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Items: 1 to 50 of 58

1.

Crystal structure of a xylulose 5-phosphate phosphoketolase. Insights into the substrate specificity for xylulose 5-phosphate.

Scheidig AJ, Horvath D, Szedlacsek SE.

J Struct Biol. 2019 Jul 1;207(1):85-102. doi: 10.1016/j.jsb.2019.04.017. Epub 2019 May 3.

PMID:
31059775
2.

KDEL Receptor 1 Contributes to Cell Surface Association of Protein Disulfide Isomerases.

Bartels AK, Göttert S, Desel C, Schäfer M, Krossa S, Scheidig AJ, Grötzinger J, Lorenzen I.

Cell Physiol Biochem. 2019;52(4):850-868. doi: 10.33594/000000059.

3.

Nanomedical Relevance of the Intermolecular Interaction Dynamics-Examples from Lysozymes and Insulins.

Zhang R, Zhang N, Mohri M, Wu L, Eckert T, Krylov VB, Antosova A, Ponikova S, Bednarikova Z, Markart P, Günther A, Norden B, Billeter M, Schauer R, Scheidig AJ, Ratha BN, Bhunia A, Hesse K, Enani MA, Steinmeyer J, Petridis AK, Kozar T, Gazova Z, Nifantiev NE, Siebert HC.

ACS Omega. 2019 Feb 28;4(2):4206-4220. doi: 10.1021/acsomega.8b02471. Epub 2019 Feb 27.

4.

Crystal structure of human mARC1 reveals its exceptional position among eukaryotic molybdenum enzymes.

Kubitza C, Bittner F, Ginsel C, Havemeyer A, Clement B, Scheidig AJ.

Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):11958-11963. doi: 10.1073/pnas.1808576115. Epub 2018 Nov 5.

5.

The Involvement of the Mitochondrial Amidoxime Reducing Component (mARC) in the Reductive Metabolism of Hydroxamic Acids.

Ginsel C, Plitzko B, Froriep D, Stolfa DA, Jung M, Kubitza C, Scheidig AJ, Havemeyer A, Clement B.

Drug Metab Dispos. 2018 Oct;46(10):1396-1402. doi: 10.1124/dmd.118.082453. Epub 2018 Jul 25.

PMID:
30045842
6.

T4 lysozyme-facilitated crystallization of the human molybdenum cofactor-dependent enzyme mARC.

Kubitza C, Ginsel C, Bittner F, Havemeyer A, Clement B, Scheidig AJ.

Acta Crystallogr F Struct Biol Commun. 2018 Jun 1;74(Pt 6):337-344. doi: 10.1107/S2053230X18006921. Epub 2018 May 17.

PMID:
29870017
7.

Crystal structure of pyrrolizidine alkaloid N-oxygenase from the grasshopper Zonocerus variegatus.

Kubitza C, Faust A, Gutt M, Gäth L, Ober D, Scheidig AJ.

Acta Crystallogr D Struct Biol. 2018 May 1;74(Pt 5):422-432. doi: 10.1107/S2059798318003510. Epub 2018 Apr 24.

PMID:
29717713
8.

Redundancy of protein disulfide isomerases in the catalysis of the inactivating disulfide switch in A Disintegrin and Metalloprotease 17.

Krossa S, Scheidig AJ, Grötzinger J, Lorenzen I.

Sci Rep. 2018 Jan 18;8(1):1103. doi: 10.1038/s41598-018-19429-4.

9.

Lysozyme's lectin-like characteristics facilitates its immune defense function.

Zhang R, Wu L, Eckert T, Burg-Roderfeld M, Rojas-Macias MA, Lütteke T, Krylov VB, Argunov DA, Datta A, Markart P, Guenther A, Norden B, Schauer R, Bhunia A, Enani MA, Billeter M, Scheidig AJ, Nifantiev NE, Siebert HC.

Q Rev Biophys. 2017 Jan;50:e9. doi: 10.1017/S0033583517000075.

PMID:
29233221
10.

Crystal structure and catalytic characterization of the dehydrogenase/reductase SDR family member 4 (DHRS4) from Caenorhabditis elegans.

Kisiela M, Faust A, Ebert B, Maser E, Scheidig AJ.

FEBS J. 2018 Jan;285(2):275-293. doi: 10.1111/febs.14337. Epub 2017 Nov 28.

11.

GRP78 protects a disintegrin and metalloprotease 17 against protein-disulfide isomerase A6 catalyzed inactivation.

Schäfer M, Granato DC, Krossa S, Bartels AK, Yokoo S, Düsterhöft S, Koudelka T, Scheidig AJ, Tholey A, Paes Leme AF, Grötzinger J, Lorenzen I.

FEBS Lett. 2017 Nov;591(21):3567-3587. doi: 10.1002/1873-3468.12858. Epub 2017 Oct 11.

12.

Structure of NDP-forming Acetyl-CoA synthetase ACD1 reveals a large rearrangement for phosphoryl transfer.

Weiße RH, Faust A, Schmidt M, Schönheit P, Scheidig AJ.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E519-28. doi: 10.1073/pnas.1518614113. Epub 2016 Jan 19.

13.
14.

Down regulation of Akirin-2 increases chemosensitivity in human glioblastomas more efficiently than Twist-1.

Krossa S, Schmitt AD, Hattermann K, Fritsch J, Scheidig AJ, Mehdorn HM, Held-Feindt J.

Oncotarget. 2015 Aug 28;6(25):21029-45.

15.

Beta-aminoketones as prodrugs for selective irreversible inhibitors of type-1 methionine aminopeptidases.

Altmeyer M, Amtmann E, Heyl C, Marschner A, Scheidig AJ, Klein CD.

Bioorg Med Chem Lett. 2014 Nov 15;24(22):5310-4. doi: 10.1016/j.bmcl.2014.09.047. Epub 2014 Sep 23.

PMID:
25293447
16.

The structure of substrate-free 1,5-anhydro-D-fructose reductase from Sinorhizobium meliloti 1021 reveals an open enzyme conformation.

Schu M, Faust A, Stosik B, Kohring GW, Giffhorn F, Scheidig AJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Aug;69(Pt 8):844-9. doi: 10.1107/S1744309113019490. Epub 2013 Jul 27.

17.

EcoTILLING in Beta vulgaris reveals polymorphisms in the FLC-like gene BvFL1 that are associated with annuality and winter hardiness.

Frerichmann SL, Kirchhoff M, Müller AE, Scheidig AJ, Jung C, Kopisch-Obuch FJ.

BMC Plant Biol. 2013 Mar 25;13:52. doi: 10.1186/1471-2229-13-52.

18.

Mass spectrometric analysis of hepatitis C viral envelope protein E2 reveals extended microheterogeneity of mucin-type O-linked glycosylation.

Bräutigam J, Scheidig AJ, Egge-Jacobsen W.

Glycobiology. 2013 Apr;23(4):453-74. doi: 10.1093/glycob/cws171. Epub 2012 Dec 14.

PMID:
23242014
19.

Structural basis for the oxidation of protein-bound sulfur by the sulfur cycle molybdohemo-enzyme sulfane dehydrogenase SoxCD.

Zander U, Faust A, Klink BU, de Sanctis D, Panjikar S, Quentmeier A, Bardischewsky F, Friedrich CG, Scheidig AJ.

J Biol Chem. 2011 Mar 11;286(10):8349-60. doi: 10.1074/jbc.M110.193631. Epub 2010 Dec 8.

20.
21.

Preliminary X-ray crystallographic analysis of the D-xylulose 5-phosphate phosphoketolase from Lactococcus lactis.

Petrareanu G, Balasu MC, Zander U, Scheidig AJ, Szedlacsek SE.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jul 1;66(Pt 7):805-7. doi: 10.1107/S174430911001732X. Epub 2010 Jun 24.

22.

Structural insight into substrate differentiation of the sugar-metabolizing enzyme galactitol dehydrogenase from Rhodobacter sphaeroides D.

Carius Y, Christian H, Faust A, Zander U, Klink BU, Kornberger P, Kohring GW, Giffhorn F, Scheidig AJ.

J Biol Chem. 2010 Jun 25;285(26):20006-14. doi: 10.1074/jbc.M110.113738. Epub 2010 Apr 21.

23.

Interface analysis of the complex between ERK2 and PTP-SL.

Balasu MC, Spiridon LN, Miron S, Craescu CT, Scheidig AJ, Petrescu AJ, Szedlacsek SE.

PLoS One. 2009;4(5):e5432. doi: 10.1371/journal.pone.0005432. Epub 2009 May 8.

24.

The structure of the periplasmic thiol-disulfide oxidoreductase SoxS from Paracoccus pantotrophus indicates a triple Trx/Grx/DsbC functionality in chemotrophic sulfur oxidation.

Carius Y, Rother D, Friedrich CG, Scheidig AJ.

Acta Crystallogr D Biol Crystallogr. 2009 Mar;65(Pt 3):229-40. doi: 10.1107/S0907444908043023. Epub 2009 Feb 20.

PMID:
19237745
25.

The unusual binding mode of cnicin to the antibacterial target enzyme MurA revealed by X-ray crystallography.

Steinbach A, Scheidig AJ, Klein CD.

J Med Chem. 2008 Aug 28;51(16):5143-7. doi: 10.1021/jm800609p. Epub 2008 Aug 1.

PMID:
18672863
26.

Quantitative labeling of long plasmid DNA with nanometer precision.

Pljevaljcić G, Schmidt F, Scheidig AJ, Lurz R, Weinhold E.

Chembiochem. 2007 Sep 3;8(13):1516-9. No abstract available.

PMID:
17654629
27.

2-Aminopurine flipped into the active site of the adenine-specific DNA methyltransferase M.TaqI: crystal structures and time-resolved fluorescence.

Lenz T, Bonnist EY, Pljevaljcić G, Neely RK, Dryden DT, Scheidig AJ, Jones AC, Weinhold E.

J Am Chem Soc. 2007 May 16;129(19):6240-8. Epub 2007 Apr 25.

PMID:
17455934
28.

Sulfate acts as phosphate analog on the monomeric catalytic fragment of the CPx-ATPase CopB from Sulfolobus solfataricus.

Lübben M, Güldenhaupt J, Zoltner M, Deigweiher K, Haebel P, Urbanke C, Scheidig AJ.

J Mol Biol. 2007 Jun 1;369(2):368-85. Epub 2007 Mar 20.

PMID:
17434529
30.

A newly designed microspectrofluorometer for kinetic studies on protein crystals in combination with x-ray diffraction.

Klink BU, Goody RS, Scheidig AJ.

Biophys J. 2006 Aug 1;91(3):981-92. Epub 2006 May 12.

31.

Structure of the cytochrome complex SoxXA of Paracoccus pantotrophus, a heme enzyme initiating chemotrophic sulfur oxidation.

Dambe T, Quentmeier A, Rother D, Friedrich C, Scheidig AJ.

J Struct Biol. 2005 Dec;152(3):229-34. Epub 2005 Nov 2.

PMID:
16297640
32.

High resolution crystal structures of human Rab4a in its active and inactive conformations.

Huber SK, Scheidig AJ.

FEBS Lett. 2005 May 23;579(13):2821-9. Epub 2005 Apr 25.

33.

The crystal structure of human PAPS synthetase 1 reveals asymmetry in substrate binding.

Harjes S, Bayer P, Scheidig AJ.

J Mol Biol. 2005 Apr 1;347(3):623-35. Epub 2005 Jan 26.

PMID:
15755455
34.
35.

Molecular basis of transmembrane signalling by sensory rhodopsin II-transducer complex.

Gordeliy VI, Labahn J, Moukhametzianov R, Efremov R, Granzin J, Schlesinger R, Büldt G, Savopol T, Scheidig AJ, Klare JP, Engelhard M.

Nature. 2002 Oct 3;419(6906):484-7.

PMID:
12368857
36.

Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases.

Constantinescu AT, Rak A, Alexandrov K, Esters H, Goody RS, Scheidig AJ.

Structure. 2002 Apr;10(4):569-79.

37.

Crystal structure of PTP-SL/PTPBR7 catalytic domain: implications for MAP kinase regulation.

Szedlacsek SE, Aricescu AR, Fulga TA, Renault L, Scheidig AJ.

J Mol Biol. 2001 Aug 17;311(3):557-68.

PMID:
11493009
38.

Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins.

Esters H, Alexandrov K, Iakovenko A, Ivanova T, Thomä N, Rybin V, Zerial M, Scheidig AJ, Goody RS.

J Mol Biol. 2001 Jun 29;310(1):141-56.

PMID:
11419942
39.

Fluorescence methods for monitoring interactions of Rab proteins with nucleotides, Rab escort protein, and geranylgeranyltransferase.

Alexandrov K, Scheidig AJ, Goody RS.

Methods Enzymol. 2001;329:14-31. No abstract available.

PMID:
11210530
40.

Structure of the N6-adenine DNA methyltransferase M.TaqI in complex with DNA and a cofactor analog.

Goedecke K, Pignot M, Goody RS, Scheidig AJ, Weinhold E.

Nat Struct Biol. 2001 Feb;8(2):121-5.

PMID:
11175899
41.

Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins.

Rak A, Fedorov R, Alexandrov K, Albert S, Goody RS, Gallwitz D, Scheidig AJ.

EMBO J. 2000 Oct 2;19(19):5105-13.

42.

High-resolution crystal structure of S. cerevisiae Ypt51(DeltaC15)-GppNHp, a small GTP-binding protein involved in regulation of endocytosis.

Esters H, Alexandrov K, Constantinescu AT, Goody RS, Scheidig AJ.

J Mol Biol. 2000 Apr 21;298(1):111-21.

PMID:
10756108
43.
44.

2'Halo-ATP and -GTP analogues: rational phasing tools for protein crystallography.

Gruen M, Becker C, Beste A, Reinstein J, Scheidig AJ, Goody RS.

Protein Sci. 1999 Nov;8(11):2524-8.

45.

Binding of nucleotides to guanylate kinase, p21(ras), and nucleoside-diphosphate kinase studied by nano-electrospray mass spectrometry.

Prinz H, Lavie A, Scheidig AJ, Spangenberg O, Konrad M.

J Biol Chem. 1999 Dec 10;274(50):35337-42.

47.

Characterization of the ternary complex between Rab7, REP-1 and Rab geranylgeranyl transferase.

Alexandrov K, Simon I, Yurchenko V, Iakovenko A, Rostkova E, Scheidig AJ, Goody RS.

Eur J Biochem. 1999 Oct 1;265(1):160-70.

48.

Chemo-Enzymatic Synthesis of Fluorescent Rab 7 Proteins: Tools to Study Vesicular Trafficking in Cells.

Owen DJ, Alexandrov K, Rostkova E, Scheidig AJ, Goody RS, Waldmann H.

Angew Chem Int Ed Engl. 1999 Feb 15;38(4):509-512. doi: 10.1002/(SICI)1521-3773(19990215)38:4<509::AID-ANIE509>3.0.CO;2-3.

PMID:
29711783
49.

Time-resolved FTIR studies of the GTPase reaction of H-ras p21 reveal a key role for the beta-phosphate.

Cepus V, Scheidig AJ, Goody RS, Gerwert K.

Biochemistry. 1998 Jul 14;37(28):10263-71.

PMID:
9665734
50.

Use of caged nucleotides to characterize unstable intermediates by X-ray crystallography.

Scheidig AJ, Burmester C, Goody RS.

Methods Enzymol. 1998;291:251-64. No abstract available.

PMID:
9661153

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