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Human Immunodeficiency Virus Tat Protein Aids V Region Somatic Hypermutation in Human B Cells.

Wang X, Duan Z, Yu G, Fan M, Scharff MD.

mBio. 2018 Apr 17;9(2). pii: e02315-17. doi: 10.1128/mBio.02315-17.


Overlapping hotspots in CDRs are critical sites for V region diversification.

Wei L, Chahwan R, Wang S, Wang X, Pham PT, Goodman MF, Bergman A, Scharff MD, MacCarthy T.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E728-37. doi: 10.1073/pnas.1500788112. Epub 2015 Feb 2.


A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation.

Wang X, Fan M, Kalis S, Wei L, Scharff MD.

Nat Commun. 2014 Jun 13;5:4137. doi: 10.1038/ncomms5137.


Isotype switching increases efficacy of antibody protection against staphylococcal enterotoxin B-induced lethal shock and Staphylococcus aureus sepsis in mice.

Varshney AK, Wang X, Aguilar JL, Scharff MD, Fries BC.

mBio. 2014 Jun 10;5(3):e01007-14. doi: 10.1128/mBio.01007-14.


The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair.

van Oers JM, Edwards Y, Chahwan R, Zhang W, Smith C, Pechuan X, Schaetzlein S, Jin B, Wang Y, Bergman A, Scharff MD, Edelmann W.

Oncogene. 2014 Jul 24;33(30):3939-46. doi: 10.1038/onc.2013.365. Epub 2013 Sep 9.


Staphylococcal Enterotoxin B-specific monoclonal antibody 20B1 successfully treats diverse Staphylococcus aureus infections.

Varshney AK, Wang X, Scharff MD, MacIntyre J, Zollner RS, Kovalenko OV, Martinez LR, Byrne FR, Fries BC.

J Infect Dis. 2013 Dec 15;208(12):2058-66. doi: 10.1093/infdis/jit421. Epub 2013 Aug 6.


Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes.

Schaetzlein S, Chahwan R, Avdievich E, Roa S, Wei K, Eoff RL, Sellers RS, Clark AB, Kunkel TA, Scharff MD, Edelmann W.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2470-9. doi: 10.1073/pnas.1308512110. Epub 2013 Jun 10.


HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function.

Zhao R, Chinai JM, Buhl S, Scandiuzzi L, Ray A, Jeon H, Ohaegbulam KC, Ghosh K, Zhao A, Scharff MD, Zang X.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9879-84. doi: 10.1073/pnas.1303524110. Epub 2013 May 28.


AID and Apobec3G haphazard deamination and mutational diversity.

Jaszczur M, Bertram JG, Pham P, Scharff MD, Goodman MF.

Cell Mol Life Sci. 2013 Sep;70(17):3089-108. doi: 10.1007/s00018-012-1212-1. Epub 2012 Nov 22. Review.


IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions.

Patten PE, Chu CC, Albesiano E, Damle RN, Yan XJ, Kim D, Zhang L, Magli AR, Barrientos J, Kolitz JE, Allen SL, Rai KR, Roa S, Mongini PK, MacCarthy T, Scharff MD, Chiorazzi N.

Blood. 2012 Dec 6;120(24):4802-11. doi: 10.1182/blood-2012-08-449744. Epub 2012 Oct 15.


AIDing antibody diversity by error-prone mismatch repair.

Chahwan R, Edelmann W, Scharff MD, Roa S.

Semin Immunol. 2012 Aug;24(4):293-300. doi: 10.1016/j.smim.2012.05.005. Epub 2012 Jun 14. Review.


The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination.

Chahwan R, van Oers JM, Avdievich E, Zhao C, Edelmann W, Scharff MD, Roa S.

J Exp Med. 2012 Apr 9;209(4):671-8. doi: 10.1084/jem.20111531. Epub 2012 Mar 26.


The use of Bcl-2 over-expression to stabilize hybridomas specific to the HERG potassium channel.

Sroubek J, Krishnan Y, Chinai J, Buhl S, Scharff MD, McDonald TV.

J Immunol Methods. 2012 Jan 31;375(1-2):215-22. doi: 10.1016/j.jim.2011.10.014. Epub 2011 Nov 15.


Mismatch-mediated error prone repair at the immunoglobulin genes.

Chahwan R, Edelmann W, Scharff MD, Roa S.

Biomed Pharmacother. 2011 Dec;65(8):529-36. doi: 10.1016/j.biopha.2011.09.001. Epub 2011 Oct 24. Review.


Recombinase-mediated cassette exchange as a novel method to study somatic hypermutation in Ramos cells.

Baughn LB, Kalis SL, MacCarthy T, Wei L, Fan M, Bergman A, Scharff MD.

mBio. 2011 Oct 11;2(5). pii: e00186-11. doi: 10.1128/mBio.00186-11. Print 2011.


Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells.

Calissano C, Damle RN, Marsilio S, Yan XJ, Yancopoulos S, Hayes G, Emson C, Murphy EJ, Hellerstein MK, Sison C, Kaufman MS, Kolitz JE, Allen SL, Rai KR, Ivanovic I, Dozmorov IM, Roa S, Scharff MD, Li W, Chiorazzi N.

Mol Med. 2011;17(11-12):1374-82. doi: 10.2119/molmed.2011.00360. Epub 2011 Sep 23.


Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin B-induced lethal shock.

Varshney AK, Wang X, Cook E, Dutta K, Scharff MD, Goger MJ, Fries BC.

J Biol Chem. 2011 Mar 18;286(11):9737-47. doi: 10.1074/jbc.M110.212407. Epub 2011 Jan 13. Erratum in: J Biol Chem. 2014 May 16;289(20):13706.


Msh6 protects mature B cells from lymphoma by preserving genomic stability.

Peled JU, Sellers RS, Iglesias-Ussel MD, Shin DM, Montagna C, Zhao C, Li Z, Edelmann W, Morse HC 3rd, Scharff MD.

Am J Pathol. 2010 Nov;177(5):2597-608. doi: 10.2353/ajpath.2010.100234. Epub 2010 Oct 7.


A requirement for FcγR in antibody-mediated bacterial toxin neutralization.

Abboud N, Chow SK, Saylor C, Janda A, Ravetch JV, Scharff MD, Casadevall A.

J Exp Med. 2010 Oct 25;207(11):2395-405. doi: 10.1084/jem.20100995. Epub 2010 Oct 4.


PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.

van Oers JM, Roa S, Werling U, Liu Y, Genschel J, Hou H Jr, Sellers RS, Modrich P, Scharff MD, Edelmann W.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13384-9. doi: 10.1073/pnas.1008589107. Epub 2010 Jul 12.


MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites.

Roa S, Li Z, Peled JU, Zhao C, Edelmann W, Scharff MD.

PLoS One. 2010 Jun 17;5(6):e11182. doi: 10.1371/journal.pone.0011182.


Requirement for cyclin D3 in germinal center formation and function.

Peled JU, Yu JJ, Venkatesh J, Bi E, Ding BB, Krupski-Downs M, Shaknovich R, Sicinski P, Diamond B, Scharff MD, Ye BH.

Cell Res. 2010 Jun;20(6):631-46. doi: 10.1038/cr.2010.55. Epub 2010 Apr 20.


The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination.

Ramachandran S, Chahwan R, Nepal RM, Frieder D, Panier S, Roa S, Zaheen A, Durocher D, Scharff MD, Martin A.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):809-14. doi: 10.1073/pnas.0913790107. Epub 2009 Dec 22.


Molecular characterization of hybridoma subclones spontaneously switching at high frequencies in vitro.

Iglesias-Ussel MD, Zavadil J, Scharff MD.

J Immunol Methods. 2009 Oct 31;350(1-2):71-8. doi: 10.1016/j.jim.2009.07.003. Epub 2009 Jul 17.


V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environment.

MacCarthy T, Kalis SL, Roa S, Pham P, Goodman MF, Scharff MD, Bergman A.

Proc Natl Acad Sci U S A. 2009 May 26;106(21):8629-34. doi: 10.1073/pnas.0903803106. Epub 2009 May 14.


H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination.

Kuang FL, Luo Z, Scharff MD.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5288-93. doi: 10.1073/pnas.0901368106. Epub 2009 Mar 10.


SHMTool: a webserver for comparative analysis of somatic hypermutation datasets.

Maccarthy T, Roa S, Scharff MD, Bergman A.

DNA Repair (Amst). 2009 Jan 1;8(1):137-41. doi: 10.1016/j.dnarep.2008.09.006. Epub 2008 Nov 8.


Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.

Roa S, Avdievich E, Peled JU, Maccarthy T, Werling U, Kuang FL, Kan R, Zhao C, Bergman A, Cohen PE, Edelmann W, Scharff MD.

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16248-53. doi: 10.1073/pnas.0808182105. Epub 2008 Oct 14.


Does antisense make sense of AID targeting?

Roa S, Kuang FL, Scharff MD.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3661-2. doi: 10.1073/pnas.0800935105. Epub 2008 Mar 5. No abstract available.


The biochemistry of somatic hypermutation.

Peled JU, Kuang FL, Iglesias-Ussel MD, Roa S, Kalis SL, Goodman MF, Scharff MD.

Annu Rev Immunol. 2008;26:481-511. doi: 10.1146/annurev.immunol.26.021607.090236. Review.


Human recombinant Fab fragments with sub-nanomolar affinities for acetylated histones.

Batova I, Kowal C, May R, Scharff MD, Diamond B.

J Immunol Methods. 2008 Jan 1;329(1-2):1-10. Epub 2007 Oct 11.


AID-initiated purposeful mutations in immunoglobulin genes.

Goodman MF, Scharff MD, Romesberg FE.

Adv Immunol. 2007;94:127-55. Review.


Targeting AID to the Ig genes.

Li Z, Luo Z, Ronai D, Kuang FL, Peled JU, Iglesias-Ussel MD, Scharff MD.

Adv Exp Med Biol. 2007;596:93-109. Review. No abstract available.


Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.

Ronai D, Iglesias-Ussel MD, Fan M, Li Z, Martin A, Scharff MD.

J Exp Med. 2007 Jan 22;204(1):181-90. Epub 2007 Jan 16.


Forced expression of AID facilitates the isolation of class switch variants from hybridoma cells.

Iglesias-Ussel MD, Fan M, Li Z, Martin A, Scharff MD.

J Immunol Methods. 2006 Oct 20;316(1-2):59-66. Epub 2006 Sep 5.


The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus.

Li Z, Zhao C, Iglesias-Ussel MD, Polonskaya Z, Zhuang M, Yang G, Luo Z, Edelmann W, Scharff MD.

Immunity. 2006 Apr;24(4):393-403.


A role for Mlh3 in somatic hypermutation.

Li Z, Peled JU, Zhao C, Svetlanov A, Ronai D, Cohen PE, Scharff MD.

DNA Repair (Amst). 2006 Jun 10;5(6):675-82. Epub 2006 Mar 27.


Tumor necrosis factor-alpha and CD40L modulate cell surface morphology and induce aggregation in Ramos Burkitt's lymphoma cells.

Laskov R, Berger N, Scharff MD, Horwitz MS.

Leuk Lymphoma. 2006 Mar;47(3):507-19.


Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells.

Ronai D, Iglesias-Ussel MD, Fan M, Shulman MJ, Scharff MD.

Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11829-34. Epub 2005 Aug 8.


Identifying protein-protein interactions in somatic hypermutation.

Goodman MF, Scharff MD.

J Exp Med. 2005 Feb 21;201(4):493-6. Epub 2005 Feb 14.


Variable-region-identical antibodies differing in isotype demonstrate differences in fine specificity and idiotype.

Torres M, May R, Scharff MD, Casadevall A.

J Immunol. 2005 Feb 15;174(4):2132-42.


Methylation protects cytidines from AID-mediated deamination.

Larijani M, Frieder D, Sonbuchner TM, Bransteitter R, Goodman MF, Bouhassira EE, Scharff MD, Martin A.

Mol Immunol. 2005 Mar;42(5):599-604.


Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching.

Li Z, Luo Z, Scharff MD.

Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15428-33. Epub 2004 Oct 14.


The role of activation-induced cytidine deaminase in antibody diversification, immunodeficiency, and B-cell malignancies.

Luo Z, Ronai D, Scharff MD.

J Allergy Clin Immunol. 2004 Oct;114(4):726-35; quiz 736. Review.


Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification.

Li Z, Scherer SJ, Ronai D, Iglesias-Ussel MD, Peled JU, Bardwell PD, Zhuang M, Lee K, Martin A, Edelmann W, Scharff MD.

J Exp Med. 2004 Jul 5;200(1):47-59.


The generation of antibody diversity through somatic hypermutation and class switch recombination.

Li Z, Woo CJ, Iglesias-Ussel MD, Ronai D, Scharff MD.

Genes Dev. 2004 Jan 1;18(1):1-11. Review. No abstract available.


Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice.

Bardwell PD, Woo CJ, Wei K, Li Z, Martin A, Sack SZ, Parris T, Edelmann W, Scharff MD.

Nat Immunol. 2004 Feb;5(2):224-9. Epub 2004 Jan 11.


Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination.

Martin A, Li Z, Lin DP, Bardwell PD, Iglesias-Ussel MD, Edelmann W, Scharff MD.

J Exp Med. 2003 Oct 20;198(8):1171-8.


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