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Items: 49

1.

Latest advances in aging research and drug discovery.

Bakula D, Ablasser A, Aguzzi A, Antebi A, Barzilai N, Bittner MI, Jensen MB, Calkhoven CF, Chen D, Grey ADNJ, Feige JN, Georgievskaya A, Gladyshev VN, Golato T, Gudkov AV, Hoppe T, Kaeberlein M, Katajisto P, Kennedy BK, Lal U, Martin-Villalba A, Moskalev AA, Ozerov I, Petr MA, Reason, Rubinsztein DC, Tyshkovskiy A, Vanhaelen Q, Zhavoronkov A, Scheibye-Knudsen M.

Aging (Albany NY). 2019 Nov 21;11(22):9971-9981. doi: 10.18632/aging.102487. Epub 2019 Nov 21.

2.

Lamin A/C promotes DNA base excision repair.

Maynard S, Keijzers G, Akbari M, Ezra MB, Hall A, Morevati M, Scheibye-Knudsen M, Gonzalo S, Bartek J, Bohr VA.

Nucleic Acids Res. 2019 Oct 24. pii: gkz912. doi: 10.1093/nar/gkz912. [Epub ahead of print]

PMID:
31647095
3.

A defined human aging phenome.

Andreassen SN, Ben Ezra M, Scheibye-Knudsen M.

Aging (Albany NY). 2019 Aug 12;11(15):5786-5806. doi: 10.18632/aging.102166. Epub 2019 Aug 12.

4.

Mitophagy and Neuroprotection.

Lou G, Palikaras K, Lautrup S, Scheibye-Knudsen M, Tavernarakis N, Fang EF.

Trends Mol Med. 2019 Jul 30. pii: S1471-4914(19)30176-5. doi: 10.1016/j.molmed.2019.07.002. [Epub ahead of print] Review.

PMID:
31375365
5.

Blood Biochemistry Analysis to Detect Smoking Status and Quantify Accelerated Aging in Smokers.

Mamoshina P, Kochetov K, Cortese F, Kovalchuk A, Aliper A, Putin E, Scheibye-Knudsen M, Cantor CR, Skjodt NM, Kovalchuk O, Zhavoronkov A.

Sci Rep. 2019 Jan 15;9(1):142. doi: 10.1038/s41598-018-35704-w.

6.

Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in Cancer.

Keijzers G, Bakula D, Petr MA, Madsen NGK, Teklu A, Mkrtchyan G, Osborne B, Scheibye-Knudsen M.

Int J Mol Sci. 2018 Dec 25;20(1). pii: E74. doi: 10.3390/ijms20010074. Review.

7.

Artificial intelligence for aging and longevity research: Recent advances and perspectives.

Zhavoronkov A, Mamoshina P, Vanhaelen Q, Scheibye-Knudsen M, Moskalev A, Aliper A.

Ageing Res Rev. 2019 Jan;49:49-66. doi: 10.1016/j.arr.2018.11.003. Epub 2018 Nov 22. Review.

8.

Aging and drug discovery.

Bakula D, Aliper AM, Mamoshina P, Petr MA, Teklu A, Baur JA, Campisi J, Ewald CY, Georgievskaya A, Gladyshev VN, Kovalchuk O, Lamming DW, Luijsterburg MS, Martín-Montalvo A, Maudsley S, Mkrtchyan GV, Moskalev A, Olshansky SJ, Ozerov IV, Pickett A, Ristow M, Zhavoronkov A, Scheibye-Knudsen M.

Aging (Albany NY). 2018 Nov 13;10(11):3079-3088. doi: 10.18632/aging.101646.

9.

Emerging Antitumor Activities of the Bitter Melon (Momordica charantia).

Fang EF, Froetscher L, Scheibye-Knudsen M, Bohr VA, Wong JH, Ng TB.

Curr Protein Pept Sci. 2019;20(3):296-301. doi: 10.2174/1389203719666180622095800. Review.

10.

Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization.

Cortese F, Klokov D, Osipov A, Stefaniak J, Moskalev A, Schastnaya J, Cantor C, Aliper A, Mamoshina P, Ushakov I, Sapetsky A, Vanhaelen Q, Alchinova I, Karganov M, Kovalchuk O, Wilkins R, Shtemberg A, Moreels M, Baatout S, Izumchenko E, de Magalhães JP, Artemov AV, Costes SV, Beheshti A, Mao XW, Pecaut MJ, Kaminskiy D, Ozerov IV, Scheibye-Knudsen M, Zhavoronkov A.

Oncotarget. 2018 Feb 12;9(18):14692-14722. doi: 10.18632/oncotarget.24461. eCollection 2018 Mar 6. Review.

11.

Monogenic Diseases of DNA Repair.

Keijzers G, Bakula D, Scheibye-Knudsen M.

N Engl J Med. 2018 Feb 1;378(5):491-492. doi: 10.1056/NEJMc1716072. No abstract available.

PMID:
29385361
12.

Population Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations.

Mamoshina P, Kochetov K, Putin E, Cortese F, Aliper A, Lee WS, Ahn SM, Uhn L, Skjodt N, Kovalchuk O, Scheibye-Knudsen M, Zhavoronkov A.

J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1482-1490. doi: 10.1093/gerona/gly005.

13.

Monogenic Diseases of DNA Repair.

Keijzers G, Bakula D, Scheibye-Knudsen M.

N Engl J Med. 2017 Nov 9;377(19):1868-1876. doi: 10.1056/NEJMra1703366. Review. No abstract available.

PMID:
29117491
14.

Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway.

Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG.

Sci Rep. 2017 Apr 11;7:46208. doi: 10.1038/srep46208.

15.

Mitophagy in neurodegeneration and aging.

Fivenson EM, Lautrup S, Sun N, Scheibye-Knudsen M, Stevnsner T, Nilsen H, Bohr VA, Fang EF.

Neurochem Int. 2017 Oct;109:202-209. doi: 10.1016/j.neuint.2017.02.007. Epub 2017 Feb 21. Review.

16.

Neurodegeneration in accelerated aging.

Scheibye-Knudsen M.

Dan Med J. 2016 Nov;63(11). pii: B5308. Review.

PMID:
27808039
17.

Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA.

Scheibye-Knudsen M, Tseng A, Borch Jensen M, Scheibye-Alsing K, Fang EF, Iyama T, Bharti SK, Marosi K, Froetscher L, Kassahun H, Eckley DM, Maul RW, Bastian P, De S, Ghosh S, Nilsen H, Goldberg IG, Mattson MP, Wilson DM 3rd, Brosh RM Jr, Gorospe M, Bohr VA.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12502-12507. Epub 2016 Oct 18.

18.

Cockayne syndrome: Clinical features, model systems and pathways.

Karikkineth AC, Scheibye-Knudsen M, Fivenson E, Croteau DL, Bohr VA.

Ageing Res Rev. 2017 Jan;33:3-17. doi: 10.1016/j.arr.2016.08.002. Epub 2016 Aug 6. Review.

19.

3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons.

Marosi K, Kim SW, Moehl K, Scheibye-Knudsen M, Cheng A, Cutler R, Camandola S, Mattson MP.

J Neurochem. 2016 Dec;139(5):769-781. doi: 10.1111/jnc.13868. Epub 2016 Nov 14.

20.

NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair.

Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA.

Cell Metab. 2016 Oct 11;24(4):566-581. doi: 10.1016/j.cmet.2016.09.004.

21.

A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain.

Lauritzen KH, Hasan-Olive MM, Regnell CE, Kleppa L, Scheibye-Knudsen M, Gjedde A, Klungland A, Bohr VA, Storm-Mathisen J, Bergersen LH.

Neurobiol Aging. 2016 Dec;48:34-47. doi: 10.1016/j.neurobiolaging.2016.08.005. Epub 2016 Aug 18.

22.

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R.

Cell Metab. 2016 Jun 14;23(6):1093-1112. doi: 10.1016/j.cmet.2016.05.027.

23.

Cytochrome b5 reductase and the control of lipid metabolism and healthspan.

Martin-Montalvo A, Sun Y, Diaz-Ruiz A, Ali A, Gutierrez V, Palacios HH, Curtis J, Siendones E, Ariza J, Abulwerdi GA, Sun X, Wang AX, Pearson KJ, Fishbein KW, Spencer RG, Wang M, Han X, Scheibye-Knudsen M, Baur JA, Shertzer HG, Navas P, Villalba JM, Zou S, Bernier M, de Cabo R.

NPJ Aging Mech Dis. 2016 May 12;2:16006. doi: 10.1038/npjamd.2016.6. eCollection 2016.

24.

Nuclear DNA damage signalling to mitochondria in ageing.

Fang EF, Scheibye-Knudsen M, Chua KF, Mattson MP, Croteau DL, Bohr VA.

Nat Rev Mol Cell Biol. 2016 May;17(5):308-21. doi: 10.1038/nrm.2016.14. Epub 2016 Mar 9. Review.

25.

DNA Damage, DNA Repair, Aging, and Neurodegeneration.

Maynard S, Fang EF, Scheibye-Knudsen M, Croteau DL, Bohr VA.

Cold Spring Harb Perspect Med. 2015 Sep 18;5(10). pii: a025130. doi: 10.1101/cshperspect.a025130. Review.

26.

A research agenda for aging in China in the 21st century.

Fang EF, Scheibye-Knudsen M, Jahn HJ, Li J, Ling L, Guo H, Zhu X, Preedy V, Lu H, Bohr VA, Chan WY, Liu Y, Ng TB.

Ageing Res Rev. 2015 Nov;24(Pt B):197-205. doi: 10.1016/j.arr.2015.08.003. Epub 2015 Aug 22. Review.

27.

A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function.

Hey-Mogensen M, Gram M, Jensen MB, Lund MT, Hansen CN, Scheibye-Knudsen M, Bohr VA, Dela F.

J Physiol. 2015 Sep 1;593(17):3991-4010. doi: 10.1113/JP270204. Epub 2015 Aug 12.

28.

Animal models of aging research: implications for human aging and age-related diseases.

Mitchell SJ, Scheibye-Knudsen M, Longo DL, de Cabo R.

Annu Rev Anim Biosci. 2015;3:283-303. doi: 10.1146/annurev-animal-022114-110829. Review.

PMID:
25689319
29.

Protecting the mitochondrial powerhouse.

Scheibye-Knudsen M, Fang EF, Croteau DL, Wilson DM 3rd, Bohr VA.

Trends Cell Biol. 2015 Mar;25(3):158-70. doi: 10.1016/j.tcb.2014.11.002. Epub 2014 Dec 11. Review.

30.

Loss of NEIL1 causes defects in olfactory function in mice.

Canugovi C, Misiak M, Scheibye-Knudsen M, Croteau DL, Mattson MP, Bohr VA.

Neurobiol Aging. 2015 Feb;36(2):1007-12. doi: 10.1016/j.neurobiolaging.2014.09.026. Epub 2014 Oct 14.

31.

A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.

Scheibye-Knudsen M, Mitchell SJ, Fang EF, Iyama T, Ward T, Wang J, Dunn CA, Singh N, Veith S, Hasan-Olive MM, Mangerich A, Wilson MA, Mattson MP, Bergersen LH, Cogger VC, Warren A, Le Couteur DG, Moaddel R, Wilson DM 3rd, Croteau DL, de Cabo R, Bohr VA.

Cell Metab. 2014 Nov 4;20(5):840-855. doi: 10.1016/j.cmet.2014.10.005. Epub 2014 Nov 4.

32.

Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis.

Li X, Fang EF, Scheibye-Knudsen M, Cui H, Qiu L, Li J, He Y, Huang J, Bohr VA, Ng TB, Guo H.

Sci Rep. 2014 Sep 22;4:6434. doi: 10.1038/srep06434.

33.

Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders.

Scheibye-Knudsen M, Fang EF, Croteau DL, Bohr VA.

Autophagy. 2014 Aug;10(8):1468-9. doi: 10.4161/auto.29321. Epub 2014 Jun 12.

34.

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.

Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R.

Aging Cell. 2014 Oct;13(5):787-96. doi: 10.1111/acel.12220. Epub 2014 Jun 16.

35.

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

Fang EF, Scheibye-Knudsen M, Brace LE, Kassahun H, SenGupta T, Nilsen H, Mitchell JR, Croteau DL, Bohr VA.

Cell. 2014 May 8;157(4):882-896. doi: 10.1016/j.cell.2014.03.026.

36.

Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair.

Akbari M, Keijzers G, Maynard S, Scheibye-Knudsen M, Desler C, Hickson ID, Bohr VA.

DNA Repair (Amst). 2014 Apr;16:44-53. doi: 10.1016/j.dnarep.2014.01.015. Epub 2014 Feb 27.

37.

Long-term artificial sweetener acesulfame potassium treatment alters neurometabolic functions in C57BL/6J mice.

Cong WN, Wang R, Cai H, Daimon CM, Scheibye-Knudsen M, Bohr VA, Turkin R, Wood WH 3rd, Becker KG, Moaddel R, Maudsley S, Martin B.

PLoS One. 2013 Aug 7;8(8):e70257. doi: 10.1371/journal.pone.0070257. eCollection 2013.

38.

Metformin improves healthspan and lifespan in mice.

Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, Bohr VA, Ingram DK, Sinclair DA, Wolf NS, Spindler SR, Bernier M, de Cabo R.

Nat Commun. 2013;4:2192. doi: 10.1038/ncomms3192.

39.

A novel diagnostic tool reveals mitochondrial pathology in human diseases and aging.

Scheibye-Knudsen M, Scheibye-Alsing K, Canugovi C, Croteau DL, Bohr VA.

Aging (Albany NY). 2013 Mar;5(3):192-208.

40.

Mitochondrial deficiency in Cockayne syndrome.

Scheibye-Knudsen M, Croteau DL, Bohr VA.

Mech Ageing Dev. 2013 May-Jun;134(5-6):275-83. doi: 10.1016/j.mad.2013.02.007. Epub 2013 Feb 19. Review.

41.

The biarylpyrazole compound AM251 alters mitochondrial physiology via proteolytic degradation of ERRα.

Krzysik-Walker SM, González-Mariscal I, Scheibye-Knudsen M, Indig FE, Bernier M.

Mol Pharmacol. 2013 Jan;83(1):157-66. doi: 10.1124/mol.112.082651. Epub 2012 Oct 12.

42.

Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype.

Ramamoorthy M, Sykora P, Scheibye-Knudsen M, Dunn C, Kasmer C, Zhang Y, Becker KG, Croteau DL, Bohr VA.

Free Radic Biol Med. 2012 Sep 15;53(6):1371-80. doi: 10.1016/j.freeradbiomed.2012.07.018. Epub 2012 Aug 3.

43.

Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy.

Scheibye-Knudsen M, Ramamoorthy M, Sykora P, Maynard S, Lin PC, Minor RK, Wilson DM 3rd, Cooper M, Spencer R, de Cabo R, Croteau DL, Bohr VA.

J Exp Med. 2012 Apr 9;209(4):855-69. doi: 10.1084/jem.20111721. Epub 2012 Apr 2.

44.

SRT1720 improves survival and healthspan of obese mice.

Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R.

Sci Rep. 2011;1:70. doi: 10.1038/srep00070. Epub 2011 Aug 18. Erratum in: Sci Rep. 2013;3():1131.

45.

Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein.

Bernier M, Paul RK, Martin-Montalvo A, Scheibye-Knudsen M, Song S, He HJ, Armour SM, Hubbard BP, Bohr VA, Wang L, Zong Y, Sinclair DA, de Cabo R.

J Biol Chem. 2011 Jun 3;286(22):19270-9. doi: 10.1074/jbc.M110.200311. Epub 2011 Apr 5.

46.

Mitochondrial base excision repair assays.

Maynard S, de Souza-Pinto NC, Scheibye-Knudsen M, Bohr VA.

Methods. 2010 Aug;51(4):416-25. doi: 10.1016/j.ymeth.2010.02.020. Epub 2010 Feb 25. Review.

47.

Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane.

Aamann MD, Sorensen MM, Hvitby C, Berquist BR, Muftuoglu M, Tian J, de Souza-Pinto NC, Scheibye-Knudsen M, Wilson DM 3rd, Stevnsner T, Bohr VA.

FASEB J. 2010 Jul;24(7):2334-46. doi: 10.1096/fj.09-147991. Epub 2010 Feb 24.

48.

Changed mitochondrial function by pre- and/or postpartum diet alterations in sheep.

Jørgensen W, Gam C, Andersen JL, Schjerling P, Scheibye-Knudsen M, Mortensen OH, Grunnet N, Nielsen MO, Quistorff B.

Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1349-57. doi: 10.1152/ajpendo.00505.2009. Epub 2009 Oct 13.

49.

Regulation of mitochondrial respiration by inorganic phosphate; comparing permeabilized muscle fibers and isolated mitochondria prepared from type-1 and type-2 rat skeletal muscle.

Scheibye-Knudsen M, Quistorff B.

Eur J Appl Physiol. 2009 Jan;105(2):279-87. doi: 10.1007/s00421-008-0901-9. Epub 2008 Nov 7.

PMID:
18989695

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