;89(6):571-4.


In vivo effects of horse and rabbit antithymocyte globulin in patients with severe aplastic anemia.

Feng X, Scheinberg P, Biancotto A, Rios O, Donaldson S, Wu C, Zheng H, Sato K, Townsley DM, McCoy JP, Young NS.

Haematologica. 2014 Sep;99(9):1433-40. doi: 10.3324/haematol.2014.106542. Epub 2014 Jun 6.


Outcome of children with severe acquired aplastic anemia treated with rabbit antithymocyte globulin and cyclosporine A.

Garanito MP, Carneiro JD, Odone Filho V, Scheinberg P.

J Pediatr (Rio J). 2014 Sep-Oct;90(5):523-7. doi: 10.1016/j.jped.2014.02.004. Epub 2014 May 27.


Long-term outcome of fludarabine-based reduced-intensity allogeneic hematopoietic cell transplantation for debilitating paroxysmal nocturnal hemoglobinuria.

Pantin J, Tian X, Geller N, Ramos C, Cook L, Cho E, Scheinberg P, Vasu S, Khuu H, Stroncek D, Barrett J, Young NS, Donohue T, Childs RW.

Biol Blood Marrow Transplant. 2014 Sep;20(9):1435-9. doi: 10.1016/j.bbmt.2014.05.012. Epub 2014 May 17.


Successful platelet count recovery in lupus-associated thrombocytopenia with the thrombopoietin agonist eltrombopag.

Scheinberg P, Singulane CC, Barbosa LS, Scheinberg M.

Clin Rheumatol. 2014 Sep;33(9):1347-9. doi: 10.1007/s10067-014-2600-8. Epub 2014 Apr 17.


Horse antithymocyte globulin as salvage therapy after rabbit antithymocyte globulin for severe aplastic anemia.

Scheinberg P, Townsley D, Dumitriu B, Scheinberg P, Weinstein B, Rios O, Wu CO, Young NS.

Am J Hematol. 2014 May;89(5):467-9. doi: 10.1002/ajh.23669. Epub 2014 Mar 7.


Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug.

Desmond R, Townsley DM, Dumitriu B, Olnes MJ, Scheinberg P, Bevans M, Parikh AR, Broder K, Calvo KR, Wu CO, Young NS, Dunbar CE.

Blood. 2014 Mar 20;123(12):1818-25. doi: 10.1182/blood-2013-10-534743. Epub 2013 Dec 17.


Aplastic anemia: what have we learned from animal models and from the clinic.

Scheinberg P, Chen J.

Semin Hematol. 2013 Apr;50(2):156-64. doi: 10.1053/j.seminhematol.2013.03.028. Epub 2013 Jun 11. Review.


Mesenchymal stromal cells: filling the void of immunosuppressive therapy in aplastic anemia?

Scheinberg P.

Cytotherapy. 2013 Jul;15(7):751-2. doi: 10.1016/j.jcyt.2013.05.010. No abstract available.


Prognostic value of telomere attrition in patients with aplastic anemia.

Scheinberg P.

Int J Hematol. 2013 May;97(5):553-7. doi: 10.1007/s12185-013-1332-x. Epub 2013 May 1. Review.


Thymus transplantation restores the repertoires of forkhead box protein 3 (FoxP3)+ and FoxP3- T cells in complete DiGeorge anomaly.

Chinn IK, Milner JD, Scheinberg P, Douek DC, Markert ML.

Clin Exp Immunol. 2013 Jul;173(1):140-9. doi: 10.1111/cei.12088.


Aplastic anemia: therapeutic updates in immunosuppression and transplantation.

Scheinberg P.

Hematology Am Soc Hematol Educ Program. 2012;2012:292-300. doi: 10.1182/asheducation-2012.1.292. Review.


Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis.

Lionakis MS, Fischer BG, Lim JK, Swamydas M, Wan W, Richard Lee CC, Cohen JI, Scheinberg P, Gao JL, Murphy PM.

PLoS Pathog. 2012;8(8):e1002865. doi: 10.1371/journal.ppat.1002865. Epub 2012 Aug 16.


Eltrombopag and improved hematopoiesis in refractory aplastic anemia.

Olnes MJ, Scheinberg P, Calvo KR, Desmond R, Tang Y, Dumitriu B, Parikh AR, Soto S, Biancotto A, Feng X, Lozier J, Wu CO, Young NS, Dunbar CE.

N Engl J Med. 2012 Jul 5;367(1):11-9. doi: 10.1056/NEJMoa1200931. Erratum in: N Engl J Med. 2012 Jul 19;367(3):284.


Decreased plasma cytokines are associated with low platelet counts in aplastic anemia and immune thrombocytopenic purpura.

Feng X, Scheinberg P, Samsel L, Rios O, Chen J, McCoy JP Jr, Ghanima W, Bussel JB, Young NS.

J Thromb Haemost. 2012 Aug;10(8):1616-23. doi: 10.1111/j.1538-7836.2012.04757.x.


Directed therapy for patients with myelodysplastic syndromes (MDS) by suppression of cyclin D1 with ON 01910.Na.

Olnes MJ, Shenoy A, Weinstein B, Pfannes L, Loeliger K, Tucker Z, Tian X, Kwak M, Wilhelm F, Yong AS, Maric I, Maniar M, Scheinberg P, Groopman J, Young NS, Sloand EM.

Leuk Res. 2012 Aug;36(8):982-9. doi: 10.1016/j.leukres.2012.04.002. Epub 2012 Apr 21.


How I treat acquired aplastic anemia.

Scheinberg P, Young NS.

Blood. 2012 Aug 9;120(6):1185-96. doi: 10.1182/blood-2011-12-274019. Epub 2012 Apr 19. Review.


Clonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation.

Janbazian L, Price DA, Canderan G, Filali-Mouhim A, Asher TE, Ambrozak DR, Scheinberg P, Boulassel MR, Routy JP, Koup RA, Douek DC, Sekaly RP, Trautmann L.

J Immunol. 2012 Feb 1;188(3):1156-67. doi: 10.4049/jimmunol.1102610. Epub 2011 Dec 30.


Cytopenia and leukocyte recovery shape cytokine fluctuations after myeloablative allogeneic hematopoietic stem cell transplantation.

Melenhorst JJ, Tian X, Xu D, Sandler NG, Scheinberg P, Biancotto A, Scheinberg P, McCoy JP Jr, Hensel NF, McIver Z, Douek DC, Barrett AJ.

Haematologica. 2012 Jun;97(6):867-73. doi: 10.3324/haematol.2011.053363. Epub 2011 Dec 1.


Activity of alemtuzumab monotherapy in treatment-naive, relapsed, and refractory severe acquired aplastic anemia.

Scheinberg P, Nunez O, Weinstein B, Scheinberg P, Wu CO, Young NS.

Blood. 2012 Jan 12;119(2):345-54. doi: 10.1182/blood-2011-05-352328. Epub 2011 Nov 8.


Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia.

Calado RT, Cooper JN, Padilla-Nash HM, Sloand EM, Wu CO, Scheinberg P, Ried T, Young NS.

Leukemia. 2012 Apr;26(4):700-7. doi: 10.1038/leu.2011.272. Epub 2011 Oct 18.


Horse versus rabbit antithymocyte globulin in acquired aplastic anemia.

Scheinberg P, Nunez O, Weinstein B, Scheinberg P, Biancotto A, Wu CO, Young NS.

N Engl J Med. 2011 Aug 4;365(5):430-8. doi: 10.1056/NEJMoa1103975. Erratum in: N Engl J Med. 2018 Jun 13;:null.


Current management of severe acquired aplastic anemia.

Scheinberg P.

Einstein (Sao Paulo). 2011 Jun;9(2):229-35. doi: 10.1590/S1679-45082011RW2156. English, Portuguese.


Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity.

Hippen KL, Merkel SC, Schirm DK, Sieben CM, Sumstad D, Kadidlo DM, McKenna DH, Bromberg JS, Levine BL, Riley JL, June CH, Scheinberg P, Douek DC, Miller JS, Wagner JE, Blazar BR.

Sci Transl Med. 2011 May 18;3(83):83ra41. doi: 10.1126/scitranslmed.3001809.


Decreased infection-related mortality and improved survival in severe aplastic anemia in the past two decades.

Valdez JM, Scheinberg P, Nunez O, Wu CO, Young NS, Walsh TJ.

Clin Infect Dis. 2011 Mar 15;52(6):726-35. doi: 10.1093/cid/ciq245.


Alloreactivity across HLA barriers is mediated by both naïve and antigen-experienced T cells.

Melenhorst JJ, Scheinberg P, Williams A, Ambrozak DR, Keyvanfar K, Smith M, McCoy JP Jr, Hensel NF, Douek DC, Barrett AJ.

Biol Blood Marrow Transplant. 2011 Jun;17(6):800-9. doi: 10.1016/j.bbmt.2010.12.711. Epub 2011 Jan 6.


Cytokine signature profiles in acquired aplastic anemia and myelodysplastic syndromes.

Feng X, Scheinberg P, Wu CO, Samsel L, Nunez O, Prince C, Ganetzky RD, McCoy JP Jr, Maciejewski JP, Young NS.

Haematologica. 2011 Apr;96(4):602-6. doi: 10.3324/haematol.2010.030536. Epub 2010 Dec 15.


T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy.

Sloand EM, Melenhorst JJ, Tucker ZC, Pfannes L, Brenchley JM, Yong A, Visconte V, Wu C, Gostick E, Scheinberg P, Olnes MJ, Douek DC, Price DA, Barrett AJ, Young NS.

Blood. 2011 Mar 3;117(9):2691-9. doi: 10.1182/blood-2010-04-277921. Epub 2010 Nov 19.


Alemtuzumab treatment of intermediate-1 myelodysplasia patients is associated with sustained improvement in blood counts and cytogenetic remissions.

Sloand EM, Olnes MJ, Shenoy A, Weinstein B, Boss C, Loeliger K, Wu CO, More K, Barrett AJ, Scheinberg P, Young NS.

J Clin Oncol. 2010 Dec 10;28(35):5166-73. doi: 10.1200/JCO.2010.29.7010. Epub 2010 Nov 1.


Optimization of therapy for severe aplastic anemia based on clinical, biologic, and treatment response parameters: conclusions of an international working group on severe aplastic anemia convened by the Blood and Marrow Transplant Clinical Trials Network, March 2010.

Pulsipher MA, Young NS, Tolar J, Risitano AM, Deeg HJ, Anderlini P, Calado R, Kojima S, Eapen M, Harris R, Scheinberg P, Savage S, Maciejewski JP, Tiu RV, DiFronzo N, Horowitz MM, Antin JH.

Biol Blood Marrow Transplant. 2011 Mar;17(3):291-9. doi: 10.1016/j.bbmt.2010.10.028. Epub 2010 Oct 27.


Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia.

Scheinberg P, Cooper JN, Sloand EM, Wu CO, Calado RT, Young NS.

JAMA. 2010 Sep 22;304(12):1358-64. doi: 10.1001/jama.2010.1376. Erratum in: JAMA. 2010 Nov 3;304(17):1901.


Posterior segment ophthalmic complications of aplastic anemia.

Agarwal M, Yeh S, Faia LJ, Bishop RJ, Lai MM, Pantin J, Scheinberg P, Chew EY, Weichel ED.

Ophthalmic Surg Lasers Imaging. 2010 Jun 30;41 Online. doi: 10.3928/15428877-20100625-04.


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