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Items: 40


Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits.

Toch M, Harris A, Schakman O, Kondratskaya E, Boulland JL, Dauguet N, Debrulle S, Baudouin C, Hidalgo-Figueroa M, Gow A, Glover JC, Tissir F, Clotman F.

Sci Rep. 2020 Jan 22;10(1):996. doi: 10.1038/s41598-020-57945-4.


Sex-regulated gene dosage effect of PPARα on synaptic plasticity.

Pierrot N, Ris L, Stancu IC, Doshina A, Ribeiro F, Tyteca D, Baugé E, Lalloyer F, Malong L, Schakman O, Leroy K, Kienlen-Campard P, Gailly P, Brion JP, Dewachter I, Staels B, Octave JN.

Life Sci Alliance. 2019 Mar 20;2(2). pii: e201800262. doi: 10.26508/lsa.201800262. Print 2019 Apr.


Genetic deletion of soluble 5'-nucleotidase II reduces body weight gain and insulin resistance induced by a high-fat diet.

Johanns M, Kviklyte S, Chuang SJ, Corbeels K, Jacobs R, Herinckx G, Vertommen D, Schakman O, Duparc T, Cani PD, Bouzin C, Andersén H, Bohlooly-Y M, Van der Schueren B, Oscarsson J, Rider MH.

Mol Genet Metab. 2019 Apr;126(4):377-387. doi: 10.1016/j.ymgme.2019.01.017. Epub 2019 Feb 14.


Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory.

Lepannetier S, Gualdani R, Tempesta S, Schakman O, Seghers F, Kreis A, Yerna X, Slimi A, de Clippele M, Tajeddine N, Voets T, Bon RS, Beech DJ, Tissir F, Gailly P.

Front Cell Neurosci. 2018 Sep 14;12:318. doi: 10.3389/fncel.2018.00318. eCollection 2018.


Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects.

Corbet C, Bastien E, Draoui N, Doix B, Mignion L, Jordan BF, Marchand A, Vanherck JC, Chaltin P, Schakman O, Becker HM, Riant O, Feron O.

Nat Commun. 2018 Mar 23;9(1):1208. doi: 10.1038/s41467-018-03525-0.


Neural progenitor fate decision defects, cortical hypoplasia and behavioral impairment in Celsr1-deficient mice.

Boucherie C, Boutin C, Jossin Y, Schakman O, Goffinet AM, Ris L, Gailly P, Tissir F.

Mol Psychiatry. 2018 Mar;23(3):723-734. doi: 10.1038/mp.2017.236. Epub 2017 Dec 19.


Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord.

Francius C, Hidalgo-Figueroa M, Debrulle S, Pelosi B, Rucchin V, Ronellenfitch K, Panayiotou E, Makrides N, Misra K, Harris A, Hassani H, Schakman O, Parras C, Xiang M, Malas S, Chow RL, Clotman F.

Front Mol Neurosci. 2016 Dec 26;9:145. doi: 10.3389/fnmol.2016.00145. eCollection 2016.


Defective adaptive thermogenesis contributes to metabolic syndrome and liver steatosis in obese mice.

Poekes L, Legry V, Schakman O, Detrembleur C, Bol A, Horsmans Y, Farrell GC, Leclercq IA.

Clin Sci (Lond). 2017 Feb 1;131(4):285-296. doi: 10.1042/CS20160469. Epub 2016 Nov 1.


TRPV4 is associated with central rather than nephrogenic osmoregulation.

Janas S, Seghers F, Schakman O, Alsady M, Deen P, Vriens J, Tissir F, Nilius B, Loffing J, Gailly P, Devuyst O.

Pflugers Arch. 2016 Sep;468(9):1595-607. doi: 10.1007/s00424-016-1850-5. Epub 2016 Jun 30.


Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease.

Couturier J, Stancu IC, Schakman O, Pierrot N, Huaux F, Kienlen-Campard P, Dewachter I, Octave JN.

J Neuroinflammation. 2016 Jan 27;13:20. doi: 10.1186/s12974-016-0477-y.


Involvement of adiponectin in the pathogenesis of dystrophinopathy.

Abou-Samra M, Lecompte S, Schakman O, Noel L, Many MC, Gailly P, Brichard SM.

Skelet Muscle. 2015 Aug 7;5:25. doi: 10.1186/s13395-015-0051-9. eCollection 2015.


Early ALS-type gait abnormalities in AMP-dependent protein kinase-deficient mice suggest a role for this metabolic sensor in early stages of the disease.

Vergouts M, Marinangeli C, Ingelbrecht C, Genard G, Schakman O, Sternotte A, Calas AG, Hermans E.

Metab Brain Dis. 2015 Dec;30(6):1369-77. doi: 10.1007/s11011-015-9706-9. Epub 2015 Jul 9.


Osmosensation in TRPV2 dominant negative expressing skeletal muscle fibres.

Zanou N, Mondin L, Fuster C, Seghers F, Dufour I, de Clippele M, Schakman O, Tajeddine N, Iwata Y, Wakabayashi S, Voets T, Allard B, Gailly P.

J Physiol. 2015 Sep 1;593(17):3849-63. doi: 10.1113/JP270522. Epub 2015 Aug 10.


A mouse model of L-2-hydroxyglutaric aciduria, a disorder of metabolite repair.

Rzem R, Achouri Y, Marbaix E, Schakman O, Wiame E, Marie S, Gailly P, Vincent MF, Veiga-da-Cunha M, Van Schaftingen E.

PLoS One. 2015 Mar 12;10(3):e0119540. doi: 10.1371/journal.pone.0119540. eCollection 2015.


Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of Alzheimer disease.

Hendrickx A, Pierrot N, Tasiaux B, Schakman O, Kienlen-Campard P, De Smet C, Octave JN.

PLoS One. 2014 Jun 11;9(6):e99467. doi: 10.1371/journal.pone.0099467. eCollection 2014.


Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease.

Stancu IC, Ris L, Vasconcelos B, Marinangeli C, Goeminne L, Laporte V, Haylani LE, Couturier J, Schakman O, Gailly P, Pierrot N, Kienlen-Campard P, Octave JN, Dewachter I.

FASEB J. 2014 Jun;28(6):2620-31. doi: 10.1096/fj.13-246702. Epub 2014 Mar 6.


Myosin light chain kinase controls voltage-dependent calcium channels in vascular smooth muscle.

Martinsen A, Schakman O, Yerna X, Dessy C, Morel N.

Pflugers Arch. 2014 Jul;466(7):1377-89. doi: 10.1007/s00424-013-1380-3. Epub 2013 Oct 27.


Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty.

Hendrickx A, Pierrot N, Tasiaux B, Schakman O, Brion JP, Kienlen-Campard P, De Smet C, Octave JN.

PLoS One. 2013 Sep 16;8(9):e74305. doi: 10.1371/journal.pone.0074305. eCollection 2013.


Vascular endothelial growth factor-loaded injectable hydrogel enhances plasticity in the injured spinal cord.

des Rieux A, De Berdt P, Ansorena E, Ucakar B, Damien J, Schakman O, Audouard E, Bouzin C, Auhl D, Simón-Yarza T, Feron O, Blanco-Prieto MJ, Carmeliet P, Bailly C, Clotman F, Préat V.

J Biomed Mater Res A. 2014 Jul;102(7):2345-55. doi: 10.1002/jbm.a.34915. Epub 2013 Aug 30.


Injectable alginate hydrogel loaded with GDNF promotes functional recovery in a hemisection model of spinal cord injury.

Ansorena E, De Berdt P, Ucakar B, Simón-Yarza T, Jacobs D, Schakman O, Jankovski A, Deumens R, Blanco-Prieto MJ, Préat V, des Rieux A.

Int J Pharm. 2013 Oct 15;455(1-2):148-58. doi: 10.1016/j.ijpharm.2013.07.045. Epub 2013 Jul 31.


Glucocorticoid-induced skeletal muscle atrophy.

Schakman O, Kalista S, Barbé C, Loumaye A, Thissen JP.

Int J Biochem Cell Biol. 2013 Oct;45(10):2163-72. doi: 10.1016/j.biocel.2013.05.036. Epub 2013 Jun 24. Review.


The Onecut transcription factor HNF-6 contributes to proper reorganization of Purkinje cells during postnatal cerebellum development.

Audouard E, Schakman O, Ginion A, Bertrand L, Gailly P, Clotman F.

Mol Cell Neurosci. 2013 Sep;56:159-68. doi: 10.1016/j.mcn.2013.05.001. Epub 2013 May 10.


The Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctions.

Audouard E, Schakman O, René F, Huettl RE, Huber AB, Loeffler JP, Gailly P, Clotman F.

PLoS One. 2012;7(12):e50509. doi: 10.1371/journal.pone.0050509. Epub 2012 Dec 5.


Multiparametric functional nuclear magnetic resonance imaging shows alterations associated with plasmid electrotransfer in mouse skeletal muscle.

Baligand C, Jouvion G, Schakman O, Gilson H, Wary C, Thissen JP, Carlier PG.

J Gene Med. 2012 Sep-Oct;14(9-10):598-608. doi: 10.1002/jgm.2671.


Loss of Maged1 results in obesity, deficits of social interactions, impaired sexual behavior and severe alteration of mature oxytocin production in the hypothalamus.

Dombret C, Nguyen T, Schakman O, Michaud JL, Hardin-Pouzet H, Bertrand MJ, De Backer O.

Hum Mol Genet. 2012 Nov 1;21(21):4703-17. doi: 10.1093/hmg/dds310. Epub 2012 Aug 2.


Restoring specific lactobacilli levels decreases inflammation and muscle atrophy markers in an acute leukemia mouse model.

Bindels LB, Beck R, Schakman O, Martin JC, De Backer F, Sohet FM, Dewulf EM, Pachikian BD, Neyrinck AM, Thissen JP, Verrax J, Calderon PB, Pot B, Grangette C, Cani PD, Scott KP, Delzenne NM.

PLoS One. 2012;7(6):e37971. doi: 10.1371/journal.pone.0037971. Epub 2012 Jun 27.


Role of IGF-I and the TNFα/NF-κB pathway in the induction of muscle atrogenes by acute inflammation.

Schakman O, Dehoux M, Bouchuari S, Delaere S, Lause P, Decroly N, Shoelson SE, Thissen JP.

Am J Physiol Endocrinol Metab. 2012 Sep 15;303(6):E729-39. doi: 10.1152/ajpendo.00060.2012. Epub 2012 Jun 26.


Hexafluorobenzene in comparison with perfluoro-15-crown-5-ether for repeated monitoring of oxygenation using 19F MRI in a mouse model.

Mignion L, Magat J, Schakman O, Marbaix E, Gallez B, Jordan BF.

Magn Reson Med. 2013 Jan;69(1):248-54. doi: 10.1002/mrm.24245. Epub 2012 Mar 22.


Trpc1 ion channel modulates phosphatidylinositol 3-kinase/Akt pathway during myoblast differentiation and muscle regeneration.

Zanou N, Schakman O, Louis P, Ruegg UT, Dietrich A, Birnbaumer L, Gailly P.

J Biol Chem. 2012 Apr 27;287(18):14524-34. doi: 10.1074/jbc.M112.341784. Epub 2012 Mar 6.


The type 1 insulin-like growth factor receptor (IGF-IR) pathway is mandatory for the follistatin-induced skeletal muscle hypertrophy.

Kalista S, Schakman O, Gilson H, Lause P, Demeulder B, Bertrand L, Pende M, Thissen JP.

Endocrinology. 2012 Jan;153(1):241-53. doi: 10.1210/en.2011-1687. Epub 2011 Nov 15.


Functional assessment of skeletal muscle in intact mice lacking myostatin by concurrent NMR imaging and spectroscopy.

Baligand C, Gilson H, Ménard JC, Schakman O, Wary C, Thissen JP, Carlier PG.

Gene Ther. 2010 Mar;17(3):328-37. doi: 10.1038/gt.2009.141. Epub 2009 Dec 10.


Mechanisms of muscle atrophy induced by glucocorticoids.

Schakman O, Gilson H, Kalista S, Thissen JP.

Horm Res. 2009 Nov;72 Suppl 1:36-41. doi: 10.1159/000229762. Epub 2009 Nov 27. Review.


Role of TRPC1 channel in skeletal muscle function.

Zanou N, Shapovalov G, Louis M, Tajeddine N, Gallo C, Van Schoor M, Anguish I, Cao ML, Schakman O, Dietrich A, Lebacq J, Ruegg U, Roulet E, Birnbaumer L, Gailly P.

Am J Physiol Cell Physiol. 2010 Jan;298(1):C149-62. doi: 10.1152/ajpcell.00241.2009. Epub 2009 Oct 21.


Essential role of TRPV2 ion channel in the sensitivity of dystrophic muscle to eccentric contractions.

Zanou N, Iwata Y, Schakman O, Lebacq J, Wakabayashi S, Gailly P.

FEBS Lett. 2009 Nov 19;583(22):3600-4. doi: 10.1016/j.febslet.2009.10.033. Epub 2009 Oct 17.


Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin.

Gilson H, Schakman O, Kalista S, Lause P, Tsuchida K, Thissen JP.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E157-64. doi: 10.1152/ajpendo.00193.2009. Epub 2009 May 12.


Role of Akt/GSK-3beta/beta-catenin transduction pathway in the muscle anti-atrophy action of insulin-like growth factor-I in glucocorticoid-treated rats.

Schakman O, Kalista S, Bertrand L, Lause P, Verniers J, Ketelslegers JM, Thissen JP.

Endocrinology. 2008 Aug;149(8):3900-8. doi: 10.1210/en.2008-0439. Epub 2008 May 8.


Mechanisms of glucocorticoid-induced myopathy.

Schakman O, Gilson H, Thissen JP.

J Endocrinol. 2008 Apr;197(1):1-10. doi: 10.1677/JOE-07-0606. Review.


Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy.

Gilson H, Schakman O, Combaret L, Lause P, Grobet L, Attaix D, Ketelslegers JM, Thissen JP.

Endocrinology. 2007 Jan;148(1):452-60. Epub 2006 Oct 12.


Gene therapy with anabolic growth factors to prevent muscle atrophy.

Schakman O, Thissen JP.

Curr Opin Clin Nutr Metab Care. 2006 May;9(3):207-13. Review.


Insulin-like growth factor-I gene transfer by electroporation prevents skeletal muscle atrophy in glucocorticoid-treated rats.

Schakman O, Gilson H, de Coninck V, Lause P, Verniers J, Havaux X, Ketelslegers JM, Thissen JP.

Endocrinology. 2005 Apr;146(4):1789-97. Epub 2005 Jan 20.


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