Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 108

1.

The TCR is an allosterically regulated macromolecular machinery changing its conformation while working.

Schamel WW, Alarcon B, Minguet S.

Immunol Rev. 2019 Sep;291(1):8-25. doi: 10.1111/imr.12788. Review.

PMID:
31402501
2.

Proximal Lck Promoter-Driven Cre Function Is Limited in Neonatal and Ineffective in Adult γδ T Cell Development.

Fiala GJ, Schaffer AM, Merches K, Morath A, Swann J, Herr LA, Hils M, Esser C, Minguet S, Schamel WWA.

J Immunol. 2019 Jul 15;203(2):569-579. doi: 10.4049/jimmunol.1701521. Epub 2019 Jun 5.

PMID:
31167772
3.

Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response.

Baeuerle PA, Ding J, Patel E, Thorausch N, Horton H, Gierut J, Scarfo I, Choudhary R, Kiner O, Krishnamurthy J, Le B, Morath A, Baldeviano GC, Quinn J, Tavares P, Wei Q, Weiler S, Maus MV, Getts D, Schamel WW, Hofmeister R.

Nat Commun. 2019 May 7;10(1):2087. doi: 10.1038/s41467-019-10097-0.

4.

Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor.

Yousefi OS, Günther M, Hörner M, Chalupsky J, Wess M, Brandl SM, Smith RW, Fleck C, Kunkel T, Zurbriggen MD, Höfer T, Weber W, Schamel WW.

Elife. 2019 Apr 5;8. pii: e42475. doi: 10.7554/eLife.42475.

5.

Light-Controlled Affinity Purification of Protein Complexes Exemplified by the Resting ZAP70 Interactome.

Hörner M, Eble J, Yousefi OS, Schwarz J, Warscheid B, Weber W, Schamel WWA.

Front Immunol. 2019 Feb 26;10:226. doi: 10.3389/fimmu.2019.00226. eCollection 2019.

6.

Phytochrome-Based Extracellular Matrix with Reversibly Tunable Mechanical Properties.

Hörner M, Raute K, Hummel B, Madl J, Creusen G, Thomas OS, Christen EH, Hotz N, Gübeli RJ, Engesser R, Rebmann B, Lauer J, Rolauffs B, Timmer J, Schamel WWA, Pruszak J, Römer W, Zurbriggen MD, Friedrich C, Walther A, Minguet S, Sawarkar R, Weber W.

Adv Mater. 2019 Mar;31(12):e1806727. doi: 10.1002/adma.201806727. Epub 2019 Jan 27.

PMID:
30687975
7.

Optogenetic control of integrin-matrix interaction.

Baaske J, Mühlhäuser WWD, Yousefi OS, Zanner S, Radziwill G, Hörner M, Schamel WWA, Weber W.

Commun Biol. 2019 Jan 8;2:15. doi: 10.1038/s42003-018-0264-7. eCollection 2019.

8.

Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells.

Baaske J, Gonschorek P, Engesser R, Dominguez-Monedero A, Raute K, Fischbach P, Müller K, Cachat E, Schamel WWA, Minguet S, Davies JA, Timmer J, Weber W, Zurbriggen MD.

Sci Rep. 2018 Oct 9;8(1):15024. doi: 10.1038/s41598-018-32929-7.

9.

Anti-CD3 Fab Fragments Enhance Tumor Killing by Human γδ T Cells Independent of Nck Recruitment to the γδ T Cell Antigen Receptor.

Juraske C, Wipa P, Morath A, Hidalgo JV, Hartl FA, Raute K, Oberg HH, Wesch D, Fisch P, Minguet S, Pongcharoen S, Schamel WW.

Front Immunol. 2018 Jul 9;9:1579. doi: 10.3389/fimmu.2018.01579. eCollection 2018.

10.

A window of opportunity for cooperativity in the T Cell Receptor.

Martin-Blanco N, Blanco R, Alda-Catalinas C, Bovolenta ER, Oeste CL, Palmer E, Schamel WW, Lythe G, Molina-París C, Castro M, Alarcon B.

Nat Commun. 2018 Jul 5;9(1):2618. doi: 10.1038/s41467-018-05050-6.

11.

Erratum for Maler et al., "Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages".

Maler MD, Nielsen PJ, Stichling N, Cohen I, Ruzsics Z, Wood C, Engelhard P, Suomalainen M, Gyory I, Huber M, Müller-Quernheim J, Schamel WW, Gordon S, Jakob T, Martin SF, Jahnen-Dechent W, Greber UF, Freudenberg MA, Fejer G.

MBio. 2017 Sep 26;8(5). pii: e01445-17. doi: 10.1128/mBio.01445-17. No abstract available.

12.

Selected signalling proteins recruited to the T-cell receptor-CD3 complex.

Ngoenkam J, Schamel WW, Pongcharoen S.

Immunology. 2018 Jan;153(1):42-50. doi: 10.1111/imm.12809. Epub 2017 Sep 5. Review.

13.

Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages.

Maler MD, Nielsen PJ, Stichling N, Cohen I, Ruzsics Z, Wood C, Engelhard P, Suomalainen M, Gyory I, Huber M, Müller-Quernheim J, Schamel WWA, Gordon S, Jakob T, Martin SF, Jahnen-Dechent W, Greber UF, Freudenberg MA, Fejer G.

MBio. 2017 Aug 1;8(4). pii: e00670-17. doi: 10.1128/mBio.00670-17. Erratum in: MBio. 2017 Sep 26;8(5):.

14.

Correction: Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.

Keller B, Zaidman I, Yousefi OS, Hershkovitz D, Stein J, Unger S, Schachtrup K, Sigvardsson M, Kuperman AA, Shaag A, Schamel WW, Elpeleg O, Warnatz K, Stepensky P.

J Exp Med. 2017 Jul 3;214(7):2165. doi: 10.1084/jem.2015111005242017c. Epub 2017 Jun 1. No abstract available.

15.

The Allostery Model of TCR Regulation.

Schamel WW, Alarcon B, Höfer T, Minguet S.

J Immunol. 2017 Jan 1;198(1):47-52. Review.

16.

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.

Keller B, Zaidman I, Yousefi OS, Hershkovitz D, Stein J, Unger S, Schachtrup K, Sigvardsson M, Kuperman AA, Shaag A, Schamel WW, Elpeleg O, Warnatz K, Stepensky P.

J Exp Med. 2016 Jun 27;213(7):1185-99. doi: 10.1084/jem.20151110. Epub 2016 May 30. Erratum in: J Exp Med. 2017 Jun 1;:.

17.

Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol.

Wang F, Beck-García K, Zorzin C, Schamel WW, Davis MM.

Nat Immunol. 2016 Jul;17(7):844-50. doi: 10.1038/ni.3462. Epub 2016 May 23.

18.

Correction: Nck Binds to the T Cell Antigen Receptor Using Its SH3.1 and SH2 Domains in a Cooperative Manner, Promoting TCR Functioning.

Paensuwan P, Hartl FA, Yousefi OS, Ngoenkam J, Wipa P, Beck-Garcia E, Dopfer EP, Khamsri B, Sanguansermsri D, Minguet S, Schamel WW, Pongcharoen S.

J Immunol. 2016 Jun 1;196(11):4833. doi: 10.4049/jimmunol.1600551. No abstract available.

19.

A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation.

Swamy M, Beck-Garcia K, Beck-Garcia E, Hartl FA, Morath A, Yousefi OS, Dopfer EP, Molnár E, Schulze AK, Blanco R, Borroto A, Martín-Blanco N, Alarcon B, Höfer T, Minguet S, Schamel WW.

Immunity. 2016 May 17;44(5):1091-101. doi: 10.1016/j.immuni.2016.04.011.

20.

Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants.

Köhler M, Röring M, Schorch B, Heilmann K, Stickel N, Fiala GJ, Schmitt LC, Braun S, Ehrenfeld S, Uhl FM, Kaltenbacher T, Weinberg F, Herzog S, Zeiser R, Schamel WW, Jumaa H, Brummer T.

EMBO J. 2016 Jan 18;35(2):143-61. doi: 10.15252/embj.201592097. Epub 2015 Dec 10.

21.

Nck Binds to the T Cell Antigen Receptor Using Its SH3.1 and SH2 Domains in a Cooperative Manner, Promoting TCR Functioning.

Paensuwan P, Hartl FA, Yousefi OS, Ngoenkam J, Wipa P, Beck-Garcia E, Dopfer EP, Khamsri B, Sanguansermsri D, Minguet S, Schamel WW, Pongcharoen S.

J Immunol. 2016 Jan 1;196(1):448-58. doi: 10.4049/jimmunol.1500958. Epub 2015 Nov 20. Erratum in: J Immunol. 2016 Jun 1;196(11):4833.

22.

Response to Comment on "A Novel Thymoma-Associated Immunodeficiency with Increased Naive T Cells and Reduced CD247 Expression".

Fisch P, Christopoulos P, Marx A, Schamel WW.

J Immunol. 2015 Oct 15;195(8):3505-6. doi: 10.4049/jimmunol.1501787. No abstract available.

23.

Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.

Fiala GJ, Janowska I, Prutek F, Hobeika E, Satapathy A, Sprenger A, Plum T, Seidl M, Dengjel J, Reth M, Cesca F, Brummer T, Minguet S, Schamel WW.

J Exp Med. 2015 Sep 21;212(10):1693-708. doi: 10.1084/jem.20141271. Epub 2015 Aug 31.

24.

The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells.

Dufner A, Kisser A, Niendorf S, Basters A, Reissig S, Schönle A, Aichem A, Kurz T, Schlosser A, Yablonski D, Groettrup M, Buch T, Waisman A, Schamel WW, Prinz M, Knobeloch KP.

Nat Immunol. 2015 Sep;16(9):950-60. doi: 10.1038/ni.3230. Epub 2015 Jul 27.

PMID:
26214742
25.

SYK expression endows human ZAP70-deficient CD8 T cells with residual TCR signaling.

Hauck F, Blumenthal B, Fuchs S, Lenoir C, Martin E, Speckmann C, Vraetz T, Mannhardt-Laakmann W, Lambert N, Gil M, Borte S, Audrain M, Schwarz K, Lim A, Schamel WW, Fischer A, Ehl S, Rensing-Ehl A, Picard C, Latour S.

Clin Immunol. 2015 Dec;161(2):103-9. doi: 10.1016/j.clim.2015.07.002. Epub 2015 Jul 14.

PMID:
26187144
26.

Red Light-Regulated Reversible Nuclear Localization of Proteins in Mammalian Cells and Zebrafish.

Beyer HM, Juillot S, Herbst K, Samodelov SL, Müller K, Schamel WW, Römer W, Schäfer E, Nagy F, Strähle U, Weber W, Zurbriggen MD.

ACS Synth Biol. 2015 Sep 18;4(9):951-8. doi: 10.1021/acssynbio.5b00004. Epub 2015 Mar 30.

PMID:
25803699
27.

A novel thymoma-associated immunodeficiency with increased naive T cells and reduced CD247 expression.

Christopoulos P, Dopfer EP, Malkovsky M, Esser PR, Schaefer HE, Marx A, Kock S, Rupp N, Lorenz MR, Schwarz K, Harder J, Martin SF, Werner M, Bogdan C, Schamel WW, Fisch P.

J Immunol. 2015 Apr 1;194(7):3045-53. doi: 10.4049/jimmunol.1402805. Epub 2015 Mar 2.

28.

T cell expansion is the limiting factor of virus control in mice with attenuated TCR signaling: implications for human immunodeficiency.

Hillen KM, Gather R, Enders A, Pircher H, Aichele P, Fisch P, Blumenthal B, Schamel WW, Straub T, Goodnow CC, Ehl S.

J Immunol. 2015 Mar 15;194(6):2725-34. doi: 10.4049/jimmunol.1400328. Epub 2015 Feb 11.

29.

Nanoclusters of the resting T cell antigen receptor (TCR) localize to non-raft domains.

Beck-García K, Beck-García E, Bohler S, Zorzin C, Sezgin E, Levental I, Alarcón B, Schamel WW.

Biochim Biophys Acta. 2015 Apr;1853(4):802-9. doi: 10.1016/j.bbamcr.2014.12.017. Epub 2014 Dec 20.

30.

The CD3 conformational change in the γδ T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing.

Dopfer EP, Hartl FA, Oberg HH, Siegers GM, Yousefi OS, Kock S, Fiala GJ, Garcillán B, Sandstrom A, Alarcón B, Regueiro JR, Kabelitz D, Adams EJ, Minguet S, Wesch D, Fisch P, Schamel WWA.

Cell Rep. 2014 Jun 12;7(5):1704-1715. doi: 10.1016/j.celrep.2014.04.049. Epub 2014 May 22.

31.

Non-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation.

Ngoenkam J, Paensuwan P, Preechanukul K, Khamsri B, Yiemwattana I, Beck-García E, Minguet S, Schamel WW, Pongcharoen S.

Cell Commun Signal. 2014 Mar 26;12:21. doi: 10.1186/1478-811X-12-21.

32.

Relevance of Nck-CD3 epsilon interaction for T cell activation in vivo.

Borroto A, Arellano I, Blanco R, Fuentes M, Orfao A, Dopfer EP, Prouza M, Suchànek M, Schamel WW, Alarcón B.

J Immunol. 2014 Mar 1;192(5):2042-53. doi: 10.4049/jimmunol.1203414. Epub 2014 Jan 27.

33.

A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency.

Pieper K, Rizzi M, Speletas M, Smulski CR, Sic H, Kraus H, Salzer U, Fiala GJ, Schamel WW, Lougaris V, Plebani A, Hammarstrom L, Recher M, Germenis AE, Grimbacher B, Warnatz K, Rolink AG, Schneider P, Notarangelo LD, Eibel H.

J Allergy Clin Immunol. 2014 Apr;133(4):1222-5. doi: 10.1016/j.jaci.2013.11.021. Epub 2014 Jan 7. No abstract available. Erratum in: J Allergy Clin Immunol. 2014 Aug;134(2):495.

PMID:
24406071
34.

Pre-clustering of the B cell antigen receptor demonstrated by mathematically extended electron microscopy.

Fiala GJ, Kaschek D, Blumenthal B, Reth M, Timmer J, Schamel WW.

Front Immunol. 2013 Dec 6;4:427. doi: 10.3389/fimmu.2013.00427. eCollection 2013.

35.

Activation of the TCR complex by small chemical compounds.

Louis-Dit-Sully C, Schamel WW.

Exp Suppl. 2014;104:25-39. doi: 10.1007/978-3-0348-0726-5_3. Review.

PMID:
24214616
36.

Activation of the TCR complex by peptide-MHC and superantigens.

Louis-Dit-Sully C, Blumenthal B, Duchniewicz M, Beck-Garcia K, Fiala GJ, Beck-García E, Mukenhirn M, Minguet S, Schamel WW.

Exp Suppl. 2014;104:9-23. doi: 10.1007/978-3-0348-0726-5_2. Review.

PMID:
24214615
37.

Visualization of TCR nanoclusters via immunogold labeling, freeze-etching, and surface replication.

Fiala GJ, Rejas MT, Schamel WW, van Santen HM.

Methods Cell Biol. 2013;117:391-410. doi: 10.1016/B978-0-12-408143-7.00021-9.

PMID:
24143989
38.

Analysis of interactions between proteins and fatty acids or cholesterol using a fatty acid/cholesterol pull-down assay.

Beck-García E, Beck-García K, Schlosser A, Schamel WW.

Anal Biochem. 2013 May 15;436(2):75-7. doi: 10.1016/j.ab.2013.01.026. Epub 2013 Jan 31.

PMID:
23376572
39.

Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells.

Deswal S, Meyer A, Fiala GJ, Eisenhardt AE, Schmitt LC, Salek M, Brummer T, Acuto O, Schamel WW.

J Immunol. 2013 Mar 1;190(5):1927-35. doi: 10.4049/jimmunol.1200653. Epub 2013 Jan 28.

40.

Organization of the resting TCR in nanoscale oligomers.

Schamel WW, Alarcón B.

Immunol Rev. 2013 Jan;251(1):13-20. doi: 10.1111/imr.12019. Review.

PMID:
23278737
41.

Semi-automatic determination of cell surface areas used in systems biology.

Morath V, Keuper M, Rodriguez-Franco M, Deswal S, Fiala G, Blumenthal B, Kaschek D, Timmer J, Neuhaus G, Ehl S, Ronneberger O, Schamel WW.

Front Biosci (Elite Ed). 2013 Jan 1;5:533-45.

PMID:
23277009
42.

Nck recruitment to the TCR required for ZAP70 activation during thymic development.

Borroto A, Arellano I, Dopfer EP, Prouza M, Suchànek M, Fuentes M, Orfao A, Schamel WW, Alarcón B.

J Immunol. 2013 Feb 1;190(3):1103-12. doi: 10.4049/jimmunol.1202055. Epub 2012 Dec 24.

43.

Antitumor activities of PSMA×CD3 diabodies by redirected T-cell lysis of prostate cancer cells.

Baum V, Bühler P, Gierschner D, Herchenbach D, Fiala GJ, Schamel WW, Wolf P, Elsässer-Beile U.

Immunotherapy. 2013 Jan;5(1):27-38. doi: 10.2217/imt.12.136. Erratum in: Immunotherapy. 2014 Mar;6(3):362.

PMID:
23256796
44.

γδ T-cell conference 2012: close encounters for the fifth time.

Silva-Santos B, Schamel WW, Fisch P, Eberl M.

Eur J Immunol. 2012 Dec;42(12):3101-5. doi: 10.1002/eji.201270101. Erratum in: Eur J Immunol. 2013 Feb;43(2):562.

45.

Cholesterol and sphingomyelin drive ligand-independent T-cell antigen receptor nanoclustering.

Molnár E, Swamy M, Holzer M, Beck-García K, Worch R, Thiele C, Guigas G, Boye K, Luescher IF, Schwille P, Schubert R, Schamel WW.

J Biol Chem. 2012 Dec 14;287(51):42664-74. doi: 10.1074/jbc.M112.386045. Epub 2012 Oct 22.

46.

Meeting report: Signal transduction meets systems biology.

Louis-Dit-Sully C, Kubatzky KF, Lindquist JA, Blattner C, Janssen O, Schamel WW.

Cell Commun Signal. 2012 Apr 30;10(1):11. doi: 10.1186/1478-811X-10-11.

47.

Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling.

Röring M, Herr R, Fiala GJ, Heilmann K, Braun S, Eisenhardt AE, Halbach S, Capper D, von Deimling A, Schamel WW, Saunders DN, Brummer T.

EMBO J. 2012 May 30;31(11):2629-47. doi: 10.1038/emboj.2012.100. Epub 2012 Apr 17.

48.

Synthetic immune signaling.

Schamel WW, Reth M.

Curr Opin Biotechnol. 2012 Oct;23(5):780-4. doi: 10.1016/j.copbio.2012.01.010. Epub 2012 Feb 10. Review.

PMID:
22326912
49.

Antiviral and regulatory T cell immunity in a patient with stromal interaction molecule 1 deficiency.

Fuchs S, Rensing-Ehl A, Speckmann C, Bengsch B, Schmitt-Graeff A, Bondzio I, Maul-Pavicic A, Bass T, Vraetz T, Strahm B, Ankermann T, Benson M, Caliebe A, Fölster-Holst R, Kaiser P, Thimme R, Schamel WW, Schwarz K, Feske S, Ehl S.

J Immunol. 2012 Feb 1;188(3):1523-33. doi: 10.4049/jimmunol.1102507. Epub 2011 Dec 21.

50.

A leaky mutation in CD3D differentially affects αβ and γδ T cells and leads to a Tαβ-Tγδ+B+NK+ human SCID.

Gil J, Busto EM, Garcillán B, Chean C, García-Rodríguez MC, Díaz-Alderete A, Navarro J, Reiné J, Mencía A, Gurbindo D, Beléndez C, Gordillo I, Duchniewicz M, Höhne K, García-Sánchez F, Fernández-Cruz E, López-Granados E, Schamel WW, Moreno-Pelayo MA, Recio MJ, Regueiro JR.

J Clin Invest. 2011 Oct;121(10):3872-6. doi: 10.1172/JCI44254. Epub 2011 Sep 19.

Supplemental Content

Loading ...
Support Center