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Circulating ceramide ratios and risk of vascular brain aging and dementia.

McGrath ER, Himali JJ, Xanthakis V, Duncan MS, Schaffer JE, Ory DS, Peterson LR, DeCarli C, Pase MP, Satizabal CL, Vasan RS, Beiser AS, Seshadri S.

Ann Clin Transl Neurol. 2020 Jan 16. doi: 10.1002/acn3.50973. [Epub ahead of print]


Brassicaceae-specific Gretchen Hagen 3 acyl acid amido synthetases conjugate amino acids to chorismate, a precursor of aromatic amino acids and salicylic acid.

Holland CK, Westfall CS, Schaffer JE, De Santiago A, Zubieta C, Alvarez S, Jez JM.

J Biol Chem. 2019 Nov 8;294(45):16855-16864. doi: 10.1074/jbc.RA119.009949. Epub 2019 Oct 1.


The structural basis of N-acyl-α-amino-β-lactone formation catalyzed by a nonribosomal peptide synthetase.

Kreitler DF, Gemmell EM, Schaffer JE, Wencewicz TA, Gulick AM.

Nat Commun. 2019 Jul 31;10(1):3432. doi: 10.1038/s41467-019-11383-7.


N-acyl-O-phosphocholineserines: structures of a novel class of lipids that are biomarkers for Niemann-Pick C1 disease.

Sidhu R, Mondjinou Y, Qian M, Song H, Kumar AB, Hong X, Hsu FF, Dietzen DJ, Yanjanin NM, Porter FD, Berry-Kravis E, Vite CH, Gelb MH, Schaffer JE, Ory DS, Jiang X.

J Lipid Res. 2019 Aug;60(8):1410-1424. doi: 10.1194/jlr.RA119000157. Epub 2019 Jun 14.


2-Hydroxypropyl-β-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 disease.

Davidson J, Molitor E, Moores S, Gale SE, Subramanian K, Jiang X, Sidhu R, Kell P, Zhang J, Fujiwara H, Davidson C, Helquist P, Melancon BJ, Grigalunas M, Liu G, Salahi F, Wiest O, Xu X, Porter FD, Pipalia NH, Cruz DL, Holson EB, Schaffer JE, Walkley SU, Maxfield FR, Ory DS.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1545-1561. doi: 10.1016/j.bbalip.2019.04.011. Epub 2019 Apr 30.


Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking.

Feltes M, Moores S, Gale SE, Krishnan K, Mydock-McGrane L, Covey DF, Ory DS, Schaffer JE.

J Lipid Res. 2019 Mar;60(3):707-716. doi: 10.1194/jlr.D091470. Epub 2019 Jan 7.


Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs.

Ter Meer M, Dillion R, Nielsen SM, Walther R, Meyer RL, Daamen WF, van den Heuvel LP, van der Vliet JA, Lomme RMLM, Hoogeveen YL, Schultze Kool LJ, Schaffer JE, Zelikin AN.

Chem Commun (Camb). 2019 Jan 3;55(4):443-446. doi: 10.1039/c8cc08737g.


Diagnosis of niemann-pick C1 by measurement of bile acid biomarkers in archived newborn dried blood spots.

Jiang X, Sidhu R, Orsini JJ, Farhat NY, Porter FD, Berry-Kravis E, Schaffer JE, Ory DS.

Mol Genet Metab. 2019 Feb;126(2):183-187. doi: 10.1016/j.ymgme.2018.08.007. Epub 2018 Aug 24.


Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop.

Goldberg IJ, Reue K, Abumrad NA, Bickel PE, Cohen S, Fisher EA, Galis ZS, Granneman JG, Lewandowski ED, Murphy R, Olive M, Schaffer JE, Schwartz-Longacre L, Shulman GI, Walther TC, Chen J.

Circulation. 2018 Jul 17;138(3):305-315. doi: 10.1161/CIRCULATIONAHA.118.033704. Review.


Long-range function of secreted small nucleolar RNAs that direct 2'-O-methylation.

Rimer JM, Lee J, Holley CL, Crowder RJ, Chen DL, Hanson PI, Ory DS, Schaffer JE.

J Biol Chem. 2018 Aug 24;293(34):13284-13296. doi: 10.1074/jbc.RA118.003410. Epub 2018 Jul 6.


Ceramide Remodeling and Risk of Cardiovascular Events and Mortality.

Peterson LR, Xanthakis V, Duncan MS, Gross S, Friedrich N, Völzke H, Felix SB, Jiang H, Sidhu R, Nauck M, Jiang X, Ory DS, Dörr M, Vasan RS, Schaffer JE.

J Am Heart Assoc. 2018 May 3;7(10). pii: e007931. doi: 10.1161/JAHA.117.007931.


Enzyme Prodrug Therapy Achieves Site-Specific, Personalized Physiological Responses to the Locally Produced Nitric Oxide.

Winther AK, Fejerskov B, Ter Meer M, Jensen NBS, Dillion R, Schaffer JE, Chandrawati R, Stevens MM, Schultze Kool LJ, Simonsen U, Zelikin AN.

ACS Appl Mater Interfaces. 2018 Apr 4;10(13):10741-10751. doi: 10.1021/acsami.8b01658. Epub 2018 Mar 23.


A HILIC-MS/MS method for simultaneous quantification of the lysosomal disease markers galactosylsphingosine and glucosylsphingosine in mouse serum.

Sidhu R, Mikulka CR, Fujiwara H, Sands MS, Schaffer JE, Ory DS, Jiang X.

Biomed Chromatogr. 2018 Jul;32(7):e4235. doi: 10.1002/bmc.4235. Epub 2018 Apr 26.


Manifestations and mechanisms of myocardial lipotoxicity in obesity.

Sletten AC, Peterson LR, Schaffer JE.

J Intern Med. 2018 Nov;284(5):478-491. doi: 10.1111/joim.12728. Epub 2018 Jan 31. Review.


Bariatric Surgery-Induced Cardiac and Lipidomic Changes in Obesity-Related Heart Failure with Preserved Ejection Fraction.

Mikhalkova D, Holman SR, Jiang H, Saghir M, Novak E, Coggan AR, O'Connor R, Bashir A, Jamal A, Ory DS, Schaffer JE, Eagon JC, Peterson LR.

Obesity (Silver Spring). 2018 Feb;26(2):284-290. doi: 10.1002/oby.22038. Epub 2017 Dec 15.


Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission.

Tsushima K, Bugger H, Wende AR, Soto J, Jenson GA, Tor AR, McGlauflin R, Kenny HC, Zhang Y, Souvenir R, Hu XX, Sloan CL, Pereira RO, Lira VA, Spitzer KW, Sharp TL, Shoghi KI, Sparagna GC, Rog-Zielinska EA, Kohl P, Khalimonchuk O, Schaffer JE, Abel ED.

Circ Res. 2018 Jan 5;122(1):58-73. doi: 10.1161/CIRCRESAHA.117.311307. Epub 2017 Nov 1.


Nuclear export factor 3 regulates localization of small nucleolar RNAs.

Li MW, Sletten AC, Lee J, Pyles KD, Matkovich SJ, Ory DS, Schaffer JE.

J Biol Chem. 2017 Dec 8;292(49):20228-20239. doi: 10.1074/jbc.M117.818146. Epub 2017 Oct 11.


An in vitro and in vivo characterization of fine WE43B magnesium wire with varied thermomechanical processing conditions.

Griebel AJ, Schaffer JE, Hopkins TM, Alghalayini A, Mkorombindo T, Ojo KO, Xu Z, Little KJ, Pixley SK.

J Biomed Mater Res B Appl Biomater. 2018 Jul;106(5):1987-1997. doi: 10.1002/jbm.b.34008. Epub 2017 Oct 9.


Effects of Inhibiting VPS4 Support a General Role for ESCRTs in Extracellular Vesicle Biogenesis.

Jackson CE, Scruggs BS, Schaffer JE, Hanson PI.

Biophys J. 2017 Sep 19;113(6):1342-1352. doi: 10.1016/j.bpj.2017.05.032. Epub 2017 Jun 16.


β-Lactone formation during product release from a nonribosomal peptide synthetase.

Schaffer JE, Reck MR, Prasad NK, Wencewicz TA.

Nat Chem Biol. 2017 Jul;13(7):737-744. doi: 10.1038/nchembio.2374. Epub 2017 May 15.


Continuously Grooved Stent Struts for Enhanced Endothelial Cell Seeding.

Ter Meer M, Daamen WF, Hoogeveen YL, van Son GJF, Schaffer JE, van der Vliet JA, Kool LJS, van den Heuvel LP.

Cardiovasc Intervent Radiol. 2017 Aug;40(8):1237-1245. doi: 10.1007/s00270-017-1659-4. Epub 2017 May 3.


Interlimb differences in coordination of unsupported reaching movements.

Schaffer JE, Sainburg RL.

Neuroscience. 2017 May 14;350:54-64. doi: 10.1016/j.neuroscience.2017.03.025. Epub 2017 Mar 24.


Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis.

McCommis KS, Hodges WT, Brunt EM, Nalbantoglu I, McDonald WG, Holley C, Fujiwara H, Schaffer JE, Colca JR, Finck BN.

Hepatology. 2017 May;65(5):1543-1556. doi: 10.1002/hep.29025. Epub 2017 Mar 30.


Rpl13a small nucleolar RNAs regulate systemic glucose metabolism.

Lee J, Harris AN, Holley CL, Mahadevan J, Pyles KD, Lavagnino Z, Scherrer DE, Fujiwara H, Sidhu R, Zhang J, Huang SC, Piston DW, Remedi MS, Urano F, Ory DS, Schaffer JE.

J Clin Invest. 2016 Dec 1;126(12):4616-4625. doi: 10.1172/JCI88069. Epub 2016 Nov 7.


RNA Regulation of Lipotoxicity and Metabolic Stress.

Caputa G, Schaffer JE.

Diabetes. 2016 Jul;65(7):1816-23. doi: 10.2337/db16-0147. Epub 2016 Jun 10. Review.


Lipotoxicity: Many Roads to Cell Dysfunction and Cell Death: Introduction to a Thematic Review Series.

Schaffer JE.

J Lipid Res. 2016 Aug;57(8):1327-8. doi: 10.1194/jlr.E069880. Epub 2016 Jun 3. No abstract available.


Development of a bile acid-based newborn screen for Niemann-Pick disease type C.

Jiang X, Sidhu R, Mydock-McGrane L, Hsu FF, Covey DF, Scherrer DE, Earley B, Gale SE, Farhat NY, Porter FD, Dietzen DJ, Orsini JJ, Berry-Kravis E, Zhang X, Reunert J, Marquardt T, Runz H, Giugliani R, Schaffer JE, Ory DS.

Sci Transl Med. 2016 May 4;8(337):337ra63. doi: 10.1126/scitranslmed.aaf2326.


A Diet Rich in Medium-Chain Fatty Acids Improves Systolic Function and Alters the Lipidomic Profile in Patients With Type 2 Diabetes: A Pilot Study.

Airhart S, Cade WT, Jiang H, Coggan AR, Racette SB, Korenblat K, Spearie CA, Waller S, O'Connor R, Bashir A, Ory DS, Schaffer JE, Novak E, Farmer M, Waggoner AD, Dávila-Román VG, Javidan-Nejad C, Peterson LR.

J Clin Endocrinol Metab. 2016 Feb;101(2):504-12. doi: 10.1210/jc.2015-3292. Epub 2015 Dec 10.


A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol.

Iaea DB, Gale SE, Bielska AA, Krishnan K, Fujiwara H, Jiang H, Maxfield FR, Schlesinger PH, Covey DF, Schaffer JE, Ory DS.

J Lipid Res. 2015 Dec;56(12):2408-19. doi: 10.1194/jlr.D064287. Epub 2015 Oct 24.


RNASET2 is required for ROS propagation during oxidative stress-mediated cell death.

Caputa G, Zhao S, Criado AE, Ory DS, Duncan JG, Schaffer JE.

Cell Death Differ. 2016 Feb;23(2):347-57. doi: 10.1038/cdd.2015.105. Epub 2015 Jul 24.


A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele.

Praggastis M, Tortelli B, Zhang J, Fujiwara H, Sidhu R, Chacko A, Chen Z, Chung C, Lieberman AP, Sikora J, Davidson C, Walkley SU, Pipalia NH, Maxfield FR, Schaffer JE, Ory DS.

J Neurosci. 2015 May 27;35(21):8091-106. doi: 10.1523/JNEUROSCI.4173-14.2015.


snoRNA U17 regulates cellular cholesterol trafficking.

Jinn S, Brandis KA, Ren A, Chacko A, Dudley-Rucker N, Gale SE, Sidhu R, Fujiwara H, Jiang H, Olsen BN, Schaffer JE, Ory DS.

Cell Metab. 2015 Jun 2;21(6):855-67. doi: 10.1016/j.cmet.2015.04.010. Epub 2015 May 14.


A validated LC-MS/MS assay for quantification of 24(S)-hydroxycholesterol in plasma and cerebrospinal fluid.

Sidhu R, Jiang H, Farhat NY, Carrillo-Carrasco N, Woolery M, Ottinger E, Porter FD, Schaffer JE, Ory DS, Jiang X.

J Lipid Res. 2015 Jun;56(6):1222-33. doi: 10.1194/jlr.D058487. Epub 2015 Apr 12.


Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase.

Holley CL, Li MW, Scruggs BS, Matkovich SJ, Ory DS, Schaffer JE.

J Biol Chem. 2015 May 1;290(18):11741-8. doi: 10.1074/jbc.M115.637413. Epub 2015 Mar 19.


Magnetically Inserted Neural Electrodes: Tissue Response and Functional Lifetime.

Dryg ID, Ward MP, Qing KY, Mei H, Schaffer JE, Irazoqui PP.

IEEE Trans Neural Syst Rehabil Eng. 2015 Jul;23(4):562-71. doi: 10.1109/TNSRE.2015.2399856. Epub 2015 Feb 18.


Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload.

Elezaby A, Sverdlov AL, Tu VH, Soni K, Luptak I, Qin F, Liesa M, Shirihai OS, Rimer J, Schaffer JE, Colucci WS, Miller EJ.

J Mol Cell Cardiol. 2015 Feb;79:275-83. doi: 10.1016/j.yjmcc.2014.12.001. Epub 2014 Dec 9.


Plasma sphingolipids associated with chronic obstructive pulmonary disease phenotypes.

Bowler RP, Jacobson S, Cruickshank C, Hughes GJ, Siska C, Ory DS, Petrache I, Schaffer JE, Reisdorph N, Kechris K.

Am J Respir Crit Care Med. 2015 Feb 1;191(3):275-84. doi: 10.1164/rccm.201410-1771OC.


Cholesterol homeostatic responses provide biomarkers for monitoring treatment for the neurodegenerative disease Niemann-Pick C1 (NPC1).

Tortelli B, Fujiwara H, Bagel JH, Zhang J, Sidhu R, Jiang X, Yanjanin NM, Shankar RK, Carillo-Carasco N, Heiss J, Ottinger E, Porter FD, Schaffer JE, Vite CH, Ory DS.

Hum Mol Genet. 2014 Nov 15;23(22):6022-33. doi: 10.1093/hmg/ddu331. Epub 2014 Jun 25.


Box C/D small nucleolar RNA (snoRNA) U60 regulates intracellular cholesterol trafficking.

Brandis KA, Gale S, Jinn S, Langmade SJ, Dudley-Rucker N, Jiang H, Sidhu R, Ren A, Goldberg A, Schaffer JE, Ory DS.

J Biol Chem. 2013 Dec 13;288(50):35703-13. doi: 10.1074/jbc.M113.488577. Epub 2013 Oct 30.


Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling.

Fan M, Sidhu R, Fujiwara H, Tortelli B, Zhang J, Davidson C, Walkley SU, Bagel JH, Vite C, Yanjanin NM, Porter FD, Schaffer JE, Ory DS.

J Lipid Res. 2013 Oct;54(10):2800-14. doi: 10.1194/jlr.M040618. Epub 2013 Jul 23.


Development and validation of LC-MS/MS method for determination of very long acyl chain (C22:0 and C24:0) ceramides in human plasma.

Jiang H, Hsu FF, Farmer MS, Peterson LR, Schaffer JE, Ory DS, Jiang X.

Anal Bioanal Chem. 2013 Sep;405(23):7357-65. doi: 10.1007/s00216-013-7166-9. Epub 2013 Jul 16.


TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway.

Schilling JD, Machkovech HM, He L, Diwan A, Schaffer JE.

J Immunol. 2013 Feb 1;190(3):1285-96. doi: 10.4049/jimmunol.1202208. Epub 2012 Dec 28.


Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophages.

Schilling JD, Machkovech HM, He L, Sidhu R, Fujiwara H, Weber K, Ory DS, Schaffer JE.

J Biol Chem. 2013 Feb 1;288(5):2923-32. doi: 10.1074/jbc.M112.419978. Epub 2012 Dec 18.


Endothelial acyl-CoA synthetase 1 is not required for inflammatory and apoptotic effects of a saturated fatty acid-rich environment.

Li X, Gonzalez O, Shen X, Barnhart S, Kramer F, Kanter JE, Vivekanandan-Giri A, Tsuchiya K, Handa P, Pennathur S, Kim F, Coleman RA, Schaffer JE, Bornfeldt KE.

Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):232-40. doi: 10.1161/ATVBAHA.112.252239. Epub 2012 Dec 13.


Macrophages modulate cardiac function in lipotoxic cardiomyopathy.

Schilling JD, Machkovech HM, Kim AH, Schwendener R, Schaffer JE.

Am J Physiol Heart Circ Physiol. 2012 Dec 1;303(11):H1366-73. doi: 10.1152/ajpheart.00111.2012. Epub 2012 Oct 5. Erratum in: Am J Physiol Heart Circ Physiol. 2013 Feb 15;304(4):H632. Schwedwener, Reto [corrected to Schwendener, Reto].


Cold drawn bioabsorbable ferrous and ferrous composite wires: an evaluation of in vitro vascular cytocompatibility.

Schaffer JE, Nauman EA, Stanciu LA.

Acta Biomater. 2013 Nov;9(10):8574-84. doi: 10.1016/j.actbio.2012.07.043. Epub 2012 Aug 8.


SmD3 regulates intronic noncoding RNA biogenesis.

Scruggs BS, Michel CI, Ory DS, Schaffer JE.

Mol Cell Biol. 2012 Oct;32(20):4092-103. Epub 2012 Aug 6.


Metabolic stress in the myocardium: adaptations of gene expression.

Crawford PA, Schaffer JE.

J Mol Cell Cardiol. 2013 Feb;55:130-8. doi: 10.1016/j.yjmcc.2012.06.008. Epub 2012 Jun 21. Review.


Diabetic cardiovascular disease: getting to the heart of the matter.

Peterson LR, McKenzie CR, Schaffer JE.

J Cardiovasc Transl Res. 2012 Aug;5(4):436-45. doi: 10.1007/s12265-012-9374-7. Epub 2012 May 26. Review.


Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress.

Michel CI, Holley CL, Scruggs BS, Sidhu R, Brookheart RT, Listenberger LL, Behlke MA, Ory DS, Schaffer JE.

Cell Metab. 2011 Jul 6;14(1):33-44. doi: 10.1016/j.cmet.2011.04.009.

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