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Items: 1 to 50 of 158

1.

Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer's Disease Model.

Fu CH, Iascone DM, Petrof I, Hazra A, Zhang X, Pyfer MS, Tosi U, Corbett BF, Cai J, Lee J, Park J, Iacovitti L, Scharfman HE, Enikolopov G, Chin J.

Cell Rep. 2019 Jun 25;27(13):3741-3751.e4. doi: 10.1016/j.celrep.2019.05.101.

2.

The Dentate Gyrus and Temporal Lobe Epilepsy: An "Exciting" Era.

Scharfman HE.

Epilepsy Curr. 2019 Jun 24:1535759719855952. doi: 10.1177/1535759719855952. [Epub ahead of print]

PMID:
31232111
3.

Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus.

Luna VM, Anacker C, Burghardt NS, Khandaker H, Andreu V, Millette A, Leary P, Ravenelle R, Jimenez JC, Mastrodonato A, Denny CA, Fenton AA, Scharfman HE, Hen R.

Science. 2019 May 10;364(6440):578-583. doi: 10.1126/science.aat8789. Epub 2019 May 9.

PMID:
31073064
4.

Adult neurogenesis in the mouse dentate gyrus protects the hippocampus from neuronal injury following severe seizures.

Jain S, LaFrancois JJ, Botterill JJ, Alcantara-Gonzalez D, Scharfman HE.

Hippocampus. 2019 Aug;29(8):683-709. doi: 10.1002/hipo.23062. Epub 2019 Jan 23.

PMID:
30672046
5.

Common data elements (CDEs) for preclinical epilepsy research: Introduction to CDEs and description of core CDEs. A TASK3 report of the ILAE/AES joint translational task force.

Harte-Hargrove LC, Galanopoulou AS, French JA, Pitkänen A, Whittemore V, Scharfman HE.

Epilepsia Open. 2018 Jul 26;3(Suppl Suppl 1):13-23. doi: 10.1002/epi4.12234. eCollection 2018 Nov.

6.

Preclinical common data elements (CDEs) for epilepsy: A joint ILAE/AES and NINDS translational initiative.

Scharfman HE, Galanopoulou AS, French JA, Pitkänen A, Whittemore V, Harte-Hargrove LC.

Epilepsia Open. 2018 Jul 18;3(Suppl Suppl 1):9-12. doi: 10.1002/epi4.12235. eCollection 2018 Nov. No abstract available.

7.

A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force.

Gorter JA, van Vliet EA, Dedeurwaerdere S, Buchanan GF, Friedman D, Borges K, Grabenstatter H, Lukasiuk K, Scharfman HE, Nehlig A.

Epilepsia Open. 2018 Oct 11;3(Suppl Suppl 1):69-89. doi: 10.1002/epi4.12261. eCollection 2018 Nov.

8.

Controlling learning and epilepsy together.

Scharfman HE.

Science. 2018 Feb 16;359(6377):740-741. doi: 10.1126/science.aas8993. No abstract available.

9.

A Novel Neuroprotective Mechanism for Lithium That Prevents Association of the p75NTR-Sortilin Receptor Complex and Attenuates proNGF-Induced Neuronal Death In Vitro and In Vivo.

Greenwood SG, Montroull L, Volosin M, Scharfman HE, Teng KK, Light M, Torkin R, Maxfield F, Hempstead BL, Friedman WJ.

eNeuro. 2018 Jan 17;5(1). pii: ENEURO.0257-17.2017. doi: 10.1523/ENEURO.0257-17.2017. eCollection 2018 Jan-Feb.

10.

Advances in understanding hilar mossy cells of the dentate gyrus.

Scharfman HE.

Cell Tissue Res. 2018 Sep;373(3):643-652. doi: 10.1007/s00441-017-2750-5. Epub 2017 Dec 8. Review.

PMID:
29222692
11.

Common data elements for preclinical epilepsy research: Standards for data collection and reporting. A TASK3 report of the AES/ILAE Translational Task Force of the ILAE.

Harte-Hargrove LC, French JA, Pitkänen A, Galanopoulou AS, Whittemore V, Scharfman HE.

Epilepsia. 2017 Nov;58 Suppl 4:78-86. doi: 10.1111/epi.13906.

12.

Epilepsy as a Network Disorder (2): What can we learn from other network disorders such as dementia and schizophrenia, and what are the implications for translational research?

Scharfman HE, Kanner AM, Friedman A, Blümcke I, Crocker CE, Cendes F, Diaz-Arrastia R, Förstl H, Fenton AA, Grace AA, Palop J, Morrison J, Nehlig A, Prasad A, Wilcox KS, Jette N, Pohlmann-Eden B.

Epilepsy Behav. 2018 Jan;78:302-312. doi: 10.1016/j.yebeh.2017.09.016. Epub 2017 Oct 31. Review.

13.

Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits.

You JC, Muralidharan K, Park JW, Petrof I, Pyfer MS, Corbett BF, LaFrancois JJ, Zheng Y, Zhang X, Mohila CA, Yoshor D, Rissman RA, Nestler EJ, Scharfman HE, Chin J.

Nat Med. 2017 Nov;23(11):1377-1383. doi: 10.1038/nm.4413. Epub 2017 Oct 16.

14.

Increased gyrification and aberrant adult neurogenesis of the dentate gyrus in adult rats.

Magagna-Poveda A, Moretto JN, Scharfman HE.

Brain Struct Funct. 2017 Dec;222(9):4219-4237. doi: 10.1007/s00429-017-1457-4. Epub 2017 Jun 27.

15.

Hilar granule cells of the mouse dentate gyrus: effects of age, septotemporal location, strain, and selective deletion of the proapoptotic gene BAX.

Bermudez-Hernandez K, Lu YL, Moretto J, Jain S, LaFrancois JJ, Duffy AM, Scharfman HE.

Brain Struct Funct. 2017 Sep;222(7):3147-3161. doi: 10.1007/s00429-017-1391-5. Epub 2017 Mar 17.

16.

Acute restraint stress decreases c-fos immunoreactivity in hilar mossy cells of the adult dentate gyrus.

Moretto JN, Duffy ÁM, Scharfman HE.

Brain Struct Funct. 2017 Jul;222(5):2405-2419. doi: 10.1007/s00429-016-1349-z. Epub 2017 Feb 11.

17.

Sex differences in hippocampal area CA3 pyramidal cells.

Scharfman HE, MacLusky NJ.

J Neurosci Res. 2017 Jan 2;95(1-2):563-575. doi: 10.1002/jnr.23927. Review.

18.

The enigmatic mossy cell of the dentate gyrus.

Scharfman HE.

Nat Rev Neurosci. 2016 Sep;17(9):562-75. doi: 10.1038/nrn.2016.87. Epub 2016 Jul 28. Review.

19.

Expansion of mossy fibers and CA3 apical dendritic length accompanies the fall in dendritic spine density after gonadectomy in male, but not female, rats.

Mendell AL, Atwi S, Bailey CD, McCloskey D, Scharfman HE, MacLusky NJ.

Brain Struct Funct. 2017 Jan;222(1):587-601. doi: 10.1007/s00429-016-1237-6. Epub 2016 Jun 9.

20.

Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology.

Kam K, Duffy ÁM, Moretto J, LaFrancois JJ, Scharfman HE.

Sci Rep. 2016 Jan 28;6:20119. doi: 10.1038/srep20119.

21.

Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons.

Drew LJ, Kheirbek MA, Luna VM, Denny CA, Cloidt MA, Wu MV, Jain S, Scharfman HE, Hen R.

Hippocampus. 2016 Jun;26(6):763-78. doi: 10.1002/hipo.22557. Epub 2016 Feb 8.

22.

Corruption of the dentate gyrus by "dominant" granule cells: Implications for dentate gyrus function in health and disease.

Scharfman HE, Myers CE.

Neurobiol Learn Mem. 2016 Mar;129:69-82. doi: 10.1016/j.nlm.2015.09.005. Epub 2015 Sep 29. Review.

23.

Potential implications of a monosynaptic pathway from mossy cells to adult-born granule cells of the dentate gyrus.

Scharfman HE, Bernstein HL.

Front Syst Neurosci. 2015 Aug 19;9:112. doi: 10.3389/fnsys.2015.00112. eCollection 2015. Review.

24.

Observations on hippocampal mossy cells in mink (Neovison vison) with special reference to dendrites ascending to the granular and molecular layers.

Blackstad JS, Osen KK, Scharfman HE, Storm-Mathisen J, Blackstad TW, Leergaard TB.

Hippocampus. 2016 Feb;26(2):229-45. doi: 10.1002/hipo.22518. Epub 2015 Sep 12.

25.

Interictal spike frequency varies with ovarian cycle stage in a rat model of epilepsy.

D'Amour J, Magagna-Poveda A, Moretto J, Friedman D, LaFrancois JJ, Pearce P, Fenton AA, MacLusky NJ, Scharfman HE.

Exp Neurol. 2015 Jul;269:102-19. doi: 10.1016/j.expneurol.2015.04.003. Epub 2015 Apr 10.

26.

Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline.

Cho KO, Lybrand ZR, Ito N, Brulet R, Tafacory F, Zhang L, Good L, Ure K, Kernie SG, Birnbaum SG, Scharfman HE, Eisch AJ, Hsieh J.

Nat Commun. 2015 Mar 26;6:6606. doi: 10.1038/ncomms7606.

27.

Neuroscience. Metabolic control of epilepsy.

Scharfman HE.

Science. 2015 Mar 20;347(6228):1312-3. doi: 10.1126/science.aaa9607. No abstract available.

PMID:
25792315
28.

Opioid receptor-dependent sex differences in synaptic plasticity in the hippocampal mossy fiber pathway of the adult rat.

Harte-Hargrove LC, Varga-Wesson A, Duffy AM, Milner TA, Scharfman HE.

J Neurosci. 2015 Jan 28;35(4):1723-38. doi: 10.1523/JNEUROSCI.0820-14.2015.

29.

Suppression of adult neurogenesis increases the acute effects of kainic acid.

Iyengar SS, LaFrancois JJ, Friedman D, Drew LJ, Denny CA, Burghardt NS, Wu MV, Hsieh J, Hen R, Scharfman HE.

Exp Neurol. 2015 Feb;264:135-49. doi: 10.1016/j.expneurol.2014.11.009. Epub 2014 Dec 2.

30.

Preface.

Scharfman HE, Buckmaster PS.

Adv Exp Med Biol. 2014;813:xv-xviii. No abstract available.

PMID:
25371938
31.

p75NTR, but not proNGF, is upregulated following status epilepticus in mice.

VonDran MW, LaFrancois J, Padow VA, Friedman WJ, Scharfman HE, Milner TA, Hempstead BL.

ASN Neuro. 2014 Sep 25;6(5). pii: 1759091414552185. doi: 10.1177/1759091414552185. Print 2014.

32.

Entorhinal cortical defects in Tg2576 mice are present as early as 2-4 months of age.

Duffy AM, Morales-Corraliza J, Bermudez-Hernandez KM, Schaner MJ, Magagna-Poveda A, Mathews PM, Scharfman HE.

Neurobiol Aging. 2015 Jan;36(1):134-48. doi: 10.1016/j.neurobiolaging.2014.07.001. Epub 2014 Jul 11.

33.

Sex differences in the neurobiology of epilepsy: a preclinical perspective.

Scharfman HE, MacLusky NJ.

Neurobiol Dis. 2014 Dec;72 Pt B:180-92. doi: 10.1016/j.nbd.2014.07.004. Epub 2014 Jul 21. Review.

34.

Is plasticity of GABAergic mechanisms relevant to epileptogenesis?

Scharfman HE, Brooks-Kayal AR.

Adv Exp Med Biol. 2014;813:133-50. doi: 10.1007/978-94-017-8914-1_11. Review.

35.

How can we identify ictal and interictal abnormal activity?

Fisher RS, Scharfman HE, deCurtis M.

Adv Exp Med Biol. 2014;813:3-23. doi: 10.1007/978-94-017-8914-1_1. Review.

36.

proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus.

Yang J, Harte-Hargrove LC, Siao CJ, Marinic T, Clarke R, Ma Q, Jing D, Lafrancois JJ, Bath KG, Mark W, Ballon D, Lee FS, Scharfman HE, Hempstead BL.

Cell Rep. 2014 May 8;7(3):796-806. doi: 10.1016/j.celrep.2014.03.040. Epub 2014 Apr 17.

37.

Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy.

Pearce PS, Friedman D, Lafrancois JJ, Iyengar SS, Fenton AA, Maclusky NJ, Scharfman HE.

Epilepsy Behav. 2014 Mar;32:121-31. doi: 10.1016/j.yebeh.2014.01.004. Epub 2014 Feb 15. Review.

38.

Authors' response to letter by A. Mazarati.

Brooks-Kayal AR, Bath KG, Berg AT, Galanopoulou AS, Holmes GL, Jensen FE, Kanner AM, O'Brien TJ, Whittemore VH, Winawer MR, Patel M, Scharfman HE.

Epilepsia. 2013 Dec;54(12):2229-30. doi: 10.1111/epi.12414. No abstract available.

39.

Cutting through the complexity: the role of brain-derived neurotrophic factor in post-traumatic epilepsy (Commentary on Gill et al.).

Scharfman HE.

Eur J Neurosci. 2013 Dec;38(11):3552-3. doi: 10.1111/ejn.12419. No abstract available.

40.

The entorhinal cortex and neurotrophin signaling in Alzheimer's disease and other disorders.

Scharfman HE, Chao MV.

Cogn Neurosci. 2013;4(3-4):123-35. doi: 10.1080/17588928.2013.826184. Epub 2013 Aug 25. Review.

41.

Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy.

Brooks-Kayal AR, Bath KG, Berg AT, Galanopoulou AS, Holmes GL, Jensen FE, Kanner AM, O'Brien TJ, Whittemore VH, Winawer MR, Patel M, Scharfman HE.

Epilepsia. 2013 Aug;54 Suppl 4:44-60. doi: 10.1111/epi.12298. Review.

42.

The influence of ectopic migration of granule cells into the hilus on dentate gyrus-CA3 function.

Myers CE, Bermudez-Hernandez K, Scharfman HE.

PLoS One. 2013 Jun 28;8(6):e68208. doi: 10.1371/journal.pone.0068208. Print 2013.

43.

Aquaporin-4 water channels and synaptic plasticity in the hippocampus.

Scharfman HE, Binder DK.

Neurochem Int. 2013 Dec;63(7):702-11. doi: 10.1016/j.neuint.2013.05.003. Epub 2013 May 15. Review.

44.

Differential regulation of BDNF, synaptic plasticity and sprouting in the hippocampal mossy fiber pathway of male and female rats.

Scharfman HE, MacLusky NJ.

Neuropharmacology. 2014 Jan;76 Pt C:696-708. doi: 10.1016/j.neuropharm.2013.04.029. Epub 2013 May 6.

45.

Expression of c-fos in hilar mossy cells of the dentate gyrus in vivo.

Duffy AM, Schaner MJ, Chin J, Scharfman HE.

Hippocampus. 2013 Aug;23(8):649-55. doi: 10.1002/hipo.22138. Epub 2013 May 27.

46.

Hilar mossy cells of the dentate gyrus: a historical perspective.

Scharfman HE, Myers CE.

Front Neural Circuits. 2013 Jan 9;6:106. doi: 10.3389/fncir.2012.00106. eCollection 2012.

47.

Testosterone depletion in adult male rats increases mossy fiber transmission, LTP, and sprouting in area CA3 of hippocampus.

Skucas VA, Duffy AM, Harte-Hargrove LC, Magagna-Poveda A, Radman T, Chakraborty G, Schroeder CE, MacLusky NJ, Scharfman HE.

J Neurosci. 2013 Feb 6;33(6):2338-55. doi: 10.1523/JNEUROSCI.3857-12.2013.

48.

Preface to the special issue entitled "The future of translational epilepsy research".

Scharfman HE.

Epilepsy Behav. 2013 Mar;26(3):209. doi: 10.1016/j.yebeh.2012.12.016. Epub 2013 Jan 23. No abstract available.

49.

Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms.

Chin J, Scharfman HE.

Epilepsy Behav. 2013 Mar;26(3):343-51. doi: 10.1016/j.yebeh.2012.11.040. Epub 2013 Jan 13. Review.

50.

Impact of early life exposure to antiepileptic drugs on neurobehavioral outcomes based on laboratory animal and clinical research.

Bath KG, Scharfman HE.

Epilepsy Behav. 2013 Mar;26(3):427-39. doi: 10.1016/j.yebeh.2012.10.031. Epub 2013 Jan 8. Review.

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