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Items: 1 to 50 of 202


Mastering their own fates through the matrix.

Qiao EL, Kumar S, Schaffer DV.

Nat Mater. 2019 Aug;18(8):779-780. doi: 10.1038/s41563-019-0429-x. No abstract available.


CRISPR-READI: Efficient Generation of Knockin Mice by CRISPR RNP Electroporation and AAV Donor Infection.

Chen S, Sun S, Moonen D, Lee C, Lee AY, Schaffer DV, He L.

Cell Rep. 2019 Jun 25;27(13):3780-3789.e4. doi: 10.1016/j.celrep.2019.05.103.


Engineering biomaterials to control the neural differentiation of stem cells.

Zimmermann JA, Schaffer DV.

Brain Res Bull. 2019 Aug;150:50-60. doi: 10.1016/j.brainresbull.2019.05.007. Epub 2019 May 16. Review.


Cheaper and less variable expansion.

Adil MM, Schaffer DV.

Nat Biomed Eng. 2018 Mar;2(3):144-145. doi: 10.1038/s41551-018-0209-y. No abstract available.


Understanding How Wnt Influences Destruction Complex Activity and β-Catenin Dynamics.

Mukherjee A, Dhar N, Stathos M, Schaffer DV, Kane RS.

iScience. 2018 Aug 31;6:13-21. doi: 10.1016/j.isci.2018.07.007. Epub 2018 Jul 17.


High-throughput identification of factors promoting neuronal differentiation of human neural progenitor cells in microscale 3D cell culture.

Nierode GJ, Gopal S, Kwon P, Clark DS, Schaffer DV, Dordick JS.

Biotechnol Bioeng. 2019 Jan;116(1):168-180. doi: 10.1002/bit.26839. Epub 2018 Oct 27.


Corrigendum to "Engineered viral vectors for functional interrogation, deconvolution, and manipulation of neural circuits" [Curr. Opin. Neurobiol. 50 (2018) 163-170].

Sun S, Schaffer DV.

Curr Opin Neurobiol. 2018 Dec;53:220. doi: 10.1016/j.conb.2018.08.005. Epub 2018 Sep 5. No abstract available.


High-throughput combinatorial screening reveals interactions between signaling molecules that regulate adult neural stem cell fate.

Muckom R, McFarland S, Yang C, Perea B, Gentes M, Murugappan A, Tran E, Dordick JS, Clark DS, Schaffer DV.

Biotechnol Bioeng. 2019 Jan;116(1):193-205. doi: 10.1002/bit.26815. Epub 2018 Nov 6.


The Spectrin-Actin-Based Periodic Cytoskeleton as a Conserved Nanoscale Scaffold and Ruler of the Neural Stem Cell Lineage.

Hauser M, Yan R, Li W, Repina NA, Schaffer DV, Xu K.

Cell Rep. 2018 Aug 7;24(6):1512-1522. doi: 10.1016/j.celrep.2018.07.005.


Spatiomechanical Modulation of EphB4-Ephrin-B2 Signaling in Neural Stem Cell Differentiation.

Dong M, Spelke DP, Lee YK, Chung JK, Yu CH, Schaffer DV, Groves JT.

Biophys J. 2018 Sep 4;115(5):865-873. doi: 10.1016/j.bpj.2018.06.031. Epub 2018 Jul 23.


CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window.

Halperin SO, Tou CJ, Wong EB, Modavi C, Schaffer DV, Dueber JE.

Nature. 2018 Aug;560(7717):248-252. doi: 10.1038/s41586-018-0384-8. Epub 2018 Aug 1.


Proliferation versus Differentiation: Redefining Retinoic Acid's Role.

Mosher KI, Schaffer DV.

Stem Cell Reports. 2018 Jun 5;10(6):1673-1675. doi: 10.1016/j.stemcr.2018.05.011.


Thermoreversible Hyaluronic Acid-PNIPAAm Hydrogel Systems for 3D Stem Cell Culture.

Ekerdt BL, Fuentes CM, Lei Y, Adil MM, Ramasubramanian A, Segalman RA, Schaffer DV.

Adv Healthc Mater. 2018 Jun;7(12):e1800225. doi: 10.1002/adhm.201800225. Epub 2018 May 2.


hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model.

Adil MM, Gaj T, Rao AT, Kulkarni RU, Fuentes CM, Ramadoss GN, Ekman FK, Miller EW, Schaffer DV.

Stem Cell Reports. 2018 May 8;10(5):1481-1491. doi: 10.1016/j.stemcr.2018.03.007. Epub 2018 Apr 5.


Engineered viral vectors for functional interrogation, deconvolution, and manipulation of neural circuits.

Sun S, Schaffer DV.

Curr Opin Neurobiol. 2018 Jun;50:163-170. doi: 10.1016/j.conb.2017.12.011. Epub 2018 Mar 31. Review. Erratum in: Curr Opin Neurobiol. 2018 Sep 5;:.


hPSC-derived Midbrain Dopaminergic Neurons Generated in a Scalable 3-D Biomaterial.

Adil MM, Schaffer DV.

Curr Protoc Stem Cell Biol. 2018 Feb 28;44:2D.21.1-2D.21.17. doi: 10.1002/cpsc.47.


A Hypothalamic Switch for REM and Non-REM Sleep.

Chen KS, Xu M, Zhang Z, Chang WC, Gaj T, Schaffer DV, Dan Y.

Neuron. 2018 Mar 7;97(5):1168-1176.e4. doi: 10.1016/j.neuron.2018.02.005. Epub 2018 Feb 22.


Optogenetic tools for cell biological applications.

Mukherjee A, Repina NA, Schaffer DV, Kane RS.

J Thorac Dis. 2017 Dec;9(12):4867-4870. doi: 10.21037/jtd.2017.11.73. No abstract available.


In vivo genome editing improves motor function and extends survival in a mouse model of ALS.

Gaj T, Ojala DS, Ekman FK, Byrne LC, Limsirichai P, Schaffer DV.

Sci Adv. 2017 Dec 20;3(12):eaar3952. doi: 10.1126/sciadv.aar3952. eCollection 2017 Dec.


Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas.

Day TP, Byrne LC, Flannery JG, Schaffer DV.

Methods Mol Biol. 2018;1715:239-249. doi: 10.1007/978-1-4939-7522-8_17.


Matrix degradation: Making way for neural stemness.

Kang PH, Kumar S, Schaffer DV.

Nat Mater. 2017 Nov 24;16(12):1174-1176. doi: 10.1038/nmat5043. No abstract available.


Combining Engineered Nucleases with Adeno-associated Viral Vectors for Therapeutic Gene Editing.

Epstein BE, Schaffer DV.

Adv Exp Med Biol. 2017;1016:29-42. doi: 10.1007/978-3-319-63904-8_2. Review.


Influence of hippocampal niche signals on neural stem cell functions during aging.

Mosher KI, Schaffer DV.

Cell Tissue Res. 2018 Jan;371(1):115-124. doi: 10.1007/s00441-017-2709-6. Epub 2017 Nov 10. Review.


In Vivo Selection of a Computationally Designed SCHEMA AAV Library Yields a Novel Variant for Infection of Adult Neural Stem Cells in the SVZ.

Ojala DS, Sun S, Santiago-Ortiz JL, Shapiro MG, Romero PA, Schaffer DV.

Mol Ther. 2018 Jan 3;26(1):304-319. doi: 10.1016/j.ymthe.2017.09.006. Epub 2017 Sep 8.


A directed evolution approach to select for novel Adeno-associated virus capsids on an HIV-1 producer T cell line.

Wooley DP, Sharma P, Weinstein JR, Kotha Lakshmi Narayan P, Schaffer DV, Excoffon KJDA.

J Virol Methods. 2017 Dec;250:47-54. doi: 10.1016/j.jviromet.2017.09.008. Epub 2017 Sep 14.


Novel GP64 envelope variants for improved delivery to human airway epithelial cells.

Sinn PL, Hwang BY, Li N, Ortiz JLS, Shirazi E, Parekh KR, Cooney AL, Schaffer DV, McCray PB Jr.

Gene Ther. 2017 Oct;24(10):674-679. doi: 10.1038/gt.2017.78. Epub 2017 Sep 7.


At Light Speed: Advances in Optogenetic Systems for Regulating Cell Signaling and Behavior.

Repina NA, Rosenbloom A, Mukherjee A, Schaffer DV, Kane RS.

Annu Rev Chem Biomol Eng. 2017 Jun 7;8:13-39. doi: 10.1146/annurev-chembioeng-060816-101254. Review.


Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System.

Rodrigues GMC, Gaj T, Adil MM, Wahba J, Rao AT, Lorbeer FK, Kulkarni RU, Diogo MM, Cabral JMS, Miller EW, Hockemeyer D, Schaffer DV.

Stem Cell Reports. 2017 Jun 6;8(6):1770-1783. doi: 10.1016/j.stemcr.2017.04.027. Epub 2017 May 25.


Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons.

Adil MM, Vazin T, Ananthanarayanan B, Rodrigues GMC, Rao AT, Kulkarni RU, Miller EW, Kumar S, Schaffer DV.

Biomaterials. 2017 Aug;136:1-11. doi: 10.1016/j.biomaterials.2017.05.008. Epub 2017 May 5.


Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery.

Gaj T, Staahl BT, Rodrigues GMC, Limsirichai P, Ekman FK, Doudna JA, Schaffer DV.

Nucleic Acids Res. 2017 Jun 20;45(11):e98. doi: 10.1093/nar/gkx154.


High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform.

Nierode GJ, Perea BC, McFarland SK, Pascoal JF, Clark DS, Schaffer DV, Dordick JS.

Stem Cell Reports. 2016 Nov 8;7(5):970-982. doi: 10.1016/j.stemcr.2016.10.001. Epub 2016 Oct 27.


Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform.

Adil MM, Rodrigues GM, Kulkarni RU, Rao AT, Chernavsky NE, Miller EW, Schaffer DV.

Sci Rep. 2017 Jan 16;7:40573. doi: 10.1038/srep40573.


A Rationally Designed, General Strategy for Membrane Orientation of Photoinduced Electron Transfer-Based Voltage-Sensitive Dyes.

Kulkarni RU, Yin H, Pourmandi N, James F, Adil MM, Schaffer DV, Wang Y, Miller EW.

ACS Chem Biol. 2017 Feb 17;12(2):407-413. doi: 10.1021/acschembio.6b00981. Epub 2016 Dec 22.


Adeno-Associated Virus-Mediated Delivery of CRISPR-Cas Systems for Genome Engineering in Mammalian Cells.

Gaj T, Schaffer DV.

Cold Spring Harb Protoc. 2016 Nov 1;2016(11). doi: 10.1101/pdb.prot086868.


A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons.

Tervo DG, Hwang BY, Viswanathan S, Gaj T, Lavzin M, Ritola KD, Lindo S, Michael S, Kuleshova E, Ojala D, Huang CC, Gerfen CR, Schiller J, Dudman JT, Hantman AW, Looger LL, Schaffer DV, Karpova AY.

Neuron. 2016 Oct 19;92(2):372-382. doi: 10.1016/j.neuron.2016.09.021. Epub 2016 Oct 6.


CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes.

Steines B, Dickey DD, Bergen J, Excoffon KJ, Weinstein JR, Li X, Yan Z, Abou Alaiwa MH, Shah VS, Bouzek DC, Powers LS, Gansemer ND, Ostedgaard LS, Engelhardt JF, Stoltz DA, Welsh MJ, Sinn PL, Schaffer DV, Zabner J.

JCI Insight. 2016 Sep 8;1(14):e88728. doi: 10.1172/jci.insight.88728.


Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas.

Yao K, Qiu S, Tian L, Snider WD, Flannery JG, Schaffer DV, Chen B.

Cell Rep. 2016 Sep 27;17(1):165-178. doi: 10.1016/j.celrep.2016.08.078.


Dynamics of Mechanosensitive Neural Stem Cell Differentiation.

Rammensee S, Kang MS, Georgiou K, Kumar S, Schaffer DV.

Stem Cells. 2017 Feb;35(2):497-506. doi: 10.1002/stem.2489. Epub 2016 Sep 23. Erratum in: Stem Cells. 2018 Mar;36(3):467-469.


Viral infection: A key host receptor for AAV.

Sun S, Schaffer DV.

Nat Microbiol. 2016 Feb 1;1:15027. doi: 10.1038/nmicrobiol.2015.27. No abstract available.


Microelastic mapping of the rat dentate gyrus.

Luque T, Kang MS, Schaffer DV, Kumar S.

R Soc Open Sci. 2016 Apr 20;3(4):150702. doi: 10.1098/rsos.150702. eCollection 2016 Apr.


Multivalent hyaluronic acid bioconjugates improve sFlt-1 activity in vitro.

Altiok EI, Santiago-Ortiz JL, Svedlund FL, Zbinden A, Jha AK, Bhatnagar D, Loskill P, Jackson WM, Schaffer DV, Healy KE.

Biomaterials. 2016 Jul;93:95-105. doi: 10.1016/j.biomaterials.2016.03.017. Epub 2016 Mar 12.


Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In Vivo.

Zheng B, von See MP, Yu E, Gunel B, Lu K, Vazin T, Schaffer DV, Goodwill PW, Conolly SM.

Theranostics. 2016 Jan 1;6(3):291-301. doi: 10.7150/thno.13728. eCollection 2016.


Adeno-associated virus (AAV) vectors in cancer gene therapy.

Santiago-Ortiz JL, Schaffer DV.

J Control Release. 2016 Oct 28;240:287-301. doi: 10.1016/j.jconrel.2016.01.001. Epub 2016 Jan 12. Review.


Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities.

Chen S, Bremer AW, Scheideler OJ, Na YS, Todhunter ME, Hsiao S, Bomdica PR, Maharbiz MM, Gartner ZJ, Schaffer DV.

Nat Commun. 2016 Jan 12;7:10309. doi: 10.1038/ncomms10309.


Viral Vectors for Gene Therapy: Translational and Clinical Outlook.

Kotterman MA, Chalberg TW, Schaffer DV.

Annu Rev Biomed Eng. 2015;17:63-89. doi: 10.1146/annurev-bioeng-071813-104938. Review.


CRISPR-mediated Activation of Latent HIV-1 Expression.

Limsirichai P, Gaj T, Schaffer DV.

Mol Ther. 2016 Mar;24(3):499-507. doi: 10.1038/mt.2015.213. Epub 2015 Nov 26.


Challenging Regeneration to Transform Medicine.

Tsukamoto A, Abbot SE, Kadyk LC, DeWitt ND, Schaffer DV, Wertheim JA, Whittlesey KJ, Werner MJ.

Stem Cells Transl Med. 2016 Jan;5(1):1-7. doi: 10.5966/sctm.2015-0180. Epub 2015 Nov 25. Review.


Genome Engineering Using Adeno-associated Virus: Basic and Clinical Research Applications.

Gaj T, Epstein BE, Schaffer DV.

Mol Ther. 2016 Mar;24(3):458-64. doi: 10.1038/mt.2015.151. Epub 2015 Sep 16. Review.


AAV ancestral reconstruction library enables selection of broadly infectious viral variants.

Santiago-Ortiz J, Ojala DS, Westesson O, Weinstein JR, Wong SY, Steinsapir A, Kumar S, Holmes I, Schaffer DV.

Gene Ther. 2015 Dec;22(12):934-46. doi: 10.1038/gt.2015.74. Epub 2015 Jul 17.


Multivalent Conjugates of Sonic Hedgehog Accelerate Diabetic Wound Healing.

Han BW, Layman H, Rode NA, Conway A, Schaffer DV, Boudreau NJ, Jackson WM, Healy KE.

Tissue Eng Part A. 2015 Sep;21(17-18):2366-78. doi: 10.1089/ten.TEA.2014.0281.

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