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Items: 1 to 50 of 74

1.

GDP-l-fucose synthase is a CD4+ T cell-specific autoantigen in DRB3*02:02 patients with multiple sclerosis.

Planas R, Santos R, Tomas-Ojer P, Cruciani C, Lutterotti A, Faigle W, Schaeren-Wiemers N, Espejo C, Eixarch H, Pinilla C, Martin R, Sospedra M.

Sci Transl Med. 2018 Oct 10;10(462). pii: eaat4301. doi: 10.1126/scitranslmed.aat4301.

PMID:
30305453
2.

Molecular pathology of Multiple Sclerosis lesions reveals a heterogeneous expression pattern of genes involved in oligodendrogliogenesis.

Zeis T, Howell OW, Reynolds R, Schaeren-Wiemers N.

Exp Neurol. 2018 Jul;305:76-88. doi: 10.1016/j.expneurol.2018.03.012. Epub 2018 Mar 27.

3.

Selective in vivo removal of pathogenic anti-MAG autoantibodies, an antigen-specific treatment option for anti-MAG neuropathy.

Herrendorff R, Hänggi P, Pfister H, Yang F, Demeestere D, Hunziker F, Frey S, Schaeren-Wiemers N, Steck AJ, Ernst B.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3689-E3698. doi: 10.1073/pnas.1619386114. Epub 2017 Apr 17.

4.

Cocapture of cognate and bystander antigens can activate autoreactive B cells.

Sanderson NS, Zimmermann M, Eilinger L, Gubser C, Schaeren-Wiemers N, Lindberg RL, Dougan SK, Ploegh HL, Kappos L, Derfuss T.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):734-739. doi: 10.1073/pnas.1614472114. Epub 2017 Jan 5.

5.

Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction.

Patzig J, Erwig MS, Tenzer S, Kusch K, Dibaj P, Möbius W, Goebbels S, Schaeren-Wiemers N, Nave KA, Werner HB.

Elife. 2016 Aug 9;5. pii: e17119. doi: 10.7554/eLife.17119.

6.

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases.

Weil MT, Möbius W, Winkler A, Ruhwedel T, Wrzos C, Romanelli E, Bennett JL, Enz L, Goebels N, Nave KA, Kerschensteiner M, Schaeren-Wiemers N, Stadelmann C, Simons M.

Cell Rep. 2016 Jul 12;16(2):314-322. doi: 10.1016/j.celrep.2016.06.008. Epub 2016 Jun 23.

7.

Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells.

Wankel B, Ouyang J, Guo X, Hadjiolova K, Miller J, Liao Y, Tham DK, Romih R, Andrade LR, Gumper I, Simon JP, Sachdeva R, Tolmachova T, Seabra MC, Fukuda M, Schaeren-Wiemers N, Hong WJ, Sabatini DD, Wu XR, Kong X, Kreibich G, Rindler MJ, Sun TT.

Mol Biol Cell. 2016 May 15;27(10):1621-34. doi: 10.1091/mbc.E15-04-0230. Epub 2016 Mar 23.

8.

ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood-brain barrier.

Lyck R, Lécuyer MA, Abadier M, Wyss CB, Matti C, Rosito M, Enzmann G, Zeis T, Michel L, García Martín AB, Sallusto F, Gosselet F, Deutsch U, Weiner JA, Schaeren-Wiemers N, Prat A, Engelhardt B.

J Cereb Blood Flow Metab. 2017 Aug;37(8):2894-2909. doi: 10.1177/0271678X16678639. Epub 2016 Nov 14.

9.

Identification of Inflammatory, Metabolic, and Cell Survival Pathways Contributing to Cerebral Small Vessel Disease by Postmortem Gene Expression Microarray.

Ritz MF, Grond-Ginsbach C, Kloss M, Tolnay M, Fluri F, Bonati LH, Traenka C, Zeis T, Schaeren-Wiemers N, Peters N, Engelter ST, Lyrer PA.

Curr Neurovasc Res. 2016;13(1):58-67.

PMID:
26503025
10.

The immunomodulatory oligodendrocyte.

Zeis T, Enz L, Schaeren-Wiemers N.

Brain Res. 2016 Jun 15;1641(Pt A):139-148. doi: 10.1016/j.brainres.2015.09.021. Epub 2015 Sep 28. Review.

PMID:
26423932
11.

Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder.

Lossos A, Elazar N, Lerer I, Schueler-Furman O, Fellig Y, Glick B, Zimmerman BE, Azulay H, Dotan S, Goldberg S, Gomori JM, Ponger P, Newman JP, Marreed H, Steck AJ, Schaeren-Wiemers N, Mor N, Harel M, Geiger T, Eshed-Eisenbach Y, Meiner V, Peles E.

Brain. 2015 Sep;138(Pt 9):2521-36. doi: 10.1093/brain/awv204. Epub 2015 Jul 15.

12.

Clostridium perfringens Epsilon Toxin Causes Selective Death of Mature Oligodendrocytes and Central Nervous System Demyelination.

Linden JR, Ma Y, Zhao B, Harris JM, Rumah KR, Schaeren-Wiemers N, Vartanian T.

MBio. 2015 Jun 16;6(3):e02513. doi: 10.1128/mBio.02513-14.

13.

Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes.

Perriard G, Mathias A, Enz L, Canales M, Schluep M, Gentner M, Schaeren-Wiemers N, Du Pasquier RA.

J Neuroinflammation. 2015 Jun 16;12:119. doi: 10.1186/s12974-015-0335-3.

14.

The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin.

Rumah KR, Ma Y, Linden JR, Oo ML, Anrather J, Schaeren-Wiemers N, Alonso MA, Fischetti VA, McClain MS, Vartanian T.

PLoS Pathog. 2015 May 20;11(5):e1004896. doi: 10.1371/journal.ppat.1004896. eCollection 2015 May.

15.

Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling.

Zeis T, Allaman I, Gentner M, Schroder K, Tschopp J, Magistretti PJ, Schaeren-Wiemers N.

Brain Behav Immun. 2015 Aug;48:313-25. doi: 10.1016/j.bbi.2015.04.013. Epub 2015 Apr 30.

16.

Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9.

Lindner M, Thümmler K, Arthur A, Brunner S, Elliott C, McElroy D, Mohan H, Williams A, Edgar JM, Schuh C, Stadelmann C, Barnett SC, Lassmann H, Mücklisch S, Mudaliar M, Schaeren-Wiemers N, Meinl E, Linington C.

Brain. 2015 Jul;138(Pt 7):1875-93. doi: 10.1093/brain/awv102. Epub 2015 Apr 22.

PMID:
25907862
17.

Fullerenols and glucosamine fullerenes reduce infarct volume and cerebral inflammation after ischemic stroke in normotensive and hypertensive rats.

Fluri F, Grünstein D, Cam E, Ungethuem U, Hatz F, Schäfer J, Samnick S, Israel I, Kleinschnitz C, Orts-Gil G, Moch H, Zeis T, Schaeren-Wiemers N, Seeberger P.

Exp Neurol. 2015 Mar;265:142-51. doi: 10.1016/j.expneurol.2015.01.005. Epub 2015 Jan 24.

PMID:
25625851
18.

MAL overexpression leads to disturbed expression of genes that influence cytoskeletal organization and differentiation of Schwann cells.

Schmid D, Zeis T, Sobrio M, Schaeren-Wiemers N.

ASN Neuro. 2014 Sep 10;6(5). pii: 1759091414548916. doi: 10.1177/1759091414548916. Print 2014.

19.

Transcriptional regulation induced by cAMP elevation in mouse Schwann cells.

Schmid D, Zeis T, Schaeren-Wiemers N.

ASN Neuro. 2014 Apr 30;6(3):137-57. doi: 10.1042/AN20130031.

20.

DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation.

Minten C, Alt C, Gentner M, Frei E, Deutsch U, Lyck R, Schaeren-Wiemers N, Rot A, Engelhardt B.

Brain. 2014 May;137(Pt 5):1454-69. doi: 10.1093/brain/awu045. Epub 2014 Mar 12.

21.

An essential role of MAG in mediating axon-myelin attachment in Charcot-Marie-Tooth 1A disease.

Kinter J, Lazzati T, Schmid D, Zeis T, Erne B, Lützelschwab R, Steck AJ, Pareyson D, Peles E, Schaeren-Wiemers N.

Neurobiol Dis. 2013 Jan;49:221-31. doi: 10.1016/j.nbd.2012.08.009. Epub 2012 Aug 25.

22.

VIP17/MAL expression modulates epithelial cyst formation and ciliogenesis.

Takiar V, Mistry K, Carmosino M, Schaeren-Wiemers N, Caplan MJ.

Am J Physiol Cell Physiol. 2012 Oct 15;303(8):C862-71. doi: 10.1152/ajpcell.00338.2011. Epub 2012 Aug 15.

23.

Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry.

Tchorz JS, Tome M, Cloëtta D, Sivasankaran B, Grzmil M, Huber RM, Rutz-Schatzmann F, Kirchhoff F, Schaeren-Wiemers N, Gassmann M, Hemmings BA, Merlo A, Bettler B.

Cell Death Dis. 2012 Jun 21;3:e325. doi: 10.1038/cddis.2012.65.

24.

MAL facilitates the incorporation of exocytic uroplakin-delivering vesicles into the apical membrane of urothelial umbrella cells.

Zhou G, Liang FX, Romih R, Wang Z, Liao Y, Ghiso J, Luque-Garcia JL, Neubert TA, Kreibich G, Alonso MA, Schaeren-Wiemers N, Sun TT.

Mol Biol Cell. 2012 Apr;23(7):1354-66. doi: 10.1091/mbc.E11-09-0823. Epub 2012 Feb 9.

25.

Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis.

Pfeiffer F, Schäfer J, Lyck R, Makrides V, Brunner S, Schaeren-Wiemers N, Deutsch U, Engelhardt B.

Acta Neuropathol. 2011 Nov;122(5):601-14. doi: 10.1007/s00401-011-0883-2. Epub 2011 Oct 9.

26.

Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain.

Metz M, Gassmann M, Fakler B, Schaeren-Wiemers N, Bettler B.

J Comp Neurol. 2011 Jun 1;519(8):1435-54. doi: 10.1002/cne.22610.

PMID:
21452234
27.

Coronin 1-mediated naive T cell survival is essential for the development of autoimmune encephalomyelitis.

Siegmund K, Zeis T, Kunz G, Rolink T, Schaeren-Wiemers N, Pieters J.

J Immunol. 2011 Mar 15;186(6):3452-61. doi: 10.4049/jimmunol.1003491. Epub 2011 Feb 2.

28.

MAL/VIP17, a new player in the regulation of NKCC2 in the kidney.

Carmosino M, Rizzo F, Procino G, Basco D, Valenti G, Forbush B, Schaeren-Wiemers N, Caplan MJ, Svelto M.

Mol Biol Cell. 2010 Nov 15;21(22):3985-97. doi: 10.1091/mbc.E10-05-0456. Epub 2010 Sep 22.

29.

Gene expression profiling in nerve biopsy of vasculitic neuropathy.

Kinter J, Broglio L, Steck AJ, Tolnay M, Fuhr P, Latov N, Kalbermatten D, Sinnreich M, Schaeren-Wiemers N, Renaud S.

J Neuroimmunol. 2010 Aug 25;225(1-2):184-9. doi: 10.1016/j.jneuroim.2010.05.023. Epub 2010 Jun 12.

PMID:
20542337
30.

Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth.

Rauskolb S, Zagrebelsky M, Dreznjak A, Deogracias R, Matsumoto T, Wiese S, Erne B, Sendtner M, Schaeren-Wiemers N, Korte M, Barde YA.

J Neurosci. 2010 Feb 3;30(5):1739-49. doi: 10.1523/JNEUROSCI.5100-09.2010.

31.
32.

The myelin protein MAL affects peripheral nerve myelination: a new player influencing p75 neurotrophin receptor expression.

Buser AM, Schmid D, Kern F, Erne B, Lazzati T, Schaeren-Wiemers N.

Eur J Neurosci. 2009 Jun;29(12):2276-90. doi: 10.1111/j.1460-9568.2009.06785.x. Epub 2009 Jun 8.

PMID:
19508690
33.

Immunoglobulin M deposition in cutaneous nerves of anti-myelin-associated glycoprotein polyneuropathy patients correlates with axonal degeneration.

Stalder AK, Erne B, Reimann R, Renaud S, Fuhr P, Thomann S, Arnold A, Probst A, Schaeren-Wiemers N, Steck AJ.

J Neuropathol Exp Neurol. 2009 Feb;68(2):148-58. doi: 10.1097/NEN.0b013e3181958187.

PMID:
19151627
34.

The septin cytoskeleton in myelinating glia.

Buser AM, Erne B, Werner HB, Nave KA, Schaeren-Wiemers N.

Mol Cell Neurosci. 2009 Feb;40(2):156-66. doi: 10.1016/j.mcn.2008.10.002. Epub 2008 Nov 1.

PMID:
19026747
35.

Molecular changes in white matter adjacent to an active demyelinating lesion in early multiple sclerosis.

Zeis T, Probst A, Steck AJ, Stadelmann C, Brück W, Schaeren-Wiemers N.

Brain Pathol. 2009 Jul;19(3):459-66. doi: 10.1111/j.1750-3639.2008.00231.x. Epub 2008 Oct 31.

PMID:
19016740
36.

Gene expression analysis of normal appearing brain tissue in an animal model for multiple sclerosis revealed grey matter alterations, but only minor white matter changes.

Zeis T, Kinter J, Herrero-Herranz E, Weissert R, Schaeren-Wiemers N.

J Neuroimmunol. 2008 Dec 15;205(1-2):10-9. doi: 10.1016/j.jneuroim.2008.09.009. Epub 2008 Oct 23.

PMID:
18950873
37.

Allograft inflammatory factor-1: a pathogenetic factor for vasculitic neuropathy.

Broglio L, Erne B, Tolnay M, Schaeren-Wiemers N, Fuhr P, Steck AJ, Renaud S.

Muscle Nerve. 2008 Oct;38(4):1272-9. doi: 10.1002/mus.21033.

PMID:
18816612
38.

RNA profiling of MS brain tissues.

Kinter J, Zeis T, Schaeren-Wiemers N.

Int MS J. 2008 Jun;15(2):51-8. Review.

PMID:
18782500
39.

Lame ducks or fierce creatures? The role of oligodendrocytes in multiple sclerosis.

Zeis T, Schaeren-Wiemers N.

J Mol Neurosci. 2008 May;35(1):91-100. doi: 10.1007/s12031-008-9042-1. Epub 2008 Feb 16. Review.

PMID:
18278568
40.

Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection.

Zeis T, Graumann U, Reynolds R, Schaeren-Wiemers N.

Brain. 2008 Jan;131(Pt 1):288-303. Epub 2007 Dec 4.

PMID:
18056737
41.

Normal expression of myelin protein zero with frame-shift mutation correlates with mild phenotype.

Steck AJ, Erne B, Pareyson D, Sghirlanzoni A, Taroni F, Schaeren-Wiemers N.

J Peripher Nerv Syst. 2006 Mar;11(1):61-6.

PMID:
16519783
42.
43.

Reversal of non-hydroxy:alpha-hydroxy galactosylceramide ratio and unstable myelin in transgenic mice overexpressing UDP-galactose:ceramide galactosyltransferase.

Fewou SN, Büssow H, Schaeren-Wiemers N, Vanier MT, Macklin WB, Gieselmann V, Eckhardt M.

J Neurochem. 2005 Jul;94(2):469-81.

44.

[Endogenous neuroprotective mechanisms in multiple sclerosis].

Schaeren-Wiemers N.

Praxis (Bern 1994). 2005 Feb 9;94(6):205-8. German. No abstract available.

PMID:
15754532
45.

IgM deposits on skin nerves in anti-myelin-associated glycoprotein neuropathy.

Lombardi R, Erne B, Lauria G, Pareyson D, Borgna M, Morbin M, Arnold A, Czaplinski A, Fuhr P, Schaeren-Wiemers N, Steck AJ.

Ann Neurol. 2005 Feb;57(2):180-7.

PMID:
15668968
46.

The raft-associated protein MAL is required for maintenance of proper axon--glia interactions in the central nervous system.

Schaeren-Wiemers N, Bonnet A, Erb M, Erne B, Bartsch U, Kern F, Mantei N, Sherman D, Suter U.

J Cell Biol. 2004 Aug 30;166(5):731-42.

47.

Specific downregulation and mistargeting of the lipid raft-associated protein MAL in a glycolipid storage disorder.

Saravanan K, Schaeren-Wiemers N, Klein D, Sandhoff R, Schwarz A, Yaghootfam A, Gieselmann V, Franken S.

Neurobiol Dis. 2004 Jul;16(2):396-406.

PMID:
15193296
48.

Metachromatic leukodystrophy: consequences of sulphatide accumulation.

Gieselmann V, Franken S, Klein D, Mansson JE, Sandhoff R, Lüllmann Rauch R, Hartmann D, Saravanan VP, De Deyn PP, D'Hooge R, Van Der Linden AM, Schaeren-Wiemers N.

Acta Paediatr Suppl. 2003 Dec;92(443):74-9; discussion 45.

PMID:
14989469
49.
50.

Characterization of human nerve basal lamina for their binding properties of anti-MAG antibodies.

Sollberger M, Erne B, Sansano S, Steck AJ, Schaeren-Wiemers N.

J Neurocytol. 2002 Jan;31(1):5-14.

PMID:
12652083

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