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The mitochondrial carrier pathway transports non-canonical substrates with an odd number of transmembrane segments.

Rampelt H, Sucec I, Bersch B, Horten P, Perschil I, Martinou JC, van der Laan M, Wiedemann N, Schanda P, Pfanner N.

BMC Biol. 2020 Jan 6;18(1):2. doi: 10.1186/s12915-019-0733-6.


Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors.

Felix J, Weinhäupl K, Chipot C, Dehez F, Hessel A, Gauto DF, Morlot C, Abian O, Gutsche I, Velazquez-Campoy A, Schanda P, Fraga H.

Sci Adv. 2019 Sep 4;5(9):eaaw3818. doi: 10.1126/sciadv.aaw3818. eCollection 2019 Sep.


Relaxing with liquids and solids - A perspective on biomolecular dynamics.

Schanda P.

J Magn Reson. 2019 Sep;306:180-186. doi: 10.1016/j.jmr.2019.07.025. Epub 2019 Jul 11. No abstract available.


Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex.

Gauto DF, Estrozi LF, Schwieters CD, Effantin G, Macek P, Sounier R, Sivertsen AC, Schmidt E, Kerfah R, Mas G, Colletier JP, Güntert P, Favier A, Schoehn G, Schanda P, Boisbouvier J.

Nat Commun. 2019 Jun 19;10(1):2697. doi: 10.1038/s41467-019-10490-9.


Aromatic Ring Dynamics, Thermal Activation, and Transient Conformations of a 468 kDa Enzyme by Specific 1H-13C Labeling and Fast Magic-Angle Spinning NMR.

Gauto DF, Macek P, Barducci A, Fraga H, Hessel A, Terauchi T, Gajan D, Miyanoiri Y, Boisbouvier J, Lichtenecker R, Kainosho M, Schanda P.

J Am Chem Soc. 2019 Jul 17;141(28):11183-11195. doi: 10.1021/jacs.9b04219. Epub 2019 Jul 5.


relax: the analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data.

Morin S, Linnet TE, Lescanne M, Schanda P, Thompson GS, Tollinger M, Teilum K, Gagné S, Marion D, Griesinger C, Blackledge M, d'Auvergne EJ.

Bioinformatics. 2019 Oct 15;35(20):4205. doi: 10.1093/bioinformatics/btz397. No abstract available.


Mechanistic Insights into Microsecond Time-Scale Motion of Solid Proteins Using Complementary 15N and 1H Relaxation Dispersion Techniques.

Rovó P, Smith CA, Gauto D, de Groot BL, Schanda P, Linser R.

J Am Chem Soc. 2019 Jan 16;141(2):858-869. doi: 10.1021/jacs.8b09258. Epub 2019 Jan 8.


NMR for Biological Systems.

Schanda P, Chekmenev EY.

Chemphyschem. 2019 Jan 21;20(2):177. doi: 10.1002/cphc.201801100. Epub 2018 Dec 17. No abstract available.


Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane Space.

Weinhäupl K, Lindau C, Hessel A, Wang Y, Schütze C, Jores T, Melchionda L, Schönfisch B, Kalbacher H, Bersch B, Rapaport D, Brennich M, Lindorff-Larsen K, Wiedemann N, Schanda P.

Cell. 2018 Nov 15;175(5):1365-1379.e25. doi: 10.1016/j.cell.2018.10.039.


Microsecond Protein Dynamics from Combined Bloch-McConnell and Near-Rotary-Resonance R1p Relaxation-Dispersion MAS NMR.

Marion D, Gauto DF, Ayala I, Giandoreggio-Barranco K, Schanda P.

Chemphyschem. 2019 Jan 21;20(2):276-284. doi: 10.1002/cphc.201800935. Epub 2018 Dec 20.


Conformational Dynamics in the Core of Human Y145Stop Prion Protein Amyloid Probed by Relaxation Dispersion NMR.

Shannon MD, Theint T, Mukhopadhyay D, Surewicz K, Surewicz WK, Marion D, Schanda P, Jaroniec CP.

Chemphyschem. 2019 Jan 21;20(2):311-317. doi: 10.1002/cphc.201800779. Epub 2018 Nov 7.


Structural investigation of a chaperonin in action reveals how nucleotide binding regulates the functional cycle.

Mas G, Guan JY, Crublet E, Debled EC, Moriscot C, Gans P, Schoehn G, Macek P, Schanda P, Boisbouvier J.

Sci Adv. 2018 Sep 19;4(9):eaau4196. doi: 10.1126/sciadv.aau4196. eCollection 2018 Sep.


Dynamics and interactions of AAC3 in DPC are not functionally relevant.

Kurauskas V, Hessel A, Dehez F, Chipot C, Bersch B, Schanda P.

Nat Struct Mol Biol. 2018 Sep;25(9):745-747. doi: 10.1038/s41594-018-0127-4. No abstract available.


Studying intact bacterial peptidoglycan by proton-detected NMR spectroscopy at 100 kHz MAS frequency.

Bougault C, Ayala I, Vollmer W, Simorre JP, Schanda P.

J Struct Biol. 2019 Apr 1;206(1):66-72. doi: 10.1016/j.jsb.2018.07.009. Epub 2018 Jul 19.


Solid State NMR Studies of Intact Lipopolysaccharide Endotoxin.

Laguri C, Silipo A, Martorana AM, Schanda P, Marchetti R, Polissi A, Molinaro A, Simorre JP.

ACS Chem Biol. 2018 Aug 17;13(8):2106-2113. doi: 10.1021/acschembio.8b00271. Epub 2018 Jul 2.


Microsecond motions probed by near-rotary-resonance R15N MAS NMR experiments: the model case of protein overall-rocking in crystals.

Krushelnitsky A, Gauto D, Rodriguez Camargo DC, Schanda P, Saalwächter K.

J Biomol NMR. 2018 May;71(1):53-67. doi: 10.1007/s10858-018-0191-4. Epub 2018 May 30.


The antibiotic cyclomarin blocks arginine-phosphate-induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis.

Weinhäupl K, Brennich M, Kazmaier U, Lelievre J, Ballell L, Goldberg A, Schanda P, Fraga H.

J Biol Chem. 2018 Jun 1;293(22):8379-8393. doi: 10.1074/jbc.RA118.002251. Epub 2018 Apr 9.


Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies.

Chipot C, Dehez F, Schnell JR, Zitzmann N, Pebay-Peyroula E, Catoire LJ, Miroux B, Kunji ERS, Veglia G, Cross TA, Schanda P.

Chem Rev. 2018 Apr 11;118(7):3559-3607. doi: 10.1021/acs.chemrev.7b00570. Epub 2018 Feb 28. Review.


How Detergent Impacts Membrane Proteins: Atomic-Level Views of Mitochondrial Carriers in Dodecylphosphocholine.

Kurauskas V, Hessel A, Ma P, Lunetti P, Weinhäupl K, Imbert L, Brutscher B, King MS, Sounier R, Dolce V, Kunji ERS, Capobianco L, Chipot C, Dehez F, Bersch B, Schanda P.

J Phys Chem Lett. 2018 Mar 1;9(5):933-938. doi: 10.1021/acs.jpclett.8b00269. Epub 2018 Feb 8.


Mitochondrial ADP/ATP Carrier in Dodecylphosphocholine Binds Cardiolipins with Non-native Affinity.

Dehez F, Schanda P, King MS, Kunji ERS, Chipot C.

Biophys J. 2017 Dec 5;113(11):2311-2315. doi: 10.1016/j.bpj.2017.09.019. Epub 2017 Oct 20.


Solid-State NMR H-N-(C)-H and H-N-C-C 3D/4D Correlation Experiments for Resonance Assignment of Large Proteins.

Fraga H, Arnaud CA, Gauto DF, Audin M, Kurauskas V, Macek P, Krichel C, Guan JY, Boisbouvier J, Sprangers R, Breyton C, Schanda P.

Chemphyschem. 2017 Oct 6;18(19):2697-2703. doi: 10.1002/cphc.201700572. Epub 2017 Sep 5.


Methyl-Specific Isotope Labeling Strategies for NMR Studies of Membrane Proteins.

Kurauskas V, Schanda P, Sounier R.

Methods Mol Biol. 2017;1635:109-123. doi: 10.1007/978-1-4939-7151-0_6.


Slow conformational exchange and overall rocking motion in ubiquitin protein crystals.

Kurauskas V, Izmailov SA, Rogacheva ON, Hessel A, Ayala I, Woodhouse J, Shilova A, Xue Y, Yuwen T, Coquelle N, Colletier JP, Skrynnikov NR, Schanda P.

Nat Commun. 2017 Jul 27;8(1):145. doi: 10.1038/s41467-017-00165-8.


Optimized fast mixing device for real-time NMR applications.

Franco R, Favier A, Schanda P, Brutscher B.

J Magn Reson. 2017 Aug;281:125-129. doi: 10.1016/j.jmr.2017.05.016. Epub 2017 May 31.


Protein conformational dynamics studied by 15N and 1H R relaxation dispersion: Application to wild-type and G53A ubiquitin crystals.

Gauto DF, Hessel A, Rovó P, Kurauskas V, Linser R, Schanda P.

Solid State Nucl Magn Reson. 2017 Oct;87:86-95. doi: 10.1016/j.ssnmr.2017.04.002. Epub 2017 Apr 14.


Proton-Detected Solid-State NMR Spectroscopy of a Zinc Diffusion Facilitator Protein in Native Nanodiscs.

Bersch B, Dörr JM, Hessel A, Killian JA, Schanda P.

Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2508-2512. doi: 10.1002/anie.201610441. Epub 2017 Jan 27.


RNA binding and chaperone activity of the E. coli cold-shock protein CspA.

Rennella E, Sára T, Juen M, Wunderlich C, Imbert L, Solyom Z, Favier A, Ayala I, Weinhäupl K, Schanda P, Konrat R, Kreutz C, Brutscher B.

Nucleic Acids Res. 2017 Apr 20;45(7):4255-4268. doi: 10.1093/nar/gkx044.


A ring-shaped conduit connects the mother cell and forespore during sporulation in Bacillus subtilis.

Rodrigues CD, Henry X, Neumann E, Kurauskas V, Bellard L, Fichou Y, Schanda P, Schoehn G, Rudner DZ, Morlot C.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11585-11590. Epub 2016 Sep 28.


Cross-Correlated Relaxation of Dipolar Coupling and Chemical-Shift Anisotropy in Magic-Angle Spinning R1ρ NMR Measurements: Application to Protein Backbone Dynamics Measurements.

Kurauskas V, Weber E, Hessel A, Ayala I, Marion D, Schanda P.

J Phys Chem B. 2016 Sep 1;120(34):8905-13. doi: 10.1021/acs.jpcb.6b06129. Epub 2016 Aug 19.


Sensitive proton-detected solid-state NMR spectroscopy of large proteins with selective CH3 labelling: application to the 50S ribosome subunit.

Kurauskas V, Crublet E, Macek P, Kerfah R, Gauto DF, Boisbouvier J, Schanda P.

Chem Commun (Camb). 2016 Jul 21;52(61):9558-61. doi: 10.1039/c6cc04484k.


Studying Dynamics by Magic-Angle Spinning Solid-State NMR Spectroscopy: Principles and Applications to Biomolecules.

Schanda P, Ernst M.

Prog Nucl Magn Reson Spectrosc. 2016 Aug;96:1-46. Epub 2016 Feb 15. Review.


Observing the overall rocking motion of a protein in a crystal.

Ma P, Xue Y, Coquelle N, Haller JD, Yuwen T, Ayala I, Mikhailovskii O, Willbold D, Colletier JP, Skrynnikov NR, Schanda P.

Nat Commun. 2015 Oct 5;6:8361. doi: 10.1038/ncomms9361.


Atomic model of a cell-wall cross-linking enzyme in complex with an intact bacterial peptidoglycan.

Schanda P, Triboulet S, Laguri C, Bougault CM, Ayala I, Callon M, Arthur M, Simorre JP.

J Am Chem Soc. 2014 Dec 24;136(51):17852-60. doi: 10.1021/ja5105987. Epub 2014 Dec 10.


relax: the analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data.

Morin S, Linnet TE, Lescanne M, Schanda P, Thompson GS, Tollinger M, Teilum K, Gagné S, Marion D, Griesinger C, Blackledge M, d'Auvergne EJ.

Bioinformatics. 2014 Aug 1;30(15):2219-20. doi: 10.1093/bioinformatics/btu166. Epub 2014 Apr 9. Erratum in: Bioinformatics. 2019 Oct 15;35(20):4205.


Probing transient conformational states of proteins by solid-state R(1ρ) relaxation-dispersion NMR spectroscopy.

Ma P, Haller JD, Zajakala J, Macek P, Sivertsen AC, Willbold D, Boisbouvier J, Schanda P.

Angew Chem Int Ed Engl. 2014 Apr 22;53(17):4312-7. doi: 10.1002/anie.201311275. Epub 2014 Mar 18.


Oligomeric states along the folding pathways of β2-microglobulin: kinetics, thermodynamics, and structure.

Rennella E, Cutuil T, Schanda P, Ayala I, Gabel F, Forge V, Corazza A, Esposito G, Brutscher B.

J Mol Biol. 2013 Aug 9;425(15):2722-36. doi: 10.1016/j.jmb.2013.04.028. Epub 2013 May 3.


Optimal degree of protonation for ¹H detection of aliphatic sites in randomly deuterated proteins as a function of the MAS frequency.

Asami S, Szekely K, Schanda P, Meier BH, Reif B.

J Biomol NMR. 2012 Oct;54(2):155-68. Epub 2012 Aug 23.


Site-resolved measurement of microsecond-to-millisecond conformational-exchange processes in proteins by solid-state NMR spectroscopy.

Tollinger M, Sivertsen AC, Meier BH, Ernst M, Schanda P.

J Am Chem Soc. 2012 Sep 12;134(36):14800-7. doi: 10.1021/ja303591y. Epub 2012 Aug 28.


Real-time NMR characterization of structure and dynamics in a transiently populated protein folding intermediate.

Rennella E, Cutuil T, Schanda P, Ayala I, Forge V, Brutscher B.

J Am Chem Soc. 2012 May 16;134(19):8066-9. doi: 10.1021/ja302598j. Epub 2012 May 7.


A supplementary coil for ²H decoupling with commercial HCN MAS probes.

Huber M, With O, Schanda P, Verel R, Ernst M, Meier BH.

J Magn Reson. 2012 Jan;214(1):76-80. doi: 10.1016/j.jmr.2011.10.010. Epub 2011 Oct 20.


Three-dimensional deuterium-carbon correlation experiments for high-resolution solid-state MAS NMR spectroscopy of large proteins.

Lalli D, Schanda P, Chowdhury A, Retel J, Hiller M, Higman VA, Handel L, Agarwal V, Reif B, van Rossum B, Akbey U, Oschkinat H.

J Biomol NMR. 2011 Dec;51(4):477-85. doi: 10.1007/s10858-011-9578-1. Epub 2011 Oct 25.


Solid-state NMR measurements of asymmetric dipolar couplings provide insight into protein side-chain motion.

Schanda P, Huber M, Boisbouvier J, Meier BH, Ernst M.

Angew Chem Int Ed Engl. 2011 Nov 11;50(46):11005-9. doi: 10.1002/anie.201103944. Epub 2011 Sep 14. No abstract available. Erratum in: Angew Chem Int Ed Engl. 2012 Oct 1;51(40):9959.


Accurate measurement of one-bond H-X heteronuclear dipolar couplings in MAS solid-state NMR.

Schanda P, Meier BH, Ernst M.

J Magn Reson. 2011 Jun;210(2):246-59. doi: 10.1016/j.jmr.2011.03.015. Epub 2011 Mar 21.


A proton-detected 4D solid-state NMR experiment for protein structure determination.

Huber M, Hiller S, Schanda P, Ernst M, Böckmann A, Verel R, Meier BH.

Chemphyschem. 2011 Apr 4;12(5):915-8. doi: 10.1002/cphc.201100062. Epub 2011 Feb 15. No abstract available.


Probing water accessibility in HET-s(218-289) amyloid fibrils by solid-state NMR.

Van Melckebeke H, Schanda P, Gath J, Wasmer C, Verel R, Lange A, Meier BH, Böckmann A.

J Mol Biol. 2011 Jan 21;405(3):765-72. doi: 10.1016/j.jmb.2010.11.004. Epub 2010 Nov 19.


Quantitative analysis of protein backbone dynamics in microcrystalline ubiquitin by solid-state NMR spectroscopy.

Schanda P, Meier BH, Ernst M.

J Am Chem Soc. 2010 Nov 17;132(45):15957-67. doi: 10.1021/ja100726a. Epub 2010 Oct 26.


Native-unlike long-lived intermediates along the folding pathway of the amyloidogenic protein beta2-microglobulin revealed by real-time two-dimensional NMR.

Corazza A, Rennella E, Schanda P, Mimmi MC, Cutuil T, Raimondi S, Giorgetti S, Fogolari F, Viglino P, Frydman L, Gal M, Bellotti V, Brutscher B, Esposito G.

J Biol Chem. 2010 Feb 19;285(8):5827-35. doi: 10.1074/jbc.M109.061168. Epub 2009 Dec 22.


Direct detection of (3h)J(NC') hydrogen-bond scalar couplings in proteins by solid-state NMR spectroscopy.

Schanda P, Huber M, Verel R, Ernst M, Meier BH.

Angew Chem Int Ed Engl. 2009;48(49):9322-5. doi: 10.1002/anie.200904411. No abstract available.


Longitudinal-relaxation-enhanced NMR experiments for the study of nucleic acids in solution.

Farjon J, Boisbouvier J, Schanda P, Pardi A, Simorre JP, Brutscher B.

J Am Chem Soc. 2009 Jun 24;131(24):8571-7. doi: 10.1021/ja901633y.

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