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The Drosophila CPEB Protein Orb Specifies Oocyte Fate by a 3'UTR Dependent Autoregulatory Loop.

Barr J, Gilmutdinov R, Wang L, Shidlovskii Y, Schedl P.

Genetics. 2019 Oct 8. pii: genetics.302687.2019. doi: 10.1534/genetics.119.302687. [Epub ahead of print]


Distinct Elements Confer the Blocking and Bypass Functions of the Bithorax Fab-8 Boundary.

Kyrchanova O, Wolle D, Sabirov M, Kurbidaeva A, Aoki T, Maksimenko O, Kyrchanova M, Georgiev P, Schedl P.

Genetics. 2019 Sep 24. pii: genetics.302694.2019. doi: 10.1534/genetics.119.302694. [Epub ahead of print]


Complete reconstitution of bypass and blocking functions in a minimal artificial Fab-7 insulator from Drosophila bithorax complex.

Kyrchanova O, Sabirov M, Mogila V, Kurbidaeva A, Postika N, Maksimenko O, Schedl P, Georgiev P.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13462-13467. doi: 10.1073/pnas.1907190116. Epub 2019 Jun 17.


The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled).

Estrella MA, Du J, Chen L, Rath S, Prangley E, Chitrakar A, Aoki T, Schedl P, Rabinowitz J, Korennykh A.

Nat Commun. 2019 May 30;10(1):2367. doi: 10.1038/s41467-019-10125-z.


Functional analysis of Niemann-Pick disease type C family protein, NPC1a, in Drosophila melanogaster.

Bialistoky T, Manry D, Smith P, Ng C, Kim Y, Zamir S, Moyal V, Kalifa R, Schedl P, Gerlitz O, Deshpande G.

Development. 2019 May 15;146(10). pii: dev168427. doi: 10.1242/dev.168427.


Paip2 cooperates with Cbp80 at an active promoter and participates in RNA Polymerase II phosphorylation in Drosophila.

Kachaev ZM, Lebedeva LA, Shaposhnikov AV, Moresco JJ, Yates JR 3rd, Schedl P, Shidlovskii YV.

FEBS Lett. 2019 May;593(10):1102-1112. doi: 10.1002/1873-3468.13391. Epub 2019 Apr 29.


The CPEB translational regulator, Orb, functions together with Par proteins to polarize the Drosophila oocyte.

Barr J, Charania S, Gilmutdinov R, Yakovlev K, Shidlovskii Y, Schedl P.

PLoS Genet. 2019 Mar 13;15(3):e1008012. doi: 10.1371/journal.pgen.1008012. eCollection 2019 Mar.


Functional dissection of the developmentally restricted BEN domain chromatin boundary factor Insensitive.

Fedotova A, Clendinen C, Bonchuk A, Mogila V, Aoki T, Georgiev P, Schedl P.

Epigenetics Chromatin. 2019 Jan 3;12(1):2. doi: 10.1186/s13072-018-0249-2.


Boundaries mediate long-distance interactions between enhancers and promoters in the Drosophila Bithorax complex.

Postika N, Metzler M, Affolter M, Müller M, Schedl P, Georgiev P, Kyrchanova O.

PLoS Genet. 2018 Dec 12;14(12):e1007702. doi: 10.1371/journal.pgen.1007702. eCollection 2018 Dec.


Transcriptional quiescence in primordial germ cells.

Lebedeva LA, Yakovlev KV, Kozlov EN, Schedl P, Deshpande G, Shidlovskii YV.

Crit Rev Biochem Mol Biol. 2018 Dec;53(6):579-595. doi: 10.1080/10409238.2018.1506733. Epub 2018 Oct 3. Review.


The bithorax complex iab-7 Polycomb response element has a novel role in the functioning of the Fab-7 chromatin boundary.

Kyrchanova O, Kurbidaeva A, Sabirov M, Postika N, Wolle D, Aoki T, Maksimenko O, Mogila V, Schedl P, Georgiev P.

PLoS Genet. 2018 Aug 15;14(8):e1007442. doi: 10.1371/journal.pgen.1007442. eCollection 2018 Aug.


The BEN Domain Protein Insensitive Binds to the Fab-7 Chromatin Boundary To Establish Proper Segmental Identity in Drosophila.

Fedotova A, Aoki T, Rossier M, Mishra RK, Clendinen C, Kyrchanova O, Wolle D, Bonchuk A, Maeda RK, Mutero A, Cleard F, Mogila V, Karch F, Georgiev P, Schedl P.

Genetics. 2018 Oct;210(2):573-585. doi: 10.1534/genetics.118.301259. Epub 2018 Aug 6.


Paip2 is localized to active promoters and loaded onto nascent mRNA in Drosophila.

Kachaev ZM, Lebedeva LA, Kozlov EN, Toropygin IY, Schedl P, Shidlovskii YV.

Cell Cycle. 2018;17(14):1708-1720. doi: 10.1080/15384101.2018.1496738. Epub 2018 Aug 1.


Drosophila Dosage Compensation Loci Associate with a Boundary-Forming Insulator Complex.

Kaye EG, Kurbidaeva A, Wolle D, Aoki T, Schedl P, Larschan E.

Mol Cell Biol. 2017 Oct 13;37(21). pii: e00253-17. doi: 10.1128/MCB.00253-17. Print 2017 Nov 1.


Architectural protein Pita cooperates with dCTCF in organization of functional boundaries in Bithorax complex.

Kyrchanova O, Zolotarev N, Mogila V, Maksimenko O, Schedl P, Georgiev P.

Development. 2017 Jul 15;144(14):2663-2672. doi: 10.1242/dev.149815. Epub 2017 Jun 15.


Cells on the move: Modulation of guidance cues during germ cell migration.

Deshpande G, Barr J, Gerlitz O, Lebedeva L, Shidlovskii Y, Schedl P.

Fly (Austin). 2017 Jul 3;11(3):200-207. doi: 10.1080/19336934.2017.1304332. Epub 2017 Mar 16.


The GAGA factor regulatory network: Identification of GAGA factor associated proteins.

Lomaev D, Mikhailova A, Erokhin M, Shaposhnikov AV, Moresco JJ, Blokhina T, Wolle D, Aoki T, Ryabykh V, Yates JR 3rd, Shidlovskii YV, Georgiev P, Schedl P, Chetverina D.

PLoS One. 2017 Mar 15;12(3):e0173602. doi: 10.1371/journal.pone.0173602. eCollection 2017.


Boundaries of loop domains (insulators): Determinants of chromosome form and function in multicellular eukaryotes.

Chetverina D, Fujioka M, Erokhin M, Georgiev P, Jaynes JB, Schedl P.

Bioessays. 2017 Mar;39(3). doi: 10.1002/bies.201600233. Epub 2017 Jan 30. Review.


Germ Cell-less Promotes Centrosome Segregation to Induce Germ Cell Formation.

Lerit DA, Shebelut CW, Lawlor KJ, Rusan NM, Gavis ER, Schedl P, Deshpande G.

Cell Rep. 2017 Jan 24;18(4):831-839. doi: 10.1016/j.celrep.2016.12.074.


Different Evolutionary Strategies To Conserve Chromatin Boundary Function in the Bithorax Complex.

Cleard F, Wolle D, Taverner AM, Aoki T, Deshpande G, Andolfatto P, Karch F, Schedl P.

Genetics. 2017 Feb;205(2):589-603. doi: 10.1534/genetics.116.195586. Epub 2016 Dec 22.


Standardized Reporting of Prostate MRI: Comparison of the Prostate Imaging Reporting and Data System (PI-RADS) Version 1 and Version 2.

Tewes S, Mokov N, Hartung D, Schick V, Peters I, Schedl P, Pertschy S, Wacker F, Voshage G, Hueper K.

PLoS One. 2016 Sep 22;11(9):e0162879. doi: 10.1371/journal.pone.0162879. eCollection 2016.


Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex.

Kyrchanova O, Mogila V, Wolle D, Deshpande G, Parshikov A, Cléard F, Karch F, Schedl P, Georgiev P.

PLoS Genet. 2016 Jul 18;12(7):e1006188. doi: 10.1371/journal.pgen.1006188. eCollection 2016 Jul.


Role of the ABC transporter Mdr49 in Hedgehog signaling and germ cell migration.

Deshpande G, Manry D, Jourjine N, Mogila V, Mozes H, Bialistoky T, Gerlitz O, Schedl P.

Development. 2016 Jun 15;143(12):2111-20. doi: 10.1242/dev.133587. Epub 2016 Apr 27.


Determinants of Chromosome Architecture: Insulator Pairing in cis and in trans.

Fujioka M, Mistry H, Schedl P, Jaynes JB.

PLoS Genet. 2016 Feb 24;12(2):e1005889. doi: 10.1371/journal.pgen.1005889. eCollection 2016 Feb.


Establishing and maintaining cell polarity with mRNA localization in Drosophila.

Barr J, Yakovlev KV, Shidlovskii Y, Schedl P.

Bioessays. 2016 Mar;38(3):244-53. doi: 10.1002/bies.201500088. Epub 2016 Jan 15. Review.


Wnt Signaling in Sexual Dimorphism.

Deshpande G, Nouri A, Schedl P.

Genetics. 2016 Feb;202(2):661-73. doi: 10.1534/genetics.115.177857. Epub 2015 Nov 27.


Transcriptional read-through is not sufficient to induce an epigenetic switch in the silencing activity of Polycomb response elements.

Erokhin M, Elizar'ev P, Parshikov A, Schedl P, Georgiev P, Chetverina D.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14930-5. doi: 10.1073/pnas.1515276112. Epub 2015 Oct 26.


Establishment of a Developmental Compartment Requires Interactions between Three Synergistic Cis-regulatory Modules.

Bieli D, Kanca O, Requena D, Hamaratoglu F, Gohl D, Schedl P, Affolter M, Slattery M, Müller M, Estella C.

PLoS Genet. 2015 Oct 15;11(10):e1005376. doi: 10.1371/journal.pgen.1005376. eCollection 2015 Oct.


Functional Requirements for Fab-7 Boundary Activity in the Bithorax Complex.

Wolle D, Cleard F, Aoki T, Deshpande G, Schedl P, Karch F.

Mol Cell Biol. 2015 Nov;35(21):3739-52. doi: 10.1128/MCB.00456-15. Epub 2015 Aug 24.


Functional role of dimerization and CP190 interacting domains of CTCF protein in Drosophila melanogaster.

Bonchuk A, Maksimenko O, Kyrchanova O, Ivlieva T, Mogila V, Deshpande G, Wolle D, Schedl P, Georgiev P.

BMC Biol. 2015 Aug 7;13:63. doi: 10.1186/s12915-015-0168-7.


The boundary paradox in the Bithorax complex.

Kyrchanova O, Mogila V, Wolle D, Magbanua JP, White R, Georgiev P, Schedl P.

Mech Dev. 2015 Nov;138 Pt 2:122-132. doi: 10.1016/j.mod.2015.07.002. Epub 2015 Jul 26.


The Drosophila melanogaster Mutants apblot and apXasta Affect an Essential apterous Wing Enhancer.

Bieli D, Kanca O, Gohl D, Denes A, Schedl P, Affolter M, Müller M.

G3 (Bethesda). 2015 Apr 2;5(6):1129-43. doi: 10.1534/g3.115.017707.


Xenotransplantation exposes the etiology of azoospermia factor (AZF) induced male sterility.

Barr J, Gordon D, Schedl P, Deshpande G.

Bioessays. 2015 Mar;37(3):278-83. doi: 10.1002/bies.201400134. Epub 2014 Dec 18.


Spermatid cyst polarization in Drosophila depends upon apkc and the CPEB family translational regulator orb2.

Xu S, Tyagi S, Schedl P.

PLoS Genet. 2014 May 15;10(5):e1004380. doi: 10.1371/journal.pgen.1004380. eCollection 2014 May.


BMP signaling and the maintenance of primordial germ cell identity in Drosophila embryos.

Deshpande G, Willis E, Chatterjee S, Fernandez R, Dias K, Schedl P.

PLoS One. 2014 Feb 14;9(2):e88847. doi: 10.1371/journal.pone.0088847. eCollection 2014.


Making connections: insulators organize eukaryotic chromosomes into independent cis-regulatory networks.

Chetverina D, Aoki T, Erokhin M, Georgiev P, Schedl P.

Bioessays. 2014 Feb;36(2):163-72. doi: 10.1002/bies.201300125. Epub 2013 Nov 26. Review.


Bi-functional cross-linking reagents efficiently capture protein-DNA complexes in Drosophila embryos.

Aoki T, Wolle D, Preger-Ben Noon E, Dai Q, Lai EC, Schedl P.

Fly (Austin). 2014;8(1):43-51. doi: 10.4161/fly.26805. Epub 2013 Dec 13.


Rasputin functions as a positive regulator of orb in Drosophila oogenesis.

Costa A, Pazman C, Sinsimer KS, Wong LC, McLeod I, Yates J 3rd, Haynes S, Schedl P.

PLoS One. 2013 Sep 12;8(9):e72864. doi: 10.1371/journal.pone.0072864. eCollection 2013.


The hedgehog pathway gene shifted functions together with the hmgcr-dependent isoprenoid biosynthetic pathway to orchestrate germ cell migration.

Deshpande G, Zhou K, Wan JY, Friedrich J, Jourjine N, Smith D, Schedl P.

PLoS Genet. 2013;9(9):e1003720. doi: 10.1371/journal.pgen.1003720. Epub 2013 Sep 12.


Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex.

Aoki T, Sarkeshik A, Yates J, Schedl P.

Elife. 2012 Dec 13;1:e00171. doi: 10.7554/eLife.00171.


The CPEB protein Orb2 has multiple functions during spermatogenesis in Drosophila melanogaster.

Xu S, Hafer N, Agunwamba B, Schedl P.

PLoS Genet. 2012;8(11):e1003079. doi: 10.1371/journal.pgen.1003079. Epub 2012 Nov 29.


Maintaining sufficient nanos is a critical function for polar granule component in the specification of primordial germ cells.

Deshpande G, Spady E, Goodhouse J, Schedl P.

G3 (Bethesda). 2012 Nov;2(11):1397-403. doi: 10.1534/g3.112.004192. Epub 2012 Nov 1.


Cup blocks the precocious activation of the orb autoregulatory loop.

Wong LC, Schedl P.

PLoS One. 2011;6(12):e28261. doi: 10.1371/journal.pone.0028261. Epub 2011 Dec 2.


Theoretical analysis of the role of chromatin interactions in long-range action of enhancers and insulators.

Mukhopadhyay S, Schedl P, Studitsky VM, Sengupta AM.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):19919-24. doi: 10.1073/pnas.1103845108. Epub 2011 Nov 28.


Single-molecule imaging of transcriptionally coupled and uncoupled splicing.

Vargas DY, Shah K, Batish M, Levandoski M, Sinha S, Marras SA, Schedl P, Tyagi S.

Cell. 2011 Nov 23;147(5):1054-65. doi: 10.1016/j.cell.2011.10.024.


The functioning of the Drosophila CPEB protein Orb is regulated by phosphorylation and requires casein kinase 2 activity.

Wong LC, Costa A, McLeod I, Sarkeshik A, Yates J 3rd, Kyin S, Perlman D, Schedl P.

PLoS One. 2011;6(9):e24355. doi: 10.1371/journal.pone.0024355. Epub 2011 Sep 19.


The Drosophila CPEB protein Orb2 has a novel expression pattern and is important for asymmetric cell division and nervous system function.

Hafer N, Xu S, Bhat KM, Schedl P.

Genetics. 2011 Nov;189(3):907-21. doi: 10.1534/genetics.110.123646. Epub 2011 Sep 6.


The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila melanogaster.

Graham PL, Yanowitz JL, Penn JK, Deshpande G, Schedl P.

PLoS Genet. 2011 Jul;7(7):e1002185. doi: 10.1371/journal.pgen.1002185. Epub 2011 Jul 28.


The Drosophila Myc gene, diminutive, is a positive regulator of the Sex-lethal establishment promoter, Sxl-Pe.

Kappes G, Deshpande G, Mulvey BB, Horabin JI, Schedl P.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1543-8. doi: 10.1073/pnas.1017006108. Epub 2011 Jan 10.

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