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The Nε-(carboxymethyl)lysine-RAGE axis: putative implications for the pathogenesis of obesity-related complications.

Gaens KH, Stehouwer CD, Schalkwijk CG.

Expert Rev Endocrinol Metab. 2010 Nov;5(6):839-854. doi: 10.1586/eem.10.68.


Contribution of liver fat to weight loss-induced changes in serum hepatokines: a randomized-controlled trial.

Telgenkamp I, Kusters YHAM, Schalkwijk CG, Houben AJHM, Kooi ME, Lindeboom L, Bons JAP, Schaper NC, Joris PJ, Plat J, Mensink RP, Stehouwer CDA, Brouwers MCGJ.

J Clin Endocrinol Metab. 2019 Feb 11. doi: 10.1210/jc.2018-02378. [Epub ahead of print]


Adipose tissue macrophages do not affect atherosclerosis development in mice.

Bijnen M, van de Gaar J, Vroomen M, Gijbels MJ, de Winther M, Schalkwijk CG, Wouters K.

Atherosclerosis. 2018 Dec 19;281:31-37. doi: 10.1016/j.atherosclerosis.2018.12.010. [Epub ahead of print]


The Effect of Sulforaphane on Glyoxalase I Expression and Activity in Peripheral Blood Mononuclear Cells.

Alfarano M, Pastore D, Fogliano V, Schalkwijk CG, Oliviero T.

Nutrients. 2018 Nov 15;10(11). pii: E1773. doi: 10.3390/nu10111773.


Quercetin, but Not Epicatechin, Decreases Plasma Concentrations of Methylglyoxal in Adults in a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial with Pure Flavonoids.

Van den Eynde MDG, Geleijnse JM, Scheijen JLJM, Hanssen NMJ, Dower JI, Afman LA, Stehouwer CDA, Hollman PCH, Schalkwijk CG.

J Nutr. 2018 Dec 1;148(12):1911-1916. doi: 10.1093/jn/nxy236.


Association of common gene variants in glucokinase regulatory protein with cardiorenal disease: A systematic review and meta-analysis.

Simons PIHG, Simons N, Stehouwer CDA, Schalkwijk CG, Schaper NC, Brouwers MCGJ.

PLoS One. 2018 Oct 23;13(10):e0206174. doi: 10.1371/journal.pone.0206174. eCollection 2018.


RAGE deficiency does not affect non-alcoholic steatohepatitis and atherosclerosis in Western type diet-fed Ldlr-/- mice.

Bijnen M, Beelen N, Wetzels S, Gaar JV, Vroomen M, Wijnands E, Scheijen JL, van de Waarenburg MPH, Gijbels MJ, Cleutjens JP, Biessen EAL, Stehouwer CDA, Schalkwijk CG, Wouters K.

Sci Rep. 2018 Oct 15;8(1):15256. doi: 10.1038/s41598-018-33661-y.


Methylglyoxal stress, the glyoxalase system, and diabetic chronic kidney disease.

Hanssen NMJ, Stehouwer CDA, Schalkwijk CG.

Curr Opin Nephrol Hypertens. 2019 Jan;28(1):26-33. doi: 10.1097/MNH.0000000000000465.


Complement C3 and C4, but not their regulators or activated products, are associated with incident metabolic syndrome: the CODAM study.

Xin Y, Hertle E, van der Kallen CJH, Schalkwijk CG, Stehouwer CDA, van Greevenbroek MMJ.

Endocrine. 2018 Dec;62(3):617-627. doi: 10.1007/s12020-018-1712-3. Epub 2018 Aug 21.


Blood Metabolomic Measures Associate With Present and Future Glycemic Control in Type 2 Diabetes.

't Hart LM, Vogelzangs N, Mook-Kanamori DO, Brahimaj A, Nano J, van der Heijden AAWA, Willems van Dijk K, Slieker RC, Steyerberg EW, Ikram MA, Beekman M, Boomsma DI, van Duijn CM, Slagboom PE, Stehouwer CDA, Schalkwijk CG, Arts ICW, Dekker JM, Dehghan A, Muka T, van der Kallen CJH, Nijpels G, van Greevenbroek MMJ.

J Clin Endocrinol Metab. 2018 Dec 1;103(12):4569-4579. doi: 10.1210/jc.2018-01165.


Reducing sitting time versus adding exercise: differential effects on biomarkers of endothelial dysfunction and metabolic risk.

Duvivier BMFM, Bolijn JE, Koster A, Schalkwijk CG, Savelberg HHCM, Schaper NC.

Sci Rep. 2018 Jun 5;8(1):8657. doi: 10.1038/s41598-018-26616-w.


Higher Plasma Methylglyoxal Levels Are Associated With Incident Cardiovascular Disease and Mortality in Individuals With Type 2 Diabetes.

Hanssen NMJ, Westerink J, Scheijen JLJM, van der Graaf Y, Stehouwer CDA, Schalkwijk CG; SMART Study Group.

Diabetes Care. 2018 Aug;41(8):1689-1695. doi: 10.2337/dc18-0159. Epub 2018 May 21.


HDL cholesterol efflux capacity and cholesteryl ester transfer are associated with body mass, but are not changed by diet-induced weight loss: A randomized trial in abdominally obese men.

Talbot CPJ, Plat J, Joris PJ, Konings M, Kusters YHAM, Schalkwijk CG, Ritsch A, Mensink RP.

Atherosclerosis. 2018 Jul;274:23-28. doi: 10.1016/j.atherosclerosis.2018.04.029. Epub 2018 Apr 28.


Advanced Glycation Endproducts Are Increased in the Animal Model of Multiple Sclerosis but Cannot Be Reduced by Pyridoxamine Treatment or Glyoxalase 1 Overexpression.

Wetzels S, Wouters K, Miyata T, Scheijen JLJM, Hendriks JJA, Schalkwijk CG, Vanmierlo T.

Int J Mol Sci. 2018 Apr 27;19(5). pii: E1311. doi: 10.3390/ijms19051311.


Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry.

Wetzels S, Bijnen M, Wijnands E, Biessen EAL, Schalkwijk CG, Wouters K.

J Vis Exp. 2018 Mar 6;(133). doi: 10.3791/57319.


Bone markers and cardiovascular risk in type 2 diabetes patients.

Zwakenberg SR, van der Schouw YT, Schalkwijk CG, Spijkerman AMW, Beulens JWJ.

Cardiovasc Diabetol. 2018 Mar 23;17(1):45. doi: 10.1186/s12933-018-0691-2.


Classical Pathway of Complement Activation: Longitudinal Associations of C1q and C1-INH With Cardiovascular Outcomes: The CODAM Study (Cohort on Diabetes and Atherosclerosis Maastricht)-Brief Report.

Hertle E, Arts ICW, van der Kallen CJH, Feskens EJM, Schalkwijk CG, Stehouwer CDA, van Greevenbroek MMJ.

Arterioscler Thromb Vasc Biol. 2018 May;38(5):1242-1244. doi: 10.1161/ATVBAHA.118.310806. Epub 2018 Mar 22.


Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans.

Verboven K, Wouters K, Gaens K, Hansen D, Bijnen M, Wetzels S, Stehouwer CD, Goossens GH, Schalkwijk CG, Blaak EE, Jocken JW.

Sci Rep. 2018 Mar 16;8(1):4677. doi: 10.1038/s41598-018-22962-x.


Weight loss moderately affects the mixed meal challenge response of the plasma metabolome and transcriptome of peripheral blood mononuclear cells in abdominally obese subjects.

Fazelzadeh P, Hangelbroek RWJ, Joris PJ, Schalkwijk CG, Esser D, Afman L, Hankemeier T, Jacobs DM, Mihaleva VV, Kersten S, van Duynhoven J, Boekschoten MV.

Metabolomics. 2018;14(4):46. doi: 10.1007/s11306-018-1328-x. Epub 2018 Mar 5.


Prospective associations of dietary carbohydrate, fat, and protein intake with β-cell function in the CODAM study.

den Biggelaar LJCJ, Eussen SJPM, Sep SJS, Mari A, Ferrannini E, van Greevenbroek MM, van der Kallen CJ, Schalkwijk CG, Arts ICW, Stehouwer CDA, Dagnelie PC.

Eur J Nutr. 2018 Mar 10. doi: 10.1007/s00394-018-1644-y. [Epub ahead of print]


Associations between advanced glycation endproducts and matrix metalloproteinases and its inhibitor in individuals with type 1 diabetes.

Peeters SA, Engelen L, Buijs J, Theilade S, Rossing P, Schalkwijk CG, Stehouwer CDA.

J Diabetes Complications. 2018 Mar;32(3):325-329. doi: 10.1016/j.jdiacomp.2017.12.011. Epub 2018 Jan 3.


Circulating Polyunsaturated Fatty Acids as Biomarkers for Dietary Intake across Subgroups: The CODAM and Hoorn Studies.

Wanders AJ, Alssema M, De Hoon SEM, Feskens EJM, van Woudenbergh GJ, van der Kallen CJ, Zock PL, Refsum H, Drevon CA, Elshorbagy A, Schalkwijk CG, Stehouwer CDA, Dekker JM, van Greevenbroek MMJ.

Ann Nutr Metab. 2018;72(2):117-125. doi: 10.1159/000486244. Epub 2018 Jan 25.


Dietary intake of advanced glycation endproducts is associated with higher levels of advanced glycation endproducts in plasma and urine: The CODAM study.

Scheijen JLJM, Hanssen NMJ, van Greevenbroek MM, Van der Kallen CJ, Feskens EJM, Stehouwer CDA, Schalkwijk CG.

Clin Nutr. 2018 Jun;37(3):919-925. doi: 10.1016/j.clnu.2017.03.019. Epub 2017 Mar 23.


Aldosterone Is Not Associated With Metabolic and Microvascular Insulin Sensitivity in Abdominally Obese Men.

Schütten MTJ, Kusters YHAM, Houben AJHM, Scheijen JLJM, van de Waarenburg MPH, Schalkwijk CG, Joris PJ, Plat J, Mensink RP, de Leeuw PW, Stehouwer CDA.

J Clin Endocrinol Metab. 2018 Feb 1;103(2):759-767. doi: 10.1210/jc.2017-01541.


Longitudinal associations of the alternative and terminal pathways of complement activation with adiposity: The CODAM study.

Xin Y, Hertle E, van der Kallen CJH, Schalkwijk CG, Stehouwer CDA, van Greevenbroek MMJ.

Obes Res Clin Pract. 2018 May - Jun;12(3):286-292. doi: 10.1016/j.orcp.2017.11.002. Epub 2017 Nov 22.


The effect of Mindfulness-Based Stress Reduction on wound healing: a preliminary study.

Meesters A, den Bosch-Meevissen YMCI, Weijzen CAH, Buurman WA, Losen M, Schepers J, Thissen MRTM, Alberts HJEM, Schalkwijk CG, Peters ML.

J Behav Med. 2018 Jun;41(3):385-397. doi: 10.1007/s10865-017-9901-8. Epub 2017 Nov 20.


Inflammatory and Angiogenic Factors Linked to Longitudinal Microvascular Changes in Hemodialysis Patients Irrespective of Treatment Dose Intensity.

Mitsides N, Cornelis T, Broers NJH, Diederen NMP, Brenchley P, Heitink-Ter Braak N, van der Sande FM, Schalkwijk CG, Kooman JP, Mitra S.

Kidney Blood Press Res. 2017;42(5):905-918. doi: 10.1159/000485048. Epub 2017 Nov 16.


Biomarkers of inflammation and endothelial dysfunction as predictors of pulse pressure and incident hypertension in type 1 diabetes: a 20 year life-course study in an inception cohort.

Ferreira I, Hovind P, Schalkwijk CG, Parving HH, Stehouwer CDA, Rossing P.

Diabetologia. 2018 Jan;61(1):231-241. doi: 10.1007/s00125-017-4470-5. Epub 2017 Nov 3.


Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice.

Bijnen M, Josefs T, Cuijpers I, Maalsen CJ, van de Gaar J, Vroomen M, Wijnands E, Rensen SS, Greve JWM, Hofker MH, Biessen EAL, Stehouwer CDA, Schalkwijk CG, Wouters K.

Gut. 2018 Jul;67(7):1317-1327. doi: 10.1136/gutjnl-2016-313654. Epub 2017 Oct 26.


Circulating matrix metalloproteinases are associated with arterial stiffness in patients with type 1 diabetes: pooled analysis of three cohort studies.

Peeters SA, Engelen L, Buijs J, Chaturvedi N, Fuller JH, Jorsal A, Parving HH, Tarnow L, Theilade S, Rossing P, Schalkwijk CG, Stehouwer CDA.

Cardiovasc Diabetol. 2017 Oct 25;16(1):139. doi: 10.1186/s12933-017-0620-9.


The tumour suppressor CDKN2A/p16INK4a regulates adipogenesis and bone marrow-dependent development of perivascular adipose tissue.

Wouters K, Deleye Y, Hannou SA, Vanhoutte J, Maréchal X, Coisne A, Tagzirt M, Derudas B, Bouchaert E, Duhem C, Vallez E, Schalkwijk CG, Pattou F, Montaigne D, Staels B, Paumelle R.

Diab Vasc Dis Res. 2017 Nov;14(6):516-524. doi: 10.1177/1479164117728012. Epub 2017 Sep 2.


The Role of Hyperglycemia, Insulin Resistance, and Blood Pressure in Diabetes-Associated Differences in Cognitive Performance-The Maastricht Study.

Geijselaers SLC, Sep SJS, Claessens D, Schram MT, van Boxtel MPJ, Henry RMA, Verhey FRJ, Kroon AA, Dagnelie PC, Schalkwijk CG, van der Kallen CJH, Biessels GJ, Stehouwer CDA.

Diabetes Care. 2017 Nov;40(11):1537-1547. doi: 10.2337/dc17-0330. Epub 2017 Aug 25.


Extracellular overhydration linked with endothelial dysfunction in the context of inflammation in haemodialysis dependent chronic kidney disease.

Mitsides N, Cornelis T, Broers NJH, Diederen NMP, Brenchley P, van der Sande FM, Schalkwijk CG, Kooman JP, Mitra S.

PLoS One. 2017 Aug 22;12(8):e0183281. doi: 10.1371/journal.pone.0183281. eCollection 2017.


Inflammation and premature aging in advanced chronic kidney disease.

Kooman JP, Dekker MJ, Usvyat LA, Kotanko P, van der Sande FM, Schalkwijk CG, Shiels PG, Stenvinkel P.

Am J Physiol Renal Physiol. 2017 Oct 1;313(4):F938-F950. doi: 10.1152/ajprenal.00256.2017. Epub 2017 Jul 12. Review.


Independent tissue contributors to obesity-associated insulin resistance.

Kusters YH, Schalkwijk CG, Houben AJ, Kooi ME, Lindeboom L, Op 't Roodt J, Joris PJ, Plat J, Mensink RP, Barrett EJ, Stehouwer CD.

JCI Insight. 2017 Jul 6;2(13). pii: 89695. doi: 10.1172/jci.insight.89695. [Epub ahead of print]


Hyperglycemia Is the Main Mediator of Prediabetes- and Type 2 Diabetes-Associated Impairment of Microvascular Function: The Maastricht Study.

Sörensen BM, Houben AJHM, Berendschot TTJM, Schouten JSAG, Kroon AA, van der Kallen CJH, Henry RMA, Koster A, Reesink KD, Dagnelie PC, Schaper NC, Schalkwijk CG, Schram MT, Stehouwer CDA.

Diabetes Care. 2017 Aug;40(8):e103-e105. doi: 10.2337/dc17-0574. Epub 2017 Jun 16. No abstract available.


Effect of a plant sterol-enriched spread on biomarkers of endothelial dysfunction and low-grade inflammation in hypercholesterolaemic subjects.

Ras RT, Fuchs D, Koppenol WP, Schalkwijk CG, Otten-Hofman A, Garczarek U, Greyling A, Wagner F, Trautwein EA.

J Nutr Sci. 2016 Dec 6;5:e44. doi: 10.1017/jns.2016.40. eCollection 2016.


Higher Plasma Methylglyoxal Levels Are Associated With Incident Cardiovascular Disease in Individuals With Type 1 Diabetes: A 12-Year Follow-up Study.

Hanssen NMJ, Scheijen JLJM, Jorsal A, Parving HH, Tarnow L, Rossing P, Stehouwer CDA, Schalkwijk CG.

Diabetes. 2017 Aug;66(8):2278-2283. doi: 10.2337/db16-1578. Epub 2017 Jun 6.


Disparity in the micronutrient content of diets high or low in advanced glycation end products (AGEs) does not explain changes in insulin sensitivity.

Pearce K, Hatzinikolas A, Moran L, de Courten MPJ, Forbes J, Scheijen JLJM, Schalkwijk CG, Walker K, de Courten B.

Int J Food Sci Nutr. 2017 Dec;68(8):1021-1026. doi: 10.1080/09637486.2017.1319468. Epub 2017 May 2.


Plasma matrix metalloproteinases are associated with incident cardiovascular disease and all-cause mortality in patients with type 1 diabetes: a 12-year follow-up study.

Peeters SA, Engelen L, Buijs J, Jorsal A, Parving HH, Tarnow L, Rossing P, Schalkwijk CG, Stehouwer CDA.

Cardiovasc Diabetol. 2017 Apr 26;16(1):55. doi: 10.1186/s12933-017-0539-1.


A comparison of dicarbonyl stress and advanced glycation endproducts in lifelong endurance athletes vs. sedentary controls.

Maessen MFH, Schalkwijk CG, Verheggen RJHM, Aengevaeren VL, Hopman MTE, Eijsvogels TMH.

J Sci Med Sport. 2017 Oct;20(10):921-926. doi: 10.1016/j.jsams.2017.03.011. Epub 2017 Mar 23.


Diverging effects of diabetes mellitus in patients with peripheral artery disease and abdominal aortic aneurysm and the role of advanced glycation end-products: ARTERY study - protocol for a multicentre cross-sectional study.

de Vos LC, Boersema J, Hillebrands JL, Schalkwijk CG, Meerwaldt R, Breek JC, Smit AJ, Zeebregts CJ, Lefrandt JD.

BMJ Open. 2017 Apr 11;7(4):e012584. doi: 10.1136/bmjopen-2016-012584.


The systolic-diastolic difference in carotid stiffness is increased in type 2 diabetes: The Maastricht Study.

Veugen MG, Henry RM, van Sloten TT, Hermeling E, Brunner-La Rocca HP, Schram MT, Dagnelie PC, Schalkwijk CG, Kroon AA, Stehouwer CD, Reesink KD.

J Hypertens. 2017 May;35(5):1052-1060. doi: 10.1097/HJH.0000000000001298.


Alcohol and red wine consumption, but not fruit, vegetables, fish or dairy products, are associated with less endothelial dysfunction and less low-grade inflammation: the Hoorn Study.

van Bussel BCT, Henry RMA, Schalkwijk CG, Dekker JM, Nijpels G, Feskens EJM, Stehouwer CDA.

Eur J Nutr. 2018 Jun;57(4):1409-1419. doi: 10.1007/s00394-017-1420-4. Epub 2017 Mar 27.


An advanced glycation endproduct (AGE)-rich diet promotes accumulation of AGEs in Achilles tendon.

Skovgaard D, Svensson RB, Scheijen J, Eliasson P, Mogensen P, Hag AM, Kjær M, Schalkwijk CG, Schjerling P, Magnusson SP, Couppé C.

Physiol Rep. 2017 Mar;5(6). pii: e13215. doi: 10.14814/phy2.13215.


Vitreous advanced glycation endproducts and α-dicarbonyls in retinal detachment patients with type 2 diabetes mellitus and non-diabetic controls.

Fokkens BT, Mulder DJ, Schalkwijk CG, Scheijen JL, Smit AJ, Los LI.

PLoS One. 2017 Mar 6;12(3):e0173379. doi: 10.1371/journal.pone.0173379. eCollection 2017.


Methylglyoxal-Derived Advanced Glycation Endproducts in Multiple Sclerosis.

Wetzels S, Wouters K, Schalkwijk CG, Vanmierlo T, Hendriks JJ.

Int J Mol Sci. 2017 Feb 15;18(2). pii: E421. doi: 10.3390/ijms18020421. Review.


Circulating classical monocytes are associated with CD11c+ macrophages in human visceral adipose tissue.

Wouters K, Gaens K, Bijnen M, Verboven K, Jocken J, Wetzels S, Wijnands E, Hansen D, van Greevenbroek M, Duijvestijn A, Biessen EA, Blaak EE, Stehouwer CD, Schalkwijk CG.

Sci Rep. 2017 Feb 15;7:42665. doi: 10.1038/srep42665.


Increased Dicarbonyl Stress as a Novel Mechanism of Multi-Organ Failure in Critical Illness.

van Bussel BC, van de Poll MC, Schalkwijk CG, Bergmans DC.

Int J Mol Sci. 2017 Feb 7;18(2). pii: E346. doi: 10.3390/ijms18020346. Review.


BclI Glucocorticoid Receptor Polymorphism in Relation to Arterial Stiffening and Cardiac Structure and Function: The Hoorn and CODAM Studies.

van Moorsel D, Henry RM, Schaper NC, van Greevenbroek MM, van Rossum EF, 't Hart LM, Schalkwijk CG, van der Kallen CJ, Dekker JM, Stehouwer CD, Havekes B.

Am J Hypertens. 2017 Mar 1;30(3):286-294. doi: 10.1093/ajh/hpw196.


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