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Items: 16

1.

Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage.

Götz A, Mylonas N, Högel P, Silber M, Heinel H, Menig S, Vogel A, Feyrer H, Huster D, Luy B, Langosch D, Scharnagl C, Muhle-Goll C, Kamp F, Steiner H.

Biophys J. 2019 Jun 4;116(11):2103-2120. doi: 10.1016/j.bpj.2019.04.030. Epub 2019 May 3.

PMID:
31130234
2.

Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer's Disease Mutant of APP.

Götz A, Högel P, Silber M, Chaitoglou I, Luy B, Muhle-Goll C, Scharnagl C, Langosch D.

Sci Rep. 2019 Mar 29;9(1):5321. doi: 10.1038/s41598-019-41766-1.

3.

Dissecting conformational changes in APP's transmembrane domain linked to ε-efficiency in familial Alzheimer's disease.

Götz A, Scharnagl C.

PLoS One. 2018 Jul 2;13(7):e0200077. doi: 10.1371/journal.pone.0200077. eCollection 2018.

4.

Glycine Perturbs Local and Global Conformational Flexibility of a Transmembrane Helix.

Högel P, Götz A, Kuhne F, Ebert M, Stelzer W, Rand KD, Scharnagl C, Langosch D.

Biochemistry. 2018 Feb 27;57(8):1326-1337. doi: 10.1021/acs.biochem.7b01197. Epub 2018 Feb 9.

PMID:
29389107
5.

Entrapment of Water at the Transmembrane Helix-Helix Interface of Quiescin Sulfhydryl Oxidase 2.

Ried CL, Scharnagl C, Langosch D.

Biochemistry. 2016 Mar 8;55(9):1287-90. doi: 10.1021/acs.biochem.5b01239. Epub 2016 Feb 22.

PMID:
26894260
6.

Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics.

Langosch D, Scharnagl C, Steiner H, Lemberg MK.

Trends Biochem Sci. 2015 Jun;40(6):318-27. doi: 10.1016/j.tibs.2015.04.001. Epub 2015 May 1. Review.

PMID:
25941170
7.

Side-chain to main-chain hydrogen bonding controls the intrinsic backbone dynamics of the amyloid precursor protein transmembrane helix.

Scharnagl C, Pester O, Hornburg P, Hornburg D, Götz A, Langosch D.

Biophys J. 2014 Mar 18;106(6):1318-26. doi: 10.1016/j.bpj.2014.02.013.

8.

The cleavage domain of the amyloid precursor protein transmembrane helix does not exhibit above-average backbone dynamics.

Pester O, Götz A, Multhaup G, Scharnagl C, Langosch D.

Chembiochem. 2013 Oct 11;14(15):1943-8. doi: 10.1002/cbic.201300322. Epub 2013 Sep 17.

PMID:
24115334
9.

The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase.

Pester O, Barrett PJ, Hornburg D, Hornburg P, Pröbstle R, Widmaier S, Kutzner C, Dürrbaum M, Kapurniotu A, Sanders CR, Scharnagl C, Langosch D.

J Am Chem Soc. 2013 Jan 30;135(4):1317-29. doi: 10.1021/ja3112093. Epub 2013 Jan 16.

10.

Residue-specific side-chain packing determines the backbone dynamics of transmembrane model helices.

Quint S, Widmaier S, Minde D, Hornburg D, Langosch D, Scharnagl C.

Biophys J. 2010 Oct 20;99(8):2541-9. doi: 10.1016/j.bpj.2010.08.031.

11.

2-methylterrylene in hexadecane: do we see single rotational quantum jumps of methyl groups?

Sigl A, Scharnagl C, Friedrich J, Gourdon A, Orrit M.

J Chem Phys. 2008 Jan 28;128(4):044508. doi: 10.1063/1.2827461.

PMID:
18247970
12.

Hole burning spectroscopy of ribonuclease A.

Schnell C, Scharnagl C, Friedrich J.

Phys Chem Chem Phys. 2006 Mar 21;8(11):1315-20. Epub 2006 Feb 9.

PMID:
16633612
13.

Local compressibilities in insulin as determined from pressure tuning hole burning experiments and MD simulations.

Schnell C, Reif M, Scharnagl C, Friedrich J.

Phys Chem Chem Phys. 2005 May 21;7(10):2217-24.

PMID:
19791416
14.

Stability of proteins: temperature, pressure and the role of the solvent.

Scharnagl C, Reif M, Friedrich J.

Biochim Biophys Acta. 2005 Jun 1;1749(2):187-213. Epub 2005 Mar 19. Review.

PMID:
15893966
15.

Local compressibilities of proteins: comparison of optical experiments and simulations for horse heart cytochrome-c.

Scharnagl C, Reif M, Friedrich J.

Biophys J. 2005 Jul;89(1):64-75. Epub 2005 Apr 15.

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