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Items: 26

1.

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering.

van der Schoot JMS, Fennemann FL, Valente M, Dolen Y, Hagemans IM, Becker AMD, Le Gall CM, van Dalen D, Cevirgel A, van Bruggen JAC, Engelfriet M, Caval T, Bentlage AEH, Fransen MF, Nederend M, Leusen JHW, Heck AJR, Vidarsson G, Figdor CG, Verdoes M, Scheeren FA.

Sci Adv. 2019 Aug 28;5(8):eaaw1822. doi: 10.1126/sciadv.aaw1822. eCollection 2019 Aug.

2.

Metabolic stress in cancer cells induces immune escape through a PI3K-dependent blockade of IFNγ receptor signaling.

Marijt KA, Sluijter M, Blijleven L, Tolmeijer SH, Scheeren FA, van der Burg SH, van Hall T.

J Immunother Cancer. 2019 Jun 13;7(1):152. doi: 10.1186/s40425-019-0627-8.

3.

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.

Logtenberg MEW, Jansen JHM, Raaben M, Toebes M, Franke K, Brandsma AM, Matlung HL, Fauster A, Gomez-Eerland R, Bakker NAM, van der Schot S, Marijt KA, Verdoes M, Haanen JBAG, van den Berg JH, Neefjes J, van den Berg TK, Brummelkamp TR, Leusen JHW, Scheeren FA, Schumacher TN.

Nat Med. 2019 Apr;25(4):612-619. doi: 10.1038/s41591-019-0356-z. Epub 2019 Mar 4.

PMID:
30833751
4.

SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing.

Mezzadra R, de Bruijn M, Jae LT, Gomez-Eerland R, Duursma A, Scheeren FA, Brummelkamp TR, Schumacher TN.

PLoS One. 2019 Feb 12;14(2):e0212053. doi: 10.1371/journal.pone.0212053. eCollection 2019.

5.

Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis.

Sikandar SS, Kuo AH, Kalisky T, Cai S, Zabala M, Hsieh RW, Lobo NA, Scheeren FA, Sim S, Qian D, Dirbas FM, Somlo G, Quake SR, Clarke MF.

Nat Commun. 2017 Nov 21;8(1):1669. doi: 10.1038/s41467-017-01666-2.

6.

A Quiescent Bcl11b High Stem Cell Population Is Required for Maintenance of the Mammary Gland.

Cai S, Kalisky T, Sahoo D, Dalerba P, Feng W, Lin Y, Qian D, Kong A, Yu J, Wang F, Chen EY, Scheeren FA, Kuo AH, Sikandar SS, Hisamori S, van Weele LJ, Heiser D, Sim S, Lam J, Quake S, Clarke MF.

Cell Stem Cell. 2017 Feb 2;20(2):247-260.e5. doi: 10.1016/j.stem.2016.11.007. Epub 2016 Dec 29.

7.

Corrigendum: Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming.

Kwakkenbos MJ, Diehl SA, Yasuda E, Bakker AQ, van Geelen CM, Lukens MV, van Bleek GM, Widjojoatmodjo MN, Bogers WM, Mei H, Radbruch A, Scheeren FA, Spits H, Beaumont T.

Nat Med. 2016 Dec 6;22(12):1502. doi: 10.1038/nm1216-1502a. No abstract available.

PMID:
27923028
8.

Targeting Toll-like receptor 2 inhibits growth of head and neck squamous cell carcinoma.

Farnebo L, Shahangian A, Lee Y, Shin JH, Scheeren FA, Sunwoo JB.

Oncotarget. 2015 Apr 30;6(12):9897-907.

9.

CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer.

Cheah MT, Chen JY, Sahoo D, Contreras-Trujillo H, Volkmer AK, Scheeren FA, Volkmer JP, Weissman IL.

Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4725-30. doi: 10.1073/pnas.1424795112. Epub 2015 Mar 30.

10.

Cell-intrinsic TLR2/MyD88 pathway in breast and colon cancer.

Kuo AH, Scheeren FA.

Cell Cycle. 2014;13(24):3785-6. doi: 10.4161/15384101.2014.989947. No abstract available.

11.

A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis.

Scheeren FA, Kuo AH, van Weele LJ, Cai S, Glykofridis I, Sikandar SS, Zabala M, Qian D, Lam JS, Johnston D, Volkmer JP, Sahoo D, van de Rijn M, Dirbas FM, Somlo G, Kalisky T, Rothenberg ME, Quake SR, Clarke MF.

Nat Cell Biol. 2014 Dec;16(12):1238-48. doi: 10.1038/ncb3058. Epub 2014 Nov 2.

PMID:
25362351
12.

Targeting unique metabolic properties of breast tumor initiating cells.

Feng W, Gentles A, Nair RV, Huang M, Lin Y, Lee CY, Cai S, Scheeren FA, Kuo AH, Diehn M.

Stem Cells. 2014 Jul;32(7):1734-45. doi: 10.1002/stem.1662.

13.

Neuregulin autocrine signaling promotes self-renewal of breast tumor-initiating cells by triggering HER2/HER3 activation.

Lee CY, Lin Y, Bratman SV, Feng W, Kuo AH, Scheeren FA, Engreitz JM, Varma S, West RB, Diehn M.

Cancer Res. 2014 Jan 1;74(1):341-52. doi: 10.1158/0008-5472.CAN-13-1055. Epub 2013 Oct 31.

14.

A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages.

Verdoes M, Edgington LE, Scheeren FA, Leyva M, Blum G, Weiskopf K, Bachmann MH, Ellman JA, Bogyo M.

Chem Biol. 2012 May 25;19(5):619-28. doi: 10.1016/j.chembiol.2012.03.012.

15.

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.

Willingham SB, Volkmer JP, Gentles AJ, Sahoo D, Dalerba P, Mitra SS, Wang J, Contreras-Trujillo H, Martin R, Cohen JD, Lovelace P, Scheeren FA, Chao MP, Weiskopf K, Tang C, Volkmer AK, Naik TJ, Storm TA, Mosley AR, Edris B, Schmid SM, Sun CK, Chua MS, Murillo O, Rajendran P, Cha AC, Chin RK, Kim D, Adorno M, Raveh T, Tseng D, Jaiswal S, Enger PØ, Steinberg GK, Li G, So SK, Majeti R, Harsh GR, van de Rijn M, Teng NN, Sunwoo JB, Alizadeh AA, Clarke MF, Weissman IL.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6662-7. doi: 10.1073/pnas.1121623109. Epub 2012 Mar 26.

16.

Antigen-specific monoclonal antibodies isolated from B cells expressing constitutively active STAT5.

Scheeren FA, van Geelen CM, Yasuda E, Spits H, Beaumont T.

PLoS One. 2011 Apr 15;6(4):e17189. doi: 10.1371/journal.pone.0017189.

17.

Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice.

Becker PD, Legrand N, van Geelen CM, Noerder M, Huntington ND, Lim A, Yasuda E, Diehl SA, Scheeren FA, Ott M, Weijer K, Wedemeyer H, Di Santo JP, Beaumont T, Guzman CA, Spits H.

PLoS One. 2010 Oct 4;5(10). pii: e13137. doi: 10.1371/journal.pone.0013137.

18.

Thymic stromal lymphopoietin induces early human B-cell proliferation and differentiation.

Scheeren FA, van Lent AU, Nagasawa M, Weijer K, Spits H, Legrand N, Blom B.

Eur J Immunol. 2010 Apr;40(4):955-65. doi: 10.1002/eji.200939419.

19.

IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter.

Kis LL, Salamon D, Persson EK, Nagy N, Scheeren FA, Spits H, Klein G, Klein E.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):872-7. doi: 10.1073/pnas.0912920107. Epub 2009 Dec 22.

20.

Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming.

Kwakkenbos MJ, Diehl SA, Yasuda E, Bakker AQ, van Geelen CM, Lukens MV, van Bleek GM, Widjojoatmodjo MN, Bogers WM, Mei H, Radbruch A, Scheeren FA, Spits H, Beaumont T.

Nat Med. 2010 Jan;16(1):123-8. doi: 10.1038/nm.2071. Epub 2009 Dec 20. Erratum in: Nat Med. 2016 Dec 6;22(12 ):1502.

21.

AID splice variants lack deaminase activity.

van Maldegem F, Scheeren FA, Aarti Jibodh R, Bende RJ, Jacobs H, van Noesel CJ.

Blood. 2009 Feb 19;113(8):1862-4; author reply 1864. doi: 10.1182/blood-2008-08-175265. No abstract available.

PMID:
19228934
22.

T cell-independent development and induction of somatic hypermutation in human IgM+ IgD+ CD27+ B cells.

Scheeren FA, Nagasawa M, Weijer K, Cupedo T, Kirberg J, Legrand N, Spits H.

J Exp Med. 2008 Sep 1;205(9):2033-42. doi: 10.1084/jem.20070447. Epub 2008 Aug 11.

23.

Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression.

Schmidlin H, Diehl SA, Nagasawa M, Scheeren FA, Schotte R, Uittenbogaart CH, Spits H, Blom B.

Blood. 2008 Sep 1;112(5):1804-12. doi: 10.1182/blood-2008-01-136440. Epub 2008 Jun 13.

24.

STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation.

Diehl SA, Schmidlin H, Nagasawa M, van Haren SD, Kwakkenbos MJ, Yasuda E, Beaumont T, Scheeren FA, Spits H.

J Immunol. 2008 Apr 1;180(7):4805-15.

25.

IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis.

Scheeren FA, Diehl SA, Smit LA, Beaumont T, Naspetti M, Bende RJ, Blom B, Karube K, Ohshima K, van Noesel CJ, Spits H.

Blood. 2008 May 1;111(9):4706-15. doi: 10.1182/blood-2007-08-105643. Epub 2008 Feb 22.

26.

STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression.

Scheeren FA, Naspetti M, Diehl S, Schotte R, Nagasawa M, Wijnands E, Gimeno R, Vyth-Dreese FA, Blom B, Spits H.

Nat Immunol. 2005 Mar;6(3):303-13. Epub 2005 Feb 13.

PMID:
15711548

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