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Items: 1 to 50 of 109


Microvessel occlusions alter amyloid-beta plaque morphology in a mouse model of Alzheimer's disease.

Zhang Y, Bander ED, Lee Y, Muoser C, Schaffer CB, Nishimura N.

J Cereb Blood Flow Metab. 2019 Nov 19:271678X19889092. doi: 10.1177/0271678X19889092. [Epub ahead of print] No abstract available.


Advanced Circuit and Cellular Imaging Methods in Nonhuman Primates.

Macknik SL, Alexander RG, Caballero O, Chanovas J, Nielsen KJ, Nishimura N, Schaffer CB, Slovin H, Babayoff A, Barak R, Tang S, Ju N, Yazdan-Shahmorad A, Alonso JM, Malinskiy E, Martinez-Conde S.

J Neurosci. 2019 Oct 16;39(42):8267-8274. doi: 10.1523/JNEUROSCI.1168-19.2019.


Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto.

Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan BCM, Sweeney MD, Zlokovic B, Iturria-Medina Y, Iadecola C, Nishimura N, Schaffer CB, Whitehead SN, Black SE, Østergaard L, Wardlaw J, Greenberg S, Friberg L, Norrving B, Rowe B, Joanette Y, Hacke W, Kuller L, Dichgans M, Endres M, Khachaturian ZS.

Int J Stroke. 2019 Sep 22:1747493019871915. doi: 10.1177/1747493019871915. [Epub ahead of print]


Increasing cerebral blood flow improves cognition into late stages in Alzheimer's disease mice.

Bracko O, Njiru BN, Swallow M, Ali M, Haft-Javaherian M, Schaffer CB.

J Cereb Blood Flow Metab. 2019 Sep 7:271678X19873658. doi: 10.1177/0271678X19873658. [Epub ahead of print]


Preventing dementia by preventing stroke: The Berlin Manifesto.

Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan BCM, Sweeney MD, Zlokovic B, Iturria-Medina Y, Iadecola C, Nishimura N, Schaffer CB, Whitehead SN, Black SE, Østergaard L, Wardlaw J, Greenberg S, Friberg L, Norrving B, Rowe B, Joanette Y, Hacke W, Kuller L, Dichgans M, Endres M, Khachaturian ZS.

Alzheimers Dement. 2019 Jul;15(7):961-984. doi: 10.1016/j.jalz.2019.06.001. Review.


Surgical preparations, labeling strategies, and optical techniques for cell-resolved, in vivo imaging in the mouse spinal cord.

Cheng YT, Lett KM, Schaffer CB.

Exp Neurol. 2019 Aug;318:192-204. doi: 10.1016/j.expneurol.2019.05.010. Epub 2019 May 13. Review.


Brain Capillary Networks Across Species: A few Simple Organizational Requirements Are Sufficient to Reproduce Both Structure and Function.

Smith AF, Doyeux V, Berg M, Peyrounette M, Haft-Javaherian M, Larue AE, Slater JH, Lauwers F, Blinder P, Tsai P, Kleinfeld D, Schaffer CB, Nishimura N, Davit Y, Lorthois S.

Front Physiol. 2019 Mar 26;10:233. doi: 10.3389/fphys.2019.00233. eCollection 2019.


Deep convolutional neural networks for segmenting 3D in vivo multiphoton images of vasculature in Alzheimer disease mouse models.

Haft-Javaherian M, Fang L, Muse V, Schaffer CB, Nishimura N, Sabuncu MR.

PLoS One. 2019 Mar 13;14(3):e0213539. doi: 10.1371/journal.pone.0213539. eCollection 2019.


Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models.

Cruz Hernández JC, Bracko O, Kersbergen CJ, Muse V, Haft-Javaherian M, Berg M, Park L, Vinarcsik LK, Ivasyk I, Rivera DA, Kang Y, Cortes-Canteli M, Peyrounette M, Doyeux V, Smith A, Zhou J, Otte G, Beverly JD, Davenport E, Davit Y, Lin CP, Strickland S, Iadecola C, Lorthois S, Nishimura N, Schaffer CB.

Nat Neurosci. 2019 Mar;22(3):413-420. doi: 10.1038/s41593-018-0329-4. Epub 2019 Feb 11.


Aspirin treatment does not increase microhemorrhage size in young or aged mice.

Chan S, Brophy M, Nishimura N, Schaffer CB.

PLoS One. 2019 Jan 4;14(1):e0204295. doi: 10.1371/journal.pone.0204295. eCollection 2019.


In Vivo Femtosecond Laser Subsurface Cortical Microtransections Attenuate Acute Rat Focal Seizures.

Nagappan S, Liu L, Fetcho R, Nguyen J, Nishimura N, Radwanski RE, Lieberman S, Baird-Daniel E, Ma H, Zhao M, Schaffer CB, Schwartz TH.

Cereb Cortex. 2018 Sep 6. doi: 10.1093/cercor/bhy210. [Epub ahead of print]


Diverse Inflammatory Response After Cerebral Microbleeds Includes Coordinated Microglial Migration and Proliferation.

Ahn SJ, Anrather J, Nishimura N, Schaffer CB.

Stroke. 2018 Jul;49(7):1719-1726. doi: 10.1161/STROKEAHA.117.020461. Epub 2018 May 29.


Spatio-temporal dynamics of cerebral capillary segments with stalling red blood cells.

Erdener ŞE, Tang J, Sajjadi A, Kılıç K, Kura S, Schaffer CB, Boas DA.

J Cereb Blood Flow Metab. 2019 May;39(5):886-900. doi: 10.1177/0271678X17743877. Epub 2017 Nov 23.


Experimentally constrained circuit model of cortical arteriole networks for understanding flow redistribution due to occlusion and neural activation.

Bollu T, Cornelius NR, Sunwoo J, Nishimura N, Schaffer CB, Doerschuk PC.

J Cereb Blood Flow Metab. 2018 Jan;38(1):38-44. doi: 10.1177/0271678X17741086. Epub 2017 Nov 13.


Mixing injector enables time-resolved crystallography with high hit rate at X-ray free electron lasers.

Calvey GD, Katz AM, Schaffer CB, Pollack L.

Struct Dyn. 2016 Aug 29;3(5):054301. doi: 10.1063/1.4961971. eCollection 2016 Sep.


An Open Trial of Lurasidone as an Acute and Maintenance Adjunctive Treatment for Outpatients With Treatment-Resistant Bipolar Disorder: Response to Letter to the Editors.

Schaffer CB, Schaffer LC, Nordahl TE, Stark NM, Gohring CE.

J Clin Psychopharmacol. 2016 Oct;36(5):522-3. doi: 10.1097/JCP.0000000000000567. No abstract available.


A circuit motif in the zebrafish hindbrain for a two alternative behavioral choice to turn left or right.

Koyama M, Minale F, Shum J, Nishimura N, Schaffer CB, Fetcho JR.

Elife. 2016 Aug 9;5. pii: e16808. doi: 10.7554/eLife.16808.


TRAIL-coated leukocytes that prevent the bloodborne metastasis of prostate cancer.

Wayne EC, Chandrasekaran S, Mitchell MJ, Chan MF, Lee RE, Schaffer CB, King MR.

J Control Release. 2016 Feb 10;223:215-223. doi: 10.1016/j.jconrel.2015.12.048. Epub 2015 Dec 28.


An Open Trial of Lurasidone as an Acute and Maintenance Adjunctive Treatment for Outpatients With Treatment-Resistant Bipolar Disorder.

Schaffer CB, Schaffer LC, Nordahl TE, Stark NM, Gohring CE.

J Clin Psychopharmacol. 2016 Feb;36(1):88-9. doi: 10.1097/JCP.0000000000000450. No abstract available.


Use of Tethered Enzymes as a Platform Technology for Rapid Analyte Detection.

Cohen R, Lata JP, Lee Y, Hernández JC, Nishimura N, Schaffer CB, Mukai C, Nelson JL, Brangman SA, Agrawal Y, Travis AJ.

PLoS One. 2015 Nov 25;10(11):e0142326. doi: 10.1371/journal.pone.0142326. eCollection 2015.


The origin and implementation of the Broadening Experiences in Scientific Training programs: an NIH common fund initiative.

Meyers FJ, Mathur A, Fuhrmann CN, O'Brien TC, Wefes I, Labosky PA, Duncan DS, August A, Feig A, Gould KL, Friedlander MJ, Schaffer CB, Van Wart A, Chalkley R.

FASEB J. 2016 Feb;30(2):507-14. doi: 10.1096/fj.15-276139. Epub 2015 Oct 2.


Ultra-large field-of-view two-photon microscopy.

Tsai PS, Mateo C, Field JJ, Schaffer CB, Anderson ME, Kleinfeld D.

Opt Express. 2015 Jun 1;23(11):13833-47. doi: 10.1364/OE.23.013833.


Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture.

Shih AY, Rühlmann C, Blinder P, Devor A, Drew PJ, Friedman B, Knutsen PM, Lyden PD, Mateo C, Mellander L, Nishimura N, Schaffer CB, Tsai PS, Kleinfeld D.

Microcirculation. 2015 Apr;22(3):204-218. doi: 10.1111/micc.12195. Review.


Low prevalence of anterior vitreous detachment in eyes with pseudophakic retinal detachment indicates strong vitreoretinal adhesions.

Schäffer CB, Pöschl EM, Steinwender G, Wedrich A, Ivastinovic D.

Acta Ophthalmol. 2015 Dec;93(8):e687-8. doi: 10.1111/aos.12673. Epub 2015 Jan 28. No abstract available.


Characterization of blood flow in the mouse dorsal spinal venous system before and after dorsal spinal vein occlusion.

Farrar MJ, Rubin JD, Diago DM, Schaffer CB.

J Cereb Blood Flow Metab. 2015 Mar 31;35(4):667-75. doi: 10.1038/jcbfm.2014.244.


Vascular contributions to cognitive impairment and dementia including Alzheimer's disease.

Snyder HM, Corriveau RA, Craft S, Faber JE, Greenberg SM, Knopman D, Lamb BT, Montine TJ, Nedergaard M, Schaffer CB, Schneider JA, Wellington C, Wilcock DM, Zipfel GJ, Zlokovic B, Bain LJ, Bosetti F, Galis ZS, Koroshetz W, Carrillo MC.

Alzheimers Dement. 2015 Jun;11(6):710-7. doi: 10.1016/j.jalz.2014.10.008. Epub 2014 Dec 12. Review.


Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels.

Murphy PA, Kim TN, Huang L, Nielsen CM, Lawton MT, Adams RH, Schaffer CB, Wang RA.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):18007-12. doi: 10.1073/pnas.1415316111. Epub 2014 Dec 2.


Growth and hemodynamics after early embryonic aortic arch occlusion.

Lindsey SE, Menon PG, Kowalski WJ, Shekhar A, Yalcin HC, Nishimura N, Schaffer CB, Butcher JT, Pekkan K.

Biomech Model Mechanobiol. 2015 Aug;14(4):735-51. doi: 10.1007/s10237-014-0633-1. Epub 2014 Nov 23.


Stalled cerebral capillary blood flow in mouse models of essential thrombocythemia and polycythemia vera revealed by in vivo two-photon imaging.

Santisakultarm TP, Paduano CQ, Stokol T, Southard TL, Nishimura N, Skoda RC, Olbricht WL, Schafer AI, Silver RT, Schaffer CB.

J Thromb Haemost. 2014 Dec;12(12):2120-30. doi: 10.1111/jth.12738. Epub 2014 Oct 29.


TRAIL-coated leukocytes that kill cancer cells in the circulation.

Mitchell MJ, Wayne E, Rana K, Schaffer CB, King MR.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):930-5. doi: 10.1073/pnas.1316312111. Epub 2014 Jan 6.


In vivo three-photon microscopy of subcortical structures within an intact mouse brain.

Horton NG, Wang K, Kobat D, Clark CG, Wise FW, Schaffer CB, Xu C.

Nat Photonics. 2013 Mar 1;7(3). doi: 10.1038/nphoton.2012.336.


Optically induced occlusion of single blood vessels in rodent neocortex.

Shih AY, Nishimura N, Nguyen J, Friedman B, Lyden PD, Schaffer CB, Kleinfeld D.

Cold Spring Harb Protoc. 2013 Dec 1;2013(12):1153-60. doi: 10.1101/pdb.prot079509.


The challenge of connecting the dots in the B.R.A.I.N.

Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, Hämäläinen MS, Helmchen F, Hyman BT, Jasanoff A, Jernigan TL, Judd LL, Kim SG, Kleinfeld D, Kopell NJ, Kutas M, Kwong KK, Larkum ME, Lo EH, Magistretti PJ, Mandeville JB, Masliah E, Mitra PP, Mobley WC, Moskowitz MA, Nimmerjahn A, Reynolds JH, Rosen BR, Salzberg BM, Schaffer CB, Silva GA, So PT, Spitzer NC, Tootell RB, Van Essen DC, Vanduffel W, Vinogradov SA, Wald LL, Wang LV, Weber B, Yodh AG.

Neuron. 2013 Oct 16;80(2):270-4. doi: 10.1016/j.neuron.2013.09.008.


Optoporation and genetic manipulation of cells using femtosecond laser pulses.

Davis AA, Farrar MJ, Nishimura N, Jin MM, Schaffer CB.

Biophys J. 2013 Aug 20;105(4):862-71. doi: 10.1016/j.bpj.2013.07.012.


Big effects from tiny vessels: imaging the impact of microvascular clots and hemorrhages on the brain.

Nishimura N, Schaffer CB.

Stroke. 2013 Jun;44(6 Suppl 1):S90-2. doi: 10.1161/STROKEAHA.112.679621. Review. No abstract available.


Stimulus-evoked calcium transients in somatosensory cortex are temporarily inhibited by a nearby microhemorrhage.

Cianchetti FA, Kim DH, Dimiduk S, Nishimura N, Schaffer CB.

PLoS One. 2013 May 28;8(5):e65663. doi: 10.1371/journal.pone.0065663. Print 2013.


Intracerebral haemorrhage associated with antithrombotic treatment: translational insights from experimental studies.

Lauer A, Pfeilschifter W, Schaffer CB, Lo EH, Foerch C.

Lancet Neurol. 2013 Apr;12(4):394-405. doi: 10.1016/S1474-4422(13)70049-8. Epub 2013 Mar 18. Review.


Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice.

Foerch C, Rosidi NL, Schlunk F, Lauer A, Cianchetti FA, Mandeville E, Arai K, Yigitkanli K, Fan X, Wang X, van Leyen K, Steinmetz H, Schaffer CB, Lo EH.

PLoS One. 2013;8(2):e54203. doi: 10.1371/journal.pone.0054203. Epub 2013 Feb 8.


An open trial of pregabalin as an acute and maintenance adjunctive treatment for outpatients with treatment resistant bipolar disorder.

Schaffer LC, Schaffer CB, Miller AR, Manley JL, Piekut JA, Nordahl TE.

J Affect Disord. 2013 May;147(1-3):407-10. doi: 10.1016/j.jad.2012.09.005. Epub 2012 Oct 4.


Line-scanning particle image velocimetry: an optical approach for quantifying a wide range of blood flow speeds in live animals.

Kim TN, Goodwill PW, Chen Y, Conolly SM, Schaffer CB, Liepmann D, Wang RA.

PLoS One. 2012;7(6):e38590. doi: 10.1371/journal.pone.0038590. Epub 2012 Jun 26.


Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain.

Shih AY, Driscoll JD, Drew PJ, Nishimura N, Schaffer CB, Kleinfeld D.

J Cereb Blood Flow Metab. 2012 Jul;32(7):1277-309. doi: 10.1038/jcbfm.2011.196. Epub 2012 Feb 1. Review. Erratum in: J Cereb Blood Flow Metab. 2013 Feb;33(2):319. Dosage error in article text.


Cyclic strain anisotropy regulates valvular interstitial cell phenotype and tissue remodeling in three-dimensional culture.

Gould RA, Chin K, Santisakultarm TP, Dropkin A, Richards JM, Schaffer CB, Butcher JT.

Acta Biomater. 2012 May;8(5):1710-9. doi: 10.1016/j.actbio.2012.01.006. Epub 2012 Jan 11.


In vivo two-photon excited fluorescence microscopy reveals cardiac- and respiration-dependent pulsatile blood flow in cortical blood vessels in mice.

Santisakultarm TP, Cornelius NR, Nishimura N, Schafer AI, Silver RT, Doerschuk PC, Olbricht WL, Schaffer CB.

Am J Physiol Heart Circ Physiol. 2012 Apr 1;302(7):H1367-77. doi: 10.1152/ajpheart.00417.2011. Epub 2012 Jan 20.


Chronic in vivo imaging in the mouse spinal cord using an implanted chamber.

Farrar MJ, Bernstein IM, Schlafer DH, Cleland TA, Fetcho JR, Schaffer CB.

Nat Methods. 2012 Jan 22;9(3):297-302. doi: 10.1038/nmeth.1856.


Notch4 normalization reduces blood vessel size in arteriovenous malformations.

Murphy PA, Kim TN, Lu G, Bollen AW, Schaffer CB, Wang RA.

Sci Transl Med. 2012 Jan 18;4(117):117ra8. doi: 10.1126/scitranslmed.3002670.


Estimating brain microvascular blood flows from partial two-photon microscopy data by computation with a circuit model.

Sunwoo J, Cornelius NR, Doerschuk PC, Schaffer CB.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:174-7. doi: 10.1109/IEMBS.2011.6089922.


Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigration.

Huynh J, Nishimura N, Rana K, Peloquin JM, Califano JP, Montague CR, King MR, Schaffer CB, Reinhart-King CA.

Sci Transl Med. 2011 Dec 7;3(112):112ra122. doi: 10.1126/scitranslmed.3002761.


Cortical microhemorrhages cause local inflammation but do not trigger widespread dendrite degeneration.

Rosidi NL, Zhou J, Pattanaik S, Wang P, Jin W, Brophy M, Olbricht WL, Nishimura N, Schaffer CB.

PLoS One. 2011;6(10):e26612. doi: 10.1371/journal.pone.0026612. Epub 2011 Oct 19.


Real-time imaging of perivascular transport of nanoparticles during convection-enhanced delivery in the rat cortex.

Foley CP, Nishimura N, Neeves KB, Schaffer CB, Olbricht WL.

Ann Biomed Eng. 2012 Feb;40(2):292-303. doi: 10.1007/s10439-011-0440-0. Epub 2011 Oct 19.

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