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Items: 1 to 50 of 106

1.

A Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling.

Denis D, Rouleau C, Schaffhausen BS.

J Virol. 2017 Jan 3;91(2). pii: e01774-16. doi: 10.1128/JVI.01774-16. Print 2017 Jan 15.

2.

Transformation by Polyomavirus Middle T Antigen Involves a Unique Bimodal Interaction with the Hippo Effector YAP.

Rouleau C, Pores Fernando AT, Hwang JH, Faure N, Jiang T, White EA, Roberts TM, Schaffhausen BS.

J Virol. 2016 Jul 27;90(16):7032-7045. doi: 10.1128/JVI.00417-16. Print 2016 Aug 15.

3.

Correction for Hwang et al., Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation.

Hwang JH, Pores Fernando AT, Faure N, Andrabi S, Adelmant G, Hahn WC, Marto JA, Schaffhausen BS, Roberts TM.

J Virol. 2015 Jul;89(13):6971. doi: 10.1128/JVI.00952-15. No abstract available.

4.

Papillomavirus E7 oncoproteins share functions with polyomavirus small T antigens.

White EA, Kramer RE, Hwang JH, Pores Fernando AT, Naetar N, Hahn WC, Roberts TM, Schaffhausen BS, Livingston DM, Howley PM.

J Virol. 2015 Mar;89(5):2857-65. doi: 10.1128/JVI.03282-14. Epub 2014 Dec 24.

5.

Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation.

Hwang JH, Pores Fernando AT, Faure N, Andrabi S, Adelmant G, Hahn WC, Marto JA, Schaffhausen BS, Roberts TM.

J Virol. 2014 Oct;88(20):12055-64. doi: 10.1128/JVI.01399-14. Epub 2014 Aug 13. Erratum in: J Virol. 2015 Jul;89(13):6971. Adelmant, Guillaume and Marto, Jarrod A [Added].

6.

Polyoma small T antigen triggers cell death via mitotic catastrophe.

Pores Fernando AT, Andrabi S, Cizmecioglu O, Zhu C, Livingston DM, Higgins JM, Schaffhausen BS, Roberts TM.

Oncogene. 2015 May 7;34(19):2483-92. doi: 10.1038/onc.2014.192. Epub 2014 Jul 7.

7.

The phosphatidylinositol 3-kinase (PI3K) isoform dependence of tumor formation is determined by the genetic mode of PI3K pathway activation rather than by tissue type.

Utermark T, Schmit F, Lee SH, Gao X, Schaffhausen BS, Roberts TM.

J Virol. 2014 Sep;88(18):10673-9. doi: 10.1128/JVI.01409-14. Epub 2014 Jul 2.

8.

Viral interference with DNA repair by targeting of the single-stranded DNA binding protein RPA.

Banerjee P, DeJesus R, Gjoerup O, Schaffhausen BS.

PLoS Pathog. 2013 Oct;9(10):e1003725. doi: 10.1371/journal.ppat.1003725. Epub 2013 Oct 24.

9.

Polyomavirus large T antigen binds symmetrical repeats at the viral origin in an asymmetrical manner.

Harrison C, Jiang T, Banerjee P, Meinke G, D'Abramo CM, Schaffhausen B, Bohm A.

J Virol. 2013 Dec;87(24):13751-9. doi: 10.1128/JVI.01740-13. Epub 2013 Oct 9.

10.

Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt protein.

Hwang JH, Jiang T, Kulkarni S, Faure N, Schaffhausen BS.

J Biol Chem. 2013 Nov 1;288(44):32064-73. doi: 10.1074/jbc.M113.497644. Epub 2013 Sep 19.

11.

Inhibition of cell migration by PITENINs: the role of ARF6.

Miao B, Skidan I, Yang J, You Z, Fu X, Famulok M, Schaffhausen B, Torchilin V, Yuan J, Degterev A.

Oncogene. 2012 Sep 27;31(39):4317-32. doi: 10.1038/onc.2011.593. Epub 2011 Dec 19.

12.

Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function.

Andrabi S, Hwang JH, Choe JK, Roberts TM, Schaffhausen BS.

J Virol. 2011 Oct;85(20):10649-58. doi: 10.1128/JVI.05034-11. Epub 2011 Aug 10.

13.

Transgenic expression of polyomavirus middle T antigen in the mouse prostate gives rise to carcinoma.

Lee SH, Jia S, Zhu Y, Utermark T, Signoretti S, Loda M, Schaffhausen B, Roberts TM.

J Virol. 2011 Jun;85(11):5581-92. doi: 10.1128/JVI.02609-10. Epub 2011 Mar 16.

14.

Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.

Miao B, Skidan I, Yang J, Lugovskoy A, Reibarkh M, Long K, Brazell T, Durugkar KA, Maki J, Ramana CV, Schaffhausen B, Wagner G, Torchilin V, Yuan J, Degterev A.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31. doi: 10.1073/pnas.1004522107. Epub 2010 Nov 1.

15.

Lessons in signaling and tumorigenesis from polyomavirus middle T antigen.

Fluck MM, Schaffhausen BS.

Microbiol Mol Biol Rev. 2009 Sep;73(3):542-63, Table of Contents. doi: 10.1128/MMBR.00009-09. Review.

16.

Backbone assignment of the N-terminal polyomavirus large T antigen.

Knoblich K, Whittaker S, Ludwig C, Michiels P, Jiang T, Schaffhausen B, Günther U.

Biomol NMR Assign. 2009 Jun;3(1):119-23. doi: 10.1007/s12104-009-9155-7. Epub 2009 Apr 9.

PMID:
19636961
17.

Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens.

Cheng J, DeCaprio JA, Fluck MM, Schaffhausen BS.

Semin Cancer Biol. 2009 Aug;19(4):218-28. doi: 10.1016/j.semcancer.2009.03.002. Epub 2009 Mar 31. Review.

18.

Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer.

Schaffhausen BS, Roberts TM.

Virology. 2009 Feb 20;384(2):304-16. doi: 10.1016/j.virol.2008.09.042. Epub 2008 Nov 20. Review.

19.

Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors.

Siwko SK, Bu W, Gutierrez C, Lewis B, Jechlinger M, Schaffhausen B, Li Y.

Neoplasia. 2008 Jul;10(7):653-62, 1 p following 662.

20.

Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for the migration of transformed cells.

Whalen KA, Weber GF, Benjamin TL, Schaffhausen BS.

J Virol. 2008 May;82(10):4946-54. doi: 10.1128/JVI.02650-07. Epub 2008 Mar 12.

21.

Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner.

Andrabi S, Gjoerup OV, Kean JA, Roberts TM, Schaffhausen B.

Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19011-6. Epub 2007 Nov 15.

22.

Surveillance mechanism linking Bub1 loss to the p53 pathway.

Gjoerup OV, Wu J, Chandler-Militello D, Williams GL, Zhao J, Schaffhausen B, Jat PS, Roberts TM.

Proc Natl Acad Sci U S A. 2007 May 15;104(20):8334-9. Epub 2007 May 8.

23.

The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation.

Utermark T, Schaffhausen BS, Roberts TM, Zhao JJ.

J Virol. 2007 Jul;81(13):7069-76. Epub 2007 Apr 18.

24.

Essential role of PDK1 in regulating endothelial cell migration.

Primo L, di Blasio L, Roca C, Droetto S, Piva R, Schaffhausen B, Bussolino F.

J Cell Biol. 2007 Mar 26;176(7):1035-47. Epub 2007 Mar 19.

25.

Retinol modulates site-specific mobility of apo-cellular retinol-binding protein to promote ligand binding.

Mittag T, Franzoni L, Cavazzini D, Schaffhausen B, Rossi GL, Günther UL.

J Am Chem Soc. 2006 Aug 2;128(30):9844-8.

PMID:
16866541
26.

Genetic analysis of the polyomavirus DnaJ domain.

Whalen KA, de Jesus R, Kean JA, Schaffhausen BS.

J Virol. 2005 Aug;79(15):9982-90.

27.

Activation of CREB/ATF sites by polyomavirus large T antigen.

Love TM, de Jesus R, Kean JA, Sheng Q, Leger A, Schaffhausen B.

J Virol. 2005 Apr;79(7):4180-90.

28.

Tracing kinetic intermediates during ligand binding.

Mittag T, Schaffhausen B, Günther UL.

J Am Chem Soc. 2004 Jul 28;126(29):9017-23.

PMID:
15264834
29.

Attenuation of SARS coronavirus by a short hairpin RNA expression plasmid targeting RNA-dependent RNA polymerase.

Lu A, Zhang H, Zhang X, Wang H, Hu Q, Shen L, Schaffhausen BS, Hou W, Li L.

Virology. 2004 Jun 20;324(1):84-9.

30.

Direct observation of protein-ligand interaction kinetics.

Mittag T, Schaffhausen B, Günther UL.

Biochemistry. 2003 Sep 30;42(38):11128-36.

PMID:
14503863
31.
32.

A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site.

Hong YK, Mikami A, Schaffhausen B, Jun T, Roberts TM.

Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9434-9. Epub 2003 Jul 24.

33.

Probing Src homology 2 domain ligand interactions by differential line broadening.

Günther U, Mittag T, Schaffhausen B.

Biochemistry. 2002 Oct 1;41(39):11658-69.

PMID:
12269808
34.

NMRKIN: simulating line shapes from two-dimensional spectra of proteins upon ligand binding.

Günther UL, Schaffhausen B.

J Biomol NMR. 2002 Mar;22(3):201-9. Review.

PMID:
11991351
35.

PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism.

Tian X, Rusanescu G, Hou W, Schaffhausen B, Feig LA.

EMBO J. 2002 Mar 15;21(6):1327-38.

36.
37.

J domain-independent regulation of the Rb family by polyomavirus large T antigen.

Sheng Q, Love TM, Schaffhausen B.

J Virol. 2000 Jun;74(11):5280-90.

39.

Signaling from polyomavirus middle T and small T defines different roles for protein phosphatase 2A.

Mullane KP, Ratnofsky M, Culleré X, Schaffhausen B.

Mol Cell Biol. 1998 Dec;18(12):7556-64.

40.

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1.

Chou MM, Hou W, Johnson J, Graham LK, Lee MH, Chen CS, Newton AC, Schaffhausen BS, Toker A.

Curr Biol. 1998 Sep 24;8(19):1069-77.

41.

Polyomavirus large T can support DNA replication in human cells.

Sverdrup F, Schaffhausen BS, Androphy EJ.

Virology. 1998 Jan 5;240(1):50-6.

42.

Serine 257 phosphorylation regulates association of polyomavirus middle T antigen with 14-3-3 proteins.

Culleré X, Rose P, Thathamangalam U, Chatterjee A, Mullane KP, Pallas DC, Benjamin TL, Roberts TM, Schaffhausen BS.

J Virol. 1998 Jan;72(1):558-63.

43.

The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function.

Sheng Q, Denis D, Ratnofsky M, Roberts TM, DeCaprio JA, Schaffhausen B.

J Virol. 1997 Dec;71(12):9410-6.

44.
45.

DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication.

Campbell KS, Mullane KP, Aksoy IA, Stubdal H, Zalvide J, Pipas JM, Silver PA, Roberts TM, Schaffhausen BS, DeCaprio JA.

Genes Dev. 1997 May 1;11(9):1098-110.

46.

NMR analysis of interactions of a phosphatidylinositol 3'-kinase SH2 domain with phosphotyrosine peptides reveals interdependence of major binding sites.

Günther UL, Liu Y, Sanford D, Bachovchin WW, Schaffhausen B.

Biochemistry. 1996 Dec 3;35(48):15570-81.

PMID:
8952511
48.

SH2 domain structure and function.

Schaffhausen B.

Biochim Biophys Acta. 1995 Jul 28;1242(1):61-75. Review.

PMID:
7542925
49.

Association of Polyomavirus middle tumor antigen with phospholipase C-gamma 1.

Su W, Liu W, Schaffhausen BS, Roberts TM.

J Biol Chem. 1995 May 26;270(21):12331-4.

50.

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