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Items: 5

1.

Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes.

Ozog S, Timberlake ND, Hermann K, Garijo O, Haworth KG, Shi G, Glinkerman CM, Schefter LE, D'Souza S, Simpson E, Sghia-Hughes G, Carillo RR, Boger DL, Kiem HP, Slukvin I, Ryu BY, Sorrentino BP, Adair JE, Snyder SA, Compton AA, Torbett BE.

Blood. 2019 Aug 15. pii: blood.2019000040. doi: 10.1182/blood.2019000040. [Epub ahead of print]

PMID:
31416800
2.

Therapeutically relevant engraftment of a CRISPR-Cas9-edited HSC-enriched population with HbF reactivation in nonhuman primates.

Humbert O, Radtke S, Samuelson C, Carrillo RR, Perez AM, Reddy SS, Lux C, Pattabhi S, Schefter LE, Negre O, Lee CM, Bao G, Adair JE, Peterson CW, Rawlings DJ, Scharenberg AM, Kiem HP.

Sci Transl Med. 2019 Jul 31;11(503). pii: eaaw3768. doi: 10.1126/scitranslmed.aaw3768.

PMID:
31366580
3.

Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants.

Peterson CW, Adair JE, Wohlfahrt ME, Deleage C, Radtke S, Rust B, Norman KK, Norgaard ZK, Schefter LE, Sghia-Hughes GM, Repetto A, Baldessari A, Murnane RD, Estes JD, Kiem HP.

Stem Cell Reports. 2019 Jul 9;13(1):91-104. doi: 10.1016/j.stemcr.2019.05.016. Epub 2019 Jun 13.

4.

HIV infection results in clonal expansions containing integrations within pathogenesis-related biological pathways.

Haworth KG, Schefter LE, Norgaard ZK, Ironside C, Adair JE, Kiem HP.

JCI Insight. 2018 Jul 12;3(13). pii: 99127. doi: 10.1172/jci.insight.99127.

5.

A distinct hematopoietic stem cell population for rapid multilineage engraftment in nonhuman primates.

Radtke S, Adair JE, Giese MA, Chan YY, Norgaard ZK, Enstrom M, Haworth KG, Schefter LE, Kiem HP.

Sci Transl Med. 2017 Nov 1;9(414). pii: eaan1145. doi: 10.1126/scitranslmed.aan1145.

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