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Items: 12

1.

IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell.

Shao L, Hou W, Scharping NE, Vendetti FP, Srivastava R, Roy CN, Menk AV, Wang Y, Chauvin JM, Karukonda P, Thorne SH, Hornung V, Zarour HM, Bakkenist CJ, Delgoffe GM, Sarkar SN.

Cancer Immunol Res. 2019 Aug;7(8):1258-1266. doi: 10.1158/2326-6066.CIR-18-0711. Epub 2019 Jun 25.

PMID:
31239318
2.

4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses.

Menk AV, Scharping NE, Rivadeneira DB, Calderon MJ, Watson MJ, Dunstane D, Watkins SC, Delgoffe GM.

J Exp Med. 2018 Apr 2;215(4):1091-1100. doi: 10.1084/jem.20171068. Epub 2018 Mar 6.

3.

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions.

Menk AV, Scharping NE, Moreci RS, Zeng X, Guy C, Salvatore S, Bae H, Xie J, Young HA, Wendell SG, Delgoffe GM.

Cell Rep. 2018 Feb 6;22(6):1509-1521. doi: 10.1016/j.celrep.2018.01.040.

4.

Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia.

Scharping NE, Menk AV, Whetstone RD, Zeng X, Delgoffe GM.

Cancer Immunol Res. 2017 Jan;5(1):9-16. doi: 10.1158/2326-6066.CIR-16-0103. Epub 2016 Dec 9.

5.

Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity.

Scharping NE, Delgoffe GM.

Vaccines (Basel). 2016 Dec 6;4(4). pii: E46. Review.

6.

Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation.

Jackson SW, Scharping NE, Jacobs HM, Wang S, Chait A, Rawlings DJ.

J Immunol. 2016 Dec 15;197(12):4529-4534. Epub 2016 Nov 11.

7.

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.

Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, Ferris RL, Delgoffe GM.

Immunity. 2016 Sep 20;45(3):701-703. doi: 10.1016/j.immuni.2016.08.009. Epub 2016 Sep 20. No abstract available.

8.

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.

Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, Ferris RL, Delgoffe GM.

Immunity. 2016 Aug 16;45(2):374-88. doi: 10.1016/j.immuni.2016.07.009. Epub 2016 Aug 2. Erratum in: Immunity. 2016 Sep 20;45(3):701-703.

9.

B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6.

Jackson SW, Jacobs HM, Arkatkar T, Dam EM, Scharping NE, Kolhatkar NS, Hou B, Buckner JH, Rawlings DJ.

J Exp Med. 2016 May 2;213(5):733-50. doi: 10.1084/jem.20151724. Epub 2016 Apr 11.

10.

Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells.

Jacobs HM, Thouvenel CD, Leach S, Arkatkar T, Metzler G, Scharping NE, Kolhatkar NS, Rawlings DJ, Jackson SW.

J Immunol. 2016 May 1;196(9):3525-31. doi: 10.4049/jimmunol.1600017. Epub 2016 Mar 28.

11.

B-cell intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott-Aldrich syndrome.

Kolhatkar NS, Scharping NE, Sullivan JM, Jacobs HM, Schwartz MA, Khim S, Notarangelo LD, Thrasher AJ, Rawlings DJ, Jackson SW.

Eur J Immunol. 2015 Oct;45(10):2773-9. doi: 10.1002/eji.201545644. Epub 2015 Aug 31. Erratum in: Eur J Immunol. 2016 Mar;46(3):782.

12.

Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation.

Jackson SW, Scharping NE, Kolhatkar NS, Khim S, Schwartz MA, Li QZ, Hudkins KL, Alpers CE, Liggitt D, Rawlings DJ.

J Immunol. 2014 May 15;192(10):4525-32. doi: 10.4049/jimmunol.1400098. Epub 2014 Apr 7.

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