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Cell-Free Oxyhemoglobin in Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage: Biomarker and Potential Therapeutic Target.

Hugelshofer M, Sikorski CM, Seule M, Deuel J, Muroi CI, Seboek M, Akeret K, Buzzi R, Regli L, Schaer DJ, Keller E.

World Neurosurg. 2018 Aug 27. pii: S1878-8750(18)31924-7. doi: 10.1016/j.wneu.2018.08.141. [Epub ahead of print]


FcγRIIIa-dependent IFN-γ release in whole blood assay is predictive of therapeutic IgG1 antibodies safety.

Alakhras NS, Qiu J, Rocha GV, Witcher DR, Koester A, You J, Schaer DA, Holmgaard RB, Driscoll K, Willy JA, Malherbe LP.

MAbs. 2018 Aug/Sep;10(6):913-921. doi: 10.1080/19420862.2018.1474996. Epub 2018 Jul 26.


Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade.

Holmgaard RB, Schaer DA, Li Y, Castaneda SP, Murphy MY, Xu X, Inigo I, Dobkin J, Manro JR, Iversen PW, Surguladze D, Hall GE, Novosiadly RD, Benhadji KA, Plowman GD, Kalos M, Driscoll KE.

J Immunother Cancer. 2018 Jun 4;6(1):47. doi: 10.1186/s40425-018-0356-4.


Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody.

Gombos RB, Gonzalez A, Manrique M, Chand D, Savitsky D, Morin B, Breous-Nystrom E, Dupont C, Ward RA, Mundt C, Duckless B, Tang H, Findeis MA, Schuster A, Waight JD, Underwood D, Clarke C, Ritter G, Merghoub T, Schaer D, Wolchok JD, van Dijk M, Buell JS, Cuillerot JM, Stein R, Drouin EE, Wilson NS.

PLoS One. 2018 Apr 4;13(4):e0191926. doi: 10.1371/journal.pone.0191926. eCollection 2018.


Revisiting the putative role of heme as a trigger of inflammation.

Vallelian F, Schaer CA, Deuel JW, Ingoglia G, Humar R, Buehler PW, Schaer DJ.

Pharmacol Res Perspect. 2018 Mar 30;6(2):e00392. doi: 10.1002/prp2.392. eCollection 2018 Apr.


Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics.

Schaer CA, Owczarek C, Deuel JW, Schauer S, Baek JH, Yalamanoglu A, Hardy MP, Scotney PD, Schmidt PM, Pelzing M, Soupourmas P, Buehler PW, Schaer DJ.

BMC Biotechnol. 2018 Mar 15;18(1):15. doi: 10.1186/s12896-018-0424-3.


The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade.

Schaer DA, Beckmann RP, Dempsey JA, Huber L, Forest A, Amaladas N, Li Y, Wang YC, Rasmussen ER, Chin D, Capen A, Carpenito C, Staschke KA, Chung LA, Litchfield LM, Merzoug FF, Gong X, Iversen PW, Buchanan S, de Dios A, Novosiadly RD, Kalos M.

Cell Rep. 2018 Mar 13;22(11):2978-2994. doi: 10.1016/j.celrep.2018.02.053.


Impact of cell-free hemoglobin on contracting skeletal muscle microvascular oxygen pressure dynamics.

Ferguson SK, Harral JW, Pak DI, Redinius KM, Stenmark KR, Schaer DJ, Buehler PW, Irwin DC.

Nitric Oxide. 2018 Jun 1;76:29-36. doi: 10.1016/j.niox.2018.03.005. Epub 2018 Mar 8.



Mehra T, Schaer D.

Praxis (Bern 1994). 2017;106(21):1197. doi: 10.1024/1661-8157/a002786. German. No abstract available.


CME: Das Schweizer Fallpauschalensystem.

Mehra T, Schaer D.

Praxis (Bern 1994). 2017;106(20):1091-1097. doi: 10.1024/1661-8157/a002785. Review. German. No abstract available.


Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment.

Budhu S, Schaer DA, Li Y, Toledo-Crow R, Panageas K, Yang X, Zhong H, Houghton AN, Silverstein SC, Merghoub T, Wolchok JD.

Sci Signal. 2017 Aug 29;10(494). pii: eaak9702. doi: 10.1126/scisignal.aak9702.


Iron accelerates hemoglobin oxidation increasing mortality in vascular diseased guinea pigs following transfusion of stored blood.

Baek JH, Yalamanoglu A, Gao Y, Guenster R, Spahn DR, Schaer DJ, Buehler PW.

JCI Insight. 2017 May 4;2(9). pii: 93577. doi: 10.1172/jci.insight.93577. [Epub ahead of print]


Timing of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy.

Holmgaard RB, Brachfeld A, Gasmi B, Jones DR, Mattar M, Doman T, Murphy M, Schaer D, Wolchok JD, Merghoub T.

Oncoimmunology. 2016 Apr 25;5(7):e1151595. doi: 10.1080/2162402X.2016.1151595. eCollection 2016 Jul.


Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response.

Deuel JW, Schaer CA, Boretti FS, Opitz L, Garcia-Rubio I, Baek JH, Spahn DR, Buehler PW, Schaer DJ.

Cell Death Dis. 2016 Jan 21;7:e2064. doi: 10.1038/cddis.2015.392.


Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis.

Schaer CA, Deuel JW, Schildknecht D, Mahmoudi L, Garcia-Rubio I, Owczarek C, Schauer S, Kissner R, Banerjee U, Palmer AF, Spahn DR, Irwin DC, Vallelian F, Buehler PW, Schaer DJ.

Am J Respir Crit Care Med. 2016 May 15;193(10):1111-22. doi: 10.1164/rccm.201510-2058OC.


Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity.

Deuel JW, Vallelian F, Schaer CA, Puglia M, Buehler PW, Schaer DJ.

Free Radic Biol Med. 2015 Dec;89:931-43. doi: 10.1016/j.freeradbiomed.2015.09.016. Epub 2015 Oct 22.


Spin trapping combined with quantitative mass spectrometry defines free radical redistribution within the oxidized hemoglobin:haptoglobin complex.

Vallelian F, Garcia-Rubio I, Puglia M, Kahraman A, Deuel JW, Engelsberger WR, Mason RP, Buehler PW, Schaer DJ.

Free Radic Biol Med. 2015 Aug;85:259-68. doi: 10.1016/j.freeradbiomed.2015.04.023. Epub 2015 Apr 28.


Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice.

Gelderman MP, Baek JH, Yalamanoglu A, Puglia M, Vallelian F, Burla B, Vostal J, Schaer DJ, Buehler PW.

Haematologica. 2015 May;100(5):611-22. doi: 10.3324/haematol.2014.117325. Epub 2015 Jan 23.


Integrative proteome and transcriptome analysis of extramedullary erythropoiesis and its reversal by transferrin treatment in a mouse model of beta-thalassemia.

Vallelian F, Gelderman-Fuhrmann MP, Schaer CA, Puglia M, Opitz L, Baek JH, Vostal J, Buehler PW, Schaer DJ.

J Proteome Res. 2015 Feb 6;14(2):1089-100. doi: 10.1021/pr5010778. Epub 2015 Jan 23.


[CME. Biologics in vasculitis].

Scharl M, Schaer D, Vallelian F.

Praxis (Bern 1994). 2015 Jan 2;104(1):7-16; quiz 15. doi: 10.1024/1661-8157/a001876. German. No abstract available. Erratum in: Praxis (Bern 1994). 2015 Jan 28;104(3):116.


[Löfgren syndrome - the acute form of sarcoidosis].

Bayly L, Schaer D, Vallelian F.

Praxis (Bern 1994). 2014 Nov 26;103(24):1423-30. doi: 10.1024/1661-8157/a001845. Review. German. No abstract available.


Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development.

Schaer DJ, Vinchi F, Ingoglia G, Tolosano E, Buehler PW.

Front Physiol. 2014 Oct 28;5:415. doi: 10.3389/fphys.2014.00415. eCollection 2014. Review.


Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species-pharmacokinetic and therapeutic implications.

Boretti FS, Baek JH, Palmer AF, Schaer DJ, Buehler PW.

Front Physiol. 2014 Oct 9;5:385. doi: 10.3389/fphys.2014.00385. eCollection 2014.


[CME. Severe cutaneous drug reaction].

Deuel J, Schaer D, Schmid-Grendelmeier P, Vallelian F.

Praxis (Bern 1994). 2014 Oct 15;103(21):1231-43. doi: 10.1024/1661-8157/a001809. Review. German. No abstract available.


Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stress.

Vallelian F, Deuel JW, Opitz L, Schaer CA, Puglia M, Lönn M, Engelsberger W, Schauer S, Karnaukhova E, Spahn DR, Stocker R, Buehler PW, Schaer DJ.

Cell Death Differ. 2015 Apr;22(4):597-611. doi: 10.1038/cdd.2014.154. Epub 2014 Oct 10.


[Systemic glucocorticoids: diagnosis, prophylaxis and treatment of side effects].

Ritter A, Burow A, Vallelian F, Schaer D.

Praxis (Bern 1994). 2014 Aug 20;103(17):987-98; quiz 996. doi: 10.1024/1661-8157/a001747. Review. German. No abstract available.


Platelet membrane potential: unable to pull the plug on sepsis.

Schaer DA, Penn J, Jagpal S, Parikh A.

Crit Care. 2014 May 12;18(3):428. doi: 10.1186/cc13869. No abstract available.


Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy.

Schaer DA, Hirschhorn-Cymerman D, Wolchok JD.

J Immunother Cancer. 2014 Apr 15;2:7. doi: 10.1186/2051-1426-2-7. eCollection 2014. Review.


[Therapy of anaphylaxis].

Meyer M, Schaer D, Harr T, Vallelian F.

Praxis (Bern 1994). 2014 May 7;103(10):555-62; quiz 563-4. doi: 10.1024/1661-8157/a001664. German. No abstract available.


Extracellular Hb enhances cardiac toxicity in endotoxemic guinea pigs: protective role of haptoglobin.

Baek JH, Zhang X, Williams MC, Schaer DJ, Buehler PW, D'Agnillo F.

Toxins (Basel). 2014 Mar 31;6(4):1244-59. doi: 10.3390/toxins6041244.


GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability.

Schaer DA, Budhu S, Liu C, Bryson C, Malandro N, Cohen A, Zhong H, Yang X, Houghton AN, Merghoub T, Wolchok JD.

Cancer Immunol Res. 2013 Nov;1(5):320-31. doi: 10.1158/2326-6066.CIR-13-0086.


[Behçet disease].

Weber N, Schaer D, Vallelian F.

Praxis (Bern 1994). 2013 Nov 27;102(24):1445-53. doi: 10.1024/1661-8157/a001510. German. No abstract available.


Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage.

Schaer CA, Deuel JW, Bittermann AG, Rubio IG, Schoedon G, Spahn DR, Wepf RA, Vallelian F, Schaer DJ.

Cell Death Differ. 2013 Nov;20(11):1569-79. doi: 10.1038/cdd.2013.113. Epub 2013 Aug 30.


[Not a tropical, but a non the less exotic fever].

Gisler V, Schaer D, Wichmann W, Kerl K, Franzen D.

Praxis (Bern 1994). 2013 Aug 7;102(16):999-1003. doi: 10.1024/1661-8157/a001378. German.


Chloroquine interference with hemoglobin endocytic trafficking suppresses adaptive heme and iron homeostasis in macrophages: the paradox of an antimalarial agent.

Schaer CA, Laczko E, Schoedon G, Schaer DJ, Vallelian F.

Oxid Med Cell Longev. 2013;2013:870472. doi: 10.1155/2013/870472. Epub 2013 Jun 11.


Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies.

Schaer DJ, Buehler PW.

Cold Spring Harb Perspect Med. 2013 Jun 1;3(6). pii: a013433. doi: 10.1101/cshperspect.a013433. Review.


Biomarkers for immunostimulatory monoclonal antibodies in combination strategies for melanoma and other tumor types.

Ascierto PA, Kalos M, Schaer DA, Callahan MK, Wolchok JD.

Clin Cancer Res. 2013 Mar 1;19(5):1009-20. doi: 10.1158/1078-0432.CCR-12-2982.


Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity.

Lipiski M, Deuel JW, Baek JH, Engelsberger WR, Buehler PW, Schaer DJ.

Antioxid Redox Signal. 2013 Nov 10;19(14):1619-33. doi: 10.1089/ars.2012.5089. Epub 2013 Mar 28.


Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins.

Schaer DJ, Buehler PW, Alayash AI, Belcher JD, Vercellotti GM.

Blood. 2013 Feb 21;121(8):1276-84. doi: 10.1182/blood-2012-11-451229. Epub 2012 Dec 20. Review.


Inhibition of meningitis-associated neutrophil apoptosis by TNF-α depends on functional PI3-kinase in monocytes.

Recher M, Malipiero U, Schaer DJ, Koedel U, Pfister HW, Birchler T, Petrausch U, Claus H, Gast H, Fontana A.

J Leukoc Biol. 2013 Feb;93(2):259-66. doi: 10.1189/jlb.0511218. Epub 2012 Nov 8.


Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145.

Cooper CE, Schaer DJ, Buehler PW, Wilson MT, Reeder BJ, Silkstone G, Svistunenko DA, Bulow L, Alayash AI.

Antioxid Redox Signal. 2013 Jun 10;18(17):2264-73. doi: 10.1089/ars.2012.4547. Epub 2012 Aug 6.


Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy.

Baek JH, D'Agnillo F, Vallelian F, Pereira CP, Williams MC, Jia Y, Schaer DJ, Buehler PW.

J Clin Invest. 2012 Apr;122(4):1444-58. doi: 10.1172/JCI59770. Epub 2012 Mar 26.


Down selection of polymerized bovine hemoglobins for use as oxygen releasing therapeutics in a guinea pig model.

Baek JH, Zhou Y, Harris DR, Schaer DJ, Palmer AF, Buehler PW.

Toxicol Sci. 2012 Jun;127(2):567-81. doi: 10.1093/toxsci/kfs109. Epub 2012 Mar 12.


Modulation of GITR for cancer immunotherapy.

Schaer DA, Murphy JT, Wolchok JD.

Curr Opin Immunol. 2012 Apr;24(2):217-24. doi: 10.1016/j.coi.2011.12.011. Epub 2012 Jan 12. Review.


Expression of CD163 on human histiocytic cells is different in tuberculosis-induced and schistosomiasis-induced granulomas.

Strebel BM, Lepper PM, Schaer DJ, Sendensky AH, Kurrer MO.

Histopathology. 2012 Feb;60(3):511-4. doi: 10.1111/j.1365-2559.2011.04059.x. Epub 2011 Dec 14. No abstract available.


Activating transcription factor 1 directs Mhem atheroprotective macrophages through coordinated iron handling and foam cell protection.

Boyle JJ, Johns M, Kampfer T, Nguyen AT, Game L, Schaer DJ, Mason JC, Haskard DO.

Circ Res. 2012 Jan 6;110(1):20-33. doi: 10.1161/CIRCRESAHA.111.247577. Epub 2011 Nov 3.


Hiding the road signs that lead to tumor immunity.

Schaer DA, Lesokhin AM, Wolchok JD.

J Exp Med. 2011 Sep 26;208(10):1937-40. doi: 10.1084/jem.20111856. Review.


Detection of intra-tumor self antigen recognition during melanoma tumor progression in mice using advanced multimode confocal/two photon microscope.

Schaer DA, Li Y, Merghoub T, Rizzuto GA, Shemesh A, Cohen AD, Li Y, Avogadri F, Toledo-Crow R, Houghton AN, Wolchok JD.

PLoS One. 2011;6(6):e21214. doi: 10.1371/journal.pone.0021214. Epub 2011 Jun 22.


Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma.

Benezra M, Penate-Medina O, Zanzonico PB, Schaer D, Ow H, Burns A, DeStanchina E, Longo V, Herz E, Iyer S, Wolchok J, Larson SM, Wiesner U, Bradbury MS.

J Clin Invest. 2011 Jul;121(7):2768-80. doi: 10.1172/JCI45600. Epub 2011 Jun 13.


Extracellular hemoglobin polarizes the macrophage proteome toward Hb-clearance, enhanced antioxidant capacity and suppressed HLA class 2 expression.

Kaempfer T, Duerst E, Gehrig P, Roschitzki B, Rutishauser D, Grossmann J, Schoedon G, Vallelian F, Schaer DJ.

J Proteome Res. 2011 May 6;10(5):2397-408. doi: 10.1021/pr101230y. Epub 2011 Apr 14.


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