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Items: 41

1.

Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice.

Kapelyukh Y, Henderson CJ, Scheer N, Rode A, Wolf CR.

Drug Metab Dispos. 2019 Aug;47(8):907-918. doi: 10.1124/dmd.119.087718. Epub 2019 May 30.

2.

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials.

Henderson CJ, Kapelyukh Y, Scheer N, Rode A, McLaren AW, MacLeod AK, Lin D, Wright J, Stanley LA, Wolf CR.

Drug Metab Dispos. 2019 Jun;47(6):601-615. doi: 10.1124/dmd.119.086397. Epub 2019 Mar 25.

3.

Evaluation of the yield of post-clipping angiography and nationwide current practice.

Scheer N, Ghaznawi R, van Walderveen MAA, Koot RW, Willems PWA.

Acta Neurochir (Wien). 2019 Apr;161(4):783-790. doi: 10.1007/s00701-019-03834-3. Epub 2019 Feb 19.

4.

Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.

Kazuki Y, Kobayashi K, Hirabayashi M, Abe S, Kajitani N, Kazuki K, Takehara S, Takiguchi M, Satoh D, Kuze J, Sakuma T, Kaneko T, Mashimo T, Osamura M, Hashimoto M, Wakatsuki R, Hirashima R, Fujiwara R, Deguchi T, Kurihara A, Tsukazaki Y, Senda N, Yamamoto T, Scheer N, Oshimura M.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3072-3081. doi: 10.1073/pnas.1808255116. Epub 2019 Feb 4.

5.

The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice.

Wilson CE, Dickie AP, Schreiter K, Wehr R, Wilson EM, Bial J, Scheer N, Wilson ID, Riley RJ.

Arch Toxicol. 2018 Jun;92(6):1953-1967. doi: 10.1007/s00204-018-2212-1. Epub 2018 May 2.

6.

The pharmacokinetics and metabolism of lumiracoxib in chimeric humanized and murinized FRG mice.

Dickie AP, Wilson CE, Schreiter K, Wehr R, Wilson EM, Bial J, Scheer N, Wilson ID, Riley RJ.

Biochem Pharmacol. 2017 Jul 1;135:139-150. doi: 10.1016/j.bcp.2017.03.015. Epub 2017 Mar 27.

PMID:
28351678
7.

Astym Therapy Improves Bilateral Hamstring Flexibility and Achilles Tendinopathy in a Child with Cerebral Palsy: A Retrospective Case Report.

Scheer NA, Alstat LR, Van Zant RS.

Clin Med Insights Case Rep. 2016 Oct 20;9:95-98. eCollection 2016.

8.

Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling.

Zhang J, Heimbach T, Scheer N, Barve A, Li W, Lin W, He H.

J Pharm Sci. 2016 Apr;105(4):1398-404. doi: 10.1016/j.xphs.2016.01.021.

PMID:
27019957
9.

Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model.

Dallas S, Salphati L, Gomez-Zepeda D, Wanek T, Chen L, Chu X, Kunta J, Mezler M, Menet MC, Chasseigneaux S, Declèves X, Langer O, Pierre E, DiLoreto K, Hoft C, Laplanche L, Pang J, Pereira T, Andonian C, Simic D, Rode A, Yabut J, Zhang X, Scheer N.

Mol Pharmacol. 2016 May;89(5):492-504. doi: 10.1124/mol.115.102079. Epub 2016 Feb 18.

PMID:
26893303
10.

A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity.

Scheer N, Wilson ID.

Drug Discov Today. 2016 Feb;21(2):250-63. doi: 10.1016/j.drudis.2015.09.002. Epub 2015 Sep 7. Review.

11.

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model.

Scheer N, Kapelyukh Y, Rode A, Oswald S, Busch D, McLaughlin LA, Lin D, Henderson CJ, Wolf CR.

Drug Metab Dispos. 2015 Nov;43(11):1679-90. doi: 10.1124/dmd.115.065656. Epub 2015 Aug 11.

PMID:
26265742
12.

Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms.

Hough LB, Nalwalk JW, Ding X, Scheer N.

Drug Metab Dispos. 2015 Sep;43(9):1326-30. doi: 10.1124/dmd.115.065490. Epub 2015 Jun 24.

13.

Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo.

Henderson CJ, McLaughlin LA, Scheer N, Stanley LA, Wolf CR.

Mol Pharmacol. 2015 Apr;87(4):733-9. doi: 10.1124/mol.114.097394. Epub 2015 Feb 5.

PMID:
25657337
14.

Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins.

Salphati L, Chu X, Chen L, Prasad B, Dallas S, Evers R, Mamaril-Fishman D, Geier EG, Kehler J, Kunta J, Mezler M, Laplanche L, Pang J, Rode A, Soars MG, Unadkat JD, van Waterschoot RA, Yabut J, Schinkel AH, Scheer N.

Drug Metab Dispos. 2014 Aug;42(8):1301-13. doi: 10.1124/dmd.114.057976. Epub 2014 May 22.

PMID:
24855184
15.

Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.

Luisier R, Lempiäinen H, Scherbichler N, Braeuning A, Geissler M, Dubost V, Müller A, Scheer N, Chibout SD, Hara H, Picard F, Theil D, Couttet P, Vitobello A, Grenet O, Grasl-Kraupp B, Ellinger-Ziegelbauer H, Thomson JP, Meehan RR, Elcombe CR, Henderson CJ, Wolf CR, Schwarz M, Moulin P, Terranova R, Moggs JG.

Toxicol Sci. 2014 Jun;139(2):501-11. doi: 10.1093/toxsci/kfu038. Epub 2014 Apr 1.

PMID:
24690595
16.

Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism.

Scheer N, McLaughlin LA, Rode A, Macleod AK, Henderson CJ, Wolf CR.

Drug Metab Dispos. 2014 Jun;42(6):1022-30. doi: 10.1124/dmd.114.057885. Epub 2014 Mar 26.

PMID:
24671958
17.

Generation and utility of genetically humanized mouse models.

Scheer N, Snaith M, Wolf CR, Seibler J.

Drug Discov Today. 2013 Dec;18(23-24):1200-11. doi: 10.1016/j.drudis.2013.07.007. Epub 2013 Jul 18. Review.

PMID:
23872278
18.

Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications.

Scheer N, Wolf CR.

Xenobiotica. 2014 Jan;44(2):96-108. doi: 10.3109/00498254.2013.815831. Epub 2013 Jul 11. Review.

PMID:
23845026
19.

Xenobiotic receptor humanized mice and their utility.

Scheer N, Roland Wolf C.

Drug Metab Rev. 2013 Feb;45(1):110-21. doi: 10.3109/03602532.2012.738687. Epub 2012 Nov 23. Review.

PMID:
23173549
20.

Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion.

Lempiäinen H, Couttet P, Bolognani F, Müller A, Dubost V, Luisier R, Del Rio Espinola A, Vitry V, Unterberger EB, Thomson JP, Treindl F, Metzger U, Wrzodek C, Hahne F, Zollinger T, Brasa S, Kalteis M, Marcellin M, Giudicelli F, Braeuning A, Morawiec L, Zamurovic N, Längle U, Scheer N, Schübeler D, Goodman J, Chibout SD, Marlowe J, Theil D, Heard DJ, Grenet O, Zell A, Templin MF, Meehan RR, Wolf RC, Elcombe CR, Schwarz M, Moulin P, Terranova R, Moggs JG.

Toxicol Sci. 2013 Feb;131(2):375-86. doi: 10.1093/toxsci/kfs303. Epub 2012 Oct 22.

PMID:
23091169
21.

Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines.

Scheer N, Kapelyukh Y, Chatham L, Rode A, Buechel S, Wolf CR.

Mol Pharmacol. 2012 Dec;82(6):1022-9. doi: 10.1124/mol.112.080036. Epub 2012 Aug 23.

PMID:
22918969
22.

Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line.

Scheer N, Balimane P, Hayward MD, Buechel S, Kauselmann G, Wolf CR.

Drug Metab Dispos. 2012 Nov;40(11):2212-8. doi: 10.1124/dmd.112.047605. Epub 2012 Aug 23.

PMID:
22917771
23.

Modeling human cytochrome P450 2D6 metabolism and drug-drug interaction by a novel panel of knockout and humanized mouse lines.

Scheer N, Kapelyukh Y, McEwan J, Beuger V, Stanley LA, Rode A, Wolf CR.

Mol Pharmacol. 2012 Jan;81(1):63-72. doi: 10.1124/mol.111.075192. Epub 2011 Oct 11.

PMID:
21989258
24.

Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line.

Hasegawa M, Kapelyukh Y, Tahara H, Seibler J, Rode A, Krueger S, Lee DN, Wolf CR, Scheer N.

Mol Pharmacol. 2011 Sep;80(3):518-28. doi: 10.1124/mol.111.071845. Epub 2011 May 31.

PMID:
21628639
25.

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

Ross J, Plummer SM, Rode A, Scheer N, Bower CC, Vogel O, Henderson CJ, Wolf CR, Elcombe CR.

Toxicol Sci. 2010 Aug;116(2):452-66. doi: 10.1093/toxsci/kfq118. Epub 2010 Apr 19.

PMID:
20403969
26.

In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice.

Scheer N, Ross J, Kapelyukh Y, Rode A, Wolf CR.

Drug Metab Dispos. 2010 Jul;38(7):1046-53. doi: 10.1124/dmd.109.031872. Epub 2010 Mar 30.

PMID:
20354104
27.

Drug transporters: gatekeepers controlling access of xenobiotics to the cellular interior.

Stanley LA, Horsburgh BC, Ross J, Scheer N, Wolf CR.

Drug Metab Rev. 2009;41(1):27-65. doi: 10.1080/03602530802605040. Review.

PMID:
19514970
28.

Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man.

Henderson CJ, Scheer N, Wolf CR.

Expert Rev Clin Pharmacol. 2009 Mar;2(2):105-9. doi: 10.1586/17512433.2.2.105. No abstract available.

PMID:
24410638
29.

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

Scheer N, Ross J, Rode A, Zevnik B, Niehaves S, Faust N, Wolf CR.

J Clin Invest. 2008 Sep;118(9):3228-39. doi: 10.1172/JCI35483.

30.

PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.

Stanley LA, Horsburgh BC, Ross J, Scheer N, Wolf CR.

Drug Metab Rev. 2006;38(3):515-97. Review.

PMID:
16877263
31.

Asymmetric localization of Numb:EGFP in dividing neuroepithelial cells during neurulation in Danio rerio.

Reugels AM, Boggetti B, Scheer N, Campos-Ortega JA.

Dev Dyn. 2006 Apr;235(4):934-48.

32.

[Modular training in practical medicine: electronic evaluation of student education in general practice].

Himmel W, Kühne I, Chenot JF, Scheer N, Primas I, Sigle J.

Gesundheitswesen. 2004 Jul;66(7):457-61. German.

PMID:
15314738
33.

her3, a zebrafish member of the hairy-E(spl) family, is repressed by Notch signalling.

Hans S, Scheer N, Riedl I, v Weizsäcker E, Blader P, Campos-Ortega JA.

Development. 2004 Jun;131(12):2957-69.

34.

[Medical care research based on family doctor routine data--are interface-communicated treatment data feasible?].

Hummers-Pradier E, Simmenroth-Nayda A, Scheidt-Nave C, Scheer N, Fischer T, Niebling W, Kochen MM.

Gesundheitswesen. 2003 Feb;65(2):109-14. German.

PMID:
12632320
35.

A quantitative analysis of the kinetics of Gal4 activator and effector gene expression in the zebrafish.

Scheer N, Riedl I, Warren JT, Kuwada JY, Campos-Ortega JA.

Mech Dev. 2002 Mar;112(1-2):9-14.

36.

Notch signaling is required for arterial-venous differentiation during embryonic vascular development.

Lawson ND, Scheer N, Pham VN, Kim CH, Chitnis AB, Campos-Ortega JA, Weinstein BM.

Development. 2001 Oct;128(19):3675-83.

37.

An instructive function for Notch in promoting gliogenesis in the zebrafish retina.

Scheer N, Groth A, Hans S, Campos-Ortega JA.

Development. 2001 Apr;128(7):1099-107.

38.
39.

Use of the Gal4-UAS technique for targeted gene expression in the zebrafish.

Scheer N, Campos-Ortega JA.

Mech Dev. 1999 Feb;80(2):153-8.

40.

A measurement of attitudes about an activity program.

Barton GM, Scheer N.

Am J Occup Ther. 1975 May-Jun;29(5):284-7.

PMID:
1146957
41.

A comparison of patients discharged against medical advice with a matched control group.

Scheer N, Barton GM.

Am J Psychiatry. 1974 Nov;131(11):1217-20. No abstract available.

PMID:
4422185

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