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Items: 1 to 50 of 83

1.

A 6&1-FEH Encodes an Enzyme for Fructan Degradation and Interact with Invertase Inhibitor Protein in Maize (Zea mays L.).

Zhao H, Greiner S, Scheffzek K, Rausch T, Wang G.

Int J Mol Sci. 2019 Aug 4;20(15). pii: E3807. doi: 10.3390/ijms20153807.

2.

Plant glutathione biosynthesis revisited: redox-mediated activation of glutamylcysteine ligase does not require homo-dimerization.

Yang Y, Lenherr ED, Gromes R, Wang S, Wirtz M, Hell R, Peskan-Berghöfer T, Scheffzek K, Rausch T.

Biochem J. 2019 Apr 15;476(7):1191-1203. doi: 10.1042/BCJ20190072.

3.

Structural basis for the bi-functionality of human oxaloacetate decarboxylase FAHD1.

Weiss AKH, Naschberger A, Loeffler JR, Gstach H, Bowler MW, Holzknecht M, Cappuccio E, Pittl A, Etemad S, Dunzendorfer-Matt T, Scheffzek K, Liedl KR, Jansen-Dürr P.

Biochem J. 2018 Nov 20;475(22):3561-3576. doi: 10.1042/BCJ20180750.

PMID:
30348641
4.

MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms.

Kozlowski M, Corujo D, Hothorn M, Guberovic I, Mandemaker IK, Blessing C, Sporn J, Gutierrez-Triana A, Smith R, Portmann T, Treier M, Scheffzek K, Huet S, Timinszky G, Buschbeck M, Ladurner AG.

EMBO Rep. 2018 Oct;19(10). pii: e44445. doi: 10.15252/embr.201744445. Epub 2018 Sep 3.

5.

Ras-Specific GTPase-Activating Proteins-Structures, Mechanisms, and Interactions.

Scheffzek K, Shivalingaiah G.

Cold Spring Harb Perspect Med. 2019 Mar 1;9(3). pii: a031500. doi: 10.1101/cshperspect.a031500. Review.

PMID:
30104198
6.

Restoring functional neurofibromin by protein transduction.

Mellert K, Lechner S, Lüdeke M, Lamla M, Möller P, Kemkemer R, Scheffzek K, Kaufmann D.

Sci Rep. 2018 Apr 18;8(1):6171. doi: 10.1038/s41598-018-24310-5.

7.

Expression, Purification, and Biochemical Characterization of Human Afamin.

Altamirano A, Naschberger A, Fürnrohr BG, Saldova R, Struwe WB, Jennings PM, Millán Martín S, Malic S, Plangger I, Lechner S, Pisano R, Peretti N, Linke B, Aguiar MM, Fresser F, Ritsch A, Lenac Rovis T, Goode C, Rudd PM, Scheffzek K, Rupp B, Dieplinger H.

J Proteome Res. 2018 Mar 2;17(3):1269-1277. doi: 10.1021/acs.jproteome.7b00867. Epub 2018 Feb 20.

PMID:
29441788
8.

LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning.

Filipek PA, de Araujo MEG, Vogel GF, De Smet CH, Eberharter D, Rebsamen M, Rudashevskaya EL, Kremser L, Yordanov T, Tschaikner P, Fürnrohr BG, Lechner S, Dunzendorfer-Matt T, Scheffzek K, Bennett KL, Superti-Furga G, Lindner HH, Stasyk T, Huber LA.

J Cell Biol. 2017 Dec 4;216(12):4199-4215. doi: 10.1083/jcb.201703061. Epub 2017 Oct 9.

9.

Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.

de Araujo MEG, Naschberger A, Fürnrohr BG, Stasyk T, Dunzendorfer-Matt T, Lechner S, Welti S, Kremser L, Shivalingaiah G, Offterdinger M, Lindner HH, Huber LA, Scheffzek K.

Science. 2017 Oct 20;358(6361):377-381. doi: 10.1126/science.aao1583. Epub 2017 Sep 21.

PMID:
28935770
10.

NMR resonance assignments of the EVH1 domain of neurofibromin's recruitment factor Spred1.

Führer S, Ahammer L, Ausserbichler A, Scheffzek K, Dunzendorfer-Matt T, Tollinger M.

Biomol NMR Assign. 2017 Oct;11(2):305-308. doi: 10.1007/s12104-017-9768-1. Epub 2017 Aug 22.

11.

The N14 anti-afamin antibody Fab: a rare VL1 CDR glycosylation, crystallographic re-sequencing, molecular plasticity and conservative versus enthusiastic modelling.

Naschberger A, Fürnrohr BG, Lenac Rovis T, Malic S, Scheffzek K, Dieplinger H, Rupp B.

Acta Crystallogr D Struct Biol. 2016 Dec 1;72(Pt 12):1267-1280. Epub 2016 Nov 29.

12.

The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation.

Dunzendorfer-Matt T, Mercado EL, Maly K, McCormick F, Scheffzek K.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7497-502. doi: 10.1073/pnas.1607298113. Epub 2016 Jun 16.

13.

Cleaning protocols for crystallization robots: preventing protease contamination.

Naschberger A, Fürnrohr BG, Dunzendorfer-Matt T, Bonagura CA, Wright D, Scheffzek K, Rupp B.

Acta Crystallogr F Struct Biol Commun. 2015 Jan 1;71(Pt 1):100-2. doi: 10.1107/S2053230X14026053. Epub 2015 Jan 1.

14.

Functional MHC class II is upregulated in neurofibromin-deficient Schwann cells.

Reuss DE, Mucha J, Holtkamp N, Müller U, Berlien HP, Mautner VF, Ehemann V, Platten M, Scheffzek K, von Deimling A.

J Invest Dermatol. 2013 May;133(5):1372-5. doi: 10.1038/jid.2012.488. Epub 2013 Jan 10. No abstract available.

15.

Enhancing endosomal escape of transduced proteins by photochemical internalisation.

Mellert K, Lamla M, Scheffzek K, Wittig R, Kaufmann D.

PLoS One. 2012;7(12):e52473. doi: 10.1371/journal.pone.0052473. Epub 2012 Dec 21.

16.

Mutations in SYNGAP1 cause intellectual disability, autism, and a specific form of epilepsy by inducing haploinsufficiency.

Berryer MH, Hamdan FF, Klitten LL, Møller RS, Carmant L, Schwartzentruber J, Patry L, Dobrzeniecka S, Rochefort D, Neugnot-Cerioli M, Lacaille JC, Niu Z, Eng CM, Yang Y, Palardy S, Belhumeur C, Rouleau GA, Tommerup N, Immken L, Beauchamp MH, Patel GS, Majewski J, Tarnopolsky MA, Scheffzek K, Hjalgrim H, Michaud JL, Di Cristo G.

Hum Mutat. 2013 Feb;34(2):385-94. doi: 10.1002/humu.22248. Epub 2012 Dec 12.

PMID:
23161826
17.

Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms.

Scheffzek K, Welti S.

FEBS Lett. 2012 Aug 14;586(17):2662-73. doi: 10.1016/j.febslet.2012.06.006. Epub 2012 Jun 19. Review.

18.

Allosterically gated enzyme dynamics in the cysteine synthase complex regulate cysteine biosynthesis in Arabidopsis thaliana.

Feldman-Salit A, Wirtz M, Lenherr ED, Throm C, Hothorn M, Scheffzek K, Hell R, Wade RC.

Structure. 2012 Feb 8;20(2):292-302. doi: 10.1016/j.str.2011.11.019.

19.

Inhibition and termination of physiological responses by GTPase activating proteins.

Ligeti E, Welti S, Scheffzek K.

Physiol Rev. 2012 Jan;92(1):237-72. doi: 10.1152/physrev.00045.2010. Review.

20.

Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-PH module of neurofibromin.

Welti S, Kühn S, D'Angelo I, Brügger B, Kaufmann D, Scheffzek K.

Hum Mutat. 2011 Feb;32(2):191-7. doi: 10.1002/humu.21405. Epub 2011 Jan 18.

PMID:
21089070
21.

Structural insights into the pH-controlled targeting of plant cell-wall invertase by a specific inhibitor protein.

Hothorn M, Van den Ende W, Lammens W, Rybin V, Scheffzek K.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17427-32. doi: 10.1073/pnas.1004481107. Epub 2010 Sep 21.

22.

Structure and function of the hetero-oligomeric cysteine synthase complex in plants.

Wirtz M, Birke H, Heeg C, Müller C, Hosp F, Throm C, König S, Feldman-Salit A, Rippe K, Petersen G, Wade RC, Rybin V, Scheffzek K, Hell R.

J Biol Chem. 2010 Oct 22;285(43):32810-7. doi: 10.1074/jbc.M110.157446. Epub 2010 Aug 18.

23.

Activity of the Enterococcus faecalis EIIA(gnt) PTS component and its strong interaction with EIIB(gnt).

Brockmeier A, Skopnik M, Koch B, Herrmann C, Hengstenberg W, Welti S, Scheffzek K.

Biochem Biophys Res Commun. 2009 Oct 30;388(4):630-6. doi: 10.1016/j.bbrc.2009.08.100. Epub 2009 Aug 22.

PMID:
19703414
24.

Structure of the Enterococcus faecalis EIIA(gnt) PTS component.

Reinelt S, Koch B, Hothorn M, Hengstenberg W, Welti S, Scheffzek K.

Biochem Biophys Res Commun. 2009 Oct 30;388(4):626-9. doi: 10.1016/j.bbrc.2009.08.054. Epub 2009 Aug 13.

PMID:
19682976
25.

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation.

Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG.

Nat Struct Mol Biol. 2009 Sep;16(9):923-9. doi: 10.1038/nsmb.1664. Epub 2009 Aug 13.

PMID:
19680243
26.

Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis.

McGillicuddy LT, Fromm JA, Hollstein PE, Kubek S, Beroukhim R, De Raedt T, Johnson BW, Williams SM, Nghiemphu P, Liau LM, Cloughesy TF, Mischel PS, Parret A, Seiler J, Moldenhauer G, Scheffzek K, Stemmer-Rachamimov AO, Sawyers CL, Brennan C, Messiaen L, Mellinghoff IK, Cichowski K.

Cancer Cell. 2009 Jul 7;16(1):44-54. doi: 10.1016/j.ccr.2009.05.009.

27.

Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase.

Hothorn M, Neumann H, Lenherr ED, Wehner M, Rybin V, Hassa PO, Uttenweiler A, Reinhardt M, Schmidt A, Seiler J, Ladurner AG, Herrmann C, Scheffzek K, Mayer A.

Science. 2009 Apr 24;324(5926):513-6. doi: 10.1126/science.1168120.

28.

Solubility survey of fragments of the neurofibromatosis type 1 protein neurofibromin.

Bonneau F, Lenherr ED, Pena V, Hart DJ, Scheffzek K.

Protein Expr Purif. 2009 May;65(1):30-7. doi: 10.1016/j.pep.2008.12.001. Epub 2008 Dec 10.

PMID:
19111619
29.

Structural insights into the cyclin T1-Tat-TAR RNA transcription activation complex from EIAV.

Anand K, Schulte A, Vogel-Bachmayr K, Scheffzek K, Geyer M.

Nat Struct Mol Biol. 2008 Dec;15(12):1287-92. doi: 10.1038/nsmb.1513. Epub 2008 Nov 23.

PMID:
19029897
30.

Dimerization and protein binding specificity of the U2AF homology motif of the splicing factor Puf60.

Corsini L, Hothorn M, Stier G, Rybin V, Scheffzek K, Gibson TJ, Sattler M.

J Biol Chem. 2009 Jan 2;284(1):630-9. doi: 10.1074/jbc.M805395200. Epub 2008 Oct 29.

31.

Thioredoxin as a fusion tag for carrier-driven crystallization.

Corsini L, Hothorn M, Scheffzek K, Sattler M, Stier G.

Protein Sci. 2008 Dec;17(12):2070-9. doi: 10.1110/ps.037564.108. Epub 2008 Sep 9.

32.

The FACT Spt16 "peptidase" domain is a histone H3-H4 binding module.

Stuwe T, Hothorn M, Lejeune E, Rybin V, Bortfeld M, Scheffzek K, Ladurner AG.

Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8884-9. doi: 10.1073/pnas.0712293105. Epub 2008 Jun 25.

33.

The redox switch of gamma-glutamylcysteine ligase via a reversible monomer-dimer transition is a mechanism unique to plants.

Gromes R, Hothorn M, Lenherr ED, Rybin V, Scheffzek K, Rausch T.

Plant J. 2008 Jun;54(6):1063-75. doi: 10.1111/j.1365-313X.2008.03477.x. Epub 2008 Mar 12.

34.

The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction.

Pena V, Hothorn M, Eberth A, Kaschau N, Parret A, Gremer L, Bonneau F, Ahmadian MR, Scheffzek K.

EMBO Rep. 2008 Apr;9(4):350-5. doi: 10.1038/embor.2008.20. Epub 2008 Mar 7.

35.

The Leishmania tarentolae exosome: purification and structural analysis by electron microscopy.

Cristodero M, Böttcher B, Diepholz M, Scheffzek K, Clayton C.

Mol Biochem Parasitol. 2008 May;159(1):24-9. doi: 10.1016/j.molbiopara.2007.12.012. Epub 2008 Jan 4.

PMID:
18279979
36.

Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation.

Denayer E, Parret A, Chmara M, Schubbert S, Vogels A, Devriendt K, Frijns JP, Rybin V, de Ravel TJ, Shannon K, Cools J, Scheffzek K, Legius E.

Hum Mutat. 2008 Feb;29(2):232-9.

PMID:
17979197
37.

U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.

Corsini L, Bonnal S, Basquin J, Hothorn M, Scheffzek K, Valcárcel J, Sattler M.

Nat Struct Mol Biol. 2007 Jul;14(7):620-9. Epub 2007 Jun 24. Erratum in: Nat Struct Mol Biol. 2007 Aug;14(8):785. Bonna, Sophie [corrected to Bonnal, Sophie].

PMID:
17589525
38.

Cyclin box structure of the P-TEFb subunit cyclin T1 derived from a fusion complex with EIAV tat.

Anand K, Schulte A, Fujinaga K, Scheffzek K, Geyer M.

J Mol Biol. 2007 Jul 27;370(5):826-36. Epub 2007 May 10.

39.

The sec14 homology module of neurofibromin binds cellular glycerophospholipids: mass spectrometry and structure of a lipid complex.

Welti S, Fraterman S, D'Angelo I, Wilm M, Scheffzek K.

J Mol Biol. 2007 Feb 16;366(2):551-62. Epub 2006 Nov 18.

PMID:
17187824
40.

Structure of the full-length enzyme I of the phosphoenolpyruvate-dependent sugar phosphotransferase system.

Márquez J, Reinelt S, Koch B, Engelmann R, Hengstenberg W, Scheffzek K.

J Biol Chem. 2006 Oct 27;281(43):32508-15. Epub 2006 Jul 25.

41.

Structural basis for the redox control of plant glutamate cysteine ligase.

Hothorn M, Wachter A, Gromes R, Stuwe T, Rausch T, Scheffzek K.

J Biol Chem. 2006 Sep 15;281(37):27557-65. Epub 2006 Jun 9.

42.

Multiple crystal forms of the cell-wall invertase inhibitor from tobacco support high conformational rigidity over a broad pH range.

Hothorn M, Scheffzek K.

Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):665-70. Epub 2006 May 12.

PMID:
16699194
43.

A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein.

D'Angelo I, Welti S, Bonneau F, Scheffzek K.

EMBO Rep. 2006 Feb;7(2):174-9.

44.

GTPase activating proteins: structural and functional insights 18 years after discovery.

Scheffzek K, Ahmadian MR.

Cell Mol Life Sci. 2005 Dec;62(24):3014-38. Review.

PMID:
16314935
45.

Human Lsg1 defines a family of essential GTPases that correlates with the evolution of compartmentalization.

Reynaud EG, Andrade MA, Bonneau F, Ly TB, Knop M, Scheffzek K, Pepperkok R.

BMC Biol. 2005 Oct 7;3:21.

46.

Splicing regulates NAD metabolite binding to histone macroH2A.

Kustatscher G, Hothorn M, Pugieux C, Scheffzek K, Ladurner AG.

Nat Struct Mol Biol. 2005 Jul;12(7):624-5. Epub 2005 Jun 19.

PMID:
15965484
47.

Expression, purification and preliminary crystallographic characterization of a novel segment from the neurofibromatosis type 1 protein.

Bonneau F, D'Angelo I, Welti S, Stier G, Ylänne J, Scheffzek K.

Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 2):2364-7. Epub 2004 Nov 26.

PMID:
15583390
48.

Structural insights into the target specificity of plant invertase and pectin methylesterase inhibitory proteins.

Hothorn M, Wolf S, Aloy P, Greiner S, Scheffzek K.

Plant Cell. 2004 Dec;16(12):3437-47. Epub 2004 Nov 4.

49.

The invertase inhibitor Nt-CIF from tobacco: a highly thermostable four-helix bundle with an unusual N-terminal extension.

Hothorn M, D'Angelo I, Márquez JA, Greiner S, Scheffzek K.

J Mol Biol. 2004 Jan 23;335(4):987-95.

PMID:
14698293
50.

Bacterial expression, purification and preliminary X-ray crystallographic characterization of the invertase inhibitor Nt-CIF from tobacco.

Hothorn M, Bonneau F, Stier G, Greiner S, Scheffzek K.

Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2279-82. Epub 2003 Nov 27.

PMID:
14646094

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