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Items: 1 to 50 of 392


CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington's Disease Mouse Model.

Ekman FK, Ojala DS, Adil MM, Lopez PA, Schaffer DV, Gaj T.

Mol Ther Nucleic Acids. 2019 Sep 6;17:829-839. doi: 10.1016/j.omtn.2019.07.009. Epub 2019 Jul 26.


Mastering their own fates through the matrix.

Qiao EL, Kumar S, Schaffer DV.

Nat Mater. 2019 Aug;18(8):779-780. doi: 10.1038/s41563-019-0429-x. No abstract available.


Optimization of flare management in patients with rheumatoid arthritis: results of a randomized controlled trial.

Myasoedova E, Crowson CS, Giblon RE, McCarthy-Fruin K, Schaffer DE, Wright K, Matteson EL, Davis JM 3rd.

Clin Rheumatol. 2019 Jul 1. doi: 10.1007/s10067-019-04664-5. [Epub ahead of print]


CRISPR-READI: Efficient Generation of Knockin Mice by CRISPR RNP Electroporation and AAV Donor Infection.

Chen S, Sun S, Moonen D, Lee C, Lee AY, Schaffer DV, He L.

Cell Rep. 2019 Jun 25;27(13):3780-3789.e4. doi: 10.1016/j.celrep.2019.05.103.


Engineering biomaterials to control the neural differentiation of stem cells.

Zimmermann JA, Schaffer DV.

Brain Res Bull. 2019 Aug;150:50-60. doi: 10.1016/j.brainresbull.2019.05.007. Epub 2019 May 16. Review.


Cheaper and less variable expansion.

Adil MM, Schaffer DV.

Nat Biomed Eng. 2018 Mar;2(3):144-145. doi: 10.1038/s41551-018-0209-y. No abstract available.



Smith BJ, Bolster MB, Slusher B, Stamatos C, Scott JR, Benham H, Kazi S, Schlenk EA, Schaffer DE, Majithia V, Brown CR Jr.,, Von Feldt JM, Flood J, Haag DM, Smarr KL.

Arthritis Care Res (Hoboken). 2019 Oct;71(10):1398-1399. doi: 10.1002/acr.23895. Epub 2019 Aug 23. No abstract available.


Engineering the AAV capsid to evade immune responses.

Barnes C, Scheideler O, Schaffer D.

Curr Opin Biotechnol. 2019 Feb 23;60:99-103. doi: 10.1016/j.copbio.2019.01.002. [Epub ahead of print] Review.


Longitudinal Occurrence and Predictors of Patient-Provider Discordance Between Global Assessments of Disease Activity in Rheumatoid Arthritis: A Case-Control Study.

Challa DNV, Kvrgic Z, Crowson CS, Matteson EL, Mason TG, Michet CJ Jr, Schaffer DE, Wright KA, Davis JM III.

Arthritis Care Res (Hoboken). 2018 Nov 30. doi: 10.1002/acr.23819. [Epub ahead of print]


Understanding How Wnt Influences Destruction Complex Activity and β-Catenin Dynamics.

Mukherjee A, Dhar N, Stathos M, Schaffer DV, Kane RS.

iScience. 2018 Aug 31;6:13-21. doi: 10.1016/j.isci.2018.07.007. Epub 2018 Jul 17.


High-throughput identification of factors promoting neuronal differentiation of human neural progenitor cells in microscale 3D cell culture.

Nierode GJ, Gopal S, Kwon P, Clark DS, Schaffer DV, Dordick JS.

Biotechnol Bioeng. 2019 Jan;116(1):168-180. doi: 10.1002/bit.26839. Epub 2018 Oct 27.


Corrigendum to "Engineered viral vectors for functional interrogation, deconvolution, and manipulation of neural circuits" [Curr. Opin. Neurobiol. 50 (2018) 163-170].

Sun S, Schaffer DV.

Curr Opin Neurobiol. 2018 Dec;53:220. doi: 10.1016/j.conb.2018.08.005. Epub 2018 Sep 5. No abstract available.


High-throughput combinatorial screening reveals interactions between signaling molecules that regulate adult neural stem cell fate.

Muckom R, McFarland S, Yang C, Perea B, Gentes M, Murugappan A, Tran E, Dordick JS, Clark DS, Schaffer DV.

Biotechnol Bioeng. 2019 Jan;116(1):193-205. doi: 10.1002/bit.26815. Epub 2018 Nov 6.


The Spectrin-Actin-Based Periodic Cytoskeleton as a Conserved Nanoscale Scaffold and Ruler of the Neural Stem Cell Lineage.

Hauser M, Yan R, Li W, Repina NA, Schaffer DV, Xu K.

Cell Rep. 2018 Aug 7;24(6):1512-1522. doi: 10.1016/j.celrep.2018.07.005.


Editorial overview: Tissue, cell and pathway engineering.

Schaffer D, Shvartsman SY.

Curr Opin Biotechnol. 2018 Aug;52:iv-v. doi: 10.1016/j.copbio.2018.07.004. No abstract available.


Spatiomechanical Modulation of EphB4-Ephrin-B2 Signaling in Neural Stem Cell Differentiation.

Dong M, Spelke DP, Lee YK, Chung JK, Yu CH, Schaffer DV, Groves JT.

Biophys J. 2018 Sep 4;115(5):865-873. doi: 10.1016/j.bpj.2018.06.031. Epub 2018 Jul 23.


CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window.

Halperin SO, Tou CJ, Wong EB, Modavi C, Schaffer DV, Dueber JE.

Nature. 2018 Aug;560(7717):248-252. doi: 10.1038/s41586-018-0384-8. Epub 2018 Aug 1.



Smith BJ, Bolster MB, Slusher B, Stamatos C, Scott JR, Benham H, Kazi S, Schlenk EA, Schaffer DE, Majithia V, Brown CR, Von Feldt JM, Flood J, Haag DM, Smarr KL.

Arthritis Care Res (Hoboken). 2019 Aug;71(8):1147-1148. doi: 10.1002/acr.23699. Epub 2019 Jul 4. No abstract available.


Proliferation versus Differentiation: Redefining Retinoic Acid's Role.

Mosher KI, Schaffer DV.

Stem Cell Reports. 2018 Jun 5;10(6):1673-1675. doi: 10.1016/j.stemcr.2018.05.011.


Engineered microfluidic bioreactor for examining the three-dimensional breast tumor microenvironment.

Rogers M, Sobolik T, Schaffer DK, Samson PC, Johnson AC, Owens P, Codreanu SG, Sherrod SD, McLean JA, Wikswo JP, Richmond A.

Biomicrofluidics. 2018 May 7;12(3):034102. doi: 10.1063/1.5016433. eCollection 2018 May.


Thermoreversible Hyaluronic Acid-PNIPAAm Hydrogel Systems for 3D Stem Cell Culture.

Ekerdt BL, Fuentes CM, Lei Y, Adil MM, Ramasubramanian A, Segalman RA, Schaffer DV.

Adv Healthc Mater. 2018 Jun;7(12):e1800225. doi: 10.1002/adhm.201800225. Epub 2018 May 2.


Core Curriculum to Facilitate the Expansion of a Rheumatology Practice to Include Nurse Practitioners and Physician Assistants.

Smith BJ, Bolster MB, Slusher B, Stamatos C, Scott JR, Benham H, Kazi S, Schlenk EA, Schaffer DE, Majithia V, Brown CR Jr, Von Feldt JM, Flood J, Haag DM, Smarr KL.

Arthritis Care Res (Hoboken). 2018 May;70(5):672-678. doi: 10.1002/acr.23546. Epub 2018 Apr 17.


hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model.

Adil MM, Gaj T, Rao AT, Kulkarni RU, Fuentes CM, Ramadoss GN, Ekman FK, Miller EW, Schaffer DV.

Stem Cell Reports. 2018 May 8;10(5):1481-1491. doi: 10.1016/j.stemcr.2018.03.007. Epub 2018 Apr 5.


Engineered viral vectors for functional interrogation, deconvolution, and manipulation of neural circuits.

Sun S, Schaffer DV.

Curr Opin Neurobiol. 2018 Jun;50:163-170. doi: 10.1016/j.conb.2017.12.011. Epub 2018 Mar 31. Review. Erratum in: Curr Opin Neurobiol. 2018 Sep 5;:.


hPSC-derived Midbrain Dopaminergic Neurons Generated in a Scalable 3-D Biomaterial.

Adil MM, Schaffer DV.

Curr Protoc Stem Cell Biol. 2018 Feb 28;44:2D.21.1-2D.21.17. doi: 10.1002/cpsc.47.


A Hypothalamic Switch for REM and Non-REM Sleep.

Chen KS, Xu M, Zhang Z, Chang WC, Gaj T, Schaffer DV, Dan Y.

Neuron. 2018 Mar 7;97(5):1168-1176.e4. doi: 10.1016/j.neuron.2018.02.005. Epub 2018 Feb 22.


Novel biomaterials to study neural stem cell mechanobiology and improve cell-replacement therapies.

Kang P, Kumar S, Schaffer D.

Curr Opin Biomed Eng. 2017 Dec;4:13-20. doi: 10.1016/j.cobme.2017.09.005. Epub 2017 Sep 22.


Optogenetic tools for cell biological applications.

Mukherjee A, Repina NA, Schaffer DV, Kane RS.

J Thorac Dis. 2017 Dec;9(12):4867-4870. doi: 10.21037/jtd.2017.11.73. No abstract available.


In vivo genome editing improves motor function and extends survival in a mouse model of ALS.

Gaj T, Ojala DS, Ekman FK, Byrne LC, Limsirichai P, Schaffer DV.

Sci Adv. 2017 Dec 20;3(12):eaar3952. doi: 10.1126/sciadv.aar3952. eCollection 2017 Dec.


Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas.

Day TP, Byrne LC, Flannery JG, Schaffer DV.

Methods Mol Biol. 2018;1715:239-249. doi: 10.1007/978-1-4939-7522-8_17.


Matrix degradation: Making way for neural stemness.

Kang PH, Kumar S, Schaffer DV.

Nat Mater. 2017 Nov 24;16(12):1174-1176. doi: 10.1038/nmat5043. No abstract available.


Combining Engineered Nucleases with Adeno-associated Viral Vectors for Therapeutic Gene Editing.

Epstein BE, Schaffer DV.

Adv Exp Med Biol. 2017;1016:29-42. doi: 10.1007/978-3-319-63904-8_2. Review.


Influence of hippocampal niche signals on neural stem cell functions during aging.

Mosher KI, Schaffer DV.

Cell Tissue Res. 2018 Jan;371(1):115-124. doi: 10.1007/s00441-017-2709-6. Epub 2017 Nov 10. Review.


In Vivo Selection of a Computationally Designed SCHEMA AAV Library Yields a Novel Variant for Infection of Adult Neural Stem Cells in the SVZ.

Ojala DS, Sun S, Santiago-Ortiz JL, Shapiro MG, Romero PA, Schaffer DV.

Mol Ther. 2018 Jan 3;26(1):304-319. doi: 10.1016/j.ymthe.2017.09.006. Epub 2017 Sep 8.


Patient-provider discordance between global assessments of disease activity in rheumatoid arthritis: a comprehensive clinical evaluation.

Challa DN, Kvrgic Z, Cheville AL, Crowson CS, Bongartz T, Mason TG 2nd, Matteson EL, Michet CJ Jr, Persellin ST, Schaffer DE, Muskardin TLW, Wright K, Davis JM 3rd.

Arthritis Res Ther. 2017 Sep 26;19(1):212. doi: 10.1186/s13075-017-1419-5.


A directed evolution approach to select for novel Adeno-associated virus capsids on an HIV-1 producer T cell line.

Wooley DP, Sharma P, Weinstein JR, Kotha Lakshmi Narayan P, Schaffer DV, Excoffon KJDA.

J Virol Methods. 2017 Dec;250:47-54. doi: 10.1016/j.jviromet.2017.09.008. Epub 2017 Sep 14.


Sedative Effects of Intranasal Midazolam Administration in Wild Caught Blue-fronted Amazon (Amazona aestiva) and Orange-winged Amazon (Amazona amazonica) Parrots.

Schaffer DPH, de Araújo NLLC, Raposo ACS, Filho EFM, Vieira JVR, Oriá AP.

J Avian Med Surg. 2017 Sep;31(3):213-218. doi: 10.1647/2016-201.


Novel GP64 envelope variants for improved delivery to human airway epithelial cells.

Sinn PL, Hwang BY, Li N, Ortiz JLS, Shirazi E, Parekh KR, Cooney AL, Schaffer DV, McCray PB Jr.

Gene Ther. 2017 Oct;24(10):674-679. doi: 10.1038/gt.2017.78. Epub 2017 Sep 7.


Cardiorespiratory effects of epidural anesthesia using lidocaine with morphine or dexmedetomidine in capuchin monkeys (Sapajus sp.) undergoing bilateral tubal ligation surgery, anesthetized with isoflurane.

Schäffer DPH, de Araujo NLLC, Otero AR, Dórea Neto FA, Barbosa VF, Martins Filho EF, Oriá AP.

J Med Primatol. 2017 Dec;46(6):311-319. doi: 10.1111/jmp.12304. Epub 2017 Aug 18.


At Light Speed: Advances in Optogenetic Systems for Regulating Cell Signaling and Behavior.

Repina NA, Rosenbloom A, Mukherjee A, Schaffer DV, Kane RS.

Annu Rev Chem Biomol Eng. 2017 Jun 7;8:13-39. doi: 10.1146/annurev-chembioeng-060816-101254. Review.


Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System.

Rodrigues GMC, Gaj T, Adil MM, Wahba J, Rao AT, Lorbeer FK, Kulkarni RU, Diogo MM, Cabral JMS, Miller EW, Hockemeyer D, Schaffer DV.

Stem Cell Reports. 2017 Jun 6;8(6):1770-1783. doi: 10.1016/j.stemcr.2017.04.027. Epub 2017 May 25.


Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons.

Adil MM, Vazin T, Ananthanarayanan B, Rodrigues GMC, Rao AT, Kulkarni RU, Miller EW, Kumar S, Schaffer DV.

Biomaterials. 2017 Aug;136:1-11. doi: 10.1016/j.biomaterials.2017.05.008. Epub 2017 May 5.


Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery.

Gaj T, Staahl BT, Rodrigues GMC, Limsirichai P, Ekman FK, Doudna JA, Schaffer DV.

Nucleic Acids Res. 2017 Jun 20;45(11):e98. doi: 10.1093/nar/gkx154.


Development of novel murine mammary imaging windows to examine wound healing effects on leukocyte trafficking in mammary tumors with intravital imaging.

Sobolik T, Su YJ, Ashby W, Schaffer DK, Wells S, Wikswo JP, Zijlstra A, Richmond A.

Intravital. 2016 Jan 13;5(1):e1125562. doi: 10.1080/21659087.2015.1125562. eCollection 2016.


High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform.

Nierode GJ, Perea BC, McFarland SK, Pascoal JF, Clark DS, Schaffer DV, Dordick JS.

Stem Cell Reports. 2016 Nov 8;7(5):970-982. doi: 10.1016/j.stemcr.2016.10.001. Epub 2016 Oct 27.


Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform.

Adil MM, Rodrigues GM, Kulkarni RU, Rao AT, Chernavsky NE, Miller EW, Schaffer DV.

Sci Rep. 2017 Jan 16;7:40573. doi: 10.1038/srep40573.


Innovation contests to promote sexual health in China: a qualitative evaluation.

Zhang W, Schaffer D, Tso LS, Tang S, Tang W, Huang S, Yang B, Tucker JD.

BMC Public Health. 2017 Jan 14;17(1):78. doi: 10.1186/s12889-016-4006-9.


A Rationally Designed, General Strategy for Membrane Orientation of Photoinduced Electron Transfer-Based Voltage-Sensitive Dyes.

Kulkarni RU, Yin H, Pourmandi N, James F, Adil MM, Schaffer DV, Wang Y, Miller EW.

ACS Chem Biol. 2017 Feb 17;12(2):407-413. doi: 10.1021/acschembio.6b00981. Epub 2016 Dec 22.


Adeno-Associated Virus-Mediated Delivery of CRISPR-Cas Systems for Genome Engineering in Mammalian Cells.

Gaj T, Schaffer DV.

Cold Spring Harb Protoc. 2016 Nov 1;2016(11). doi: 10.1101/pdb.prot086868.


A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons.

Tervo DG, Hwang BY, Viswanathan S, Gaj T, Lavzin M, Ritola KD, Lindo S, Michael S, Kuleshova E, Ojala D, Huang CC, Gerfen CR, Schiller J, Dudman JT, Hantman AW, Looger LL, Schaffer DV, Karpova AY.

Neuron. 2016 Oct 19;92(2):372-382. doi: 10.1016/j.neuron.2016.09.021. Epub 2016 Oct 6.

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