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Items: 1 to 50 of 93

1.

Intramolecular Proton Transfer Controls Protein Structural Changes in Phytochrome.

Kraskov A, Nguyen AD, Goerling J, Buhrke D, Velazquez Escobar F, Fernandez Lopez M, Michael N, Sauthof L, Schmidt A, Piwowarski P, Yang Y, Stensitzki T, Adam S, Bartl F, Schapiro I, Heyne K, Siebert F, Scheerer P, Mroginski MA, Hildebrandt P.

Biochemistry. 2020 Mar 10;59(9):1023-1037. doi: 10.1021/acs.biochem.0c00053. Epub 2020 Feb 28.

PMID:
32073262
2.

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands.

Paisdzior S, Dimitriou IM, Schöpe PC, Annibale P, Scheerer P, Krude H, Lohse MJ, Biebermann H, Kühnen P.

Int J Mol Sci. 2020 Feb 12;21(4). pii: E1224. doi: 10.3390/ijms21041224.

3.

The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches.

Brosig A, Fuchs J, Ipek F, Kroon C, Schrötter S, Vadhvani M, Polyzou A, Ledderose J, van Diepen M, Holzhütter HG, Trimbuch T, Gimber N, Schmoranzer J, Lieberam I, Rosenmund C, Spahn C, Scheerer P, Szczepek M, Leondaritis G, Eickholt BJ.

Cell Rep. 2019 Nov 12;29(7):2028-2040.e8. doi: 10.1016/j.celrep.2019.10.039.

4.

The Pathogenic TSH β-subunit Variant C105Vfs114X Causes a Modified Signaling Profile at TSHR.

Kalveram L, Kleinau G, Szymańska K, Scheerer P, Rivero-Müller A, Grüters-Kieslich A, Biebermann H.

Int J Mol Sci. 2019 Nov 7;20(22). pii: E5564. doi: 10.3390/ijms20225564.

5.

Recurrent convergent evolution at amino acid residue 261 in fish rhodopsin.

Hill J, Enbody ED, Pettersson ME, Sprehn CG, Bekkevold D, Folkvord A, Laikre L, Kleinau G, Scheerer P, Andersson L.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18473-18478. doi: 10.1073/pnas.1908332116. Epub 2019 Aug 26.

6.

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective.

Heyder N, Kleinau G, Szczepek M, Kwiatkowski D, Speck D, Soletto L, Cerdá-Reverter JM, Krude H, Kühnen P, Biebermann H, Scheerer P.

Front Endocrinol (Lausanne). 2019 Jul 31;10:515. doi: 10.3389/fendo.2019.00515. eCollection 2019.

7.

Role of the Propionic Side Chains for the Photoconversion of Bacterial Phytochromes.

Fernandez Lopez M, Nguyen AD, Velazquez Escobar F, González R, Michael N, Nogacz Ż, Piwowarski P, Bartl F, Siebert F, Heise I, Scheerer P, Gärtner W, Mroginski MA, Hildebrandt P.

Biochemistry. 2019 Aug 20;58(33):3504-3519. doi: 10.1021/acs.biochem.9b00526. Epub 2019 Aug 6.

PMID:
31348653
8.

Design of a light-gated proton channel based on the crystal structure of Coccomyxa rhodopsin.

Fudim R, Szczepek M, Vierock J, Vogt A, Schmidt A, Kleinau G, Fischer P, Bartl F, Scheerer P, Hegemann P.

Sci Signal. 2019 Mar 19;12(573). pii: eaav4203. doi: 10.1126/scisignal.aav4203.

PMID:
30890657
9.

Evaluation of a rare glucose-dependent insulinotropic polypeptide receptor variant in a patient with diabetes.

Jacobi SF, Khajavi N, Kleinau G, Teumer A, Scheerer P, Homuth G, Völzke H, Wiegand S, Kühnen P, Krude H, Gong M, Raile K, Biebermann H.

Diabetes Obes Metab. 2019 May;21(5):1168-1176. doi: 10.1111/dom.13634. Epub 2019 Feb 19.

PMID:
30784161
10.

Melanocortin Receptor Accessory Protein 2-Induced Adrenocorticotropic Hormone Response of Human Melanocortin 4 Receptor.

Soletto L, Hernández-Balfagó S, Rocha A, Scheerer P, Kleinau G, Cerdá-Reverter JM.

J Endocr Soc. 2018 Dec 6;3(2):314-323. doi: 10.1210/js.2018-00370. eCollection 2019 Feb 1.

11.

Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway.

Klein W, Rutz C, Eckhard J, Provinciael B, Specker E, Neuenschwander M, Kleinau G, Scheerer P, von Kries JP, Nazaré M, Vermeire K, Schülein R.

PLoS One. 2018 Dec 13;13(12):e0208641. doi: 10.1371/journal.pone.0208641. eCollection 2018.

12.

Structural snapshot of a bacterial phytochrome in its functional intermediate state.

Schmidt A, Sauthof L, Szczepek M, Lopez MF, Escobar FV, Qureshi BM, Michael N, Buhrke D, Stevens T, Kwiatkowski D, von Stetten D, Mroginski MA, Krauß N, Lamparter T, Hildebrandt P, Scheerer P.

Nat Commun. 2018 Nov 21;9(1):4912. doi: 10.1038/s41467-018-07392-7.

13.

A New Multisystem Disorder Caused by the Gαs Mutation p.F376V.

Biebermann H, Kleinau G, Schnabel D, Bockenhauer D, Wilson LC, Tully I, Kiff S, Scheerer P, Reyes M, Paisdzior S, Gregory JW, Allgrove J, Krude H, Mannstadt M, Gardella TJ, Dattani M, Jüppner H, Grüters A.

J Clin Endocrinol Metab. 2019 Apr 1;104(4):1079-1089. doi: 10.1210/jc.2018-01250.

14.

Protein structures guide the design of a much-needed tool for neuroscience.

Scheerer P, Unger E, Tian L.

Nature. 2018 Sep;561(7723):312-313. doi: 10.1038/d41586-018-06670-0. No abstract available.

PMID:
30224730
15.

An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation.

Khajavi N, Finan B, Kluth O, Müller TD, Mergler S, Schulz A, Kleinau G, Scheerer P, Schürmann A, Gudermann T, Tschöp MH, Krude H, DiMarchi RD, Biebermann H.

Cell Signal. 2018 Nov;51:13-22. doi: 10.1016/j.cellsig.2018.07.006. Epub 2018 Jul 25.

PMID:
30055232
16.

Binding, Thermodynamics, and Selectivity of a Non-peptide Antagonist to the Melanocortin-4 Receptor.

Saleh N, Kleinau G, Heyder N, Clark T, Hildebrand PW, Scheerer P.

Front Pharmacol. 2018 Jun 1;9:560. doi: 10.3389/fphar.2018.00560. eCollection 2018.

17.

Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction.

Borchert A, Kalms J, Roth SR, Rademacher M, Schmidt A, Holzhutter HG, Kuhn H, Scheerer P.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Sep;1863(9):1095-1107. doi: 10.1016/j.bbalip.2018.06.006. Epub 2018 Jun 5.

PMID:
29883798
18.

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency.

Clément K, Biebermann H, Farooqi IS, Van der Ploeg L, Wolters B, Poitou C, Puder L, Fiedorek F, Gottesdiener K, Kleinau G, Heyder N, Scheerer P, Blume-Peytavi U, Jahnke I, Sharma S, Mokrosinski J, Wiegand S, Müller A, Weiß K, Mai K, Spranger J, Grüters A, Blankenstein O, Krude H, Kühnen P.

Nat Med. 2018 May;24(5):551-555. doi: 10.1038/s41591-018-0015-9. Epub 2018 May 7.

PMID:
29736023
19.

The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor.

Bräunig J, Dinter J, Höfig CS, Paisdzior S, Szczepek M, Scheerer P, Rosowski M, Mittag J, Kleinau G, Biebermann H.

Front Pharmacol. 2018 Mar 12;9:222. doi: 10.3389/fphar.2018.00222. eCollection 2018.

20.

Tracking the route of molecular oxygen in O2-tolerant membrane-bound [NiFe] hydrogenase.

Kalms J, Schmidt A, Frielingsdorf S, Utesch T, Gotthard G, von Stetten D, van der Linden P, Royant A, Mroginski MA, Carpentier P, Lenz O, Scheerer P.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2229-E2237. doi: 10.1073/pnas.1712267115. Epub 2018 Feb 20.

21.

The arrestin-1 finger loop interacts with two distinct conformations of active rhodopsin.

Elgeti M, Kazmin R, Rose AS, Szczepek M, Hildebrand PW, Bartl FJ, Scheerer P, Hofmann KP.

J Biol Chem. 2018 Mar 23;293(12):4403-4410. doi: 10.1074/jbc.M117.817890. Epub 2018 Jan 23.

22.

Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6.

Qureshi BM, Schmidt A, Behrmann E, Bürger J, Mielke T, Spahn CMT, Heck M, Scheerer P.

Nat Commun. 2018 Jan 8;9(1):90. doi: 10.1038/s41467-017-02569-y.

23.

Corrigendum: Double-flow focused liquid injector for efficient serial femtosecond crystallography.

Oberthuer D, Knoška J, Wiedorn MO, Beyerlein KR, Bushnell DA, Kovaleva EG, Heymann M, Gumprecht L, Kirian RA, Barty A, Mariani V, Tolstikova A, Adriano L, Awel S, Barthelmess M, Dörner K, Xavier PL, Yefanov O, James DR, Nelson G, Wang D, Calvey G, Chen Y, Schmidt A, Szczepek M, Frielingsdorf S, Lenz O, Snell E, Robinson PJ, Šarler B, Belšak G, Maček M, Wilde F, Aquila A, Boutet S, Liang M, Hunter MS, Scheerer P, Lipscomb JD, Weierstall U, Kornberg RD, Spence JCH, Pollack L, Chapman HN, Bajt S.

Sci Rep. 2017 Jun 21;7:46846. doi: 10.1038/srep46846.

24.

Structural mechanism of arrestin activation.

Scheerer P, Sommer ME.

Curr Opin Struct Biol. 2017 Aug;45:160-169. doi: 10.1016/j.sbi.2017.05.001. Epub 2017 Jun 7. Review.

25.

Common Structural Elements in the Chromophore Binding Pocket of the Pfr State of Bathy Phytochromes.

Velázquez Escobar F, Buhrke D, Michael N, Sauthof L, Wilkening S, Tavraz NN, Salewski J, Frankenberg-Dinkel N, Mroginski MA, Scheerer P, Friedrich T, Siebert F, Hildebrandt P.

Photochem Photobiol. 2017 May;93(3):724-732. doi: 10.1111/php.12742.

PMID:
28500706
26.

Phytochromes from Agrobacterium fabrum.

Lamparter T, Krauß N, Scheerer P.

Photochem Photobiol. 2017 May;93(3):642-655. doi: 10.1111/php.12761. Review.

PMID:
28500698
27.

Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work.

Kleinau G, Worth CL, Kreuchwig A, Biebermann H, Marcinkowski P, Scheerer P, Krause G.

Front Endocrinol (Lausanne). 2017 Apr 24;8:86. doi: 10.3389/fendo.2017.00086. eCollection 2017. Review.

28.

Double-flow focused liquid injector for efficient serial femtosecond crystallography.

Oberthuer D, Knoška J, Wiedorn MO, Beyerlein KR, Bushnell DA, Kovaleva EG, Heymann M, Gumprecht L, Kirian RA, Barty A, Mariani V, Tolstikova A, Adriano L, Awel S, Barthelmess M, Dörner K, Xavier PL, Yefanov O, James DR, Nelson G, Wang D, Calvey G, Chen Y, Schmidt A, Szczepek M, Frielingsdorf S, Lenz O, Snell E, Robinson PJ, Šarler B, Belšak G, Maček M, Wilde F, Aquila A, Boutet S, Liang M, Hunter MS, Scheerer P, Lipscomb JD, Weierstall U, Kornberg RD, Spence JC, Pollack L, Chapman HN, Bajt S.

Sci Rep. 2017 Mar 16;7:44628. doi: 10.1038/srep44628. Erratum in: Sci Rep. 2017 Jun 21;7:46846.

29.

Intersubunit distances in full-length, dimeric, bacterial phytochrome Agp1, as measured by pulsed electron-electron double resonance (PELDOR) between different spin label positions, remain unchanged upon photoconversion.

Kacprzak S, Njimona I, Renz A, Feng J, Reijerse E, Lubitz W, Krauss N, Scheerer P, Nagano S, Lamparter T, Weber S.

J Biol Chem. 2017 May 5;292(18):7598-7606. doi: 10.1074/jbc.M116.761882. Epub 2017 Mar 13.

30.

The crystal structure of Pseudomonas aeruginosa lipoxygenase Ala420Gly mutant explains the improved oxygen affinity and the altered reaction specificity.

Kalms J, Banthiya S, Galemou Yoga E, Hamberg M, Holzhutter HG, Kuhn H, Scheerer P.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 May;1862(5):463-473. doi: 10.1016/j.bbalip.2017.01.003. Epub 2017 Jan 14.

PMID:
28093240
31.

Divalent Cations Increase DNA Repair Activities of Bacterial (6-4) Photolyases.

Ma H, Zhang F, Ignatz E, Suehnel M, Xue P, Scheerer P, Essen LO, Krauß N, Lamparter T.

Photochem Photobiol. 2017 Jan;93(1):323-330. doi: 10.1111/php.12698.

PMID:
27992646
32.

Crystal Structures of Bacterial (6-4) Photolyase Mutants with Impaired DNA Repair Activity.

Zhang F, Ma H, Bowatte K, Kwiatkowski D, Mittmann E, Qasem H, Krauß N, Zeng X, Ren Z, Scheerer P, Yang X, Lamparter T.

Photochem Photobiol. 2017 Jan;93(1):304-314. doi: 10.1111/php.12699. Epub 2017 Jan 27.

PMID:
27992645
33.

Insights into Basal Signaling Regulation, Oligomerization, and Structural Organization of the Human G-Protein Coupled Receptor 83.

Müller A, Berkmann JC, Scheerer P, Biebermann H, Kleinau G.

PLoS One. 2016 Dec 9;11(12):e0168260. doi: 10.1371/journal.pone.0168260. eCollection 2016.

34.

Structural and functional basis of phospholipid oxygenase activity of bacterial lipoxygenase from Pseudomonas aeruginosa.

Banthiya S, Kalms J, Galemou Yoga E, Ivanov I, Carpena X, Hamberg M, Kuhn H, Scheerer P.

Biochim Biophys Acta. 2016 Nov;1861(11):1681-1692. doi: 10.1016/j.bbalip.2016.08.002. Epub 2016 Aug 5.

PMID:
27500637
35.

The Crystal Structures of the N-terminal Photosensory Core Module of Agrobacterium Phytochrome Agp1 as Parallel and Anti-parallel Dimers.

Nagano S, Scheerer P, Zubow K, Michael N, Inomata K, Lamparter T, Krauß N.

J Biol Chem. 2016 Sep 23;291(39):20674-91. doi: 10.1074/jbc.M116.739136. Epub 2016 Jul 26.

36.

Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association.

Sprink T, Ramrath DJ, Yamamoto H, Yamamoto K, Loerke J, Ismer J, Hildebrand PW, Scheerer P, Bürger J, Mielke T, Spahn CM.

Sci Adv. 2016 Mar 4;2(3):e1501502. doi: 10.1126/sciadv.1501502. eCollection 2016 Mar.

37.

Krypton Derivatization of an O2 -Tolerant Membrane-Bound [NiFe] Hydrogenase Reveals a Hydrophobic Tunnel Network for Gas Transport.

Kalms J, Schmidt A, Frielingsdorf S, van der Linden P, von Stetten D, Lenz O, Carpentier P, Scheerer P.

Angew Chem Int Ed Engl. 2016 Apr 25;55(18):5586-90. doi: 10.1002/anie.201508976. Epub 2016 Feb 23.

PMID:
26913499
38.

Role of Structural Dynamics at the Receptor G Protein Interface for Signal Transduction.

Rose AS, Zachariae U, Grubmüller H, Hofmann KP, Scheerer P, Hildebrand PW.

PLoS One. 2015 Nov 25;10(11):e0143399. doi: 10.1371/journal.pone.0143399. eCollection 2015.

39.

Molecular architecture of the ribosome-bound Hepatitis C Virus internal ribosomal entry site RNA.

Yamamoto H, Collier M, Loerke J, Ismer J, Schmidt A, Hilal T, Sprink T, Yamamoto K, Mielke T, Bürger J, Shaikh TR, Dabrowski M, Hildebrand PW, Scheerer P, Spahn CM.

EMBO J. 2015 Dec 14;34(24):3042-58. doi: 10.15252/embj.201592469. Epub 2015 Nov 24.

40.

Key Amino Acids in the Bacterial (6-4) Photolyase PhrB from Agrobacterium fabrum.

Graf D, Wesslowski J, Ma H, Scheerer P, Krauß N, Oberpichler I, Zhang F, Lamparter T.

PLoS One. 2015 Oct 21;10(10):e0140955. doi: 10.1371/journal.pone.0140955. eCollection 2015.

41.

Resonance Raman Spectroscopic Analysis of the [NiFe] Active Site and the Proximal [4Fe-3S] Cluster of an O2-Tolerant Membrane-Bound Hydrogenase in the Crystalline State.

Siebert E, Rippers Y, Frielingsdorf S, Fritsch J, Schmidt A, Kalms J, Katz S, Lenz O, Scheerer P, Paasche L, Pelmenschikov V, Kuhlmann U, Mroginski MA, Zebger I, Hildebrandt P.

J Phys Chem B. 2015 Oct 29;119(43):13785-96. doi: 10.1021/acs.jpcb.5b04119. Epub 2015 Aug 7.

PMID:
26201814
42.

The Activation Pathway of Human Rhodopsin in Comparison to Bovine Rhodopsin.

Kazmin R, Rose A, Szczepek M, Elgeti M, Ritter E, Piechnick R, Hofmann KP, Scheerer P, Hildebrand PW, Bartl FJ.

J Biol Chem. 2015 Aug 14;290(33):20117-27. doi: 10.1074/jbc.M115.652172. Epub 2015 Jun 23.

43.

Structural snapshots of actively translating human ribosomes.

Behrmann E, Loerke J, Budkevich TV, Yamamoto K, Schmidt A, Penczek PA, Vos MR, Bürger J, Mielke T, Scheerer P, Spahn CM.

Cell. 2015 May 7;161(4):845-57. doi: 10.1016/j.cell.2015.03.052.

44.

A protonation-coupled feedback mechanism controls the signalling process in bathy phytochromes.

Velazquez Escobar F, Piwowarski P, Salewski J, Michael N, Fernandez Lopez M, Rupp A, Qureshi BM, Scheerer P, Bartl F, Frankenberg-Dinkel N, Siebert F, Andrea Mroginski M, Hildebrandt P.

Nat Chem. 2015 May;7(5):423-30. doi: 10.1038/nchem.2225. Epub 2015 Apr 13.

PMID:
25901821
45.

Structure-based biophysical analysis of the interaction of rhodopsin with G protein and arrestin.

Sommer ME, Elgeti M, Hildebrand PW, Szczepek M, Hofmann KP, Scheerer P.

Methods Enzymol. 2015;556:563-608. doi: 10.1016/bs.mie.2014.12.014. Epub 2015 Mar 6.

PMID:
25857800
46.

The class III cyclobutane pyrimidine dimer photolyase structure reveals a new antenna chromophore binding site and alternative photoreduction pathways.

Scheerer P, Zhang F, Kalms J, von Stetten D, Krauß N, Oberpichler I, Lamparter T.

J Biol Chem. 2015 May 1;290(18):11504-14. doi: 10.1074/jbc.M115.637868. Epub 2015 Mar 17.

47.

Crystal structure of a common GPCR-binding interface for G protein and arrestin.

Szczepek M, Beyrière F, Hofmann KP, Elgeti M, Kazmin R, Rose A, Bartl FJ, von Stetten D, Heck M, Sommer ME, Hildebrand PW, Scheerer P.

Nat Commun. 2014 Sep 10;5:4801. doi: 10.1038/ncomms5801.

48.

Position of transmembrane helix 6 determines receptor G protein coupling specificity.

Rose AS, Elgeti M, Zachariae U, Grubmüller H, Hofmann KP, Scheerer P, Hildebrand PW.

J Am Chem Soc. 2014 Aug 13;136(32):11244-7. doi: 10.1021/ja5055109. Epub 2014 Jul 31.

PMID:
25046433
49.

Reversible [4Fe-3S] cluster morphing in an O(2)-tolerant [NiFe] hydrogenase.

Frielingsdorf S, Fritsch J, Schmidt A, Hammer M, Löwenstein J, Siebert E, Pelmenschikov V, Jaenicke T, Kalms J, Rippers Y, Lendzian F, Zebger I, Teutloff C, Kaupp M, Bittl R, Hildebrandt P, Friedrich B, Lenz O, Scheerer P.

Nat Chem Biol. 2014 May;10(5):378-85. doi: 10.1038/nchembio.1500. Epub 2014 Apr 6.

PMID:
24705592
50.

Molecular basis for the catalytic inactivity of a naturally occurring near-null variant of human ALOX15.

Horn T, Ivanov I, Di Venere A, Kakularam KR, Reddanna P, Conrad ML, Richter C, Scheerer P, Kuhn H.

Biochim Biophys Acta. 2013 Dec;1831(12):1702-13. doi: 10.1016/j.bbalip.2013.08.004. Epub 2013 Aug 16.

PMID:
23958500

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