Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 161

1.

The supply chain of human pancreatic β cell lines.

Scharfmann R, Staels W, Albagli O.

J Clin Invest. 2019 Sep 3;129(9):3511-3520. doi: 10.1172/JCI129484. Review.

2.

New α- and SIN γ-retrovectors for safe transduction and specific transgene expression in pancreatic β cell lines.

Albagli O, Maugein A, Huijbregts L, Bredel D, Carlier G, Martin P, Scharfmann R.

BMC Biotechnol. 2019 Jun 17;19(1):35. doi: 10.1186/s12896-019-0531-9.

3.

Fostering improved human islet research: a European perspective.

Marchetti P, Schulte AM, Marselli L, Schoniger E, Bugliani M, Kramer W, Overbergh L, Ullrich S, Gloyn AL, Ibberson M, Rutter G, Froguel P, Groop L, McCarthy MI, Dotta F, Scharfmann R, Magnan C, Eizirik DL, Mathieu C, Cnop M, Thorens B, Solimena M.

Diabetologia. 2019 Aug;62(8):1514-1516. doi: 10.1007/s00125-019-4911-4. Epub 2019 Jun 13. No abstract available.

4.

Structure and function of the exocrine pancreas in patients with type 1 diabetes.

Alexandre-Heymann L, Mallone R, Boitard C, Scharfmann R, Larger E.

Rev Endocr Metab Disord. 2019 Jun;20(2):129-149. doi: 10.1007/s11154-019-09501-3. Review.

PMID:
31077020
5.

Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling.

Roberts GP, Larraufie P, Richards P, Kay RG, Galvin SG, Miedzybrodzka EL, Leiter A, Li HJ, Glass LL, Ma MKL, Lam B, Yeo GSH, Scharfmann R, Chiarugi D, Hardwick RH, Reimann F, Gribble FM.

Diabetes. 2019 May;68(5):1062-1072. doi: 10.2337/db18-0883. Epub 2019 Feb 7.

PMID:
30733330
6.

Bromodomain and Extra Terminal Protein Inhibitors Promote Pancreatic Endocrine Cell Fate.

Huijbregts L, Petersen MBK, Berthault C, Hansson M, Aiello V, Rachdi L, Grapin-Botton A, Honore C, Scharfmann R.

Diabetes. 2019 Apr;68(4):761-773. doi: 10.2337/db18-0224. Epub 2019 Jan 17.

PMID:
30655386
7.

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells.

Hastoy B, Godazgar M, Clark A, Nylander V, Spiliotis I, van de Bunt M, Chibalina MV, Barrett A, Burrows C, Tarasov AI, Scharfmann R, Gloyn AL, Rorsman P.

Sci Rep. 2018 Nov 19;8(1):16994. doi: 10.1038/s41598-018-34743-7.

8.

TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology.

Stoupa A, Adam F, Kariyawasam D, Strassel C, Gawade S, Szinnai G, Kauskot A, Lasne D, Janke C, Natarajan K, Schmitt A, Bole-Feysot C, Nitschke P, Léger J, Jabot-Hanin F, Tores F, Michel A, Munnich A, Besmond C, Scharfmann R, Lanza F, Borgel D, Polak M, Carré A.

EMBO Mol Med. 2018 Dec;10(12). pii: e9569. doi: 10.15252/emmm.201809569.

9.

Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa.

Demine S, Balhuizen A, Debaille V, Joosten L, Fereau M, Chilla SNM, Millard I, Scharfmann R, Egrise D, Goldman S, Marchetti P, Gotthardt M, Laurent S, Burtea C, Eizirik DL.

Molecules. 2018 Aug 21;23(9). pii: E2100. doi: 10.3390/molecules23092100.

10.

Solid pseudopapillary neoplasms of the pancreas do not express major pancreatic markers in pediatric patients.

Calvani J, Lopez P, Sarnacki S, Molina TJ, Gibault L, Fabre M, Scharfmann R, Capito C, Galmiche L.

Hum Pathol. 2019 Jan;83:29-35. doi: 10.1016/j.humpath.2018.08.010. Epub 2018 Aug 18.

PMID:
30130629
11.

Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors.

Gonzalez-Duque S, Azoury ME, Colli ML, Afonso G, Turatsinze JV, Nigi L, Lalanne AI, Sebastiani G, Carré A, Pinto S, Culina S, Corcos N, Bugliani M, Marchetti P, Armanet M, Diedisheim M, Kyewski B, Steinmetz LM, Buus S, You S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Dotta F, Scharfmann R, Eizirik DL, Verdier Y, Vinh J, Mallone R.

Cell Metab. 2018 Dec 4;28(6):946-960.e6. doi: 10.1016/j.cmet.2018.07.007. Epub 2018 Aug 2.

12.

Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling.

Ramond C, Beydag-Tasöz BS, Azad A, van de Bunt M, Petersen MBK, Beer NL, Glaser N, Berthault C, Gloyn AL, Hansson M, McCarthy MI, Honoré C, Grapin-Botton A, Scharfmann R.

Development. 2018 Aug 15;145(16). pii: dev165480. doi: 10.1242/dev.165480.

13.

Author Correction: Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes.

Rouxel O, DaSilva J, Beaudoin L, Nel I, Tard C, Cagninacci L, Kiaf B, Oshima M, Diedisheim M, Salou M, Corbett A, Rossjohn J, McCluskey J, Scharfmann R, Battaglia M, Polak M, Lantz O, Beltrand J, Lehuen A.

Nat Immunol. 2018 Sep;19(9):1035. doi: 10.1038/s41590-017-0023-9.

PMID:
29880894
14.

Modeling human pancreatic beta cell dedifferentiation.

Diedisheim M, Oshima M, Albagli O, Huldt CW, Ahlstedt I, Clausen M, Menon S, Aivazidis A, Andreasson AC, Haynes WG, Marchetti P, Marselli L, Armanet M, Chimienti F, Scharfmann R.

Mol Metab. 2018 Apr;10:74-86. doi: 10.1016/j.molmet.2018.02.002. Epub 2018 Feb 8.

15.

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors.

Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R; ImMaDiab Study Group.

Sci Immunol. 2018 Feb 2;3(20). pii: eaao4013. doi: 10.1126/sciimmunol.aao4013.

16.

Virus-like infection induces human β cell dedifferentiation.

Oshima M, Knoch KP, Diedisheim M, Petzold A, Cattan P, Bugliani M, Marchetti P, Choudhary P, Huang GC, Bornstein SR, Solimena M, Albagli-Curiel O, Scharfmann R.

JCI Insight. 2018 Feb 8;3(3). pii: 97732. doi: 10.1172/jci.insight.97732. eCollection 2018 Feb 8.

17.

MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells.

Richards P, Rachdi L, Oshima M, Marchetti P, Bugliani M, Armanet M, Postic C, Guilmeau S, Scharfmann R.

Diabetes. 2018 Mar;67(3):461-472. doi: 10.2337/db17-0595. Epub 2017 Dec 27.

18.

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

Solimena M, Schulte AM, Marselli L, Ehehalt F, Richter D, Kleeberg M, Mziaut H, Knoch KP, Parnis J, Bugliani M, Siddiq A, Jörns A, Burdet F, Liechti R, Suleiman M, Margerie D, Syed F, Distler M, Grützmann R, Petretto E, Moreno-Moral A, Wegbrod C, Sönmez A, Pfriem K, Friedrich A, Meinel J, Wollheim CB, Baretton GB, Scharfmann R, Nogoceke E, Bonifacio E, Sturm D, Meyer-Puttlitz B, Boggi U, Saeger HD, Filipponi F, Lesche M, Meda P, Dahl A, Wigger L, Xenarios I, Falchi M, Thorens B, Weitz J, Bokvist K, Lenzen S, Rutter GA, Froguel P, von Bülow M, Ibberson M, Marchetti P.

Diabetologia. 2018 Mar;61(3):641-657. doi: 10.1007/s00125-017-4500-3. Epub 2017 Nov 28.

19.

A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells.

Balhuizen A, Massa S, Mathijs I, Turatsinze JV, De Vos J, Demine S, Xavier C, Villate O, Millard I, Egrise D, Capito C, Scharfmann R, In't Veld P, Marchetti P, Muyldermans S, Goldman S, Lahoutte T, Bouwens L, Eizirik DL, Devoogdt N.

Sci Rep. 2017 Nov 9;7(1):15130. doi: 10.1038/s41598-017-15417-2.

20.

Mitochondrial Protein UCP2 Controls Pancreas Development.

Broche B, Ben Fradj S, Aguilar E, Sancerni T, Bénard M, Makaci F, Berthault C, Scharfmann R, Alves-Guerra MC, Duvillié B.

Diabetes. 2018 Jan;67(1):78-84. doi: 10.2337/db17-0118. Epub 2017 Oct 27.

21.

Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes.

Rouxel O, Da Silva J, Beaudoin L, Nel I, Tard C, Cagninacci L, Kiaf B, Oshima M, Diedisheim M, Salou M, Corbett A, Rossjohn J, McCluskey J, Scharfmann R, Battaglia M, Polak M, Lantz O, Beltrand J, Lehuen A.

Nat Immunol. 2017 Dec;18(12):1321-1331. doi: 10.1038/ni.3854. Epub 2017 Oct 9. Erratum in: Nat Immunol. 2018 Jun 7;:.

22.

Reconstructing human pancreatic differentiation by mapping specific cell populations during development.

Ramond C, Glaser N, Berthault C, Ameri J, Kirkegaard JS, Hansson M, Honoré C, Semb H, Scharfmann R.

Elife. 2017 Jul 21;6. pii: e27564. doi: 10.7554/eLife.27564.

23.

Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion.

Ndiaye FK, Ortalli A, Canouil M, Huyvaert M, Salazar-Cardozo C, Lecoeur C, Verbanck M, Pawlowski V, Boutry R, Durand E, Rabearivelo I, Sand O, Marselli L, Kerr-Conte J, Chandra V, Scharfmann R, Poulain-Godefroy O, Marchetti P, Pattou F, Abderrahmani A, Froguel P, Bonnefond A.

Mol Metab. 2017 Apr 8;6(6):459-470. doi: 10.1016/j.molmet.2017.03.011. eCollection 2017 Jun.

24.

Efficient Generation of Glucose-Responsive Beta Cells from Isolated GP2+ Human Pancreatic Progenitors.

Ameri J, Borup R, Prawiro C, Ramond C, Schachter KA, Scharfmann R, Semb H.

Cell Rep. 2017 Apr 4;19(1):36-49. doi: 10.1016/j.celrep.2017.03.032.

25.

Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion.

Cruciani-Guglielmacci C, Bellini L, Denom J, Oshima M, Fernandez N, Normandie-Levi P, Berney XP, Kassis N, Rouch C, Dairou J, Gorman T, Smith DM, Marley A, Liechti R, Kuznetsov D, Wigger L, Burdet F, Lefèvre AL, Wehrle I, Uphues I, Hildebrandt T, Rust W, Bernard C, Ktorza A, Rutter GA, Scharfmann R, Xenarios I, Le Stunff H, Thorens B, Magnan C, Ibberson M.

Mol Metab. 2017 Jan 26;6(4):340-351. doi: 10.1016/j.molmet.2017.01.009. eCollection 2017 Apr.

26.

EndoC-βH1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium.

Krizhanovskii C, Kristinsson H, Elksnis A, Wang X, Gavali H, Bergsten P, Scharfmann R, Welsh N.

Islets. 2017 May 4;9(3):e1296995. doi: 10.1080/19382014.2017.1296995. Epub 2017 Feb 28.

27.

Mutations in BOREALIN cause thyroid dysgenesis.

Carré A, Stoupa A, Kariyawasam D, Gueriouz M, Ramond C, Monus T, Léger J, Gaujoux S, Sebag F, Glaser N, Zenaty D, Nitschke P, Bole-Feysot C, Hubert L, Lyonnet S, Scharfmann R, Munnich A, Besmond C, Taylor W, Polak M.

Hum Mol Genet. 2017 Feb 1;26(3):599-610. doi: 10.1093/hmg/ddw419.

28.

Aggregation of Engineered Human β-Cells Into Pseudoislets: Insulin Secretion and Gene Expression Profile in Normoxic and Hypoxic Milieu.

Lecomte MJ, Pechberty S, Machado C, Da Barroca S, Ravassard P, Scharfmann R, Czernichow P, Duvillié B.

Cell Med. 2016 Aug 12;8(3):99-112. doi: 10.3727/215517916X692843. eCollection 2016 Dec 3.

29.

Mass production of functional human pancreatic β-cells: why and how?

Scharfmann R, Didiesheim M, Richards P, Chandra V, Oshima M, Albagli O.

Diabetes Obes Metab. 2016 Sep;18 Suppl 1:128-36. doi: 10.1111/dom.12728. Review. Erratum in: Diabetes Obes Metab. 2016 Dec;18(12 ):1288.

PMID:
27615142
30.

Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants.

Thomsen SK, Ceroni A, van de Bunt M, Burrows C, Barrett A, Scharfmann R, Ebner D, McCarthy MI, Gloyn AL.

Diabetes. 2016 Dec;65(12):3805-3811. Epub 2016 Aug 23.

31.

Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells.

Chandra V, Karamitri A, Richards P, Cormier F, Ramond C, Jockers R, Armanet M, Albagli-Curiel O, Scharfmann R.

Sci Rep. 2016 May 11;6:25765. doi: 10.1038/srep25765.

32.

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.

Arda HE, Li L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K, Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang HY, Kim SK.

Cell Metab. 2016 May 10;23(5):909-20. doi: 10.1016/j.cmet.2016.04.002. Epub 2016 Apr 28.

33.

A human beta cell line with drug inducible excision of immortalizing transgenes.

Benazra M, Lecomte MJ, Colace C, Müller A, Machado C, Pechberty S, Bricout-Neveu E, Grenier-Godard M, Solimena M, Scharfmann R, Czernichow P, Ravassard P.

Mol Metab. 2015 Oct 20;4(12):916-25. doi: 10.1016/j.molmet.2015.09.008. eCollection 2015 Dec.

34.

Xenotropic retrovirus Bxv1 in human pancreatic β cell lines.

Kirkegaard JS, Ravassard P, Ingvarsen S, Diedisheim M, Bricout-Neveu E, Grønborg M, Frogne T, Scharfmann R, Madsen OD, Rescan C, Albagli O.

J Clin Invest. 2016 Mar 1;126(3):1109-13. doi: 10.1172/JCI83573. Epub 2016 Feb 22.

35.

Erratum. Sulfonylurea Therapy Benefits Neurological and Psychomotor Functions in Patients With Neonatal Diabetes Owing to Potassium Channel Mutations. Diabetes Care 2015;38:2033-2041.

Beltrand J, Elie C, Busiah K, Fournier E, Boddaert N, Bahi-Buisson N, Vera M, Bui-Quoc E, Ingster-Moati I, Berdugo M, Simon A, Gozalo C, Djerada Z, Flechtner I, Treluyer JM, Scharfmann R, Cavé H, Vaivre-Douret L, Polak M; GlidKir Study Group.

Diabetes Care. 2016 Jan;39(1):175. doi: 10.2337/dc16-er01. No abstract available.

PMID:
26696658
36.

Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans.

Pal A, Potjer TP, Thomsen SK, Ng HJ, Barrett A, Scharfmann R, James TJ, Bishop DT, Karpe F, Godsland IF, Vasen HF, Newton-Bishop J, Pijl H, McCarthy MI, Gloyn AL.

Diabetes. 2016 Feb;65(2):527-33. doi: 10.2337/db15-0602. Epub 2015 Nov 5.

37.

Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy.

van der Torren CR, Zaldumbide A, Roelen DL, Duinkerken G, Brand-Schaaf SH, Peakman M, Czernichow P, Ravassard P, Scharfmann R, Roep BO.

Diabetologia. 2016 Jan;59(1):170-175. doi: 10.1007/s00125-015-3779-1.

38.

Sulfonylurea Therapy Benefits Neurological and Psychomotor Functions in Patients With Neonatal Diabetes Owing to Potassium Channel Mutations.

Beltrand J, Elie C, Busiah K, Fournier E, Boddaert N, Bahi-Buisson N, Vera M, Bui-Quoc E, Ingster-Moati I, Berdugo M, Simon A, Gozalo C, Djerada Z, Flechtner I, Treluyer JM, Scharfmann R, Cavé H, Vaivre-Douret L, Polak M; GlidKir Study Group.

Diabetes Care. 2015 Nov;38(11):2033-41. doi: 10.2337/dc15-0837. Epub 2015 Oct 5. Erratum in: Diabetes Care. 2016 Jan;39(1):175.

PMID:
26438614
39.

Role of the AMP kinase in cytokine-induced human EndoC-βH1 cell death.

Fred RG, Kappe C, Ameur A, Cen J, Bergsten P, Ravassard P, Scharfmann R, Welsh N.

Mol Cell Endocrinol. 2015 Oct 15;414:53-63. doi: 10.1016/j.mce.2015.07.015. Epub 2015 Jul 26.

PMID:
26213325
40.

Ex Vivo Expansion and Differentiation of Human and Mouse Fetal Pancreatic Progenitors Are Modulated by Epidermal Growth Factor.

Bonfanti P, Nobecourt E, Oshima M, Albagli-Curiel O, Laurysens V, Stangé G, Sojoodi M, Heremans Y, Heimberg H, Scharfmann R.

Stem Cells Dev. 2015 Aug 1;24(15):1766-78. doi: 10.1089/scd.2014.0550. Epub 2015 Jun 8.

PMID:
25925840
41.

Characterization of stimulus-secretion coupling in the human pancreatic EndoC-βH1 beta cell line.

Andersson LE, Valtat B, Bagge A, Sharoyko VV, Nicholls DG, Ravassard P, Scharfmann R, Spégel P, Mulder H.

PLoS One. 2015 Mar 24;10(3):e0120879. doi: 10.1371/journal.pone.0120879. eCollection 2015.

42.

RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells.

Chandra V, Albagli-Curiel O, Hastoy B, Piccand J, Randriamampita C, Vaillant E, Cavé H, Busiah K, Froguel P, Vaxillaire M, Rorsman P, Polak M, Scharfmann R.

Cell Rep. 2014 Dec 24;9(6):2206-18. doi: 10.1016/j.celrep.2014.11.010. Epub 2014 Dec 11.

43.

DYRK1A BAC transgenic mouse: a new model of thyroid dysgenesis in Down syndrome.

Kariyawasam D, Rachdi L, Carré A, Martin M, Houlier M, Janel N, Delabar JM, Scharfmann R, Polak M.

Endocrinology. 2015 Mar;156(3):1171-80. doi: 10.1210/en.2014-1329. Epub 2014 Dec 9.

PMID:
25490145
44.

Pro-oxidant/antioxidant balance controls pancreatic β-cell differentiation through the ERK1/2 pathway.

Hoarau E, Chandra V, Rustin P, Scharfmann R, Duvillie B.

Cell Death Dis. 2014 Oct 23;5:e1487. doi: 10.1038/cddis.2014.441.

45.

Human fucci pancreatic Beta cell lines: new tools to study Beta cell cycle and terminal differentiation.

Carlier G, Maugein A, Cordier C, Pechberty S, Garfa-Traoré M, Martin P, Scharfmann R, Albagli O.

PLoS One. 2014 Sep 26;9(9):e108202. doi: 10.1371/journal.pone.0108202. eCollection 2014.

46.

von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-α and VEGF-A upregulation.

Soggia A, Ramond C, Akiyama H, Scharfmann R, Duvillie B.

Diabetologia. 2014 Nov;57(11):2348-56. doi: 10.1007/s00125-014-3365-y. Epub 2014 Sep 4.

PMID:
25186293
47.

Human pancreas endocrine cell populations and activating ABCC8 mutations.

Busiah K, Verkarre V, Cavé H, Scharfmann R, Polak M.

Horm Res Paediatr. 2014;82(1):59-64. doi: 10.1159/000360004. Epub 2014 Jun 14.

PMID:
24941889
48.

Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance.

Rachdi L, Kariyawasam D, Aïello V, Herault Y, Janel N, Delabar JM, Polak M, Scharfmann R.

Cell Cycle. 2014;13(14):2221-9. doi: 10.4161/cc.29250. Epub 2014 May 28.

49.

Development of a conditionally immortalized human pancreatic β cell line.

Scharfmann R, Pechberty S, Hazhouz Y, von Bülow M, Bricout-Neveu E, Grenier-Godard M, Guez F, Rachdi L, Lohmann M, Czernichow P, Ravassard P.

J Clin Invest. 2014 May;124(5):2087-98. doi: 10.1172/JCI72674. Epub 2014 Mar 25.

50.

Neuropsychological dysfunction and developmental defects associated with genetic changes in infants with neonatal diabetes mellitus: a prospective cohort study [corrected].

Busiah K, Drunat S, Vaivre-Douret L, Bonnefond A, Simon A, Flechtner I, Gérard B, Pouvreau N, Elie C, Nimri R, De Vries L, Tubiana-Rufi N, Metz C, Bertrand AM, Nivot-Adamiak S, de Kerdanet M, Stuckens C, Jennane F, Souchon PF, Le Tallec C, Désirée C, Pereira S, Dechaume A, Robert JJ, Phillip M, Scharfmann R, Czernichow P, Froguel P, Vaxillaire M, Polak M, Cavé H; French NDM study group.

Lancet Diabetes Endocrinol. 2013 Nov;1(3):199-207. doi: 10.1016/S2213-8587(13)70059-7. Epub 2013 Sep 6. Erratum in: Lancet Diabetes Endocrinol. 2013 Nov;1(3):e14.

PMID:
24622368

Supplemental Content

Loading ...
Support Center